These mice carry the YAC-CD46 transgene coding for the human CD46 protein (also known as MCP), which serves as the receptor for the human measles virus, group B adenoviruses, the human herpes simplex VI virus and Neisseria gonorrhoeae. The expression of this transgene is under the direction of the human CD46 promoter. Transgene expression is detected by in situ hybridization examination of whole animal sections, by Northern blot analysis of brain, spleen, lymph nodes, thymus, kidney, liver, gut and lung, and by FACS analysis of CD4+/CD8+ lymphocytes. Levels of transgenic protein on cell surfaces are similar to levels found in human cells. This line carries 10 to 12 copies of the transgene. Transgenic mice are susceptible to measles virus (MV) infection, expressing MV antigens and releasing infectious viral particles. The spread of the virus throughout the nervous system and the suppression of the immune system mimic the course of MV infection in humans. Transgenic mice infected with MV exhibit reduced numbers of macrophages, neutrophils and IFN-gamma producing T-cells, and are more susceptible to Listeria monocytogenes bacteria infection. Mice that are homozygous for this transgene are viable and fertile. This mutant mouse strain may be useful in the study of pathogenesis and treatment of microbial infections by the various viruses that are able to utilize CD46/MCP as a receptor.

These MY II mice express a transgene coding for the human CD46 protein (MCP) and are susceptible to measles virus infection.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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