C57BL/6J-Chr 14^PWD/Ph/ForeJ

Stock number: 005264
Product name: B6.PWD-Chr14
Research areas: Research Tools

Description

Chromosome 14 from PWD/Ph has replaced the homologous chromosome of C57BL/6J in this strain of the set of consomic strains with C57BL/6J as background.

Detailed description

This strain represents one of a panel of inter-species chromosome substitution (or consomic) strains (IC-ISS). Each strain carries a chromosome from the Mus musculus musculus wild-derived strain PWD/Ph introgressed into a Mus musculus domesticus C57BL/6J background. The two species are believed to have diverged 350,000 to one million years ago and exhibit multiple genetic and phenotypic differences. The strain set also includes a conplastic strain (mt^PWD/Ph) created by sequential backcrossing of the donor female to the host male. A conplastic strain carries the mitochondrial genome of the donor strain. The IC-ISS strains represent a tool for dissection of quantitative trait loci.

Development

Dr. Jiri Forejt from The Institute of Molecular Genetics, Prague, Czech Republic developed the C57BL/6J-Chr #^PWD/Ph/ForeJ strain set by replacing individual chromosomes from the PWD/Ph donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses. The set was donated to The Jackson Laboratory in 2005.