The ear pinnae of homozygotes are ragged around the edges, yet uniform, and smaller than normal.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous (Null/Knockout) | Agtpbp1 | ATP/GTP binding protein 1 |
Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Bmp5 | bone morphogenetic protein 5 |
This cryopreserved bankstock is still segregating for Agtpbp1pcd-3J so recovered pups may or may not carry one copy of this recessive allele.
The ear pinnae of homozygotes are ragged around the edges, yet uniform, and smaller than normal.
The cauliflower ear 6 Jackson mutation arose spontaneously on the BALB/cByJ-Agtpbp1pcd-3J/J background at The Jackson Laboratory in 2004 and was maintained on this background by sibling intercrossing. In 2005 sperm was cryopreserved from homozygous males at generation +F4. When recovered from cryopreservation the recessive pcd-3J mutation was found still segregating in this cryopreserved mutant subline.
Allele Name | Purkinje cell degeneration 3 Jackson |
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Allele Type | Spontaneous (Null/Knockout) |
Allele Synonym(s) | Ccp1- |
Gene Symbol and Name | Agtpbp1, ATP/GTP binding protein 1 |
Gene Synonym(s) | |
Strain of Origin | BALB/cByJ |
Chromosome | 13 |
Molecular Note | This allele comprises a deletion estimated at approximately 12.2 kb, creating a splice junction between exons 5 and 9 that introduces a premature stop codon. Northern analysis of brain and testis samples showed that mRNA was reduced in abundance and size using probes derived from exons 16 to 19. mRNA was undetectable with a probe from exon 8. |
Allele Name | cauliflower ear short ear 6 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | Bmp5, bone morphogenetic protein 5 |
Gene Synonym(s) | |
Strain of Origin | BALB/cByJ-Agtpbp1pcd-3J/J |
Chromosome | 9 |
Molecular Note | A failed complementation test with the Bmp5cfe-se7J mutation showed that this mutation is an allele of Bmp5. |
When using the BALB/cByJ Agtpbp1pcd-3J-Bmp5cfe-se6J/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #005348 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Progeny testing required but not provided. No genotyping assay is available for these recessive cryo-recovered animals of undefined genotype |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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