JAX
Mouse Strain Datasheet - 004746
STOCK Tg(Tagln-cre)1Her/J
A C57BL/6 congenic version of this strain is available as Stock No. 017491.
These transgenic mice express Cre recombinase under the control of the mouse transgelin (smooth muscle protein 22-alpha) promoter. Cre recombinase activity is observed in vascular smooth muscle cells of hepatic and pulmonary arteries. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in vascular smooth muscle cells. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful in studies of vascular diseases such as atherosclerosis.
Donating Investigator
Dr. Joachim Herz, Univ of Texas Southwest Med Ctr Dallas
Genetic overview
| Genetic Background | Generation |
|---|---|
|
|
Tg(Tagln-cre)1Her
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Detailed Description
Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. These transgenic mice express Cre recombinase under the control of the mouse transgelin (smooth muscle protein 22-alpha) promoter. Cre recombinase expression (mRNA) closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine and uterus. Low levels of transcript are detected in all other organs tested, likely reflecting the vascular smooth muscle compartments in the these tissues. Cre recombinase activity is observed in vascular smooth muscle cells of hepatic and pulmonary arteries, with no activity detected outside the vascular walls. When crossed with a strain containing a loxP site-flanked sequence of interest, Cre-mediated recombination results in deletion of the flanked sequence in vascular smooth muscle cells. This strain represents an effective tool for generating tissue specific-targeted mutants that would be useful in studies of vascular diseases such as atherosclerosis.
Development
A transgenic construct containing cre coding sequence under the control of the mouse transgelin promoter was introduced into B6SJLF2 donor oocytes.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | vascular smooth muscle cells |
Control Suggestions
Selected References
- Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis.. In: . . MGI: J:82871
Tg(Tagln-cre)1Her
Allele Symbol: Tg(Tagln-cre)1Her
| Allele Name | transgene insertion 1, Joachim Herz |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | SM; SM22-Cre; SM22-Cretg; SM22a-Cre; Sm22alphaCre; Tag1-Cre; Tgln-Cre |
| Gene Symbol and Name | Tg(Tagln-cre)1Her, transgene insertion 1, Joachim Herz |
| Gene Synonym(s) | SM22-Cre; SM22-Cretg; Sm22alphaCre; Tag1-Cre |
| Promoter | Tagln, transgelin, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | vascular smooth muscle cells |
| Strain of Origin | (C57BL/6 x SJL)F2 |
| Chromosome | UN |
| General Note | Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities. |
| Molecular Note | The transgene consists of a Tagln (transgelin) promoter and a cre gene modified to include translational consensus and nuclear localization signals. The Tagln promoter was used to drive transgene expression in smooth muscle cells. Cre recombinase mRNA expression closely patterns endogenous transgelin expression, with the highest levels detected in the aorta, intestine, and uterus. Low levels of Cre recombinase transcript are detected in all other organs. Recombination occurs in vascular smooth muscle cells of hepatic and pulmonary arteries. No recombination has been detected in non-muscle cells. |
| Mutations Made By | Dr. Joachim Herz, Univ of Texas Southwest Med Ctr Dallas |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
- Boucher P; Gotthardt M; Li WP; Anderson RG; Herz J. 2003. LRP: role in vascular wall integrity and protection from atherosclerosis.. In: . . MGI: J:82871
Additional References
