Routine ophthalmoscopic examination at 12 weeks of age revealed mutants with a grainy retina and/or retinal spots. Standard pathology work-up on two mutants (112 or 401 days of age) revealed retinal degeneration. Male or female mutants have been identified, and the colony is maintained through heterozygote matings.
This phenotypic deviant was generated by ethylnitrosourea (ENU) mutagenesis in C57BL/6J males (Stock No. 000664), in the Neuroscience Mutagenesis facility at The Jackson Laboratory. Mutagenized males were crossed to C57BL/6J females; G3 descendants of the mutagenized males were selected for neurological impairment.
|Allele Name||neuroscience mutagenesis facility, 246|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||nmf246, neuroscience mutagenesis facility, 246|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutation was identified in an ENU mutagenesis screen.|