C3HeB/FeJ-Cacnb4^lh-3J/GrsrJ

Stock number: 004951
Product name: lethargic 3 Jackson
Research areas: Cell Biology Research, Neurobiology Research

Description

These mutant mice are characterized by lethargy and a wobbly gait.

Detailed description

Mice homozygous for lethargic 3 Jackson are recognizable at 14 days of age. They exhibit a behavior characteristic of lethargic with a wobbly gait resembling an unsteady wide legged shuffle. Some Cacnb4^lh-3J homozygotes also have a stargazing phenotype, but seizures have not been reported. The homozygotes are smaller than their wildtype littermates but live a normal lifespan. Both sexes may breed but they produce smaller litters or stop breeding earlier than heterozygous sibs.

Development

The lethargic 3 Jackson mutation arose spontaneously in the C3HeB/FeJ colony at The Jackson Laboratory in the Spring of 2001 when that colony was at F182. After one backcross to C3HeB/FeJ, the strain was maintained by sibling mating, primarily homozygous female x heterozygous male since homozygous males do not tend to breed. In 2004 this strain reached F182+N1F6.

Allele

Symbol: Cacnb4^lh-3J
Name: lethargic 3 Jackson
MGI accession ID: MGI:2684216
Generation method: Spontaneous
Marker symbol: Cacnb4
Marker name: calcium channel, voltage-dependent, beta 4 subunit
Chromosome: 2
Strain of origin: C3HeB/FeJ
Molecular note: The allelic nature of this mouse to this locus was determined by complementation analysis with the original lh mouse.