- Holtwick R; Gotthardt M; Skryabin B; Steinmetz M; Potthast R; Zetsche B; Hammer RE; Herz J; Kuhn M. 2002. Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.. In: . . MGI: J:76460
Additional - Tg(Tagln-cre)1Her related
- Adams EJ; Chen XW; O'Shea KS; Ginsburg D. 2014. Mammalian COPII coat component SEC24C is required for embryonic development in mice.. In: . . MGI: J:232065
- Albinsson S; Suarez Y; Skoura A; Offermanns S; Miano JM; Sessa WC. 2010. MicroRNAs are necessary for vascular smooth muscle growth, differentiation, and function.. In: . . MGI: J:176638
- Arboleda-Velasquez JF; Manent J; Lee JH; Tikka S; Ospina C; Vanderburg CR; Frosch MP; Rodriguez-Falcon M; Villen J; Gygi S; Lopera F; Kalimo H; Moskowitz MA; Ayata C; Louvi A; Artavanis-Tsakonas S. 2011. PNAS Plus: Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease.. In: . . MGI: J:171887
- Arboleda-Velasquez JF; Zhou Z; Shin HK; Louvi A; Kim HH; Savitz SI; Liao JK; Salomone S; Ayata C; Moskowitz MA; Artavanis-Tsakonas S. 2008. Linking Notch signaling to ischemic stroke.. In: . . MGI: J:133358
- Basford JE; Moore ZW; Zhou L; Herz J; Hui DY. 2009. Smooth muscle LDL receptor-related protein-1 inactivation reduces vascular reactivity and promotes injury-induced neointima formation.. In: . . MGI: J:167799
- Biddinger JE; Fox EA. 2014. Reduced intestinal brain-derived neurotrophic factor increases vagal sensory innervation of the intestine and enhances satiation.. In: . . MGI: J:215773
- Boucher P; Li WP; Matz RL; Takayama Y; Auwerx J; Anderson RG; Herz J. 2007. LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome.. In: . . MGI: J:129347
- Brunet I; Gordon E; Han J; Cristofaro B; Broqueres-You D; Liu C; Bouvree K; Zhang J; del Toro R; Mathivet T; Larrivee B; Jagu J; Pibouin-Fragner L; Pardanaud L; Machado MJ; Kennedy TE; Zhuang Z; Simons M; Levy BI; Tessier-Lavigne M; Grenz A; Eltzschig H;Eichmann A. 2014. Netrin-1 controls sympathetic arterial innervation.. In: . . MGI: J:213784
- Burstyn-Cohen T; Heeb MJ; Lemke G. 2009. Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis.. In: . . MGI: J:198769
- Cantalupo A; Zhang Y; Kothiya M; Galvani S; Obinata H; Bucci M; Giordano FJ; Jiang XC; Hla T; Di Lorenzo A. 2015. Nogo-B regulates endothelial sphingolipid homeostasis to control vascular function and blood pressure.. In: . . MGI: J:228796
- Carvalho RL; Itoh F; Goumans MJ; Lebrin F; Kato M; Takahashi S; Ema M; Itoh S; van Rooijen M; Bertolino P; Ten Dijke P; Mummery CL. 2007. Compensatory signalling induced in the yolk sac vasculature by deletion of TGF receptors in mice.. In: . . MGI: J:128498
- Chen L; Yang G; Monslow J; Todd L; Cormode DP; Tang J; Grant GR; DeLong JH; Tang SY; Lawson JA; Pure E; Fitzgerald GA. 2014. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice.. In: . . MGI: J:211086
- Chen L; Yang G; Xu X; Grant G; Lawson JA; Bohlooly-Y M; FitzGerald GA. 2013. Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1.. In: . . MGI: J:210141
- Chen Z; Wu J; Yang C; Fan P; Balazs L; Jiao Y; Lu M; Gu W; Li C; Pfeffer LM; Tigyi G; Yue J. 2012. DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice.. In: . . MGI: J:186203
- Cheng SL; Behrmann A; Shao JS; Ramachandran B; Krchma K; Bello Arredondo Y; Kovacs A; Mead M; Maxson R; Towler DA. 2014. Targeted reduction of vascular Msx1 and Msx2 mitigates arteriosclerotic calcification and aortic stiffness in LDLR-deficient mice fed diabetogenic diets.. In: . . MGI: J:230113
- Choi EJ; Chen W; Jun K; Arthur HM; Young WL; Su H. 2014. Novel brain arteriovenous malformation mouse models for type 1 hereditary hemorrhagic telangiectasia.. In: . . MGI: J:212952
- Cleary RA; Wang R; Wang T; Tang DD. 2013. Role of Abl in airway hyperresponsiveness and airway remodeling.. In: . . MGI: J:202814
