B6.Cg-A^y Slc7a11^sut/LmLlp

Stock number: 005505
Research areas: Dermatology Research, Diabetes and Obesity Research, Endocrine Deficiency Research, Immunology, Inflammation and Autoimmunity Research, Internal/Organ Research, Mouse/Human Gene Homologs, Reproductive Biology Research, Research Tools

Description

This strain is extinct, please refer to Stock No. 001310

Allele

Symbol: A^y
Name: agouti yellow
MGI accession ID: MGI:1856798
Generation method: Spontaneous
Marker symbol: a
Marker name: nonagouti
Chromosome: 2
Strain of origin: old mutant of the mouse fancy
Molecular note: The A^y mutation appears to be a DNA structural alteration that disrupts a gene, hnRNP associated with lethal yellow (Raly), 5' to the agouti locus and places the agouti locus under the control of the Raly promotor. A report of recombination between A^y and the a and a^x alleles suggests that A^y was a pseudoallele of the a locus on the proximal side. However, cloning of the agouti locus and molecular analysis of a showed that the coding region of the three alleles is identical.

Allele

Symbol: Slc7a11^sut
Name: subtle gray
MGI accession ID: MGI:1857061
Generation method: Spontaneous
Marker symbol: Slc7a11
Marker name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Chromosome: 3
Strain of origin: C3H/HeSnJ
Molecular note: Sequencing revealed a large deletion extending from intron 11 through exon 12 and into the intergenic region, creating a new splice site and the replacement of exon 12 with exon 12'. 3' RACE revealed a new stop codon in exon 12' and predicted a modified and truncated protein carboxyl terminus.