This strain is homozygous for the retinal degeneration allele Pde6brd1.
Mice homozygous for this recessive mutation are recognized by 15 days of age by their shaky, unsteady, wobbly gait. Mutants die around three weeks of age. The agitans-like mutation maps to Chromosome 14 between D14Mit39 and D14Mit115 which are near the neurological mouse mutation agitans (ag). The agitans mutants exhibit a similar phenotype.
The agil mutation arose spontaneously in 1999 at The Jackson Laboratory on the C3H/HeJ background when that inbred was at F233. It has been maintained by sibling breeding.
|Gene Symbol and Name||Atp8a2, ATPase, aminophospholipid transporter-like, class I, type 8A, member 2|
|Strain of Origin||C3H/HeJ|
|Molecular Note||This allele failed to complement the agil-3J allele of this gene.|
When using the C3H/HeJ-Atp8a2agil/GrsrJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #004780 in your Materials and Methods section.