JAX
Mouse Strain Datasheet - 004746
STOCK Tg(Tagln-cre)1Her/J
A C57BL/6 congenic version of this strain is available as Stock No. 017491.
These transgenic mice express Cre recombinase under the control of the mouse transgelin (smooth muscle protein 22-alpha) promoter. Cre recombinase activity is observed in vascular smooth muscle cells of hepatic and pulmonary arteries. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in vascular smooth muscle cells. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful in studies of vascular diseases such as atherosclerosis.
Donating Investigator
Dr. Joachim Herz, Univ of Texas Southwest Med Ctr Dallas
Genetic overview
| Genetic Background | Generation |
|---|---|
|
|
Tg(Tagln-cre)1Her
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Detailed Description
Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the mouse transgelin (smooth muscle protein 22-alpha) promoter. Cre recombinase expression (mRNA) closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine and uterus. Low levels of transcript are detected in all other organs tested, likely reflecting the vascular smooth muscle compartments in the these tissues. Cre recombinase activity is observed in vascular smooth muscle cells of hepatic and pulmonary arteries, with no activity detected outside the vascular walls. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in vascular smooth muscle cells. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful in studies of vascular diseases such as atherosclerosis.
Development
A transgenic construct containing cre coding sequence under the control of the mouse transgelin promoter was introduced into B6SJLF2 donor oocytes.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | vascular smooth muscle cells |
Control Suggestions
Selected References
- Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300(5617):329-32. PubMed: 12690199MGI: J:82871
Tg(Tagln-cre)1Her
Allele Symbol: Tg(Tagln-cre)1Her
| Allele Name | transgene insertion 1, Joachim Herz |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | SM; SM22-Cre; SM22-Cretg; SM22a-Cre; Sm22alphaCre; Tag1-Cre; Tgln-Cre |
| Gene Symbol and Name | Tg(Tagln-cre)1Her, transgene insertion 1, Joachim Herz |
| Gene Synonym(s) | SM22-Cre; SM22-Cretg; Sm22alphaCre; Tag1-Cre |
| Promoter | Tagln, transgelin, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | vascular smooth muscle cells |
| Strain of Origin | (C57BL/6 x SJL)F2 |
| Chromosome | UN |
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. |
| Molecular Note | The transgene consists of a Tagln (transgelin) promoter and a cre gene modified to include translational consensus and nuclear localization signals. The Tagln promoter was used to drive transgene expression in smooth muscle cells. Cre recombinase mRNA expression closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine, and uterus. Low levels of Cre recombinase transcript are detected in all other organs. Recombination occurs in vascular smooth muscle cells of hepatic and pulmonary arteries. No recombination has been detected in non-muscle cells. |
| Mutations Made By | Dr. Joachim Herz, Univ of Texas Southwest Med Ctr Dallas |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
- Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis. Science 300(5617):329-32. PubMed: 12690199MGI: J:82871
Additional References
- Holtwick R; Gotthardt M; Skryabin B; Steinmetz M; Potthast R; Zetsche B; Hammer RE; Herz J; Kuhn M. 2002. Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure. Proc Natl Acad Sci U S A 99(10):7142-7. PubMed: 11997476MGI: J:76460
Additional - Tg(Tagln-cre)1Her related
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- Basford JE; Moore ZW; Zhou L; Herz J; Hui DY. 2009. Smooth muscle LDL receptor-related protein-1 inactivation reduces vascular reactivity and promotes injury-induced neointima formation. Arterioscler Thromb Vasc Biol 29(11):1772-8. PubMed: 19729608MGI: J:167799
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