DctSlt-lt3J heterozygous mice are diluted to a dark brown and homozygous mice are diluted to a light brown.
The slaty light 3 Jackson allele of dopachrome tautomerase arose spontaneously on the B6.V-Lepob/J background at The Jackson Laboratory in 1999. This strain has been maintained via sibling breeding and in 2004 reached generation +F18 with no record of Lepob homozygotes in the 10 preceding generations.
|Allele Name||slaty light 3 Jackson|
|Gene Symbol and Name||Dct, dopachrome tautomerase|
|Strain of Origin||B6.Cg-Lepob/J|
|Molecular Note||A single base pair mutation of G-to-A resulted in an amino acid substitution of glycine with arginine at position 486 (p.G486R) within the transmembrane domain encoded by exon 8.|
When using the slaty light 3 Jackson mouse strain in a publication, please cite the originating article(s) and include JAX stock #005071 in your Materials and Methods section.