JAX
Mouse Strain Datasheet - 005491
B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
Also Known As: htau
Mice that are homozygous for the targeted allele and hemizygous for the transgene express all six isoforms (including both 3R and 4R forms) of human microtubule-associated protein tau (MAPT). These mutant mice may be useful in studies examining the relationship between human MAPT and Alzheimer's disease pathogenesis
Donating Investigator
Peter Davies, Albert Einstein College of Medicine
Karen Duff, Nathan Kline Institute
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N9+N2F8
|
Mapttm1(EGFP)Klt
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout, Reporter) | Mapt | microtubule-associated protein tau |
Tg(MAPT)8cPdav
| Allele Type |
|---|
| Transgenic (Humanized sequence, Inserted expressed sequence) |
Base Price
Starting at:
| $246.50 Domestic price for female |
| $510.00 Domestic price for breeder pair |
Detailed Description
Mice that are homozygous for the targeted allele and hemizygous for the transgene are viable and fertile. Although no endogenous mouse MAPT is detected, all six isoforms (including both 3R and 4R forms) of human MAPT are expressed. Hyperphosphorylated MAPT is detected in cell bodies and dendrites by three months of age. Paired helical filaments of aggregated insoluble MAPT can be isolated from brain tissue as early as two months of age. These mutant mice may be useful in studies examining the relationship between human MAPT and Alzheimer's disease pathogenesis
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
Double mutant mice were generated by crossing transgenic mice (mouse line 8C) with Mapt targeted mutant mice. The targeted mutant allele was created by inserting EGFP coding sequence into the first Mapt exon, disrupting expression of the Mapt gene and producing a cytoplasmic EGFP protein fused to the first 31 MAPT amino acids (see Stock Number 004779). The transgenic allele consists of a PAC insert of 200-250 kb that includes the coding sequence, intronic regions and regulatory elements of the human MAPT gene. The targeted allele was created in 129S4/SvJae-derived J1 embryonic stem cells which were subsequently injected into C57BL/6 blastocysts. The transgenic allele was generated in embryos derived from a cross between Swiss Webster females and B6D2F1 males. Mice containing both alleles were crossed to C57BL/6 mice for nine generations by the donating investigator. Upon arrival at The Jackson Laboratory, the mice were crossed once more to C57BL/6 (N10). Offspring were mated to generate mice that are homozygous at the targeted mutant allele.
Expression Data
| Expressed Gene | GFP, Green Fluorescent Protein, |
|---|---|
| Site of Expression | GFP signal is detected beginning a embryonic day 9 in the trigeminal ganglion and throughout the developing central nervous system by embryonic day 10.75. GFP expression persists in adults and closely resembles the expression of neuron specific beta-tubulin III. |
| Expressed Gene | MAPT, microtubule associated protein tau, human |
| Site of Expression | Neurons: EGFP signal observed at 9.0 dpc (days post-coitum) in the trilgeminal ganglion. At 10.75 dpc. EGFP was seen throughout the developing nervous system. |
Control Suggestions
- Mice from the colony that are homozygous for the targeted mutation and noncarrier for the transgene should be considered for use as controls. The most appropriate control animal will depend on the nature of the experiment.
