The Jackson circler 2 Jackson mutation (Sobpjc-2J) arose spontaneously in the strain B6.129S2-Il6tm1Kopf/J in 2000. This mutant subline was then backcrossed once to C57BL/6J and intercrossed to breed out the Il6tm1Kopf, and has been maintained by sibling breeding ever since.
|Allele Name||Jackson circler 2 Jackson|
|Gene Symbol and Name||Sobp, sine oculis binding protein|
|Strain of Origin||B6.129S2-Il6tm1Kopf/J|
|Molecular Note||This spontaneous mutation, discovered in a production colony at The Jackson Laboratory, was shown to be allelic with the original Jackson circler mutation by failure of the two alleles to complement one another. A G-to-T transversion occurs at coding nucleotide position 1894 (c.1894G>T) that converts the glycine codon at amino acid residue 632 to a stop codon (p.G632*). The resulting protein is reduced in length by 28%.|