These mice carry an ENU-induced mutation that is characterized by grainy appearing retina.
The Jackson Laboratory cannot guarantee that cryorecovery of strains from the discontinued NIH-funded Neuroscience Mutagenesis Facility (NMF) will be successful or that the anticipated phenotype or genotype will be obtained. The cryorecovery fee for this effort will not be refunded or prorated if the recovery is unsuccessful or is in any way unsatisfactory. Genotyping will be the responsibility of the Purchaser.Read More +
Routine ophthalmoscopic examination at 12 weeks of age revealed a grainy appearance of the retina, suggesting a pigmentation defect. Standard pathology work-up on two mutants (93 or 347 days of age) revealed no gross abnormalities. Additional pathology is in progress.
The colony is maintained through normal breeding.
This phenotypic deviant was generated by ethylnitrosourea (ENU) mutagenesis in C57BL/6J males (Stock No. 000664), in the Neuroscience Mutagenesis facility at The Jackson Laboratory. Mutagenized males were crossed to C57BL/6J females; G3 descendants of the mutagenized males were selected for neurological impairment.
|Allele Name||neuroscience mutagenesis facility 195|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||nmf195, neuroscience mutagenesis facility 195|
|Strain of Origin||C57BL/6J|
|Molecular Note||This mutation was discovered in an ENU mutagenesis screen.|