Carriers of this transgene express the transcripts of the adenoviral E3 19K, 11.6K, 14.5K, 14.7K, and 10.4K glycoproteins in the islets but the adenovirus death protein is not expressed due to point mutations in the first two methionines of the 11.6K open reading frame.  Female carriers of this transgene have slower kinetics and rates of development of diabetes through 30 weeks of age relative to NOD/Lt controls.  These carriers do not display a significantly different diabetes rate than un-mutated adenovirus E3 carriers.

These DL734/NOD3 mice express a transgene containing adenovirus early region 3 (E3) sequences with two point mutations under direction of a rat insulin promoter
and develop diabetes slower than control NOD mice.


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