- 000664 C57BL/6J
Additional Information
Selected References
- Andorfer C; Kress Y; Espinoza M; de Silva R; Tucker KL; Barde YA; Duff K; Davies P. 2003. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 86(3):582-90. PubMed: 12859672MGI: J:84638
Mapttm1(EGFP)Klt
Allele Symbol: Mapttm1(EGFP)Klt
| Allele Name | targeted mutation 1, Kerry Lee Tucker |
|---|---|
| Allele Type | Targeted (Null/Knockout, Reporter) |
| Allele Synonym(s) | Mapttm1(GFP)Klt; tau ko; tauGFP |
| Gene Symbol and Name | Mapt, microtubule-associated protein tau |
| Gene Synonym(s) | AI413597; AW045860; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; Mtapt; Mtapt; PPND; PPP1R103; RNPTAU; TAU; Tau; Tau; expressed sequence AI413597; expressed sequence AW045860; pTau |
| Expressed Gene | GFP, Green Fluorescent Protein, |
| Site of Expression | GFP signal is detected beginning a embryonic day 9 in the trigeminal ganglion and throughout the developing central nervous system by embryonic day 10.75. GFP expression persists in adults and closely resembles the expression of neuron specific beta-tubulin III. |
| Strain of Origin | 129S4/SvJae |
| Chromosome | 11 |
| Molecular Note | Exon 1 was disrupted by the insertion of a cassette encoding EGFP and neo. Fusion protein including GFP was detected by Western blot analysis of homozygous mutant brain lysates. Fluorescent illumination indicated that expression of the reporter gene was similar to that of the endogenous gene. |
| Mutations Made By | Dr. Kerry Tucker, Ruprecht Karls University of Heidelberg |
Tg(MAPT)8cPdav
Allele Symbol: Tg(MAPT)8cPdav
| Allele Name | transgene insertion 8c, Peter Davies |
|---|---|
| Allele Type | Transgenic (Humanized sequence, Inserted expressed sequence) |
| Allele Synonym(s) | 8c; hTau |
| Gene Symbol and Name | Tg(MAPT)8cPdav, transgene insertion 8c, Peter Davies |
| Gene Synonym(s) | 8c |
| Promoter | MAPT, microtubule associated protein tau, human |
| Expressed Gene | MAPT, microtubule associated protein tau, human |
| Site of Expression | Neurons: EGFP signal observed at 9.0 dpc (days post-coitum) in the trilgeminal ganglion. At 10.75 dpc. EGFP was seen throughout the developing nervous system. |
| Strain of Origin | Swiss Webster x (C57BL/6 x DBA)F1 |
| Chromosome | UN |
| General Note | Mice that are homozygous for the Mapttm1(GFP)Klt allele and hemizygous for the transgene are viable and fertile. Although no endogenous mouse MAPT is detected, all six isoforms (including both 3R and 4R forms) of human MAPT are expressed. Hyperphosphorylated MAPT is detected in cell bodies and dendrites by 3 months of age. Paired helical filaments of aggregated insoluble MAPT can be isolated from brain tissue as early as 2 months of age. |
| Molecular Note | The transgene contains the coding sequence, intronic regions, and regulatory elements of the human microtubule-associated protein tau (MAPT) gene. |
| Mutations Made By | Peter Davies, Albert Einstein College of Medicine |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Neurobiology Research
- Alzheimer's Disease
- Research Tools
- Fluorescent Proteins
- Genetics Research
- Tissue/Cell Markers
- Tissue/Cell Markers: neurons
- Neurobiology Research
- cell marker
Genotype: GFP related
- Research Tools
- Fluorescent Proteins
Genotype: MAPT related
- Neurobiology Research
- Alzheimer's Disease
- Parkinson's Disease
Genotype: Mapttm1(EGFP)Klt related
- Neurobiology Research
- Alzheimer's Disease
- Tau (Mapt) mutants
- Alzheimer's Disease
Genotype: Tg(MAPT)8cPdav related
- Neurobiology Research
- Alzheimer's Disease
- Tau (Mapt) mutants
- Alzheimer's Disease
Mammalian Phenotype Terms by Genotype
Genotype: Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/0
B6.Cg-Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/J
behavior/neurological phenotype
- abnormal spatial learning
- 6 month old mutants exhibit slower visuospatial learning than control mice (MGI Ref ID J:172426)
- however, mutants perform better than Tg(APPswe,PSEN1dE9)85Dbo mice on the visuospatial re-learning test at 9 and 18 months of age (MGI Ref ID J:172426)
- in the visuospatial re-learning test performed at 7, 8, 9, and 15 months of age, mutants exhibit a decrease in the speed of re-learning the task compared to controls (MGI Ref ID J:172426)
taste/olfaction phenotype
- taste/olfaction phenotype
- mutants do not exhibit Alzheimer's disease-related impairment in olfactory performance in tests based on an operant conditioning procedure and in tests based on a habituation/dishabituation procedure (MGI Ref ID J:172426)
nervous system phenotype
- neurofibrillary tangles
- (MGI Ref ID J:172426)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Mapttm1(EGFP)Klt/Mapttm1(EGFP)Klt Tg(MAPT)8cPdav/?
