JAX
Mouse Strain Datasheet - 005427
B6.129P2-Ccr5tm1Kuz/J
Also Known As: CCR5 KO
Absence of chemokine (C-C motif) receptor 5 in these knock-out mice affects immune and a number of other physiological responses. They are useful for widespread studies of innate immunity.
Donating Investigator
Israel F. Charo, Gladstone Inst of Cardiovascular Disease, UCSF
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N11+F6
|
Ccr5tm1Kuz
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Ccr5 | chemokine (C-C motif) receptor 5 |
Research Applications
- Cancer Research
- Immunology, Inflammation and Autoimmunity Research
Detailed Description
At birth, mice homozygous for the targeted allele are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. No transcript is detected in splenocytes or peritoneal macrophages. Thioglycollate-elicited peritoneal macrophages from homozygotes exhibit a delayed period before reaching peak mobilization (72 hours vs. 36 for wild type mice).
In an attempt to offer alleles on well-characterized or multiple genetic backgrounds, alleles are frequently moved to a genetic background different from that on which an allele was first characterized. This is the case for the strain 5427. It should be noted that the phenotype could vary from that originally described. We will modify the strain description if necessary as published results become available.
Development
A targeting vector containing a neomycin resistance gene was used to disrupt the single coding exon of the targeted gene. The construct was electroporated into 129P2/OlaHsd-derived E14TG2A embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts to obtain chimeric animals. Mutant mice were maintained on a mixed C57BL/6 and 129P2 background for a period of time before they were donated to the Jackson Laboratory Induced Mutant Resource (IMR) by Dr. William Kuziel. Subsequently they were obtained by Dr. Israel Charo (Gladstone Institute of Cardiovascular Disease, UCSF) and backcrossed to C57BL/6 ten times before being imported once more into the IMR. The mice were crossed to C57BL/6J once upon arrival.
Control Suggestions
Selected References
- Kuziel WA; Dawson TC; Quinones M; Garavito E; Chenaux G; Ahuja SS; Reddick RL; Maeda N. 2003. CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice. Atherosclerosis 167(1):25-32. PubMed: 12618265MGI: J:84243
Ccr5tm1Kuz
Allele Symbol: Ccr5tm1Kuz
| Allele Name | targeted mutation 1, William A Kuziel |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | CCR5 KO; CCR5-; Cmkbr5tm1Kuz |
| Gene Symbol and Name | Ccr5, chemokine (C-C motif) receptor 5 |
| Gene Synonym(s) | CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; CMKBR5; Ckr5; Cmkbr5; Cmkbr5; IDDM22; chemokine (C-C) receptor 5 |
| Strain of Origin | 129P2/OlaHsd |
| Chromosome | 9 |
| Molecular Note | The exon containing the entire coding region was replaced with a neomycin resistance gene inserted by homologous recombination. |
| Mutations Made By | Dr. William Kuziel, Protein Design Laboratories |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Ccr5tm1Kuz related
- Cancer Research
- Growth Factors/Receptors/Cytokines
- Immunology, Inflammation and Autoimmunity Research
- Growth Factors/Receptors/Cytokines
Mammalian Phenotype Terms by Genotype
Genotype: Ccr5tm1Kuz/Ccr5tm1Kuz
B6.129P2-Ccr5tm1Kuz
behavior/neurological phenotype
- abnormal conditioned taste aversion behavior
- female mice develop a stronger ethanol-induced conditioned taste aversion compared with similarly treated wild-type mice (MGI Ref ID J:102583)
