|Allele Name||agouti yellow|
|Allele Synonym(s)||A(y); Ay|
|Gene Symbol and Name||a, nonagouti|
|Gene Synonym(s)||AGSW; AGTI; AGTIL; ASP; As; As; SHEP9; agouti; agouti signal protein; agouti suppressor|
|Strain of Origin||old mutant of the mouse fancy|
|General Note||Phenotypic Similarity to Human Syndrome: Metabolic Syndrome in mice homozygous for Apoetm1Unc and heterozygous for Ay and a (J:177084) |
|Molecular Note||The Ay mutation appears to be a DNA structural alteration that disrupts a gene, hnRNP associated with lethal yellow (Raly), 5' to the agouti locus and places the agouti locus under the control of the Raly promotor. A report of recombination between Ay and the a and ax alleles suggests that Ay was a pseudoallele of the a locus on the proximal side. However, cloning of the agouti locus and molecular analysis of a showed that the coding region of the three allelesis identical.|
|Allele Name||subtle gray|
|Gene Symbol and Name||Slc7a11, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11|
|Gene Synonym(s)||9930009M05Rik; 9930009M05Rik; AI451155; CCBR1; RIKEN cDNA 9930009M05 gene; System xc; expressed sequence AI451155; subtle gray; sut; sut; xc; xCT|
|Strain of Origin||C3H/HeSnJ|
|General Note||Phenotypic Similarity to Human Syndrome: Hermansky-Pudlak Syndrome (J:31616)|
|Molecular Note||Sequencing revealed a large deletion extending from intron 11 through exon 12 and into the intergenic region, creating a new splice site and the replacement of exon 12 with exon 12'. 3' RACE revealed a new stop codon in exon 12' and predicted a modified and truncated protein carboxyl terminus.|
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