JAX Mouse Strain Datasheet - 004631

B6.Cg-Tg(GFAP-APOE_i4)1Hol Apoe^tm1Unc/J

Stock No:: 004631 |; GFAP-apoE4

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Overview

Also Known As: GFAP-apoE4, Tg(GFAP-APOE*4)1Hol

These transgenic mice express the human apolipoprotein E4 isoform (APOE4) under the direction of the human glial fibrillary acidic protein (GFAP) promoter and do not express endogenous mouse apolipoprotein E (APOE). Human APOE4 is detectable in glia and neuropil in developing and adult mutant mice. This mutant mouse strain represents a model that may be useful in studies examining the function of APOE4 in the central nervous system and how APOE4 may contribute to the pathology of Alzheimer's disease.

Donating Investigator

Dr. David M. Holtzman, Washington University

Genetic overview

Genetic Background	Generation
	N6+N3F14 (03-OCT-16)

Apoe^tm1Unc

Allele Type	Gene Symbol	Gene Name
Targeted (Null/Knockout)	Apoe	apolipoprotein E

Tg(GFAP-APOE_i4)1Hol

Allele Type
Transgenic (Humanized sequence, Inserted expressed sequence)

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Research Applications

Cardiovascular Research
Neurobiology Research

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Base Price

Starting at:

$333.00 Domestic price for female

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Details

Detailed Description

These transgenic mice express the human apolipoprotein E4 isoform (APOE4) under the direction of the human glial fibrillary acidic protein (GFAP) promoter and do not express endogenous mouse apolipoprotein E (Apoe). The transgenic isoform expression pattern follows the endogenous mouse Apoe and GFAP expression patterns in the brain. Human APOE4 is immunodetectable in glia and neuropil in developing and adult mutant mice. Cultured astrocytes from transgenic mice secrete APOE4 in lipoproteins that are similar in size to high-density (HDL) plasma lipoproteins. Detergent-soluble APOE4 protein levels in hemizygous mice forebrain tissue and in adult human cortex tissue are similar. Mice that are hemizygous or homozygous for the transgenic insert and homozygous for the targeted allele are viable, normal in size and do not display any gross physical or behavioral abnormalities. This mutant mouse strain represents a model that may be useful in studies examining the function of APOE4 in the central nervous system and how APOE4 may contribute to the pathology of Alzheimer's disease.

According to the donating investigator, mice that are hemizygous for the transgene and homozygous for the null mutation show dyslipidemia similar to non-transgenic Apoe-null mutant mice (B6.129P2-Apoe/J - Stock # 002052) in peripheral blood. Although some transgene-derived APOE protein does make it to the periphery, it is not enough to lower peripheral cholesterol significantly.

Development

A transgenic construct containing sequence encoding human apolipoprotein E4 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter was introduced into B6;CBA donor eggs.

Expression Data

Expressed Gene	APOE, apolipoprotein E, human
Site of Expression

Control Suggestions

000664 C57BL/6J

Additional Information

Considerations for Choosing Controls

Selected References

Sun Y; Wu S; Bu G; Onifade MK; Patel SN; LaDu MJ; Fagan AM; Holtzman DM. 1998. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci 18(9):3261-72. PubMed: 9547235 MGI: J:93487

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Genetics

Apoe^tm1Unc

Allele Symbol: Apoe^tm1Unc

Allele Name	targeted mutation 1, University of North Carolina
Allele Type	Targeted (Null/Knockout)
Allele Synonym(s)	APOE KO; AopE(-); ApoE-KO; Apoe^tm1Un; EKO; apoE-; apoE0; epsilon-; mE^-; mEKO
Gene Symbol and Name	Apoe, apolipoprotein E
Gene Synonym(s)	AD2; AI255918; APO-E; APOEA; ApoE4; LDLCQ5; LPG; expressed sequence AI255918
Strain of Origin	129P2/OlaHsd
Chromosome	7
Molecular Note	Insertion of a neomycin resistance cassette deleted part of exon 3 and part of intron 3 of the Apoe gene. Plasma from homozygous mutant mice gave no detectable immunoprecipitate by the Ouchterlony double immunodiffusion test using a rabbit antibody to rat APOE.
Mutations Made By	Dr. Nobuyo Maeda, University of North Carolina at Chapel Hill

Tg(GFAP-APOE_i4)1Hol

Allele Symbol: Tg(GFAP-APOE_i4)1Hol

Allele Name	transgene insertion 1, David M Holtzman
Allele Type	Transgenic (Humanized sequence, Inserted expressed sequence)
Allele Synonym(s)	GFAP-apoE4 line1; Tg(GFAP-APOE*4)1Hol; Tg(GFAP-APOE4)1Hol
Gene Symbol and Name	Tg(GFAP-APOE_i4)1Hol, transgene insertion 1, David M Holtzman
Gene Synonym(s)	GFAP-apoE4 line1; Tg(GFAP-APOE4)1Hol; Tg(GFAP-APOE4)1Hol; Tg(GFAP-APOE4)1Hol; Tg(GFAP-APOE4)1Hol
Promoter	GFAP, glial fibrillary acidic protein, human
Expressed Gene	APOE, apolipoprotein E, human
Strain of Origin	C57BL/6 and CBA
Chromosome	UN
Molecular Note	The transgene contains sequence encoding human apolipoprotein E4 isoform under the control of the human glial fibrillary acidic protein (GFAP) promoter. Five lines were created (lines 1, 3, 11, 19 and 22) with line 1 being chosen as the representative line based on submission to the Jax repository. The pattern of expression of the human apolipoprotein E3 isoform (APOE3) transgenic product in these mice follows the endogenous mouse APOE and GFAP expression patterns in the brain. Human APOE3 is immunodetectable in glia and neuropil in developing and adult mutant mice.
Mutations Made By	Dr. David Holtzman, Washington University