involves: 129S4/SvJae * C57BL/6 * Swiss Webster
nervous system phenotype
- abnormal neuron morphology
- cells in the cortex and hippocampus appear irregularly shaped, often with distorted processes in 13 month old mice (MGI Ref ID J:84638)
- tau protein deposits
- in particular, accumulations occur in entorhinal cortex, ventromedial hypothalamus, medial septum and the nucleus of the horizontal limb of the diagonal band (MGI Ref ID J:84638)
- increase in tau phosphorylation occurs at serine 202, threonine 231 and serine 235 as determined by immunoblot (MGI Ref ID J:84638)
- insoluble tau is present in both 2 and 9 month old mice (MGI Ref ID J:84638)
- paired helical filaments are observed in 9, 12 and 14 month old mice (MGI Ref ID J:84638)
- phosphorylated tau accumulates in neuronal cell bodies and dendrites of the hippocampus and neocortex as early as 3 months of age (MGI Ref ID J:84638)
- tau aggregates in the proximal dendrites have an average width of 15 nm and are not densely packed (MGI Ref ID J:84638)
hematopoietic system phenotype
- abnormal spleen B cell follicle morphology
- splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles (MGI Ref ID J:174270)
- abnormal spleen red pulp morphology
- splenic red pulp is largely obliterated (MGI Ref ID J:174270)
immune system phenotype
- abnormal spleen B cell follicle morphology
- splenic white pulp contains follicles that are larger and more irregular in shape than normal follicles and are often fused with adjacent follicles (MGI Ref ID J:174270)
- abnormal spleen red pulp morphology
- splenic red pulp is largely obliterated (MGI Ref ID J:174270)
renal/urinary system phenotype
- abnormal renal glomerulus morphology
- kidney glomeruli are dilated probably due to obstruction from the amyloid in the lumen or walls of medullary tubules especially in the papilla (MGI Ref ID J:174270)
neoplasm
- increased follicular lymphoma incidence
- splenic architecture is replaced by proliferated immature mononuclear cells arranged in follicular aggregates indicating follicular lymphoma (MGI Ref ID J:174270)
- increased lymphoma incidence
homeostasis/metabolism phenotype
- amyloidosis
- amyloid deposits in the heart are not composed of amyloid-beta peptide, but rather amyloid A (MGI Ref ID J:174270)
- amyloid is deposited concentrically in the perifollicular sheath, partly or completely encircling the follicles in the spleen (MGI Ref ID J:174270)
- in the kidney, amyloid deposits are seen in the glomeruli (MGI Ref ID J:174270)
- in the liver, amyloid deposit is in the walls of sinusoids or central veins (MGI Ref ID J:174270)
- some mutants older than 18 months exhibit amyloid deposits in the spleen, kidneys, liver, ovary and/or heart (MGI Ref ID J:174270)
References
- Andorfer C; Kress Y; Espinoza M; de Silva R; Tucker KL; Barde YA; Duff K; Davies P. 2003. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 86(3):582-90. PubMed: 12859672MGI: J:84638
Additional - Mapttm1(EGFP)Klt related
- Acker CM; Forest SK; Zinkowski R; Davies P; d'Abramo C. 2013. Sensitive quantitative assays for tau and phospho-tau in transgenic mouse models. Neurobiol Aging 34(1):338-50. PubMed: 22727277MGI: J:191604