- behavior/neurological phenotype
- increased alcohol consumption
- in female but not male mice (MGI Ref ID J:102583)
- increased fluid intake
- of an ethanol, saccharin, or quinine solution (MGI Ref ID J:102583)
mortality/aging
- mortality/aging
- 40% mortality after kainic acid treatment (MGI Ref ID J:84037)
nervous system phenotype
- nervous system phenotype
vision/eye phenotype
- corneal vascularization
cardiovascular system phenotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Ccr5tm1Kuz/Ccr5tm1Kuz
involves: 129P2/OlaHsd * C57BL/6
immune system phenotype
- abnormal CD4-positive, alpha beta T cell morphology
- abnormal CD8-positive, alpha beta T cell morphology
- (MGI Ref ID J:110814)
- abnormal Kupffer cell morphology
- abnormal NK T cell physiology
- abnormal cytokine level
- mice expression one fifth the wild-type level of Ifng after day 3 and 7, while Il-4 is increased 75-fold and a 2-fold increase in Il-5 and -10 over wild-type (MGI Ref ID J:110814)
- decreased NK cell number
- 4 fold reduction of tumor infiltrating NK cells when mice are injected with B16 melanoma cells (MGI Ref ID J:135308)
- decreased microglial cell activation
- significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40 (MGI Ref ID J:153059)
- decreased susceptibility to induced colitis
- null mice show clinically less severe DSS-mediated colitis than wild-type or Ccr2-nulls (MGI Ref ID J:110814)
- decreased susceptibility to viral infection
- impaired macrophage chemotaxis
- increased NK T cell number
- null mice show a significant increase in NK 1.1+ T cells by day 3 and 7 of DSS-treatment; wild-type and Ccr2-null mice do not show as large of an increase (MGI Ref ID J:110814)
- increased susceptibility to fungal infection
- brains of infected mice develop loss of neural tissue integrity , and large amounts of extracellelular cryptococcal polysaccharide capsule (MGI Ref ID J:64293)
- by week 5 infected mice exhibit cryptococcal meningitis cranial swelling, ruffled fur, staggered gait, lethargy and unresponsiveness, and decreased limb function (MGI Ref ID J:64293)
- infected mice exhibit increased mononuclear cell recruitment to lungs, but not brain (MGI Ref ID J:64293)
- reduced survival following inoculation with Cryptococcus neoformans, 40% die by week 8 due to CNS infection (hydrocephalus) (MGI Ref ID J:64293)
behavior/neurological phenotype
- abnormal locomotor behavior
- mice show little reduction in activity with DSS treatment, unlike wild-type which become very lethargic with time (MGI Ref ID J:110814)
- abnormal long term spatial reference memory
- in a Morris water maze (MGI Ref ID J:153059)
- abnormal spatial learning
- improved learning performance in a Morris water maze after injection of beta amyloid 1-40 relative to controls (MGI Ref ID J:153059)
digestive/alimentary phenotype
- decreased susceptibility to induced colitis
- null mice show clinically less severe DSS-mediated colitis than wild-type or Ccr2-nulls (MGI Ref ID J:110814)
hematopoietic system phenotype
- abnormal CD4-positive, alpha beta T cell morphology
- abnormal CD8-positive, alpha beta T cell morphology
- (MGI Ref ID J:110814)
- abnormal Kupffer cell morphology
- abnormal NK T cell physiology
- decreased NK cell number
- 4 fold reduction of tumor infiltrating NK cells when mice are injected with B16 melanoma cells (MGI Ref ID J:135308)
- decreased microglial cell activation
- significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40 (MGI Ref ID J:153059)
