|Marker Symbol||Marker Name|
|D17Mit61||DNA segment, Chr 17, Massachusetts Institute of Technology 61|
|H2-D||histocompatibility 2, D region|
This congenic strain carries the H2 major histocompatibility complex from NOD/Lt on a background that is otherwise, statistically, 99.9% of ALR/Lt origin. The most proximal marker within the NOD/Lt-derived chromosomal segment of this strain is D17Mit61, at 16.4 cM just 3.6 cM from the most proximal gene of the H2 complex, and the most distal is H2-D. The H2 g7 haplotype of NOD/Lt differs from the ALR/Lt H2gx haplotype only at the H2-D locus.
This strain was derived from an initial cross between mice of strains ALR/Lt and NOD/Lt followed by a series of 10 backcrosses to ARL/Lt with selection of progeny for each subsequent backcross that were heterozygous for markers in the region of the H2 major histocompatibility complex. Following the last backcross (at N11), mice heterozygous at the H2 region were intercrossed, and progeny homozygous for NOD/Lt markers were selected to initiate a homozygous congenic strain.