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Genotype: Apoe^tm1Unc related

Cardiovascular Research
- Atherosclerosis
- Hypercholesterolemia

Genotype: Tg(GFAP-APOE_i4)1Hol related

Neurobiology Research
- Alzheimer's Disease
  - APOE mutants

Mammalian Phenotype Terms by Genotype

Genotype: Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)1Hol/0
B6.Cg-Tg(GFAP-APOE_i4)1Hol Apoe^tm1Unc/J

nervous system phenotype

abnormal astrocyte physiology
- the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoe^tm1Unc homozygotes

References

Sun Y; Wu S; Bu G; Onifade MK; Patel SN; LaDu MJ; Fagan AM; Holtzman DM. 1998. Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins. J Neurosci 18(9):3261-72. PubMed: 9547235 MGI: J:93487

Additional References

Holtzman DM; Bales KR; Tenkova T; Fagan AM; Parsadanian M; Sartorius LJ; Mackey B; Olney J; McKeel D; Wozniak D; Paul SM. 2000. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 97(6):2892-7. PubMed: 10694577 MGI: J:61176

Additional - Apoe^tm1Unc related

't Hoen PA; Van der Lans CA; Van Eck M; Bijsterbosch MK; Van Berkel TJ; Twisk J. 2003. Aorta of ApoE-deficient mice responds to atherogenic stimuli by a prelesional increase and subsequent decrease in the expression of antioxidant enzymes. Circ Res 93(3):262-9. PubMed: 12829615 MGI: J:115676
A-Gonzalez N; Bensinger SJ; Hong C; Beceiro S; Bradley MN; Zelcer N; Deniz J; Ramirez C; Diaz M; Gallardo G; de Galarreta CR; Salazar J; Lopez F; Edwards P; Parks J; Andujar M; Tontonoz P; Castrillo A. 2009. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity 31(2):245-58. PubMed: 19646905 MGI: J:151872
Abd Alla J; Langer A; Elzahwy SS; Arman-Kalcek G; Streichert T; Quitterer U. 2010. Angiotensin-converting enzyme inhibition down-regulates the pro-atherogenic chemokine receptor 9 (CCR9)-chemokine ligand 25 (CCL25) axis. J Biol Chem 285(30):23496-505. PubMed: 20504763 MGI: J:165997
Accad M; Smith SJ; Newland DL; Sanan DA; King LE Jr; Linton MF; Fazio S; Farese RV Jr. 2000. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1 [see comments] J Clin Invest 105(6):711-9. PubMed: 10727439 MGI: J:61147
Adachi H; Fujiwara Y; Kondo T; Nishikawa T; Ogawa R; Matsumura T; Ishii N; Nagai R; Miyata K; Tabata M; Motoshima H; Furukawa N; Tsuruzoe K; Kawashima J; Takeya M; Yamashita S; Koh GY; Nagy A; Suda T; Oike Y; Araki E. 2009. Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosis. Biochem Biophys Res Commun 379(4):806-11. PubMed: 19094966 MGI: J:145171
Agrawal S; Febbraio M; Podrez E; Cathcart MK; Stark GR; Chisolm GM. 2007. Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development. Circulation 115(23):2939-47. PubMed: 17533179 MGI: J:137115
Ahluwalia N; Lin AY; Tager AM; Pruitt IE; Anderson TJ; Kristo F; Shen D; Cruz AR; Aikawa M; Luster AD; Gerszten RE. 2007. Inhibited aortic aneurysm formation in BLT1-deficient mice. J Immunol 179(1):691-7. PubMed: 17579092 MGI: J:143153
Aihara K; Azuma H; Akaike M; Ikeda Y; Sata M; Takamori N; Yagi S; Iwase T; Sumitomo Y; Kawano H; Yamada T; Fukuda T; Matsumoto T; Sekine K; Sato T; Nakamichi Y; Yamamoto Y; Yoshimura K; Watanabe T; Nakamura T; Oomizu A; Tsukada M; Hayashi H; Sudo T; KatoS; Matsumoto T. 2007. Strain-dependent embryonic lethality and exaggerated vascular remodeling in heparin cofactor II-deficient mice. J Clin Invest 117(6):1514-26. PubMed: 17549254 MGI: J:122173
Aikawa E; Nahrendorf M; Sosnovik D; Lok VM; Jaffer FA; Aikawa M; Weissleder R. 2007. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 115(3):377-86. PubMed: 17224478 MGI: J:130156
Alam MM; Okazaki K; Nguyen LTT; Ota N; Kitamura H; Murakami S; Shima H; Igarashi K; Sekine H; Motohashi H. 2017. Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2. J Biol Chem 292(18):7519-7530. PubMed: 28314773 MGI: J:242499
Alberts-Grill N; Rezvan A; Son DJ; Qiu H; Kim CW; Kemp ML; Weyand CM; Jo H. 2012. Dynamic immune cell accumulation during flow-induced atherogenesis in mouse carotid artery: an expanded flow cytometry method. Arterioscler Thromb Vasc Biol 32(3):623-32. PubMed: 22247254 MGI: J:195958
Alexander MR; Knowles JW; Nishikimi T; Maeda N. 2003. Increased atherosclerosis and smooth muscle cell hypertrophy in natriuretic peptide receptor A-/-apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 23(6):1077-82. PubMed: 12702516 MGI: J:103054
Alexander MR; Moehle CW; Johnson JL; Yang Z; Lee JK; Jackson CL; Owens GK. 2012. Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice. J Clin Invest 122(1):70-9. PubMed: 22201681 MGI: J:184390
Ali K; Middleton M; Pure E; Rader DJ. 2005. Apolipoprotein E suppresses the type I inflammatory response in vivo. Circ Res 97(9):922-7. PubMed: 16179587 MGI: J:114634
