NOD.Cg-Sell^tm1Tft Itgb7^tm1Cgn/LtJ

Stock number: 004943
Product name: NOD.Itgb7^null Sell^null
Research areas: Cell Biology Research, Immunology, Inflammation and Autoimmunity Research

Development

This strain was derived from a cross between mice of strains NOD.B6-Itgb7^tm1Cgn/Lt (Stock No. 004310), then at backcross generation N9, and NOD.129P2(B6)-Sell^tm1Tft/1Lt (Stock No. 3860), at backcross generation N10. Dr. Leiter transferred this stock to the T1DR in 2005.

Allele

Symbol: Sell^tm1Tft
Name: targeted mutation 1, Thomas F Tedder
MGI accession ID: MGI:1927795
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Sell
Marker name: selectin, lymphocyte
Chromosome: 1
Strain of origin: 129P2/OlaHsd
Molecular note: A neomycin resistance gene replaced the majority of the exon encoding the L-selectin domain.

Allele

Symbol: Itgb7^tm1Cgn
Name: targeted mutation 1, University of Cologne
MGI accession ID: MGI:1861953
Generation method: Targeted
Attributes: Null/Knockout
Marker symbol: Itgb7
Marker name: integrin beta 7
Chromosome: 15
Strain of origin: C57BL/6
Molecular note: A neomycin resistance cassette replaced part of exon 12 and all of exons 13 and 14, which encode the transmembrane and part of the extracellular domains.