- impaired macrophage chemotaxis
- increased NK T cell number
- null mice show a significant increase in NK 1.1+ T cells by day 3 and 7 of DSS-treatment; wild-type and Ccr2-null mice do not show as large of an increase (MGI Ref ID J:110814)
homeostasis/metabolism phenotype
- abnormal cytokine level
- mice expression one fifth the wild-type level of Ifng after day 3 and 7, while Il-4 is increased 75-fold and a 2-fold increase in Il-5 and -10 over wild-type (MGI Ref ID J:110814)
cellular phenotype
- impaired macrophage chemotaxis
nervous system phenotype
- abnormal astrocyte physiology
- significant reduction in activated astrocytes in the hippocampus 6 hours after injection of beta amyloid 1-40 (MGI Ref ID J:153059)
- abnormal glial cell physiology
- (MGI Ref ID J:153059)
- abnormal nervous system physiology
- decreased microglial cell activation
- significant reduction in activated microglia in the hippocampus 8 hours after injection of beta amyloid 1-40 (MGI Ref ID J:153059)
cardiovascular system phenotype
- abnormal Kupffer cell morphology
liver/biliary system phenotype
- abnormal Ito cell morphology
- complete suppression of hepatic stellate cell migration (MGI Ref ID J:152548)
- abnormal Kupffer cell morphology
- abnormal hepatocyte physiology
Genotype: Ccr5tm1Kuz/Ccr5tm1Kuz
involves: 129P2/OlaHsd
homeostasis/metabolism phenotype
- decreased susceptibility to injury
- after hypoxia exposure for 18 days, mice show lower right ventricular systolic pressure, less severe right ventricular hypertrophy, less muscularization of the distal pulmonary vessels with a smaller percentage of dividing Ki67-positive pulmonary vascular cells, lower counts of lung inflammatory monocytes and lower number of macrophages surrounding pulmonary vessels or present in the BAL fluid (MGI Ref ID J:227458)
cardiovascular system phenotype
- abnormal cardiovascular system physiology
- after hypoxia exposure for 18 days, distal pulmonary vessels exhibit less muscularization than wild-type mice, with a smaller percentage of dividing Ki67-positive pulmonary vascular cells (MGI Ref ID J:227458)
- abnormal heart size
- after hypoxia exposure for 18 days, right ventricular hypertrophy is less severe in mutants than in wild-type mice (MGI Ref ID J:227458)
- decreased right ventricle systolic pressure
- after hypoxia exposure for 18 days, right ventricular systolic pressure is lower in mutants than in wild-type mice (MGI Ref ID J:227458)
immune system phenotype
- decreased inflammatory response
- mice show lower counts of lung inflammatory monocytes than wild-type mice during both normoxia and hypoxia (MGI Ref ID J:227458)
- the number of macrophages surrounding pulmonary vessels or present in BAL fluid is not increased from normoxia to hypoxia as is seen in wild-type mice (MGI Ref ID J:227458)
References
- Kuziel WA; Dawson TC; Quinones M; Garavito E; Chenaux G; Ahuja SS; Reddick RL; Maeda N. 2003. CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout mice. Atherosclerosis 167(1):25-32. PubMed: 12618265MGI: J:84243
Additional - Ccr5tm1Kuz related
- Abonia JP; Austen KF; Rollins BJ; Joshi SK; Flavell RA; Kuziel WA; Koni PA; Gurish MF. 2005. Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2. Blood 105(11):4308-13. PubMed: 15705791MGI: J:98967
- Ajuebor MN; Aspinall AI; Zhou F; Le T; Yang Y; Urbanski SJ; Sidobre S; Kronenberg M; Hogaboam CM; Swain MG. 2005. Lack of chemokine receptor CCR5 promotes murine fulminant liver failure by preventing the apoptosis of activated CD1d-restricted NKT cells. J Immunol 174(12):8027-37. PubMed: 15944310MGI: J:100869
