This strain is extinct, please refer to Stock No. 001310
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | a | nonagouti |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Slc7a11 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 |
Allele Name | agouti yellow |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | A(y); Ay |
Gene Symbol and Name | a, nonagouti |
Gene Synonym(s) | |
Strain of Origin | old mutant of the mouse fancy |
Chromosome | 2 |
Molecular Note | The Ay mutation appears to be a DNA structural alteration that disrupts a gene, hnRNP associated with lethal yellow (Raly), 5' to the agouti locus and places the agouti locus under the control of the Raly promotor. A report of recombination between Ay and the a and ax alleles suggests that Ay was a pseudoallele of the a locus on the proximal side. However, cloning of the agouti locus and molecular analysis of a showed that the coding region of the three alleles is identical. |
Allele Name | subtle gray |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | sut |
Gene Symbol and Name | Slc7a11, solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 |
Gene Synonym(s) | |
Strain of Origin | C3H/HeSnJ |
Chromosome | 3 |
Molecular Note | Sequencing revealed a large deletion extending from intron 11 through exon 12 and into the intergenic region, creating a new splice site and the replacement of exon 12 with exon 12'. 3' RACE revealed a new stop codon in exon 12' and predicted a modified and truncated protein carboxyl terminus. |
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