B6.Cg-Tg(CD2-Ifngr2)1Pbro/Dvs

Stock number: 004970
Product name: IFN-γR2
Research areas: Immunology, Inflammation and Autoimmunity Research, Research Tools

Description

These IFN-γR2 mice express a transgene containing IFN-γR2 controlled by the CD2 promoter and enhancer and display several defects in Th1-dependent immunity in vivo.

Detailed description

IFN-γR2 in these mice is controlled by the CD2 promoter and enhancer. CD4⁺ T cells from IFN-γR2 transgenic mice exhibit impaired Th1 polarization potential in vitro. These mice also display several defects in Th1-dependent immunity in vivo, including attenuated delayed-type hypersensitivity responses and decreased antigen-specific IFN-gamma production. In addition, these mice mount impaired Th1 responses against Leishmania major, as manifested by increased parasitemia and more severe lesions than their wild-type littermates.

Allele

Symbol: Tg(CD2-Ifngr2)1Pbro
Name: transgene insertion 1, Paul B Rothman
MGI accession ID: MGI:3785786
Generation method: Transgenic
Attributes: Inserted expressed sequence
Marker symbol: Tg(CD2-Ifngr2)1Pbro
Marker name: transgene insertion 1, Paul B Rothman
Chromosome: UN
Strain of origin: (C57BL/6 x CBA/J)F1
Expressed genes: Ifngr2,interferon gamma receptor 2,mouse, laboratory
Site of expression: Constitutive expression in all T cells with expression in the thymus higher than in the spleen.
Molecular note: The sequence encoding mouse IFNGR2 was placed under the control of the human CD2 promoter and enhancer.