- Ahmed T; Van der Jeugd A; Blum D; Galas MC; D'Hooge R; Buee L; Balschun D. 2014. Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletion. Neurobiol Aging :. PubMed: 24913895MGI: J:213115
- Alpar A; Tortoriello G; Calvigioni D; Niphakis MJ; Milenkovic I; Bakker J; Cameron GA; Hanics J; Morris CV; Fuzik J; Kovacs GG; Cravatt BF; Parnavelas JG; Andrews WD; Hurd YL; Keimpema E; Harkany T. 2014. Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling. Nat Commun 5:4421. PubMed: 25030704MGI: J:225214
- Ando K; Leroy K; Heraud C; Yilmaz Z; Authelet M; Suain V; De Decker R; Brion JP. 2011. Accelerated human mutant tau aggregation by knocking out murine tau in a transgenic mouse model. Am J Pathol 178(2):803-16. PubMed: 21281813MGI: J:169074
- Andorfer C; Acker CM; Kress Y; Hof PR; Duff K; Davies P. 2005. Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci 25(22):5446-54. PubMed: 15930395MGI: J:98717
- Avale ME; Rodriguez-Martin T; Gallo JM. 2013. Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing. Hum Mol Genet 22(13):2603-11. PubMed: 23459933MGI: J:198237
- Bharadwaj P; McInnis C; Madden AM; Bonthuis PJ; Zup S; Rissman EF; Park JH. 2013. Increased dendritic spine density and tau expression are associated with individual differences in steroidal regulation of male sexual behavior. PLoS One 8(7):e69672. PubMed: 23874981MGI: J:204389
- Borghgraef P; Menuet C; Theunis C; Louis JV; Devijver H; Maurin H; Smet-Nocca C; Lippens G; Hilaire G; Gijsen H; Moechars D; Van Leuven F. 2013. Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice. PLoS One 8(12):e84442. PubMed: 24376810MGI: J:209849
- Boutajangout A; Quartermain D; Sigurdsson EM. 2010. Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J Neurosci 30(49):16559-66. PubMed: 21147995MGI: J:166739
- Chanda S; Marro S; Wernig M; Sudhof TC. 2013. Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation. Proc Natl Acad Sci U S A 110(41):16622-7. PubMed: 24046374MGI: J:202326
- Chiasseu M; Cueva Vargas JL; Destroismaisons L; Vande Velde C; Leclerc N; Di Polo A. 2016. Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in Glaucoma. J Neurosci 36(21):5785-98. PubMed: 27225768MGI: J:232101
- Dassie E; Andrews MR; Bensadoun JC; Cacquevel M; Schneider BL; Aebischer P; Wouters FS; Richardson JC; Hussain I; Howlett DR; Spillantini MG; Fawcett JW. 2013. Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model. Neurobiol Aging 34(5):1355-68. PubMed: 23273572MGI: J:203375
- Dickey CA; Kamal A; Lundgren K; Klosak N; Bailey RM; Dunmore J; Ash P; Shoraka S; Zlatkovic J; Eckman CB; Patterson C; Dickson DW; Nahman NS Jr; Hutton M; Burrows F; Petrucelli L. 2007. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest 117(3):648-58. PubMed: 17304350MGI: J:120752
- Flach K; Ramminger E; Hilbrich I; Arsalan-Werner A; Albrecht F; Herrmann L; Goedert M; Arendt T; Holzer M. 2014. Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding. Biochim Biophys Acta 1842(9):1527-38. PubMed: 24905733MGI: J:217926
- Geiszler PC; Barron MR; Pardon MC. 2016. Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience 329:98-111. PubMed: 27167086MGI: J:235967
- Gratuze M; Julien J; Morin F; Calon F; Hebert SS; Marette A; Planel E. 2016. High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology. Neurobiol Aging 47:71-73. PubMed: 27565300MGI: J:239559
