B6(Cg)-Dct^Slt-lt3J/J

Stock number: 005071
Product name: slaty light 3 Jackson
Research areas: Dermatology Research

Description

This Dct^Slt-lt3J spontaneous mutation is one of several re-mutations resulting in pigment dispersion of coat color.

Detailed description

Dct^Slt-lt3J heterozygous mice are diluted to a dark brown and homozygous mice are diluted to a light brown.

Development

The slaty light 3 Jackson allele of dopachrome tautomerase arose spontaneously on the B6.V-Lep^ob/J background at The Jackson Laboratory in 1999. This strain has been maintained via sibling breeding and in 2004 reached generation +F18 with no record of Lep^ob homozygotes in the 10 preceding generations.

Allele

Symbol: Dct^Slt-lt3J
Name: slaty light 3 Jackson
MGI accession ID: MGI:3040516
Generation method: Spontaneous
Synonyms: nm2798
Marker symbol: Dct
Marker name: dopachrome tautomerase
Marker synonyms: OCA8; TRP2; TRP-2; tyrosinase-related protein-2; TYRP2; Tyrp-2
Chromosome: 14
Strain of origin: B6.Cg-Lep^ob/J
Molecular note: A single base pair mutation of G-to-A resulted in an amino acid substitution of glycine with arginine at position 486 (p.G486R) within the transmembrane domain encoded by exon 8.