Ali ZA; de Jesus Perez V; Yuan K; Orcholski M; Pan S; Qi W; Chopra G; Adams C; Kojima Y; Leeper NJ; Qu X; Zaleta-Rivera K; Kato K; Yamada Y; Oguri M; Kuchinsky A; Hazen SL; Jukema JW; Ganesh SK; Nabel EG; Channon K; Leon MB; Charest A; Quertermous T; Ashley EA. 2014. Oxido-reductive regulation of vascular remodeling by receptor tyrosine kinase ROS1. J Clin Invest 124(12):5159-74. PubMed: 25401476 MGI: J:219378
Alkemade FE; van Vliet P; Henneman P; van Dijk KW; Hierck BP; van Munsteren JC; Scheerman JA; Goeman JJ; Havekes LM; Gittenberger-de Groot AC; van den Elsen PJ; DeRuiter MC. 2010. Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature. Am J Pathol 176(2):542-8. PubMed: 20035052 MGI: J:156605
Alp NJ; McAteer MA; Khoo J; Choudhury RP; Channon KM. 2004. Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 24(3):445-50. PubMed: 14707037 MGI: J:102062
Amar S; Wu SC; Madan M. 2009. Is Porphyromonas gingivalis cell invasion required for atherogenesis? Pharmacotherapeutic implications. J Immunol 182(3):1584-92. PubMed: 19155507 MGI: J:144322
Amigo L; Quinones V; Mardones P; Zanlungo S; Miquel JF; Nervi F; Rigotti A. 2000. Impaired biliary cholesterol secretion and decreased gallstone formation in apolipoprotein E-deficient mice fed a high-cholesterol diet. Gastroenterology 118(4):772-9. PubMed: 10734029 MGI: J:107676
Amirbekian S; Long RC Jr; Consolini MA; Suo J; Willett NJ; Fielden SW; Giddens DP; Taylor WR; Oshinski JN. 2009. In vivo assessment of blood flow patterns in abdominal aorta of mice with MRI: implications for AAA localization. Am J Physiol Heart Circ Physiol 297(4):H1290-5. PubMed: 19684182 MGI: J:154334
An G; Miwa T; Song WL; Lawson JA; Rader DJ; Zhang Y; Song WC. 2009. CD59 but not DAF deficiency accelerates atherosclerosis in female ApoE knockout mice. Mol Immunol 46(8-9):1702-9. PubMed: 19297024 MGI: J:148359
An G; Wang H; Tang R; Yago T; McDaniel JM; McGee S; Huo Y; Xia L. 2008. P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice. Circulation 117(25):3227-37. PubMed: 18519846 MGI: J:155081
Anderson DR; Tsutsui JM; Xie F; Radio SJ; Porter TR. 2007. The role of complement in the adherence of microbubbles to dysfunctional arterial endothelium and atherosclerotic plaque. Cardiovasc Res 73(3):597-606. PubMed: 17196951 MGI: J:119533
Anderson R; Barnes JC; Bliss TV; Cain DP; Cambon K; Davies HA; Errington ML; Fellows LA; Gray RA; Hoh T; Stewart M; Large CH; Higgins GA. 1998. Behavioural, physiological and morphological analysis of a line of apolipoprotein E knockout mouse. Neuroscience 85(1):93-110. PubMed: 9607706 MGI: J:118390
Anderson R; Higgins GA. 1997. Absence of central cholinergic deficits in ApoE knockout mice. Psychopharmacology (Berl) 132(2):135-44. PubMed: 9266610 MGI: J:127860
Andersson IJ; Jiang YY; Davidge ST. 2009. Maternal stress and development of atherosclerosis in the adult apolipoprotein E-deficient mouse offspring. Am J Physiol Regul Integr Comp Physiol 296(3):R663-71. PubMed: 19129374 MGI: J:145701
Ando Y; Shimizugawa T; Takeshita S; Ono M; Shimamura M; Koishi R; Furukawa H. 2003. A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice. J Lipid Res 44(6):1216-23. PubMed: 12671033 MGI: J:84022
Andre P; Morooka T; Sim D; Abe K; Lowell C; Nanda N; Delaney S; Siu G; Yan Y; Hollenbach S; Pandey A; Gao H; Wang Y; Nakajima K; Parikh SA; Shi C; Phillips D; Owen W; Sinha U; Simon DI. 2011. Critical role for Syk in responses to vascular injury. Blood 118(18):5000-10. PubMed: 21881044 MGI: J:178801
Andrews-Zwilling Y; Bien-Ly N; Xu Q; Li G; Bernardo A; Yoon SY; Zwilling D; Yan TX; Chen L; Huang Y. 2010. Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice. J Neurosci 30(41):13707-17. PubMed: 20943911 MGI: J:165492
Angeli V; Llodra J; Rong JX; Satoh K; Ishii S; Shimizu T; Fisher EA; Randolph GJ. 2004. Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. Immunity 21(4):561-74. PubMed: 15485633 MGI: J:93917
Angsana J; Chen J; Smith S; Xiao J; Wen J; Liu L; Haller CA; Chaikof EL. 2015. Syndecan-1 modulates the motility and resolution responses of macrophages. Arterioscler Thromb Vasc Biol 35(2):332-40. PubMed: 25550207 MGI: J:240984
Aono J; Suzuki J; Iwai M; Horiuchi M; Nagai T; Nishimura K; Inoue K; Ogimoto A; Okayama H; Higaki J. 2012. Deletion of the angiotensin II type 1a receptor prevents atherosclerotic plaque rupture in apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 32(6):1453-9. PubMed: 22460554 MGI: J:196922
Apostolov EO; Ray D; Savenka AV; Shah SV; Basnakian AG. 2010. Chronic uremia stimulates LDL carbamylation and atherosclerosis. J Am Soc Nephrol 21(11):1852-7. PubMed: 20947625 MGI: J:185898
