ALR.NOD-(D17Mit61-H2-D)/Lt

Stock number: 004941
Research areas: Research Tools

Description

This congenic strain carries the H2-D locus from the NOD/Lt strain on the ALR/Lt genetic background.

Detailed description

This congenic strain carries the H2 major histocompatibility complex from NOD/Lt on a background that is otherwise, statistically, 99.9% of ALR/Lt origin. The most proximal marker within the NOD/Lt-derived chromosomal segment of this strain is D17Mit61, at 16.4 cM just 3.6 cM from the most proximal gene of the H2 complex, and the most distal is H2-D. The H2 ^g7 haplotype of NOD/Lt differs from the ALR/Lt H2^gx haplotype only at the H2-D locus.

Development

This strain was derived from an initial cross between mice of strains ALR/Lt and NOD/Lt followed by a series of 10 backcrosses to ARL/Lt with selection of progeny for each subsequent backcross that were heterozygous for markers in the region of the H2 major histocompatibility complex. Following the last backcross (at N11), mice heterozygous at the H2 region were intercrossed, and progeny homozygous for NOD/Lt markers were selected to initiate a homozygous congenic strain.

Allele

MGI accession ID: MGI:1933561
Marker symbol: H2-D
Marker name: histocompatibility 2, D region
Chromosome: 17

Allele

MGI accession ID: MGI:90852
Marker symbol: D17Mit61
Marker name: DNA segment, Chr 17, Massachusetts Institute of Technology 61
Chromosome: 17