- Ajuebor MN; Wondimu Z; Hogaboam CM; Le T; Proudfoot AE; Swain MG. 2007. CCR5 deficiency drives enhanced natural killer cell trafficking to and activation within the liver in murine T cell-mediated hepatitis. Am J Pathol 170(6):1975-88. PubMed: 17525265MGI: J:122162
- Algood HM; Flynn JL. 2004. CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration. J Immunol 173(5):3287-96. PubMed: 15322191MGI: J:92716
- Aliberti J; Valenzuela JG; Carruthers VB; Hieny S; Andersen J; Charest H; Reis e Sousa C; Fairlamb A; Ribeiro JM; Sher A. 2003. Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells. Nat Immunol 4(5):485-90. PubMed: 12665855MGI: J:125439
- Ambati BK; Anand A; Joussen AM; Kuziel WA; Adamis AP; Ambati J. 2003. Sustained inhibition of corneal neovascularization by genetic ablation of CCR5. Invest Ophthalmol Vis Sci 44(2):590-3. PubMed: 12556387MGI: J:118018
- Amsellem V; Lipskaia L; Abid S; Poupel L; Houssaini A; Quarck R; Marcos E; Mouraret N; Parpaleix A; Bobe R; Gary-Bobo G; Saker M; Dubois-Rande JL; Gladwin MT; Norris KA; Delcroix M; Combadiere C; Adnot S. 2014. CCR5 as a treatment target in pulmonary arterial hypertension. Circulation 130(11):880-91. PubMed: 24993099MGI: J:227458
- Andres PG; Beck PL; Mizoguchi E; Mizoguchi A; Bhan AK; Dawson T; Kuziel WA; Maeda N; MacDermott RP; Podolsky DK; Reinecker HC. 2000. Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the intestine. J Immunol 164(12):6303-12. PubMed: 10843684MGI: J:110814
- Ank N; Petersen K; Malmgaard L; Mogensen SC; Paludan SR. 2005. Age-dependent role for CCR5 in antiviral host defense against herpes simplex virus type 2. J Virol 79(15):9831-41. PubMed: 16014944MGI: J:100102
- Araujo-Pires AC; Vieira AE; Francisconi CF; Biguetti CC; Glowacki A; Yoshizawa S; Campanelli AP; Trombone AP; Sfeir CS; Little SR; Garlet GP. 2015. IL-4/CCL22/CCR4 axis controls regulatory T-cell migration that suppresses inflammatory bone loss in murine experimental periodontitis. J Bone Miner Res 30(3):412-22. PubMed: 25264308MGI: J:233363
- Ariel A; Fredman G; Sun YP; Kantarci A; Van Dyke TE; Luster AD; Serhan CN. 2006. Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat Immunol 7(11):1209-16. PubMed: 17013391MGI: J:113563
- Baba T; Nakamoto Y; Mukaida N. 2009. Crucial contribution of thymic Sirpalpha+ conventional dendritic cells to central tolerance against blood-borne antigens in a CCR2-dependent manner. J Immunol 183(5):3053-63. PubMed: 19675159MGI: J:151848
- Baba T; Tanabe Y; Yoshikawa S; Yamanishi Y; Morishita S; Komatsu N; Karasuyama H; Hirao A; Mukaida N. 2016. MIP-1alpha/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice. Blood 127(21):2607-17. PubMed: 27006388MGI: J:233075
- Belnoue E; Kayibanda M; Deschemin JC; Viguier M; Mack M; Kuziel WA; Renia L. 2003. CCR5 deficiency decreases susceptibility to experimental cerebral malaria. Blood 101(11):4253-9. PubMed: 12560237MGI: J:83961
- Bierly AL; Shufesky WJ; Sukhumavasi W; Morelli AE; Denkers EY. 2008. Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection. J Immunol 181(12):8485-91. PubMed: 19050266MGI: J:142065
- Blednov YA; Bergeson SE; Walker D; Ferreira VM; Kuziel WA; Harris RA. 2005. Perturbation of chemokine networks by gene deletion alters the reinforcing actions of ethanol. Behav Brain Res 165(1):110-25. PubMed: 16105698MGI: J:102583