- Crouthamel MH; Lau WL; Leaf EM; Chavkin NW; Wallingford MC; Peterson DF; Li X; Liu Y; Chin MT; Levi M; Giachelli CM. 2013. Sodium-dependent phosphate cotransporters and phosphate-induced calcification of vascular smooth muscle cells: redundant roles for PiT-1 and PiT-2.. In: . . MGI: J:222222
- Cyphert JM; Allen IC; Church RJ; Latour AM; Snouwaert JN; Coffman TM; Koller BH. 2012. Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse.. In: . . MGI: J:183333
- Danielson LS; Reavie L; Coussens M; Davalos V; Castillo-Martin M; Guijarro MV; Coffre M; Cordon-Cardo C; Aifantis I; Ibrahim S; Liu C; Koralov SB; Hernando E. 2015. Limited miR-17-92 overexpression drives hematologic malignancies.. In: . . MGI: J:232684
- Davis FM; Rateri DL; Balakrishnan A; Howatt DA; Strickland DK; Muratoglu SC; Haggerty CM; Fornwalt BK; Cassis LA; Daugherty A. 2015. Smooth muscle cell deletion of low-density lipoprotein receptor-related protein 1 augments angiotensin II-induced superior mesenteric arterial and ascending aortic aneurysms.. In: . . MGI: J:236589
- Defalco T; Saraswathula A; Briot A; Iruela-Arispe ML; Capel B. 2013. Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling.. In: . . MGI: J:202074
- Deng L; Huang L; Sun Y; Heath JM; Wu H; Chen Y. 2015. Inhibition of FOXO1/3 promotes vascular calcification.. In: . . MGI: J:232619
- Ding M; Carrao AC; Wagner RJ; Xie Y; Jin Y; Rzucidlo EM; Yu J; Li W; Tellides G; Hwa J; Aprahamian TR; Martin KA. 2012. Vascular smooth muscle cell-derived adiponectin: a paracrine regulator of contractile phenotype.. In: . . MGI: J:183565
- Donato AJ; Lesniewski LA; Stuart D; Walker AE; Henson G; Sorensen L; Li D; Kohan DE. 2014. Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development.. In: . . MGI: J:213691
- Dreymueller D; Martin C; Schumacher J; Groth E; Boehm JK; Reiss LK; Uhlig S; Ludwig A. 2014. Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.. In: . . MGI: J:207321
- El-Bizri N; Guignabert C; Wang L; Cheng A; Stankunas K; Chang CP; Mishina Y; Rabinovitch M. 2008. SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis.. In: . . MGI: J:139945
- Ellawindy A; Satoh K; Sunamura S; Kikuchi N; Suzuki K; Minami T; Ikeda S; Tanaka S; Shimizu T; Enkhjargal B; Miyata S; Taguchi Y; Handoh T; Kobayashi K; Kobayashi K; Nakayama K; Miura M; Shimokawa H. 2015. Rho-Kinase Inhibition During Early Cardiac Development Causes Arrhythmogenic Right Ventricular Cardiomyopathy in Mice.. In: . . MGI: J:242116
- Fahrenbach JP; Stoller D; Kim G; Aggarwal N; Yerokun B; Earley JU; Hadhazy M; Shi NQ; Makielski JC; McNally EM. 2014. Abcc9 is required for the transition to oxidative metabolism in the newborn heart.. In: . . MGI: J:216539
- Feng X; Krebs LT; Gridley T. 2010. Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion.. In: . . MGI: J:166769
- Fox EA; Biddinger JE; Baquet ZC; Jones KR; McAdams J. 2013. Loss of Neurotrophin-3 from Smooth Muscle Disrupts Vagal Gastrointestinal Afferent Signaling and Satiation.. In: . . MGI: J:201812
- Fox EA; Biddinger JE; Jones KR; McAdams J; Worman A. 2013. Mechanism of hyperphagia contributing to obesity in brain-derived neurotrophic factor knockout mice.. In: . . MGI: J:193539
- French WJ; Creemers EE; Tallquist MD. 2008. Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function.. In: . . MGI: J:140245
- Frutkin AD; Shi H; Otsuka G; Leveen P; Karlsson S; Dichek DA. 2006. A critical developmental role for tgfbr2 in myogenic cell lineages is revealed in mice expressing SM22-Cre, not SMMHC-Cre.. In: . . MGI: J:114624
- Genetic Resource Science at The Jackson Laboratory. 2013. Expression/Specificity Patterns of Cre Alleles, 2013. In: . . MGI: J:193672