- Holmes BB; Furman JL; Mahan TE; Yamasaki TR; Mirbaha H; Eades WC; Belaygorod L; Cairns NJ; Holtzman DM; Diamond MI. 2014. Proteopathic tau seeding predicts tauopathy in vivo. Proc Natl Acad Sci U S A 111(41):E4376-85. PubMed: 25261551MGI: J:216453
- Ittner A; Chua SW; Bertz J; Volkerling A; van der Hoven J; Gladbach A; Przybyla M; Bi M; van Hummel A; Stevens CH; Ippati S; Suh LS; Macmillan A; Sutherland G; Kril JJ; Silva AP; Mackay JP; Poljak A; Delerue F; Ke YD; Ittner LM. 2016. Site-specific phosphorylation of tau inhibits amyloid-beta toxicity in Alzheimer's mice. Science 354(6314):904-908. PubMed: 27856911MGI: J:237200
- Ittner LM; Ke YD; Delerue F; Bi M; Gladbach A; van Eersel J; Wolfing H; Chieng BC; Christie MJ; Napier IA; Eckert A; Staufenbiel M; Hardeman E; Gotz J. 2010. Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. Cell 142(3):387-97. PubMed: 20655099MGI: J:164597
- Keimpema E; Barabas K; Morozov YM; Tortoriello G; Torii M; Cameron G; Yanagawa Y; Watanabe M; Mackie K; Harkany T. 2010. Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding. J Neurosci 30(42):13992-4007. PubMed: 20962221MGI: J:165476
- Kelleher I; Garwood C; Hanger DP; Anderton BH; Noble W. 2007. Kinase activities increase during the development of tauopathy in htau mice. J Neurochem 103(6):2256-67. PubMed: 17908241MGI: J:128741
- Kickstein E; Krauss S; Thornhill P; Rutschow D; Zeller R; Sharkey J; Williamson R; Fuchs M; Kohler A; Glossmann H; Schneider R; Sutherland C; Schweiger S. 2010. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci U S A :. PubMed: 21098287MGI: J:167148
- Komuro Y; Xu G; Bhaskar K; Lamb BT. 2015. Human tau expression reduces adult neurogenesis in a mouse model of tauopathy. Neurobiol Aging 36(6):2034-42. PubMed: 25863528MGI: J:222621
- Korets-Smith E; Lindemann L; Tucker KL; Jiang C; Kabacs N; Belteki G; Haigh J; Gertsenstein M; Nagy A. 2004. Cre recombinase specificity defined by the tau locus. Genesis 40(3):131-8. PubMed: 15493019MGI: J:94203
- Leroy K; Ando K; Laporte V; Dedecker R; Suain V; Authelet M; Heraud C; Pierrot N; Yilmaz Z; Octave JN; Brion JP. 2012. Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice. Am J Pathol 181(6):1928-40. PubMed: 23026200MGI: J:190305
- Levine S; Saltzman A; Levy E; Ginsberg SD. 2009. Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease. Exp Mol Pathol 86(1):18-22. PubMed: 19041304MGI: J:174270
- Liu C; Song X; Nisbet R; Gotz J. 2016. Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in Disease. J Biol Chem 291(15):8173-88. PubMed: 26861879MGI: J:232722
- Nussbaum JM; Schilling S; Cynis H; Silva A; Swanson E; Wangsanut T; Tayler K; Wiltgen B; Hatami A; Ronicke R; Reymann K; Hutter-Paier B; Alexandru A; Jagla W; Graubner S; Glabe CG; Demuth HU; Bloom GS. 2012. Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-beta. Nature 485(7400):651-5. PubMed: 22660329MGI: J:186639
- Pacheco CD; Elrick MJ; Lieberman AP. 2009. Tau deletion exacerbates the phenotype of Niemann-Pick type C mice and implicates autophagy in pathogenesis. Hum Mol Genet 18(5):956-65. PubMed: 19074461MGI: J:145003
