IFN-&gamma;R2 in these mice is controlled by the CD2 promoter and enhancer. CD4+ T cells from IFN-&gamma;R2 transgenic mice exhibit impaired Th1 polarization potential in vitro. These mice also display several defects in Th1-dependent immunity in vivo, including attenuated delayed-type hypersensitivity responses and decreased antigen-specific IFN-gamma production. In addition, these mice mount impaired Th1 responses against Leishmania major, as manifested by increased parasitemia and more severe lesions than their wild-type littermates.

These IFN-&gamma;R2 mice express a transgene containing IFN-&gamma;R2 controlled by the CD2 promoter and enhancer and display several defects in Th1-dependent immunity in vivo.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

Typically mice are recovered in 12-16 weeks. <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">Contact Customer Service</a> to place an order or for more information.