These mice carry an ENU-induced mutation characterized by exaggerated hind limb movements, general wasting, and an atrophic thymus with apoptosis.
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The mutants show exaggerated hind limb movements and intense trunk swaying without much body tremor, which can be observed by weaning age (average on-set 3.5 +/- 0.7 weeks of age). Male or female mutants have been produced, though a colony needs to be maintained through ovarian transplants. Standard pathology work-up on two mutants (31 or 32 days of age) showed general wasting and an atrophic thymus with apoptosis.
This phenotypic deviant was generated by ethylnitrosourea (ENU) mutagenesis in C57BL/6J males (Stock No. 000664), in the Neuroscience Mutagenesis facility at The Jackson Laboratory. Mutagenized males were crossed to C57BL/6J females; G3 descendants of the mutagenized males were selected for neurological impairment.
|Allele Name||neuroscience mutagenesis facility, 127|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||nmf127, neuroscience mutagenesis facility, 127|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutant was identified in an ENU mutagenesis screen.|
When using the C57BL/6J-nmf127/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #004814 in your Materials and Methods section.