- Papanikolopoulou K; Skoulakis EM. 2015. Temporally distinct phosphorylations differentiate Tau-dependent learning deficits and premature mortality in Drosophila. Hum Mol Genet 24(7):2065-77. PubMed: 25524708MGI: J:219593
- Phillips M; Boman E; Osterman H; Willhite D; Laska M. 2011. Olfactory and visuospatial learning and memory performance in two strains of Alzheimer's disease model mice-a longitudinal study. PLoS One 6(5):e19567. PubMed: 21573167MGI: J:172426
- Polydoro M; Acker CM; Duff K; Castillo PE; Davies P. 2009. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci 29(34):10741-9. PubMed: 19710325MGI: J:152310
- Pozueta J; Lefort R; Shelanski ML. 2013. Synaptic changes in Alzheimer's disease and its models. Neuroscience 251:51-65. PubMed: 22687952MGI: J:207068
- Raciti M; Granzotto M; Duc MD; Fimiani C; Cellot G; Cherubini E; Mallamaci A. 2013. Reprogramming fibroblasts to neural-precursor-like cells by structured overexpression of pallial patterning genes. Mol Cell Neurosci 57:42-53. PubMed: 24128663MGI: J:215737
- Rosa E; Mahendram S; Ke YD; Ittner LM; Ginsberg SD; Fahnestock M. 2016. Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease. Neurobiol Aging 48:135-142. PubMed: 27676333MGI: J:239562
- Sherman MA; LaCroix M; Amar F; Larson ME; Forster C; Aguzzi A; Bennett DA; Ramsden M; Lesne SE. 2016. Soluble Conformers of Abeta and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci 36(37):9647-58. PubMed: 27629715MGI: J:240514
- Tucker KL; Meyer M; Barde YA. 2001. Neurotrophins are required for nerve growth during development. Nat Neurosci 4(1):29-37. PubMed: 11135642MGI: J:66561
- Wapinski OL; Vierbuchen T; Qu K; Lee QY; Chanda S; Fuentes DR; Giresi PG; Ng YH; Marro S; Neff NF; Drechsel D; Martynoga B; Castro DS; Webb AE; Sudhof TC; Brunet A; Guillemot F; Chang HY; Wernig M. 2013. Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell 155(3):621-35. PubMed: 24243019MGI: J:241054
- Wegmann S; Maury EA; Kirk MJ; Saqran L; Roe A; DeVos SL; Nicholls S; Fan Z; Takeda S; Cagsal-Getkin O; William CM; Spires-Jones TL; Pitstick R; Carlson GA; Pooler AM; Hyman BT. 2015. Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity. EMBO J 34(24):3028-41. PubMed: 26538322MGI: J:228080
- Whittington RA; Virag L; Gratuze M; Petry FR; Noel A; Poitras I; Truchetti G; Marcouiller F; Papon MA; El Khoury N; Wong K; Bretteville A; Morin F; Planel E. 2015. Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro. Neurobiol Aging 36(8):2414-28. PubMed: 26058840MGI: J:225440
- Willaredt MA; Hasenpusch-Theil K; Gardner HA; Kitanovic I; Hirschfeld-Warneken VC; Gojak CP; Gorgas K; Bradford CL; Spatz J; Wolfl S; Theil T; Tucker KL. 2008. A crucial role for primary cilia in cortical morphogenesis. J Neurosci 28(48):12887-900. PubMed: 19036983MGI: J:142500
- Xia D; Li C; Gotz J. 2015. Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines. Biochim Biophys Acta 1852(5):913-24. PubMed: 25558816MGI: J:234457
- Xiong Y; Jing XP; Zhou XW; Wang XL; Yang Y; Sun XY; Qiu M; Cao FY; Lu YM; Liu R; Wang JZ. 2013. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging 34(3):745-56. PubMed: 22892311MGI: J:194513
- Xu L; Ryu J; Nguyen JV; Arena J; Rha E; Vranis P; Hitt D; Marsh-Armstrong N; Koliatsos VE. 2015. Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury. Exp Neurol 273:168-76. PubMed: 26311071MGI: J:229560