- Bonfa G; Benevides L; Souza Mdo C; Fonseca DM; Mineo TW; Rossi MA; Silva NM; Silva JS; de Barros Cardoso CR. 2014. CCR5 controls immune and metabolic functions during Toxoplasma gondii infection. PLoS One 9(8):e104736. PubMed: 25119429MGI: J:223154
- Braunersreuther V; Zernecke A; Arnaud C; Liehn EA; Steffens S; Shagdarsuren E; Bidzhekov K; Burger F; Pelli G; Luckow B; Mach F; Weber C. 2007. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Arterioscler Thromb Vasc Biol 27(2):373-9. PubMed: 17138939MGI: J:128063
- Camargo JF; Quinones MP; Mummidi S; Srinivas S; Gaitan AA; Begum K; Jimenez F; VanCompernolle S; Unutmaz D; Ahuja SS; Ahuja SK. 2009. CCR5 expression levels influence NFAT translocation, IL-2 production, and subsequent signaling events during T lymphocyte activation. J Immunol 182(1):171-82. PubMed: 19109148MGI: J:142900
- Carr DJ; Ash J; Lane TE; Kuziel WA. 2006. Abnormal immune response of CCR5-deficient mice to ocular infection with herpes simplex virus type 1. J Gen Virol 87(Pt 3):489-99. PubMed: 16476970MGI: J:135791
- Castellino F; Huang AY; Altan-Bonnet G; Stoll S; Scheinecker C; Germain RN. 2006. Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction. Nature 440(7086):890-5. PubMed: 16612374MGI: J:107629
- Chang LY; Lin YC; Kang CW; Hsu CY; Chu YY; Huang CT; Day YJ; Chen TC; Yeh CT; Lin CY. 2012. The indispensable role of CCR5 for in vivo suppressor function of tumor-derived CD103+ effector/memory regulatory T cells. J Immunol 189(2):567-74. PubMed: 22664873MGI: J:189562
- Chang LY; Lin YC; Mahalingam J; Huang CT; Chen TW; Kang CW; Peng HM; Chu YY; Chiang JM; Dutta A; Day YJ; Chen TC; Yeh CT; Lin CY. 2012. Tumor-Derived Chemokine CCL5 Enhances TGF-beta-Mediated Killing of CD8+ T Cells in Colon Cancer by T-Regulatory Cells. Cancer Res 72(5):1092-102. PubMed: 22282655MGI: J:181486
- Chantakru S; Kuziel WA; Maeda N; Croy BA. 2001. A study on the density and distribution of uterine natural killer cells at mid pregnancy in mice genetically-ablated for CCR2, CCR 5 and the CCR5 receptor ligand, MIP-1alpha J Reprod Immunol 49(1):33-47. PubMed: 11137111MGI: J:66438
- Chatterjee S; Eby JM; Al-Khami AA; Soloshchenko M; Kang HK; Kaur N; Naga OS; Murali A; Nishimura MI; Le Poole IC; Mehrotra S. 2014. A quantitative increase in regulatory T cells controls development of vitiligo. J Invest Dermatol 134(5):1285-94. PubMed: 24366614MGI: J:208054
- Chavez-Galan L; Vesin D; Segueni N; Prasad P; Buser-Llinares R; Blaser G; Pache JC; Ryffel B; Quesniaux VF; Garcia I. 2016. Tumor Necrosis Factor and Its Receptors Are Crucial to Control Mycobacterium bovis Bacillus Calmette-Guerin Pleural Infection in a Murine Model. Am J Pathol 186(9):2364-77. PubMed: 27456129MGI: J:235296
- Chen Z; Yu S; Bakhiet M; Winblad B; Zhu J. 2003. The chemokine receptor CCR5 is not a necessary inflammatory mediator in kainic acid-induced hippocampal injury: evidence for a compensatory effect by increased CCR2 and CCR3. J Neurochem 86(1):61-8. PubMed: 12807425MGI: J:84037
- Chiu BC; Freeman CM; Stolberg VR; Hu JS; Zeibecoglou K; Lu B; Gerard C; Charo IF; Lira SA; Chensue SW. 2004. Impaired lung dendritic cell activation in CCR2 knockout mice. Am J Pathol 165(4):1199-209. PubMed: 15466386MGI: J:93675
- Chiu BC; Martin BE; Stolberg VR; Chensue SW. 2013. Cutting edge: Central memory CD8 T cells in aged mice are virtual memory cells. J Immunol 191(12):5793-6. PubMed: 24227783MGI: J:207125
- Christmann BS; Moran JM; McGraw JA; Buller RM; Corbett JA. 2011. Ccr5 regulates inflammatory gene expression in response to encephalomyocarditis virus infection. Am J Pathol 179(6):2941-51. PubMed: 22001348MGI: J:180065