- Gewies A; Castineiras-Vilarino M; Ferch U; Jahrling N; Heinrich K; Hoeckendorf U; Przemeck GK; Munding M; Gross O; Schroeder T; Horsch M; Karran EL; Majid A; Antonowicz S; Beckers J; Hrabe de Angelis M; Dodt HU; Peschel C; Forster I; Dyer MJ; Ruland J. 2013. Prdm6 is essential for cardiovascular development in vivo.. In: . . MGI: J:209773
- Gomez-Arroyo J; Saleem SJ; Mizuno S; Syed AA; Bogaard HJ; Abbate A; Taraseviciene-Stewart L; Sung Y; Kraskauskas D; Farkas D; Conrad DH; Nicolls MR; Voelkel NF. 2012. A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects.. In: . . MGI: J:190182
- Goodwin JE; Zhang J; Geller DS. 2008. A critical role for vascular smooth muscle in acute glucocorticoid-induced hypertension.. In: . . MGI: J:242124
- Greif DM; Kumar M; Lighthouse JK; Hum J; An A; Ding L; Red-Horse K; Espinoza FH; Olson L; Offermanns S; Krasnow MA. 2012. Radial construction of an arterial wall.. In: . . MGI: J:189012
- Guijarro MV; Dahiya S; Danielson LS; Segura MF; Vales-Lara FM; Menendez S; Popiolek D; Mittal K; Wei JJ; Zavadil J; Cordon-Cardo C; Pandolfi PP; Hernando E. 2013. Dual Pten/Tp53 suppression promotes sarcoma progression by activating Notch signaling.. In: . . MGI: J:199111
- Hang CT; Yang J; Han P; Cheng HL; Shang C; Ashley E; Zhou B; Chang CP. 2010. Chromatin regulation by Brg1 underlies heart muscle development and disease.. In: . . MGI: J:162637
- Hansmann G; de Jesus Perez VA; Alastalo TP; Alvira CM; Guignabert C; Bekker JM; Schellong S; Urashima T; Wang L; Morrell NW; Rabinovitch M. 2008. An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension.. In: . . MGI: J:136168
- Hassane S; Claij N; Jodar M; Dedman A; Lauritzen I; Duprat F; Koenderman JS; van der Wal A; Breuning MH; de Heer E; Honore E; Deruiter MC; Peters DJ. 2011. Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension.. In: . . MGI: J:167185
- He C; Medley SC; Hu T; Hinsdale ME; Lupu F; Virmani R; Olson LE. 2015. PDGFRbeta signalling regulates local inflammation and synergizes with hypercholesterolaemia to promote atherosclerosis.. In: . . MGI: J:224456
- Hernando E; Charytonowicz E; Dudas ME; Menendez S; Matushansky I; Mills J; Socci ND; Behrendt N; Ma L; Maki RG; Pandolfi PP; Cordon-Cardo C. 2007. The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas.. In: . . MGI: J:121901
- Hofmann JJ; Zovein AC; Koh H; Radtke F; Weinmaster G; Iruela-Arispe ML. 2010. Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome.. In: . . MGI: J:166890
- Holtwick R; Gotthardt M; Skryabin B; Steinmetz M; Potthast R; Zetsche B; Hammer RE; Herz J; Kuhn M. 2002. Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.. In: . . MGI: J:76460
- Horiguchi M; Inoue T; Ohbayashi T; Hirai M; Noda K; Marmorstein LY; Yabe D; Takagi K; Akama TO; Kita T; Kimura T; Nakamura T. 2009. Fibulin-4 conducts proper elastogenesis via interaction with cross-linking enzyme lysyl oxidase.. In: . . MGI: J:154659
- Hu D; Mohanta SK; Yin C; Peng L; Ma Z; Srikakulapu P; Grassia G; MacRitchie N; Dever G; Gordon P; Burton FL; Ialenti A; Sabir SR; McInnes IB; Brewer JM; Garside P; Weber C; Lehmann T; Teupser D; Habenicht L; Beer M; Grabner R; Maffia P; Weih F; Habenicht AJ. 2015. Artery Tertiary Lymphoid Organs Control Aorta Immunity and Protect against Atherosclerosis via Vascular Smooth Muscle Cell Lymphotoxin beta Receptors.. In: . . MGI: J:229110
- Huang J; Davis EC; Chapman SL; Budatha M; Marmorstein LY; Word RA; Yanagisawa H. 2010. Fibulin-4 deficiency results in ascending aortic aneurysms: a potential link between abnormal smooth muscle cell phenotype and aneurysm progression.. In: . . MGI: J:170883
- Huang J; Yamashiro Y; Papke CL; Ikeda Y; Lin Y; Patel M; Inagami T; Le VP; Wagenseil JE; Yanagisawa H. 2013. Angiotensin-converting enzyme-induced activation of local angiotensin signaling is required for ascending aortic aneurysms in fibulin-4-deficient mice.. In: . . MGI: J:213282
