This DctSlt-lt3J spontaneous mutation is one of several re-mutations resulting in pigment dispersion of coat color.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | Dct | dopachrome tautomerase |
DctSlt-lt3J heterozygous mice are diluted to a dark brown and homozygous mice are diluted to a light brown.
The slaty light 3 Jackson allele of dopachrome tautomerase arose spontaneously on the B6.V-Lepob/J background at The Jackson Laboratory in 1999. This strain has been maintained via sibling breeding and in 2004 reached generation +F18 with no record of Lepob homozygotes in the 10 preceding generations.
Allele Name | slaty light 3 Jackson |
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Allele Type | Spontaneous |
Allele Synonym(s) | nm2798 |
Gene Symbol and Name | Dct, dopachrome tautomerase |
Gene Synonym(s) | |
Strain of Origin | B6.Cg-Lepob/J |
Chromosome | 14 |
Molecular Note | A single base pair mutation of G-to-A resulted in an amino acid substitution of glycine with arginine at position 486 (p.G486R) within the transmembrane domain encoded by exon 8. |
When using the slaty light 3 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #005071 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous or Heterozygous for -Dct<Slt-lt3J>, 1 pair minimum |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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