These DL734/NOD4 mice express a transgene containing adenovirus early region 3 (E3) sequences with two point mutations under direction of a rat insulin promoter and develop diabetes slower than control NOD mice.
Read More +Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence) |
Carriers of this transgene express the transcripts of the adenoviral E3 19K, 11.6K, 14.5K, 14.7K, and 10.4K glycoproteins in the islets but the adenovirus death protein is not expressed due to point mutations in the first two methionines of the 11.6K open reading frame. Female carriers of this transgene have slower kinetics and rates of development of diabetes through 30 weeks of age relative to NOD/Lt controls. These carriers do not display a significantly different diabetes rate than un-mutated adenovirus E3 carriers.
Expressed Gene | E3, adenovirus early region 3, adenovirus |
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Site of Expression |
Allele Name | transgene insertion 4, David V Serreze |
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Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | |
Gene Symbol and Name | Tg(Ins2-E3*734)4Dvs, transgene insertion 4, David V Serreze |
Gene Synonym(s) | |
Promoter | Ins2, insulin 2, rat |
Expressed Gene | E3, adenovirus early region 3, adenovirus |
Strain of Origin | Not Applicable |
Chromosome | UN |
Molecular Note | The rat insulin promoter was placed upstream of the adenovirus early region 3 (E3) sequences with two point mutations inthe first two methionines of the 11.6K open reading frame. |
When using the DL734/NOD4 mouse strain in a publication, please cite the originating article(s) and include JAX stock #004990 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous for Tg(Ins2-E3*734)4Dvs |
Frozen Mouse Embryo | NOD/ShiLtDvs-Tg(Ins2-E3*734)4Dvs/DvsJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | NOD/ShiLtDvs-Tg(Ins2-E3*734)4Dvs/DvsJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | NOD/ShiLtDvs-Tg(Ins2-E3*734)4Dvs/DvsJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | NOD/ShiLtDvs-Tg(Ins2-E3*734)4Dvs/DvsJ Frozen Embryos | $3373.50 |
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