JAX
Mouse Strain Datasheet - 004746
STOCK Tg(Tagln-cre)1Her/J
These transgenic mice express Cre recombinase under the control of the mouse transgelin (smooth muscle protein 22-alpha) promoter. Cre recombinase activity is observed in vascular smooth muscle cells of hepatic and pulmonary arteries. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in vascular smooth muscle cells. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful in studies of vascular diseases such as atherosclerosis.
Donating Investigator
Dr. Joachim Herz, Univ of Texas Southwest Med Ctr Dallas
Genetic overview
| Genetic Background | Generation |
|---|---|
|
F?+F15
(24-MAR-11) |
Tg(Tagln-cre)1Her
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Base Price
Starting at:
| $333.00 Domestic price for female |
| $407.00 Domestic price for breeder pair |
Detailed Description
Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the mouse transgelin (smooth muscle protein 22-alpha) promoter. Cre recombinase expression (mRNA) closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine and uterus. Low levels of transcript are detected in all other organs tested, likely reflecting the vascular smooth muscle compartments in the these tissues. Cre recombinase activity is observed in vascular smooth muscle cells of hepatic and pulmonary arteries, with no activity detected outside the vascular walls. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in vascular smooth muscle cells. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful in studies of vascular diseases such as atherosclerosis.
Development
A transgenic construct containing cre coding sequence under the control of the mouse transgelin promoter was introduced into B6SJLF2 donor oocytes.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | vascular smooth muscle cells |
Control Suggestions
Selected References
- Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300(5617):329-32. PubMed: 12690199MGI: J:82871
Tg(Tagln-cre)1Her
Allele Symbol: Tg(Tagln-cre)1Her
| Allele Name | transgene insertion 1, Joachim Herz |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | SM; SM22-Cre; SM22-Cretg; SM22a-Cre; Sm22alphaCre; Tag1-Cre; Tgln-Cre |
| Gene Symbol and Name | Tg(Tagln-cre)1Her, transgene insertion 1, Joachim Herz |
| Gene Synonym(s) | SM22-Cre; SM22-Cretg; Sm22alphaCre; Tag1-Cre |
| Promoter | Tagln, transgelin, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | vascular smooth muscle cells |
| Strain of Origin | (C57BL/6 x SJL)F2 |
| Chromosome | UN |
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. |
| Molecular Note | The transgene consists of a Tagln (transgelin) promoter and a cre gene modified to include translational consensus and nuclear localization signals. The Tagln promoter was used to drive transgene expression in smooth muscle cells. Cre recombinase mRNA expression closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine, and uterus. Low levels of Cre recombinase transcript are detected in all other organs. Recombination occurs in vascular smooth muscle cells of hepatic and pulmonary arteries. No recombination has been detected in non-muscle cells. |
| Mutations Made By | Dr. Joachim Herz, Univ of Texas Southwest Med Ctr Dallas |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
- Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300(5617):329-32. PubMed: 12690199MGI: J:82871
Additional References
- Holtwick R; Gotthardt M; Skryabin B; Steinmetz M; Potthast R; Zetsche B; Hammer RE; Herz J; Kuhn M. 2002. Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A 99(10):7142-7. PubMed: 11997476MGI: J:76460
Additional - Tg(Tagln-cre)1Her related
- Adams EJ; Chen XW; O'Shea KS; Ginsburg D. 2014. Mammalian COPII coat component SEC24C is required for embryonic development in mice. J Biol Chem 289(30):20858-70. PubMed: 24876386MGI: J:232065
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- Arboleda-Velasquez JF; Manent J; Lee JH; Tikka S; Ospina C; Vanderburg CR; Frosch MP; Rodriguez-Falcon M; Villen J; Gygi S; Lopera F; Kalimo H; Moskowitz MA; Ayata C; Louvi A; Artavanis-Tsakonas S. 2011. PNAS Plus: Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease. Proc Natl Acad Sci U S A 108(21):E128-35. PubMed: 21555590MGI: J:171887
- Arboleda-Velasquez JF; Zhou Z; Shin HK; Louvi A; Kim HH; Savitz SI; Liao JK; Salomone S; Ayata C; Moskowitz MA; Artavanis-Tsakonas S. 2008. Linking Notch signaling to ischemic stroke. Proc Natl Acad Sci U S A 105(12):4856-61. PubMed: 18347334MGI: J:133358
- Basford JE; Moore ZW; Zhou L; Herz J; Hui DY. 2009. Smooth muscle LDL receptor-related protein-1 inactivation reduces vascular reactivity and promotes injury-induced neointima formation. Arterioscler Thromb Vasc Biol 29(11):1772-8. PubMed: 19729608MGI: J:167799
- Biddinger JE; Fox EA. 2014. Reduced intestinal brain-derived neurotrophic factor increases vagal sensory innervation of the intestine and enhances satiation. J Neurosci 34(31):10379-93. PubMed: 25080597MGI: J:215773
- Boucher P; Li WP; Matz RL; Takayama Y; Auwerx J; Anderson RG; Herz J. 2007. LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome. PLoS One 2(5):e448. PubMed: 17505534MGI: J:129347
- Brunet I; Gordon E; Han J; Cristofaro B; Broqueres-You D; Liu C; Bouvree K; Zhang J; del Toro R; Mathivet T; Larrivee B; Jagu J; Pibouin-Fragner L; Pardanaud L; Machado MJ; Kennedy TE; Zhuang Z; Simons M; Levy BI; Tessier-Lavigne M; Grenz A; Eltzschig H;Eichmann A. 2014. Netrin-1 controls sympathetic arterial innervation. J Clin Invest 124(7):3230-40. PubMed: 24937433MGI: J:213784
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- Holtwick R; Gotthardt M; Skryabin B; Steinmetz M; Potthast R; Zetsche B; Hammer RE; Herz J; Kuhn M. 2002. Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A 99(10):7142-7. PubMed: 11997476MGI: J:76460
- Horiguchi M; Inoue T; Ohbayashi T; Hirai M; Noda K; Marmorstein LY; Yabe D; Takagi K; Akama TO; Kita T; Kimura T; Nakamura T. 2009. Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase. Proc Natl Acad Sci U S A 106(45):19029-34. PubMed: 19855011MGI: J:154659
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- Huang J; Davis EC; Chapman SL; Budatha M; Marmorstein LY; Word RA; Yanagisawa H. 2010. Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression. Circ Res 106(3):583-92. PubMed: 20019329MGI: J:170883
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- Huang Z; Rivas B; Agoulnik AI. 2012. Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice. Biol Reprod 87(6):143. PubMed: 23100620MGI: J:194006
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