These congenic genome-tagged mice carry a Chromosome 13 segment between markers Mit79 to Mit198 from the DBA/2 strain.
Read More +Genetic Background | Generation |
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000664 C57BL/6J |
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Marker Symbol | Marker Name | |
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D13Mit198 | DNA segment, Chr 13, Massachusetts Institute of Technology 198 | |
D13Mit79 | DNA segment, Chr 13, Massachusetts Institute of Technology 79 |
This C57BL/6J congenic carries the proximal portion of chromosome 13 from DBA/2J. The Mit or SNP (rs) markers in the strain name define the congenic interval.
Marker-assisted breeding was used to construct a set of overlapping congenic strains called genome-tagged mice (GTM) that span the entire mouse genome. Each member of the panel carries an average of a 23 cM segment (range 8 to 58 cM) from DBA/2J introgressed on to a C57BL/6J background. The segments represent the distal (D), middle (M), and proximal (P) portions of all or most of a given chromosome. (Iakoubova OA, et. al., 2001) GTM are a valuable resource for mapping and confirmation of loci contributing to complex traits.
The Jackson Laboratory is working with Dr. Lusis' group to import and make available additional strains in the panel.
This congenic panel was initiated by a cross of B6D2F1/J (Stock #100006) females to C57BL/6J males. Male progeny at each generation were selected by marker assisted genome scan and were backcrossed to C57BL/6J females to produce the N3-N6 generations. All animals in the panel carry a C57BL/6J Y chromosome. Sibling pairs at the N6 generation were intercrossed to produce homozygotes. Iakoubova OA, et. al. provides a more detailed explanation of the chromosome intervals. Dr. Lusis donated the panel to The Jackson Laboratory in 2004.
When using the B6.D2.13P mouse strain in a publication, please cite the originating article(s) and include JAX stock #005187 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous, 1 pair minimum |
Frozen Mouse Embryo | B6.D2-(D13Mit79-D13Mit198)/LusJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.D2-(D13Mit79-D13Mit198)/LusJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.D2-(D13Mit79-D13Mit198)/LusJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6.D2-(D13Mit79-D13Mit198)/LusJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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