Aprahamian T; Bonegio R; Rizzo J; Perlman H; Lefer DJ; Rifkin IR; Walsh K. 2006. Simvastatin treatment ameliorates autoimmune disease associated with accelerated atherosclerosis in a murine lupus model. J Immunol 177(5):3028-34. PubMed: 16920939 MGI: J:139547
Aprahamian T; Bonegio RG; Richez C; Yasuda K; Chiang LK; Sato K; Walsh K; Rifkin IR. 2009. The peroxisome proliferator-activated receptor gamma agonist rosiglitazone ameliorates murine lupus by induction of adiponectin. J Immunol 182(1):340-6. PubMed: 19109165 MGI: J:142895
Aprahamian T; Rifkin I; Bonegio R; Hugel B; Freyssinet JM; Sato K; Castellot JJ Jr; Walsh K. 2004. Impaired Clearance of Apoptotic Cells Promotes Synergy between Atherogenesis and Autoimmune Disease. J Exp Med 199(8):1121-31. PubMed: 15096538 MGI: J:91058
Arakawa M; Mita T; Azuma K; Ebato C; Goto H; Nomiyama T; Fujitani Y; Hirose T; Kawamori R; Watada H. 2010. Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4. Diabetes 59(4):1030-7. PubMed: 20068138 MGI: J:164336
Arnold L; Perrin H; de Chanville CB; Saclier M; Hermand P; Poupel L; Guyon E; Licata F; Carpentier W; Vilar J; Mounier R; Chazaud B; Benhabiles N; Boissonnas A; Combadiere B; Combadiere C. 2015. CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production. Nat Commun 6:8972. PubMed: 26632270 MGI: J:228319
Arsenescu V; Arsenescu R; Parulkar M; Karounos M; Zhang X; Baker N; Cassis LA. 2011. Polychlorinated biphenyl 77 augments angiotensin II-induced atherosclerosis and abdominal aortic aneurysms in male apolipoprotein E deficient mice. Toxicol Appl Pharmacol 257(1):148-54. PubMed: 21925196 MGI: J:178556
Ashida N; Senbanerjee S; Kodama S; Foo SY; Coggins M; Spencer JA; Zamiri P; Shen D; Li L; Sciuto T; Dvorak A; Gerszten RE; Lin CP; Karin M; Rosenzweig A. 2011. IKKbeta regulates essential functions of the vascular endothelium through kinase-dependent and -independent pathways. Nat Commun 2:318. PubMed: 21587235 MGI: J:205654
Ason B; van der Hoorn JW; Chan J; Lee E; Pieterman EJ; Nguyen KK; Di M; Shetterly S; Tang J; Yeh WC; Schwarz M; Jukema JW; Scott R; Wasserman SM; Princen HM; Jackson S. 2014. PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE. J Lipid Res 55(11):2370-9. PubMed: 25258384 MGI: J:216603
Atkins GB; Wang Y; Mahabeleshwar GH; Shi H; Gao H; Kawanami D; Natesan V; Lin Z; Simon DI; Jain MK. 2008. Hemizygous deficiency of Kruppel-like factor 2 augments experimental atherosclerosis. Circ Res 103(7):690-3. PubMed: 18757824 MGI: J:155153
Atkinson RD; Coenen KR; Plummer MR; Gruen ML; Hasty AH. 2008. Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipoprotein E-deficient mice. Am J Physiol Endocrinol Metab 294(2):E284-90. PubMed: 18029445 MGI: J:133332
Auger A; Truong TQ; Rhainds D; Lapointe J; Letarte F; Brissette L. 2001. Low and high density lipoprotein metabolism in primary cultures of hepatic cells from normal and apolipoprotein E knockout mice. Eur J Biochem 268(8):2322-30. PubMed: 11298750 MGI: J:115588
Aung HH; Altman R; Nyunt T; Kim J; Nuthikattu S; Budamagunta M; Voss JC; Wilson D; Rutledge JC; Villablanca AC. 2016. Lipotoxic brain microvascular injury is mediated by activating transcription factor 3-dependent inflammatory and oxidative stress pathways. J Lipid Res 57(6):955-68. PubMed: 27087439 MGI: J:233751
Austin SA; Combs CK. 2010. Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE(-)/(-) mice. Neurobiol Aging 31(11):1854-66. PubMed: 19058878 MGI: J:165242
Avraham-Davidi I; Ely Y; Pham VN; Castranova D; Grunspan M; Malkinson G; Gibbs-Bar L; Mayseless O; Allmog G; Lo B; Warren CM; Chen TT; Ungos J; Kidd K; Shaw K; Rogachev I; Wan W; Murphy PM; Farber SA; Carmel L; Shelness GS; Iruela-Arispe ML; Weinstein BM; Yaniv K. 2012. ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nat Med 18(6):967-73. PubMed: 22581286 MGI: J:187459
Azevedo OG; Bolick DT; Roche JK; Pinkerton RF; Lima AA; Vitek MP; Warren CA; Oria RB; Guerrant RL. 2014. Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice. PLoS One 9(2):e89562. PubMed: 24586873 MGI: J:213815
Azuma K; Ichimura K; Mita T; Nakayama S; Jin WL; Hirose T; Fujitani Y; Sumiyoshi K; Shimada K; Daida H; Sakai T; Mitsumata M; Kawamori R; Watada H. 2009. Presence of alpha-smooth muscle actin-positive endothelial cells in the luminal surface of adult aorta. Biochem Biophys Res Commun 380(3):620-6. PubMed: 19285011 MGI: J:147062
Baba SP; Barski OA; Ahmed Y; O'Toole TE; Conklin DJ; Bhatnagar A; Srivastava S. 2009. Reductive metabolism of AGE precursors: a metabolic route for preventing AGE accumulation in cardiovascular tissue. Diabetes 58(11):2486-97. PubMed: 19651811 MGI: J:154389
