Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) on standard chow identified an 8 week old male (born 11/25/2002) with a 4 hour fasted plasma glucose of 516 mg/dl, which is approximately 137% higher than controls. Two siblings were similarly affected. This mutant mouse strain may be useful in studies of diabetes and hyperglycemia.
Following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), a forward genetic screen was utilized to identify phenotypic deviants in complex heart, lung, blood, and sleep disorders, at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory. hlb290 was mapped by crossing to BALB/cJ mice. Mapping identified the location of the mutation in an interval of 15 cM on Chromosome 11, between D11Mit71 and D11Mit51; the interval includes glucokinase (Gck), which has been implicated in type 2 diabetes. Heterozygotes were crossed to generate homozygotes. The mice have been maintained on a C57BL/6J background.
|Allele Name||heart, lung and blood, 290|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||Hlb290, heart, lung and blood, 290|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutation was identified in an ENU mutagenesis screen.|