- Huang Z; Rivas B; Agoulnik AI. 2012. Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice.. In: . . MGI: J:194006
- Ivins S; Chappell J; Vernay B; Suntharalingham J; Martineau A; Mohun TJ; Scambler PJ. 2015. The CXCL12/CXCR4 Axis Plays a Critical Role in Coronary Artery Development.. In: . . MGI: J:239364
- Jaffe M; Sesti C; Washington IM; Du L; Dronadula N; Chin MT; Stolz DB; Davis EC; Dichek DA. 2012. Transforming Growth Factor-beta Signaling in Myogenic Cells Regulates Vascular Morphogenesis, Differentiation, and Matrix Synthesis.. In: . . MGI: J:179089
- Kaftanovskaya EM; Huang Z; Lopez C; Conrad K; Agoulnik AI. 2015. Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice.. In: . . MGI: J:222129
- Kanekiyo T; Liu CC; Shinohara M; Li J; Bu G. 2012. LRP1 in brain vascular smooth muscle cells mediates local clearance of Alzheimer's amyloid-beta.. In: . . MGI: J:192453
- Kashima Y; Takahashi M; Shiba Y; Itano N; Izawa A; Koyama J; Nakayama J; Taniguchi S; Kimata K; Ikeda U. 2013. Crucial role of hyaluronan in neointimal formation after vascular injury.. In: . . MGI: J:199843
- Kim YM; Barnes EA; Alvira CM; Ying L; Reddy S; Cornfield DN. 2013. Hypoxia-inducible factor-1alpha in pulmonary artery smooth muscle cells lowers vascular tone by decreasing myosin light chain phosphorylation.. In: . . MGI: J:213312
- Kobayashi Y; Hirawa N; Tabara Y; Muraoka H; Fujita M; Miyazaki N; Fujiwara A; Ichikawa Y; Yamamoto Y; Ichihara N; Saka S; Wakui H; Yoshida S; Yatsu K; Toya Y; Yasuda G; Kohara K; Kita Y; Takei K; Goshima Y; Ishikawa Y; Ueshima H; Miki T; Umemura S. 2012. Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation.. In: . . MGI: J:225010
- Krebs LT; Norton CR; Gridley T. 2016. Notch signal reception is required in vascular smooth muscle cells for ductus arteriosus closure.. In: . . MGI: J:229932
- Kuhn M; Volker K; Schwarz K; Carbajo-Lozoya J; Flogel U; Jacoby C; Stypmann J; van Eickels M; Gambaryan S; Hartmann M; Werner M; Wieland T; Schrader J; Baba HA. 2009. The natriuretic peptide/guanylyl cyclase--a system functions as a stress-responsive regulator of angiogenesis in mice.. In: . . MGI: J:152580
- Kwon DH; Eom GH; Ko JH; Shin S; Joung H; Choe N; Nam YS; Min HK; Kook T; Yoon S; Kang W; Kim YS; Kim HS; Choi H; Koh JT; Kim N; Ahn Y; Cho HJ; Lee IK; Park DH; Suk K; Seo SB; Wissing ER; Mendrysa SM; Nam KI; Kook H. 2016. MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification.. In: . . MGI: J:236289
- Lasater EA; Li F; Bessler WK; Estes ML; Vemula S; Hingtgen CM; Dinauer MC; Kapur R; Conway SJ; Ingram DA Jr. 2010. Genetic and cellular evidence of vascular inflammation in neurofibromin-deficient mice and humans.. In: . . MGI: J:158570
- Li F; Downing BD; Smiley LC; Mund JA; Distasi MR; Bessler WK; Sarchet KN; Hinds DM; Kamendulis LM; Hingtgen CM; Case J; Clapp DW; Conway SJ; Stansfield BK; Ingram DA Jr. 2014. Neurofibromin-deficient myeloid cells are critical mediators of aneurysm formation in vivo.. In: . . MGI: J:219312
- Li H; Koo Y; Mao X; Sifuentes-Dominguez L; Morris LL; Jia D; Miyata N; Faulkner RA; van Deursen JM; Vooijs M; Billadeau DD; van de Sluis B; Cleaver O; Burstein E. 2015. Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling.. In: . . MGI: J:230747
- Li L; Lai EY; Huang Y; Eisner C; Mizel D; Wilcox CS; Schnermann J. 2012. Renal afferent arteriolar and tubuloglomerular feedback reactivity in mice with conditional deletions of adenosine 1 receptors.. In: . . MGI: J:189800
- Li M; Wetzel-Strong SE; Hua X; Tilley SL; Oswald E; Krummel MF; Caron KM. 2014. Deficiency of RAMP1 attenuates antigen-induced airway hyperresponsiveness in mice.. In: . . MGI: J:218915
- Lin CY; Lin CJ; Chen CH; Chen RM; Zhou B; Chang CP. 2012. The secondary heart field is a new site of calcineurin/Nfatc1 signaling for semilunar valve development.. In: . . MGI: J:183686
