Allele Name	agouti yellow
Allele Type	Spontaneous
Allele Synonym(s)	A(y); Ay
Gene Symbol and Name	a, nonagouti
Gene Synonym(s)
Strain of Origin	old mutant of the mouse fancy
Chromosome	2
Molecular Note	The A^y mutation appears to be a DNA structural alteration that disrupts a gene, hnRNP associated with lethal yellow (Raly), 5' to the agouti locus and places the agouti locus under the control of the Raly promotor. A report of recombination between A^y and the a and a^x alleles suggests that A^y was a pseudoallele of the a locus on the proximal side. However, cloning of the agouti locus and molecular analysis of a showed that the coding region of the three alleles is identical.

Slc7a11^sut

Allele Symbol: Slc7a11^sut

Allele Name	subtle gray
Allele Type	Spontaneous
Allele Synonym(s)	sut
Gene Symbol and Name	Slc7a11, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
Gene Synonym(s)
Strain of Origin	C3H/HeSnJ
Chromosome	3
Molecular Note	Sequencing revealed a large deletion extending from intron 11 through exon 12 and into the intergenic region, creating a new splice site and the replacement of exon 12 with exon 12'. 3' RACE revealed a new stop codon in exon 12' and predicted a modified and truncated protein carboxyl terminus.

Disease/Phenotype

Disease Terms

Models with phenotypic similarity to human diseases where etiology is unknown or involving genes where ortholog is unknown.

Research Areas By Phenotype

This mouse can be used to support research in many areas including:

Genotype: A^y related

Research Tools
- Reproductive Biology Research
Diabetes and Obesity Research
- Obesity With Diabetes
Endocrine Deficiency Research
- Adrenal Cortex Defects
- Adipose Defects
Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency Associated with Other Defects
Internal/Organ Research
- Adipose Defects
- Adrenal Cortex Defects
Reproductive Biology Research
- Endocrine Deficiencies Affecting Gonads
- Fertility Defects
Dermatology Research
- Color and White Spotting Defects

Genotype: Slc7a11^sut related

Dermatology Research
- Color and White Spotting Defects
Mouse/Human Gene Homologs
- Hermansky-Pudlak syndrome

Mammalian Phenotype Terms by Genotype

The following phenotype information is associated with a similar, but not exact match to this JAX^® Mice strain

Genotype: Slc7a11^sut/Slc7a11^sut
C3H/HeSnJ-Slc7a11/J

hematopoietic system phenotype

decreased platelet serotonin level
- platelet serotonin concentration is slightly reduced; no change in adenine nucleotide concentration

homeostasis/metabolism phenotype

increased bleeding time
- mutant mice have a 3.4 fold greater bleeding time compared to sib controls
- model for mild storage pool deficiency

decreased platelet serotonin level
- platelet serotonin concentration is slightly reduced; no change in adenine nucleotide concentration

integument phenotype

diluted coat color
- most easily seen with agouti especially in the juvenile coat
- yellow hair pigment is reduced; black pigment is unaffected
- on nonagouti some reduction in yellow pigment can be seen in the pinna hairs only

nervous system phenotype

decreased platelet serotonin level
- platelet serotonin concentration is slightly reduced; no change in adenine nucleotide concentration

pigmentation phenotype

diluted coat color
- most easily seen with agouti especially in the juvenile coat
- on nonagouti some reduction in yellow pigment can be seen in the pinna hairs only
- yellow hair pigment is reduced; black pigment is unaffected

References

Additional - A^y related

Additional - Slc7a11^sut related

Technical Support

CONTACT TECHNICAL SUPPORT

Genotyping Protocols
- Separated PCR:A A A Alternate2
- Genotyping resources and troubleshooting

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Genetic overview

Research Applications

Control Suggestions

Additional Information

Ay

Allele Symbol: Ay

Slc7a11sut

Allele Symbol: Slc7a11sut