This strain serves as a control for the Fragile X Syndrome model, FVB.129P2-Fmr1tm1Cgr/J strain (Stock No. 004624) which are also Fmr1 deficient.
IMR Colony, The Jackson Laboratory
Genetic Background | Generation |
---|---|
N11+N1F34
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Tyr | tyrosinase |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Not Applicable | Pde6b | phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
These mice are homozygous for the 129P2/OlaHsd wildtype Pde6b allele and do not suffer from blindness due to retinal degeneration. Mice from the colony of FVB.129P2-Fmr1tm1Cgr/J, Stock No. 004624, that no longer carried the mutant allele for Fmr1 were used to establish this line. Mice are pigmented as a result of the homozygosity of the Tyrc-ch allele. This mutant mouse strain may be useful in studies where a sighted mouse on the FVB background is an appropriate control, such as behavioral studies.
This strain originated on a FVB;129P2 background, was backcrossed for 11 generations on the FVB background. ( Please refer to Strain Development for Stock#4624 for details.) Mice from the colony of FVB.129P2-Fmr1 tm1Cgr, Stock # 4624, that no longer carried the mutant allele for Fmr1 and carried the 129P2/OlaHsd wildtype Pde6b allele were used to establish this line.
Expressed Gene | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory |
---|---|
Site of Expression | Retina. |
Allele Name | chinchilla |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | cch; cr |
Gene Symbol and Name | Tyr, tyrosinase |
Gene Synonym(s) | |
Strain of Origin | fancier's stock |
Chromosome | 7 |
Molecular Note | The mutation in the chinchilla allele was found to be a G-to-A point mutation that results in an amino acid change at position 482 or 464 from alanine to threonine (p.A482T for pre-protein, p.A464T for mature protein). |
Allele Name | wild type |
---|---|
Allele Type | Not Applicable |
Allele Synonym(s) | |
Gene Symbol and Name | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide |
Gene Synonym(s) | |
Expressed Gene | Pde6b, phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide, mouse, laboratory |
Site of Expression | Retina. |
Strain of Origin | Not Applicable |
Chromosome | 5 |
This strain originated on a FVB;129P2 background, and was backcrossed for 11 generations on the FVB background.
When using the sighted FVB mouse strain in a publication, please cite the originating article(s) and include JAX stock #004828 in your Materials and Methods section.
Service/Product | Description | Price |
---|---|---|
Homozygous, 1 pair minimum |
Frozen Mouse Embryo | FVB.129P2-Pde6b<+> Tyr<c-ch>/AntJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | FVB.129P2-Pde6b<+> Tyr<c-ch>/AntJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | FVB.129P2-Pde6b<+> Tyr<c-ch>/AntJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | FVB.129P2-Pde6b<+> Tyr<c-ch>/AntJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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