The Soab variant confers insensitivity to bitter tasting acylated sugars. This congenic strain has a congenic interval with the Soab variant from C57BL/6J on the SWR/J host background and is valuable in the study of taste preference.Read More +
The SWR/J background strain is homozygous for the retinal degeneration allele Pde6brd1.
C57BL/6J, like SJL/J, BDP/J, C57L/J, and 129P3/J, is insensitive to the bitter compound sucrose octaacetate (SOA) as well as raffinose undeca-acetate and other acylated sugars, and is therefore referred to as a non-taster for SOA. This trait is recessive to the trait of sensitivity (taster) carried by the SWR/J strain, but dominant to the trait of demi-taster, which is averse to 1mM SOA but tolerant of 0.1 mM SOA, and is a strain characteristic of many inbred strains including DBA/2J, LP/J, PL/J, RF/J, NZB/BlNJ, AKR/J, ABP/Le, BALB/cByJ, BALB/cJ, C3HeB/FeJ, and C3H/HeJ (Lush, 1981, Harder et al., 1992). This trait has been mapped to distal Chromosome 6, the Soa locus, with the taster allele (aversion) being assigned Soaa, the non-taster allele being assigned Soab and the demi-taster allele being assigned Soac. The underlying gene(s) and sequence differences remain to be defined. This congenic strain has a congenic interval with the Soab variant from C57BL/6J on the SWR/J host background, and is valuable in the study of taste preference. This congenic interval is less than 10 cM (Bachmanov 2001, Inoue 2001). Please see Stock No. 006435 for a strain with the taster (Soaa) variant on a demi-taster background.
This congenic was generated in the laboratory of Dr. G. Whitney at Florida State University via the backcross-intercross breeding system using SWR/J for the host strain and C57BL/6J as the donor strain. The two-bottle SOA preference test made on the intercross offspring at each intercross generation to identify those homozygous for the C57BL/6J-derived insensitivity trait, Soab. At N10 the mice were intercrossed to homozygosity and maintained by sibling inbreeding and at N10F23 homozygotes were transferred to The Monell Chemical Senses Center in Philadelphia and maintained by Dr. Alexander Bachmanov. In 2003, at generation N10F36, homozygous mice were sent to The Jackson Laboratory where they were further sibling mated and embryos were cryopreserved from mice at approximately N10F36+F6.
|Allele Name||sucrose octaacetate aversion, b variant|
|Allele Type||Not Applicable|
|Allele Synonym(s)||sucrose octaacetate aversion, b variant; Soab|
|Gene Symbol and Name||Soa, sucrose octaacetate aversion|
|Strain of Origin||Not Applicable|
|General Note||Alleles in dominance order are : a allele - taster (avoidance at <1mM concentration) in SWR/J; b allele - nontaster (no avoidance) in BDP/J, C57BL/6J, C57BR/cdJ, C57L/J, SJL/J and 129/J; c allele - demitaster (avoidance near saturation) in ABP/Le, AKR/J, BALB/cByJ, BALB/cJ, C3HeB/FeJ, C3H/HeJ, DBA/2J, LP/J, NZB/BINJ, PL/J and RF/J. J:3143|
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
|Frozen Mouse Embryo||$2,595.00 per straw or vial|
"MICE" means mouse strains, their progeny derived by inbreeding or crossbreeding, unmodified derivatives from mouse strains or their progeny supplied by The Jackson Laboratory ("JACKSON"). "PRODUCT(S)" means biological materials supplied by JACKSON, and their derivatives. "SERVICES" means projects conducted by JACKSON for other parties that may include but are not limited to the use of MICE or PRODUCTS. "RECIPIENT" means each recipient of MICE, PRODUCTS, or SERVICES provided by JACKSON including each institution, its employees and other researchers under its control. MICE or PRODUCTS shall not be: (i) used for any purpose other than internal research, (ii) sold or otherwise provided to any third party for any use, or (iii) provided to any agent or other third party to provide breeding or other services. Acceptance of MICE, PRODUCTS or SERVICES from JACKSON shall be deemed as agreement by RECIPIENT to these conditions, and departure from these conditions requires JACKSON’s prior written authorization.
MICE, PRODUCTS AND SERVICES ARE PROVIDED "AS IS". JACKSON EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS, IMPLIED, OR STATUTORY, WITH RESPECT TO MICE, PRODUCTS OR SERVICES, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, OR ANY WARRANTY OF NON-INFRINGEMENT OF ANY PATENT, TRADEMARK, OR OTHER INTELLECTUAL PROPERTY RIGHTS.
In case of dissatisfaction for a valid reason and claimed in writing by a purchaser within ninety (90) days of receipt of, PRODUCTS or SERVICES, JACKSON will, at its option, provide credit or replacement for the PRODUCT received or the SERVICES provided; JACKSON makes no other representations and this shall be the exclusive remedy of the purchaser. Please note specific policy for live mice.
Consistent with the requirement for a written understanding regarding animal care and use, the JACKSON Animal Care and Use Committee will review the animal care and use protocol(s) associated with any SERVICES to be performed at JACKSON, and JACKSON shall have ultimate responsibility and authority for the care of animals while on site or in JACKSON custody.
In no event shall JACKSON, its trustees, directors, officers, employees, and affiliates be liable for any causes of action or damages, including any direct, indirect, special, or consequential damages, arising out of the provision of MICE, PRODUCTS, or SERVICES, including economic damage or injury to property and lost profits, and including any damage arising from acts or negligence on the part of JACKSON, its agents or employees. Unless prohibited by law, in purchasing or receiving MICE, PRODUCTS, or SERVICES from JACKSON, purchaser or recipient, or any party claiming by or through them, expressly releases and discharges JACKSON from all such causes of action or damages, and further agrees to defend and indemnify JACKSON from any costs or damages arising out of any third party claims.
MICE, PRODUCTS or SERVICES are to be used in a safe manner and in accordance with all applicable governmental rules and regulations.
The foregoing represents the General Terms and Conditions applicable to JACKSON’s MICE, PRODUCTS or SERVICES. In addition, special terms and conditions of sale of certain MICE, PRODUCTS, or SERVICES may be set forth separately in JACKSON web pages, catalogs, price lists, contracts, and/or other documents, and these special terms and conditions shall also govern the sale of these MICE, PRODUCTS and SERVICES by JACKSON, and by its licensees and distributors.
Acceptance of delivery of MICE, PRODUCTS or SERVICES shall be deemed agreement to these terms and conditions. No purchase order or other document transmitted by purchaser or recipient that may modify the terms and conditions hereof, shall be in any way binding on JACKSON, and instead the terms and conditions set forth herein, including any special terms and conditions set forth separately, shall govern the sale of MICE, PRODUCTS or SERVICES by JACKSON.