- Cochain C; Rodero MP; Vilar J; Recalde A; Richart AL; Loinard C; Zouggari Y; Guerin C; Duriez M; Combadiere B; Poupel L; Levy BI; Mallat Z; Combadiere C; Silvestre JS. 2010. Regulation of monocyte subset systemic levels by distinct chemokine receptors controls post-ischaemic neovascularization. Cardiovasc Res 88(1):186-95. PubMed: 20501509MGI: J:182115
- Crawford A; Angelosanto JM; Nadwodny KL; Blackburn SD; Wherry EJ. 2011. A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection. PLoS Pathog 7(7):e1002098. PubMed: 21814510MGI: J:183343
- Cripps JG; Celaj S; Burdick M; Strieter RM; Gorham JD. 2012. Liver inflammation in a mouse model of Th1 hepatitis despite the absence of invariant NKT cells or the Th1 chemokine receptors CXCR3 and CCR5. Lab Invest 92(10):1461-71. PubMed: 22906987MGI: J:189898
- Daley D; Zambirinis CP; Seifert L; Akkad N; Mohan N; Werba G; Barilla R; Torres-Hernandez A; Hundeyin M; Mani VR; Avanzi A; Tippens D; Narayanan R; Jang JE; Newman E; Pillarisetty VG; Dustin ML; Bar-Sagi D; Hajdu C; Miller G. 2016. gammadelta T Cells Support Pancreatic Oncogenesis by Restraining alphabeta T Cell Activation. Cell 166(6):1485-1499.e15. PubMed: 27569912MGI: J:236387
- Dawson TC; Beck MA; Kuziel WA; Henderson F; Maeda N. 2000. Contrasting effects of CCR5 and CCR2 deficiency in the pulmonary inflammatory response to influenza A virus. Am J Pathol 156(6):1951-9. PubMed: 10854218MGI: J:62675
- DePaolo RW; Lathan R; Karpus WJ. 2004. CCR5 regulates high dose oral tolerance by modulating CC chemokine ligand 2 levels in the GALT. J Immunol 173(1):314-20. PubMed: 15210789MGI: J:90955
- Dobaczewski M; Xia Y; Bujak M; Gonzalez-Quesada C; Frangogiannis NG. 2010. CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells. Am J Pathol 176(5):2177-87. PubMed: 20382703MGI: J:160376
- Fadel SA; Bromley SK; Medoff BD; Luster AD. 2008. CXCR3-deficiency protects influenza-infected CCR5-deficient mice from mortality. Eur J Immunol 38(12):3376-3387. PubMed: 19039768MGI: J:141370
- Fischer FR; Luo Y; Luo M; Santambrogio L; Dorf ME. 2001. RANTES-induced chemokine cascade in dendritic cells. J Immunol 167(3):1637-43. PubMed: 11466387MGI: J:120465
- Fukuyama Y; Tokuhara D; Sekine S; Aso K; Kataoka K; Davydova J; Yamamoto M; Gilbert RS; Tokuhara Y; Fujihashi K; Kunisawa J; Yuki Y; Kiyono H; McGhee JR; Fujihashi K. 2013. Potential roles of CCR5(+) CCR6(+) dendritic cells induced by nasal ovalbumin plus Flt3 ligand expressing adenovirus for mucosal IgA responses. PLoS One 8(4):e60453. PubMed: 23565250MGI: J:199945
- Glass WG; Lim JK; Cholera R; Pletnev AG; Gao JL; Murphy PM. 2005. Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. J Exp Med 202(8):1087-98. PubMed: 16230476MGI: J:116832
- Gonzalez-Martin A; Gomez L; Lustgarten J; Mira E; Manes S. 2011. Maximal T Cell-Mediated Antitumor Responses Rely upon CCR5 Expression in Both CD4+ and CD8+ T Cells. Cancer Res 71(16):5455-66. PubMed: 21715565MGI: J:175447
- Goser S; Ottl R; Brodner A; Dengler TJ; Torzewski J; Egashira K; Rose NR; Katus HA; Kaya Z. 2005. Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy. Circulation 112(22):3400-7. PubMed: 16316965MGI: J:116910
- Gregg RK; Nichols L; Chen Y; Lu B; Engelhard VH. 2010. Mechanisms of spatial and temporal development of autoimmune vitiligo in tyrosinase-specific TCR transgenic mice. J Immunol 184(4):1909-17. PubMed: 20083666MGI: J:159480
