NOD.NOR-(D4Mit31-D4Mit310)/DvsJ

Stock number: 005510
Product name: NOD.Idd9/11^NOR CH4^NOR
Research areas: Diabetes and Obesity Research

Description

Diabetes onset and incidence among these congenic mice is significantly later and reduced compared to NOD/Lt mice.

Detailed description

This NOD/Lt congenic strain is carrying chr 4 alleles derived from strain NOR/Lt at the insulin dependent diabetes susceptibility 9 and 11 loci. Diabetes onset and incidence among NOD.NOR-D4Mit31-D4Mit310 congenic mice is significantly later and reduced. Similar to the Irvakine et al, 2005 publication it has been reported that this NOD.NOR- Idd9/11 congenic stock is resistant to Cyclophosphamide induced insulitis in both males and females.

This strain is useful for dissecting the role of non-MHC susceptibility genes in autoimmune diabetes.

Development

Genomic segments of Chr 4 extending from D4Mit31 (51.3cM) through D4Mit310 (21.9) found in earlier linkage studies to include diabetogenic loci Idd9 (42.6cM) and Idd11 (64.6cM) transferred from NOR/Lt to NOD/Lt. This NOR/Lt derived chromosomal segment is of C57BL/6J and DBA origin. Siblings carrying the D4Mit31- D4Mit310 from NOR/Lt were intercrossed to make homozygote. Additional microsatellite analysis confirm all other known Idd regions are NOD/Lt in origin. In 2005, The T1DR received this stock at generation N5F11.

Allele

Symbol: Idd9^NOR/LtJ
Name: NOR/LtJ
MGI accession ID: MGI:3582457
Generation method: QTL
Marker symbol: Idd9
Marker name: insulin dependent diabetes susceptibility 9
Chromosome: 4
Strain of origin: NOR/LtJ
Molecular note: This allele confers resistance to cyclophosphamide-induced insulitis compared to NOD/Jsd.

Allele

MGI accession ID: MGI:102068
Marker symbol: D4Mit310
Marker name: DNA Segment, Chr 4, Massachusetts Institute of Technology 310
Chromosome: 4

Allele

MGI accession ID: MGI:92866
Marker symbol: D4Mit31
Marker name: DNA segment, Chr 4, Massachusetts Institute of Technology 31
Chromosome: 4