These mice carry an ENU-induced mutation characterized by body tremors and abnormal hind limb movement.
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These mutants have splayed hind limbs and develop a body tremor by weaning age (mean 4.4 weeks of age +/-0.48; n=17). Standard pathology work-up on one mutant (77 days of age) revealed severe mononuclear lymphocytic nephritis; lymphocytes were also noted in the lung. Mutants of either sex have been observed and the colony is obtained through homozygous matings.
This phenotypic deviant was generated by ethylnitrosourea (ENU) mutagenesis in C57BL/6J males (Stock No. 000664), in the Neuroscience Mutagenesis facility at The Jackson Laboratory. Mutagenized males were crossed to C57BL/6J females; G3 descendants of the mutagenized males were selected for neurological impairment.
|Allele Name||neuroscience mutagenesis facility, 206|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||nmf206, neuroscience mutagenesis facility, 206|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutant was identified in an ENU mutagenesis screen.|
When using the C57BL/6J-nmf206/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #004830 in your Materials and Methods section.