Babaev VR; Ding L; Reese J; Morrow JD; Breyer MD; Dey SK; Fazio S; Linton MF. 2006. Cyclooxygenase-1 deficiency in bone marrow cells increases early atherosclerosis in apolipoprotein E- and low-density lipoprotein receptor-null mice. Circulation 113(1):108-17. PubMed: 16380543 MGI: J:121507
Babaev VR; Li L; Shah S; Fazio S; Linton MF; May JM. 2010. Combined vitamin C and vitamin E deficiency worsens early atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 30(9):1751-7. PubMed: 20558818 MGI: J:179551
Bagavant H; Scindia Y; Nackiewicz D; Rao Nandula S; Doran A; Cutchins A; Oldham S; Deshmukh U; McNamara C. 2011. Deficiency of a transcriptional regulator, inhibitor of differentiation 3, induces glomerulonephritis in apolipoprotein e-deficient mice a model linking hyperlipidemia and renal disease. Am J Pathol 179(2):651-60. PubMed: 21801865 MGI: J:174603
Bai B; Liang Y; Xu C; Lee MY; Xu A; Wu D; Vanhoutte PM; Wang Y. 2012. Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation 126(6):729-40. PubMed: 22753194 MGI: J:202201
Baldan A; Pei L; Lee R; Tarr P; Tangirala RK; Weinstein MM; Frank J; Li AC; Tontonoz P; Edwards PA. 2006. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arterioscler Thromb Vasc Biol 26(10):2301-7. PubMed: 16888235 MGI: J:128048
Bales KR; Liu F; Wu S; Lin S; Koger D; DeLong C; Hansen JC; Sullivan PM; Paul SM. 2009. Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. J Neurosci 29(21):6771-9. PubMed: 19474305 MGI: J:149522
Bales KR; Verina T; Cummins DJ; Du Y; Dodel RC; Saura J; Fishman CE; DeLong CA; Piccardo P; Petegnief V; Ghetti B; Paul SM. 1999. Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 96(26):15233-8. PubMed: 10611368 MGI: J:59078
Bales KR; Verina T; Dodel RC; Du Y; Altstiel L; Bender M; Hyslop P; Johnstone EM; Little SP; Cummins DJ; Piccardo P; Ghetti B; Paul SM. 1997. Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition [letter] [see comments] Nat Genet 17(3):263-4. PubMed: 9354781 MGI: J:43845
Baltgalvis KA; White K; Li W; Claypool MD; Lang W; Alcantara R; Singh BK; Friera AM; McLaughlin J; Hansen D; McCaughey K; Nguyen H; Smith IJ; Godinez G; Shaw SJ; Goff D; Singh R; Markovtsov V; Sun TQ; Jenkins Y; Uy G; Li Y; Pan A; Gururaja T; Lau D; ParkG; Hitoshi Y; Payan DG; Kinsella TM. 2014. Exercise performance and peripheral vascular insufficiency improve with AMPK activation in high-fat diet-fed mice. Am J Physiol Heart Circ Physiol 306(8):H1128-45. PubMed: 24561866 MGI: J:210750
Barajas B; Che N; Yin F; Rowshanrad A; Orozco LD; Gong KW; Wang X; Castellani LW; Reue K; Lusis AJ; Araujo JA. 2011. NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection. Arterioscler Thromb Vasc Biol 31(1):58-66. PubMed: 20947826 MGI: J:184195
Barile GR; Pachydaki SI; Tari SR; Lee SE; Donmoyer CM; Ma W; Rong LL; Buciarelli LG; Wendt T; Horig H; Hudson BI; Qu W; Weinberg AD; Yan SF; Schmidt AM. 2005. The RAGE axis in early diabetic retinopathy. Invest Ophthalmol Vis Sci 46(8):2916-24. PubMed: 16043866 MGI: J:103714
Barlic J; Murphy PM. 2007. Chemokine regulation of atherosclerosis. J Leukoc Biol 82(2):226-36. PubMed: 17329566 MGI: J:123530
Barry-Lane PA; Patterson C; van der Merwe M; Hu Z; Holland SM; Yeh ET; Runge MS. 2001. p47phox is required for atherosclerotic lesion progression in ApoE(-/-) mice. J Clin Invest 108(10):1513-22. PubMed: 11714743 MGI: J:111638
Bartelt A; Beil FT; Schinke T; Roeser K; Ruether W; Heeren J; Niemeier A. 2010. Apolipoprotein E-dependent inverse regulation of vertebral bone and adipose tissue mass in C57Bl/6 mice: modulation by diet-induced obesity. Bone 47(4):736-45. PubMed: 20633710 MGI: J:165157
Bartelt A; Orlando P; Mele C; Ligresti A; Toedter K; Scheja L; Heeren J; Di Marzo V. 2011. Altered endocannabinoid signalling after a high-fat diet in Apoe (-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance. Diabetologia 54(11):2900-10. PubMed: 21847582 MGI: J:178356
Barton M; Haudenschild CC; d'Uscio LV; Shaw S; Munter K; Luscher TF. 1998. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 95(24):14367-72. PubMed: 9826706 MGI: J:51282
Basu A; Poddar D; Robinet P; Smith JD; Febbraio M; Baldwin WM 3rd; Mazumder B. 2014. Ribosomal protein L13a deficiency in macrophages promotes atherosclerosis by limiting translation control-dependent retardation of inflammation. Arterioscler Thromb Vasc Biol 34(3):533-42. PubMed: 24436370 MGI: J:222822
Bates KA; Fonte J; Robertson TA; Martins RN; Harvey AR. 2002. Chronic gliosis triggers Alzheimer's disease-like processing of amyloid precursor protein. Neuroscience 113(4):785-96. PubMed: 12182886 MGI: J:120711
