These IFN-γR2 mice express a transgene containing IFN-γR2 controlled by the CD2 promoter and enhancer and display several defects in Th1-dependent immunity in vivo.
Read More +Genetic Background | Generation |
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Allele Type |
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Transgenic (Inserted expressed sequence) |
IFN-γR2 in these mice is controlled by the CD2 promoter and enhancer. CD4+ T cells from IFN-γR2 transgenic mice exhibit impaired Th1 polarization potential in vitro. These mice also display several defects in Th1-dependent immunity in vivo, including attenuated delayed-type hypersensitivity responses and decreased antigen-specific IFN-gamma production. In addition, these mice mount impaired Th1 responses against Leishmania major, as manifested by increased parasitemia and more severe lesions than their wild-type littermates.
Expressed Gene | Ifngr2, interferon gamma receptor 2, mouse, laboratory |
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Site of Expression | Constitutive expression in all T cells with expression in the thymus higher than in the spleen. |
Allele Name | transgene insertion 1, Paul B Rothman |
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Allele Type | Transgenic (Inserted expressed sequence) |
Allele Synonym(s) | IFN-gammaR2 TG1; TG1 |
Gene Symbol and Name | Tg(CD2-Ifngr2)1Pbro, transgene insertion 1, Paul B Rothman |
Gene Synonym(s) | |
Promoter | CD2, CD2 molecule, human |
Expressed Gene | Ifngr2, interferon gamma receptor 2, mouse, laboratory |
Site of Expression | Constitutive expression in all T cells with expression in the thymus higher than in the spleen. |
Strain of Origin | (C57BL/6 x CBA/J)F1 |
Chromosome | UN |
Molecular Note | The sequence encoding mouse IFNGR2 was placed under the control of the human CD2 promoter and enhancer. |
Mutations Made By | Paul Rothman, Johns Hopkins University |
When using the IFN-γR2 mouse strain in a publication, please cite the originating article(s) and include JAX stock #004970 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Hemizygous for Tg(CD2-Ifngr2)1Pbro |
Frozen Mouse Embryo | B6.Cg-Tg(CD2-Ifngr2)1Pbro/Dvs | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Tg(CD2-Ifngr2)1Pbro/Dvs | $2595.00 |
Frozen Mouse Embryo | B6.Cg-Tg(CD2-Ifngr2)1Pbro/Dvs | $3373.50 |
Frozen Mouse Embryo | B6.Cg-Tg(CD2-Ifngr2)1Pbro/Dvs | $3373.50 |
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