- Yuan A; Kumar A; Peterhoff C; Duff K; Nixon RA. 2008. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci 28(7):1682-7. PubMed: 18272688MGI: J:132278
- Zaghetto AA; Paina S; Mantero S; Platonova N; Peretto P; Bovetti S; Puche A; Piccolo S; Merlo GR. 2007. Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections. J Neurosci 27(36):9757-68. PubMed: 17804636MGI: J:124891
Additional - Tg(MAPT)8cPdav related
- Andorfer C; Acker CM; Kress Y; Hof PR; Duff K; Davies P. 2005. Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci 25(22):5446-54. PubMed: 15930395MGI: J:98717
- Avale ME; Rodriguez-Martin T; Gallo JM. 2013. Trans-splicing correction of tau isoform imbalance in a mouse model of tau mis-splicing. Hum Mol Genet 22(13):2603-11. PubMed: 23459933MGI: J:198237
- Bharadwaj P; McInnis C; Madden AM; Bonthuis PJ; Zup S; Rissman EF; Park JH. 2013. Increased dendritic spine density and tau expression are associated with individual differences in steroidal regulation of male sexual behavior. PLoS One 8(7):e69672. PubMed: 23874981MGI: J:204389
- Bhaskar K; Konerth M; Kokiko-Cochran ON; Cardona A; Ransohoff RM; Lamb BT. 2010. Regulation of tau pathology by the microglial fractalkine receptor. Neuron 68(1):19-31. PubMed: 20920788MGI: J:167757
- Boutajangout A; Quartermain D; Sigurdsson EM. 2010. Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J Neurosci 30(49):16559-66. PubMed: 21147995MGI: J:166739
- Dickey CA; Kamal A; Lundgren K; Klosak N; Bailey RM; Dunmore J; Ash P; Shoraka S; Zlatkovic J; Eckman CB; Patterson C; Dickson DW; Nahman NS Jr; Hutton M; Burrows F; Petrucelli L. 2007. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest 117(3):648-58. PubMed: 17304350MGI: J:120752
- Duff K; Knight H; Refolo LM; Sanders S; Yu X; Picciano M; Malester B; Hutton M; Adamson J; Goedert M; Burki K; Davies P. 2000. Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol Dis 7(2):87-98. PubMed: 10783293MGI: J:85952
- Geiszler PC; Barron MR; Pardon MC. 2016. Impaired burrowing is the most prominent behavioral deficit of aging htau mice. Neuroscience 329:98-111. PubMed: 27167086MGI: J:235967
- Giliberto L; d'Abramo C; Acker CM; Davies P; D'Adamio L. 2010. Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo. PLoS One 5(7):e11609. PubMed: 20661273MGI: J:163095
- Gratuze M; Julien J; Morin F; Calon F; Hebert SS; Marette A; Planel E. 2016. High-fat, high-sugar, and high-cholesterol consumption does not impact tau pathogenesis in a mouse model of Alzheimer's disease-like tau pathology. Neurobiol Aging 47:71-73. PubMed: 27565300MGI: J:239559
- Guo Q; Li H; Cole AL; Hur JY; Li Y; Zheng H. 2013. Modeling Alzheimer's Disease in mouse without mutant protein overexpression: cooperative and independent effects of Abeta and tau. PLoS One 8(11):e80706. PubMed: 24278307MGI: J:209782
- Kelleher I; Garwood C; Hanger DP; Anderton BH; Noble W. 2007. Kinase activities increase during the development of tauopathy in htau mice. J Neurochem 103(6):2256-67. PubMed: 17908241MGI: J:128741
- Kickstein E; Krauss S; Thornhill P; Rutschow D; Zeller R; Sharkey J; Williamson R; Fuchs M; Kohler A; Glossmann H; Schneider R; Sutherland C; Schweiger S. 2010. Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci U S A :. PubMed: 21098287MGI: J:167148
