These congenic mice carry a Chromosome 18 segment encompassing markers D18Mit19 - D18Mit4 from Biozzi ABH mice.
Dr. Tony R Merriman, Universiity of Otago
|Allele Type||Gene Symbol||Gene Name|
|QTL||Idd21||insulin dependent diabetes susceptibility 21|
|Marker Symbol||Marker Name|
|D18Mit4||DNA segment, Chr 18, Massachusetts Institute of Technology 4|
|D18Mit19||DNA segment, Chr 18, Massachusetts Institute of Technology 19|
NOD.ABH-(D18Mit19-D18Mit4)/TrmJ, commonly referred to as NOD. Chr18ABH, has a significantly decreased diabetes rate (34%by 30 weeks of age) when compared to wild-type or NOD controls (approximately 80-85% by 30 weeks of age).
This strain is useful for dissecting the role of non-MHC susceptibility genes in autoimmune diabetes.
Idd21, a non-MHC T1D locus, located on Chr18 is orthologous to Human, IDDM6 and Rat, Iddm3. There are several candidate genes on Chr 18., including Dcc (deleted in colorectal carcinoma, Smad2, Smad4, Smad7, Cd14, and Il17B. Approximately 92% of Chr. 18 extending from D18Mit19 (2cM) through D18Mit4 (57cM) containing diabetogenic loci Idd21 (24.5cM) was transferred from ABH to NOD through 7 generations of backcrossing to NOD prior to making homozygote. Additional microsatilite analysis confirms Idd regions 1-20 are NOD in origin (Hall et al 2003, Mammalian Genome, p. 335-339). Idd21 has been further segregated into Idd21.1 (52cM) and Idd21.2 (42cM), Idd21.3 (6cM) sub-loci. This strain contains all 3 Idd21 sub-loci (Hollis-Moffatt et al, 2005. In 2006, the T1DR received this strain at generation N8F?.