Baumgartl J; Baudler S; Scherner M; Babaev V; Makowski L; Suttles J; McDuffie M; Tobe K; Kadowaki T; Fazio S; Kahn CR; Hotamisligil GS; Krone W; Linton M; Bruning JC. 2006. Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab 3(4):247-56. PubMed: 16581002 MGI: J:129654
Beaulieu LM; Clancy L; Tanriverdi K; Benjamin EJ; Kramer CD; Weinberg EO; He X; Mekasha S; Mick E; Ingalls RR; Genco CA; Freedman JE. 2015. Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans. PLoS One 10(7):e0131688. PubMed: 26148065 MGI: J:238389
Bechtholt AJ; Smith R; Raber J; Cunningham CL. 2004. Enhanced ethanol-, but not cocaine-induced, conditioned place preference in Apoe(-/-) mice. Pharmacol Biochem Behav 77(4):783-92. PubMed: 15099924 MGI: J:102259
Becker LE; Koleganova N; Piecha G; Noronha IL; Zeier M; Geldyyev A; Kokeny G; Ritz E; Gross ML. 2011. Effect of paricalcitol and calcitriol on aortic wall remodeling in uninephrectomized ApoE knockout mice. Am J Physiol Renal Physiol 300(3):F772-82. PubMed: 21159735 MGI: J:169320
Beckers L; Heeneman S; Wang L; Burkly L; Rousch M; Davidson N; Gijbels M; de Winther M; Daemen M; Lutgens E. 2007. Disruption of hedgehog signalling in ApoE - /- mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages. J Pathol 212(4):420-8. PubMed: 17573667 MGI: J:122864
Beleznai T; Takano H; Hamill C; Yarova P; Douglas G; Channon K; Dora K. 2011. Enhanced K(+)-channel-mediated endothelium-dependent local and conducted dilation of small mesenteric arteries from ApoE(-/-) mice. Cardiovasc Res 92(2):199-208. PubMed: 21690174 MGI: J:191707
Bell RD; Winkler EA; Singh I; Sagare AP; Deane R; Wu Z; Holtzman DM; Betsholtz C; Armulik A; Sallstrom J; Berk BC; Zlokovic BV. 2012. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485(7399):512-6. PubMed: 22622580 MGI: J:184835
Bengtsson E; To F; Hakansson K; Grubb A; Branen L; Nilsson J; Jovinge S. 2005. Lack of the cysteine protease inhibitor cystatin C promotes atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25(10):2151-6. PubMed: 16051881 MGI: J:114346
Bennett BJ; Scatena M; Kirk EA; Rattazzi M; Varon RM; Averill M; Schwartz SM; Giachelli CM; Rosenfeld ME. 2006. Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- mice. Arterioscler Thromb Vasc Biol 26(9):2117-24. PubMed: 16840715 MGI: J:128053
Bennett BJ; Wang SS; Wang X; Wu X; Lusis AJ. 2009. Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice. Arterioscler Thromb Vasc Biol 29(3):348-55. PubMed: 19122174 MGI: J:159783
Bentzon JF; Sondergaard CS; Kassem M; Falk E. 2007. Smooth muscle cells healing atherosclerotic plaque disruptions are of local, not blood, origin in apolipoprotein E knockout mice. Circulation 116(18):2053-61. PubMed: 17938286 MGI: J:142997
Berbee JF; Boon MR; Khedoe PP; Bartelt A; Schlein C; Worthmann A; Kooijman S; Hoeke G; Mol IM; John C; Jung C; Vazirpanah N; Brouwers LP; Gordts PL; Esko JD; Hiemstra PS; Havekes LM; Scheja L; Heeren J; Rensen PC. 2015. Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun 6:6356. PubMed: 25754609 MGI: J:232977
Berbee JF; van der Hoogt CC; Sundararaman D; Havekes LM; Rensen PC. 2005. Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL. J Lipid Res 46(2):297-306. PubMed: 15576844 MGI: J:96691
Bernhagen J; Krohn R; Lue H; Gregory JL; Zernecke A; Koenen RR; Dewor M; Georgiev I; Schober A; Leng L; Kooistra T; Fingerle-Rowson G; Ghezzi P; Kleemann R; McColl SR; Bucala R; Hickey MJ; Weber C. 2007. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med 13(5):587-596. PubMed: 17435771 MGI: J:121807
Bhattacharjee PS; Neumann DM; Stark D; Thompson HW; Hill JM. 2006. Apolipoprotein E modulates establishment of HSV-1 latency and survival in a mouse ocular model. Curr Eye Res 31(9):703-8. PubMed: 16966142 MGI: J:119878
Bien-Ly N; Andrews-Zwilling Y; Xu Q; Bernardo A; Wang C; Huang Y. 2011. C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-beta (Abeta) and acts in concert with Abeta to elicit neuronal and behavioral deficits in mice. Proc Natl Acad Sci U S A 108(10):4236-41. PubMed: 21368138 MGI: J:170827
Bien-Ly N; Gillespie AK; Walker D; Yoon SY; Huang Y. 2012. Reducing human apolipoprotein E levels attenuates age-dependent Abeta accumulation in mutant human amyloid precursor protein transgenic mice. J Neurosci 32(14):4803-11. PubMed: 22492035 MGI: J:184138
Billon-Gales A; Krust A; Fontaine C; Abot A; Flouriot G; Toutain C; Berges H; Gadeau AP; Lenfant F; Gourdy P; Chambon P; Arnal JF. 2011. Activation function 2 (AF2) of estrogen receptor-alpha is required for the atheroprotective action of estradiol but not to accelerate endothelial healing. Proc Natl Acad Sci U S A 108(32):13311-6. PubMed: 21788522 MGI: J:175619