- Komuro Y; Xu G; Bhaskar K; Lamb BT. 2015. Human tau expression reduces adult neurogenesis in a mouse model of tauopathy. Neurobiol Aging 36(6):2034-42. PubMed: 25863528MGI: J:222621
- Levine S; Saltzman A; Levy E; Ginsberg SD. 2009. Systemic pathology in aged mouse models of Down's syndrome and Alzheimer's disease. Exp Mol Pathol 86(1):18-22. PubMed: 19041304MGI: J:174270
- Ma QL; Zuo X; Yang F; Ubeda OJ; Gant DJ; Alaverdyan M; Teng E; Hu S; Chen PP; Maiti P; Teter B; Cole GM; Frautschy SA. 2013. Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. J Biol Chem 288(6):4056-65. PubMed: 23264626MGI: J:195654
- Papanikolopoulou K; Skoulakis EM. 2015. Temporally distinct phosphorylations differentiate Tau-dependent learning deficits and premature mortality in Drosophila. Hum Mol Genet 24(7):2065-77. PubMed: 25524708MGI: J:219593
- Phillips M; Boman E; Osterman H; Willhite D; Laska M. 2011. Olfactory and visuospatial learning and memory performance in two strains of Alzheimer's disease model mice-a longitudinal study. PLoS One 6(5):e19567. PubMed: 21573167MGI: J:172426
- Polydoro M; Acker CM; Duff K; Castillo PE; Davies P. 2009. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci 29(34):10741-9. PubMed: 19710325MGI: J:152310
- Pozueta J; Lefort R; Shelanski ML. 2013. Synaptic changes in Alzheimer's disease and its models. Neuroscience 251:51-65. PubMed: 22687952MGI: J:207068
- Rosa E; Mahendram S; Ke YD; Ittner LM; Ginsberg SD; Fahnestock M. 2016. Tau downregulates BDNF expression in animal and cellular models of Alzheimer's disease. Neurobiol Aging 48:135-142. PubMed: 27676333MGI: J:239562
- Schoch KM; DeVos SL; Miller RL; Chun SJ; Norrbom M; Wozniak DF; Dawson HN; Bennett CF; Rigo F; Miller TM. 2016. Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model. Neuron 90(5):941-7. PubMed: 27210553MGI: J:240208
- Sherman MA; LaCroix M; Amar F; Larson ME; Forster C; Aguzzi A; Bennett DA; Ramsden M; Lesne SE. 2016. Soluble Conformers of Abeta and Tau Alter Selective Proteins Governing Axonal Transport. J Neurosci 36(37):9647-58. PubMed: 27629715MGI: J:240514
- Tucker KL; Meyer M; Barde YA. 2001. Neurotrophins are required for nerve growth during development. Nat Neurosci 4(1):29-37. PubMed: 11135642MGI: J:66561
- Whittington RA; Virag L; Gratuze M; Petry FR; Noel A; Poitras I; Truchetti G; Marcouiller F; Papon MA; El Khoury N; Wong K; Bretteville A; Morin F; Planel E. 2015. Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro. Neurobiol Aging 36(8):2414-28. PubMed: 26058840MGI: J:225440
- Xiong Y; Jing XP; Zhou XW; Wang XL; Yang Y; Sun XY; Qiu M; Cao FY; Lu YM; Liu R; Wang JZ. 2013. Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging 34(3):745-56. PubMed: 22892311MGI: J:194513
- Xu L; Ryu J; Nguyen JV; Arena J; Rha E; Vranis P; Hitt D; Marsh-Armstrong N; Koliatsos VE. 2015. Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury. Exp Neurol 273:168-76. PubMed: 26311071MGI: J:229560
- Yuan A; Kumar A; Peterhoff C; Duff K; Nixon RA. 2008. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci 28(7):1682-7. PubMed: 18272688MGI: J:132278