- Hallgren J; Jones TG; Abonia JP; Xing W; Humbles A; Austen KF; Gurish MF. 2007. Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors. Proc Natl Acad Sci U S A 104(51):20478-83. PubMed: 18077323MGI: J:130586
- Hamrah P; Yamagami S; Liu Y; Zhang Q; Vora SS; Lu B; Gerard CJ; Dana MR. 2007. Deletion of the chemokine receptor CCR1 prolongs corneal allograft survival. Invest Ophthalmol Vis Sci 48(3):1228-36. PubMed: 17325167MGI: J:123260
- Hardison JL; Wrightsman RA; Carpenter PM; Kuziel WA; Lane TE; Manning JE. 2006. The CC chemokine receptor 5 is important in control of parasite replication and acute cardiac inflammation following infection with Trypanosoma cruzi. Infect Immun 74(1):135-43. PubMed: 16368966MGI: J:104277
- Herold S; von Wulffen W; Steinmueller M; Pleschka S; Kuziel WA; Mack M; Srivastava M; Seeger W; Maus UA; Lohmeyer J. 2006. Alveolar epithelial cells direct monocyte transepithelial migration upon influenza virus infection: impact of chemokines and adhesion molecules. J Immunol 177(3):1817-24. PubMed: 16849492MGI: J:137974
- Hickman HD; Li L; Reynoso GV; Rubin EJ; Skon CN; Mays JW; Gibbs J; Schwartz O; Bennink JR; Yewdell JW. 2011. Chemokines control naive CD8+ T cell selection of optimal lymph node antigen presenting cells. J Exp Med 208(12):2511-24. PubMed: 22042976MGI: J:178641
- Huffnagle GB; McNeil LK; McDonald RA; Murphy JW; Toews GB; Maeda N; Kuziel WA. 1999. Cutting edge: Role of C-C chemokine receptor 5 in organ-specific and innate immunity to Cryptococcus neoformans. J Immunol 163(9):4642-6. PubMed: 10528159MGI: J:64293
- Hugues S; Scholer A; Boissonnas A; Nussbaum A; Combadiere C; Amigorena S; Fetler L. 2007. Dynamic imaging of chemokine-dependent CD8(+) T cell help for CD8(+) T cell responses. Nat Immunol 8(9):921-30. PubMed: 17660821MGI: J:124274
- Ibrahim HM; Bannai H; Xuan X; Nishikawa Y. 2009. Toxoplasma gondii cyclophilin 18-mediated production of nitric oxide induces Bradyzoite conversion in a CCR5-dependent manner. Infect Immun 77(9):3686-95. PubMed: 19564392MGI: J:152248
- Islam SA; Chang DS; Colvin RA; Byrne MH; McCully ML; Moser B; Lira SA; Charo IF; Luster AD. 2011. Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ T(H)2 cells. Nat Immunol 12(2):167-77. PubMed: 21217759MGI: J:168253
- Kalkonde YV; Shelton R; Villarreal M; Sigala J; Mishra PK; Ahuja SS; Barea-Rodriguez E; Moretti P; Ahuja SK. 2011. The CC chemokine receptor 5 regulates olfactory and social recognition in mice. Neuroscience 197:153-61. PubMed: 21963866MGI: J:184043
- Kallikourdis M; Andersen KG; Welch KA; Betz AG. 2007. Alloantigen-enhanced accumulation of CCR5+ 'effector' regulatory T cells in the gravid uterus. Proc Natl Acad Sci U S A 104(2):594-9. PubMed: 17197426MGI: J:119074
- Kang SJ; Liang HE; Reizis B; Locksley RM. 2008. Regulation of hierarchical clustering and activation of innate immune cells by dendritic cells. Immunity 29(5):819-33. PubMed: 19006696MGI: J:142395
- Kastenmuller W; Brandes M; Wang Z; Herz J; Egen JG; Germain RN. 2013. Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8(+) T Cell Responses in the Lymph Node. Immunity 38(3):502-13. PubMed: 23352234MGI: J:194479
- Kaul M; Ma Q; Medders KE; Desai MK; Lipton SA. 2007. HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ 14(2):296-305. PubMed: 16841089MGI: J:132342
- Kennedy A; Webb CD; Hill AA; Gruen ML; Jackson LG; Hasty AH. 2013. Loss of CCR5 results in glucose intolerance in diet-induced obese mice. Am J Physiol Endocrinol Metab 305(7):E897-906. PubMed: 23941876MGI: J:203854
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