Biswas S; Xin L; Panigrahi S; Zimman A; Wang H; Yakubenko VP; Byzova TV; Salomon RG; Podrez EA. 2016. Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2. Blood 127(21):2618-29. PubMed: 27015965 MGI: J:233074
Biswas SK; Newby DE; Rahman I; Megson IL. 2005. Depressed glutathione synthesis precedes oxidative stress and atherogenesis in Apo-E(-/-) mice. Biochem Biophys Res Commun 338(3):1368-73. PubMed: 16263083 MGI: J:103465
Bjorkbacka H; Kunjathoor VV; Moore KJ; Koehn S; Ordija CM; Lee MA; Means T; Halmen K; Luster AD; Golenbock DT; Freeman MW. 2004. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med 10(4):416-21. PubMed: 15034566 MGI: J:90091
Blasiole DA; Oler AT; Attie AD. 2008. Regulation of ApoB secretion by the low density lipoprotein receptor requires exit from the endoplasmic reticulum and interaction with ApoE or ApoB. J Biol Chem 283(17):11374-81. PubMed: 18272520 MGI: J:136523
Bobkova D; Honsova E; Kovar J; Poledne R. 2004. Effect of diets on lipoprotein concentrations in heterozygous apolipoprotein E-deficient mice. Physiol Res 53(6):635-43. PubMed: 15588132 MGI: J:102284
Bobryshev YV; Babaev VR; Lord RS; Watanabe T. 1999. Ultrastructural identification of cells with dendritic cell appearance in atherosclerotic aorta of apolipoprotein E deficient mice J Submicrosc Cytol Pathol 31(4):527-31. PubMed: 10685393 MGI: J:60456
Bodary PF; Shen Y; Vargas FB; Bi X; Ostenso KA; Gu S; Shayman JA; Eitzman DT. 2005. Alpha-galactosidase A deficiency accelerates atherosclerosis in mice with apolipoprotein E deficiency Circulation 111(5):629-32. PubMed: 15668341 MGI: J:108541
Boesten LS; Zadelaar AS; van Nieuwkoop A; Hu L; Jonkers J; van de Water B; Gijbels MJ; van der Made I; de Winther MP; Havekes LM; van Vlijmen BJ. 2006. Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice. FASEB J 20(7):953-5. PubMed: 16585057 MGI: J:111494
Boisvert WA; Black AS; Curtiss LK. 1999. ApoA1 reduces free cholesterol accumulation in atherosclerotic lesions of ApoE-deficient mice transplanted with ApoE-expressing macrophages. Arterioscler Thromb Vasc Biol 19(3):525-30. PubMed: 10073953 MGI: J:55595
Bolick DT; Skaflen MD; Johnson LE; Kwon SC; Howatt D; Daugherty A; Ravichandran KS; Hedrick CC. 2009. G2A deficiency in mice promotes macrophage activation and atherosclerosis. Circ Res 104(3):318-27. PubMed: 19106413 MGI: J:163438
Bollmann F; Jackel S; Schmidtke L; Schrick K; Reinhardt C; Jurk K; Wu Z; Xia N; Li H; Erkel G; Walter U; Kleinert H; Pautz A. 2015. Anti-Inflammatory and Anti-Thrombotic Effects of the Fungal Metabolite Galiellalactone in Apolipoprotein E-Deficient Mice. PLoS One 10(6):e0130401. PubMed: 26076475 MGI: J:237809
Boord JB; Maeda K; Makowski L; Babaev VR; Fazio S; Linton MF; Hotamisligil GS. 2002. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. Arterioscler Thromb Vasc Biol 22(10):1686-91. PubMed: 12377750 MGI: J:103224
Boord JB; Maeda K; Makowski L; Babaev VR; Fazio S; Linton MF; Hotamisligil GS. 2004. Combined adipocyte-macrophage fatty acid-binding protein deficiency improves metabolism, atherosclerosis, and survival in apolipoprotein E-deficient mice. Circulation 110(11):1492-8. PubMed: 15353487 MGI: J:102223
Boring L; Gosling J; Cleary M; Charo IF. 1998. Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis. Nature 394(6696):894-7. PubMed: 9732872 MGI: J:111471
Bot I; Bot M; van Heiningen SH; van Santbrink PJ; Lankhuizen IM; Hartman P; Gruener S; Hilpert H; van Berkel TJ; Fingerle J; Biessen EA. 2011. Mast cell chymase inhibition reduces atherosclerotic plaque progression and improves plaque stability in ApoE-/- mice. Cardiovasc Res 89(1):244-52. PubMed: 20693162 MGI: J:186045
Bot M; de Jager SC; MacAleese L; Lagraauw HM; van Berkel TJ; Quax PH; Kuiper J; Heeren RM; Biessen EA; Bot I. 2013. Lysophosphatidic acid triggers mast cell-driven atherosclerotic plaque destabilization by increasing vascular inflammation. J Lipid Res 54(5):1265-74. PubMed: 23396975 MGI: J:196303
Bour A; Grootendorst J; Vogel E; Kelche C; Dodart JC; Bales K; Moreau PH; Sullivan PM; Mathis C. 2008. Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks. Behav Brain Res 193(2):174-82. PubMed: 18572260 MGI: J:139186
Bourdillon MC; Poston RN; Covacho C; Chignier E; Bricca G; McGregor JL. 2000. ICAM-1 deficiency reduces atherosclerotic lesions in double-knockout mice (ApoE(-/-)/ICAM-1(-/-)) fed a fat or a chow diet. Arterioscler Thromb Vasc Biol 20(12):2630-5. PubMed: 11116064 MGI: J:103384
Bourquard N; Ng CJ; Reddy ST. 2011. Impaired hepatic insulin signalling in PON2-deficient mice: a novel role for the PON2/apoE axis on the macrophage inflammatory response. Biochem J 436(1):91-100. PubMed: 21361875 MGI: J:172089
