C57BL/6J-hlb385/J

Stock number: 005496
Strain synonyms: HLB-385, HLB385
Research areas: Hematological Research

Description

These mice carry an ENU-induced mutation resulting in lower levels of white blood cells.

Detailed description

Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) on standard chow identified a 7 week old female (born 12/13/2003) with a complete blood count (CBC) of 3.2 x 103 white blood cells (WBC)/ul, approximately 60% lower than controls. Retesting 2 weeks later confirmed the phenotype. This mutant mouse strain may be useful in studies of leukopeniia.

Development

Following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), a forward genetic screen was utilized to identify phenotypic deviants in complex heart, lung, blood, and sleep disorders, at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory. Initial mapping identified the location of the mutation in an interval of 42-48 cM on Chromosome 10.

Allele

Symbol: hlb385
Name: heart, lung and blood 385
MGI accession ID: MGI:3575131
Generation method: Chemically induced (ENU)
Marker symbol: hlb385
Marker name: heart, lung and blood 385
Chromosome: 10
Strain of origin: C57BL/6J
Molecular note: This phenotypic mutant was identified in an ENU mutagenesis screen.