- Lindberg K; Olauson H; Amin R; Ponnusamy A; Goetz R; Taylor RF; Mohammadi M; Canfield A; Kublickiene K; Larsson TE. 2013. Arterial klotho expression and FGF23 effects on vascular calcification and function.. In: . . MGI: J:199936
- Liu S; Zhang Y; Moayeri M; Liu J; Crown D; Fattah RJ; Wein AN; Yu ZX; Finkel T; Leppla SH. 2013. Key tissue targets responsible for anthrax-toxin-induced lethality.. In: . . MGI: J:205421
- Loga F; Domes K; Freichel M; Flockerzi V; Dietrich A; Birnbaumer L; Hofmann F; Wegener JW. 2013. The role of cGMP/cGKI signalling and Trpc channels in regulation of vascular tone.. In: . . MGI: J:219324
- Long JB; Jay SM; Segal SS; Madri JA. 2009. VEGF-A and Semaphorin3A: modulators of vascular sympathetic innervation.. In: . . MGI: J:153552
- Lopes M; Gooupille O; Saint Cloment C; Robert B. 2012. Msx1 is expressed in retina endothelial cells at artery branching sites. In: . . MGI: J:184582
- Lukowski R; Weinmeister P; Bernhard D; Feil S; Gotthardt M; Herz J; Massberg S; Zernecke A; Weber C; Hofmann F; Feil R. 2008. Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis.. In: . . MGI: J:149021
- Malhowski AJ; Hira H; Bashiruddin S; Warburton R; Goto J; Robert B; Kwiatkowski DJ; Finlay GA. 2011. Smooth muscle protein-22-mediated deletion of Tsc1 results in cardiac hypertrophy that is mTORC1-mediated and reversed by rapamycin.. In: . . MGI: J:169239
- Mao X; Debenedittis P; Sun Y; Chen J; Yuan K; Jiao K; Chen Y. 2012. Vascular smooth muscle cell Smad4 gene is important for mouse vascular development.. In: . . MGI: J:200735
- Messaoudi S; He Y; Gutsol A; Wight A; Hebert RL; Vilmundarson RO; Makrigiannis AP; Chalmers J; Hamet P; Tremblay J; McPherson R; Stewart AF; Touyz RM; Nemer M. 2015. Endothelial Gata5 transcription factor regulates blood pressure.. In: . . MGI: J:227997
- Michiels CF; Fransen P; De Munck DG; De Meyer GR; Martinet W. 2015. Defective autophagy in vascular smooth muscle cells alters contractility and Ca(2)(+) homeostasis in mice.. In: . . MGI: J:220748
- Mlih M; Host L; Martin S; Niederhoffer N; Monassier L; Terrand J; Messaddeq N; Radke M; Gotthardt M; Bruban V; Kober F; Bernard M; Canet-Soulas E; Abt-Jijon F; Boucher P; Matz RL. 2015. The Src Homology and Collagen A (ShcA) Adaptor Protein Is Required for the Spatial Organization of the Costamere/Z-disk Network during Heart Development.. In: . . MGI: J:217881
- Murphy PA; Hynes RO. 2014. Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall.. In: . . MGI: J:227103
- Nanba D; Kinugasa Y; Morimoto C; Koizumi M; Yamamura H; Takahashi K; Takakura N; Mekada E; Hashimoto K; Higashiyama S. 2006. Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation.. In: . . MGI: J:116051
- Nandadasa S; Nelson CM; Apte SS. 2015. ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation.. In: . . MGI: J:228583
- Navankasattusas S; Whitehead KJ; Suli A; Sorensen LK; Lim AH; Zhao J; Park KW; Wythe JD; Thomas KR; Chien CB; Li DY. 2008. The netrin receptor UNC5B promotes angiogenesis in specific vascular beds.. In: . . MGI: J:131817
- Olson LE; Soriano P. 2011. PDGFRbeta Signaling Regulates Mural Cell Plasticity and Inhibits Fat Development.. In: . . MGI: J:173602
- Otsuka G; Stempien-Otero A; Frutkin AD; Dichek DA. 2007. Mechanisms of TGF-beta1-induced intimal growth: plasminogen-independent activities of plasminogen activator inhibitor-1 and heterogeneous origin of intimal cells.. In: . . MGI: J:137777
- Pan Y; Balazs L; Tigyi G; Yue J. 2011. Conditional deletion of Dicer in vascular smooth muscle cells leads to the developmental delay and embryonic mortality.. In: . . MGI: J:172088
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