Mitochondria from this conplastic ALR.mt(NOD) strain produce more reactive oxygen species than mice from parental or reciprocal conplastic strains.
Read More +ALR mice are resistant to chemically induced and autoimmune type 1 diabetes and encode the mitochondrial mt-Nd2a allele which is associated with resistance to type 1 diabetes. NOD mice are susceptible to type 1 diabetes and encode the mt-Nd2c allele. Although basal mitchondrial respiration is unchanged, mitochondria from this conplastic produce more reactive oxygen species than either parent or the reciprocal conplastic.
Dr. Clayton Mathews developed the ALR/Lt-mtNOD/LtDvs/MxLt conplastic strain by crossing ALR/Lt males to the donor NOD/LtDvs females. F1 progeny from the cross carry NOD/LtDvs mitochondrial DNA. Female progeny were then sequentially backcrossed for 10 generations to ALR/Lt males . A conplastic strain carries the mitochondrial genome of the donor strain.
Currently there are no related genes or alleles for this strain.
When using the ALR.mt(NOD) mouse strain in a publication, please cite the originating article(s) and include JAX stock #005333 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous for mt<NOD/ShiLtDvs>, 1 pair minimum |
Frozen Mouse Embryo | ALR/Lt-mt<NOD/ShiLtDvs>/MxLt Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | ALR/Lt-mt<NOD/ShiLtDvs>/MxLt Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | ALR/Lt-mt<NOD/ShiLtDvs>/MxLt Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | ALR/Lt-mt<NOD/ShiLtDvs>/MxLt Frozen Embryos | $3373.50 |
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