Bousette N; D'Orleans-Juste P; Kiss RS; You Z; Genest J; Al-Ramli W; Qureshi ST; Gramolini A; Behm D; Ohlstein EH; Harrison SM; Douglas SA; Giaid A. 2009. Urotensin II receptor knockout mice on an ApoE knockout background fed a high-fat diet exhibit an enhanced hyperlipidemic and atherosclerotic phenotype. Circ Res 105(7):686-95, 19 p following 695. PubMed: 19696412 MGI: J:169964
Bowes AJ; Khan MI; Shi Y; Robertson L; Werstuck GH. 2009. Valproate attenuates accelerated atherosclerosis in hyperglycemic apoE-deficient mice: evidence in support of a role for endoplasmic reticulum stress and glycogen synthase kinase-3 in lesion development and hepatic steatosis. Am J Pathol 174(1):330-42. PubMed: 19095952 MGI: J:144211
Boyanovsky B; Zack M; Forrest K; Webb NR. 2009. The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo. Arterioscler Thromb Vasc Biol 29(4):532-8. PubMed: 19164803 MGI: J:159779
Boyanovsky BB; Bailey W; Dixon L; Shridas P; Webb NR. 2012. Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice. Am J Pathol 181(3):1088-98. PubMed: 22813854 MGI: J:188499
Bradley MN; Hong C; Chen M; Joseph SB; Wilpitz DC; Wang X; Lusis AJ; Collins A; Hseuh WA; Collins JL; Tangirala RK; Tontonoz P. 2007. Ligand activation of LXR beta reverses atherosclerosis and cellular cholesterol overload in mice lacking LXR alpha and apoE. J Clin Invest 117(8):2337-46. PubMed: 17657314 MGI: J:123957
Branen L; Hovgaard L; Nitulescu M; Bengtsson E; Nilsson J; Jovinge S. 2004. Inhibition of tumor necrosis factor-alpha reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 24(11):2137-42. PubMed: 15345516 MGI: J:103699
Braun NA; Mendez-Fernandez YV; Covarrubias R; Porcelli SA; Savage PB; Yagita H; Van Kaer L; Major AS. 2010. Development of spontaneous anergy in invariant natural killer T cells in a mouse model of dyslipidemia. Arterioscler Thromb Vasc Biol 30(9):1758-65. PubMed: 20539017 MGI: J:179553
Braunersreuther V; Zernecke A; Arnaud C; Liehn EA; Steffens S; Shagdarsuren E; Bidzhekov K; Burger F; Pelli G; Luckow B; Mach F; Weber C. 2007. Ccr5 but not Ccr1 deficiency reduces development of diet-induced atherosclerosis in mice. Arterioscler Thromb Vasc Biol 27(2):373-9. PubMed: 17138939 MGI: J:128063
Brecht WJ; Harris FM; Chang S; Tesseur I; Yu GQ; Xu Q; Dee Fish J; Wyss-Coray T; Buttini M; Mucke L; Mahley RW; Huang Y. 2004. Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J Neurosci 24(10):2527-34. PubMed: 15014128 MGI: J:90126
Bro S; Borup R; Andersen CB; Moeller F; Olgaard K; Nielsen LB. 2006. Uremia-specific effects in the arterial media during development of uremic atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 26(3):570-5. PubMed: 16373611 MGI: J:127966
Broedl UC; Maugeais C; Millar JS; Jin W; Moore RE; Fuki IV; Marchadier D; Glick JM; Rader DJ. 2004. Endothelial lipase promotes the catabolism of ApoB-containing lipoproteins. Circ Res 94(12):1554-61. PubMed: 15117821 MGI: J:100064
Broisat A; Toczek J; Mesnier N; Tracqui P; Ghezzi C; Ohayon J; Riou LM. 2011. Assessing low levels of mechanical stress in aortic atherosclerotic lesions from apolipoprotein E-/- mice--brief report. Arterioscler Thromb Vasc Biol 31(5):1007-10. PubMed: 21393579 MGI: J:191479
Brown MD; Jin L; Jien ML; Matsumoto AH; Helm GA; Lusis AJ; Frank JS; Shi W. 2004. Lipid retention in the arterial wall of two mouse strains with different atherosclerosis susceptibility. J Lipid Res 45(6):1155-61. PubMed: 15105414 MGI: J:89769
Bruemmer D; Collins AR; Noh G; Wang W; Territo M; Arias-Magallona S; Fishbein MC; Blaschke F; Kintscher U; Graf K; Law RE; Hsueh WA. 2003. Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. J Clin Invest 112(9):1318-31. PubMed: 14597759 MGI: J:86531
Brunham LR; Singaraja RR; Duong M; Timmins JM; Fievet C; Bissada N; Kang MH; Samra A; Fruchart JC; McManus B; Staels B; Parks JS; Hayden MR. 2009. Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Arterioscler Thromb Vasc Biol 29(4):548-54. PubMed: 19201688 MGI: J:159775
Bu DX; Rai V; Shen X; Rosario R; Lu Y; D'Agati V; Yan SF; Friedman RA; Nuglozeh E; Schmidt AM. 2010. Activation of the ROCK1 branch of the transforming growth factor-beta pathway contributes to RAGE-dependent acceleration of atherosclerosis in diabetic ApoE-null mice. Circ Res 106(6):1040-51. PubMed: 20133903 MGI: J:170862
Buchheiser A; Ebner A; Burghoff S; Ding Z; Romio M; Viethen C; Lindecke A; Kohrer K; Fischer JW; Schrader J. 2011. Inactivation of CD73 promotes atherogenesis in apolipoprotein E-deficient mice. Cardiovasc Res 92(2):338-47. PubMed: 21955554 MGI: J:191695
Buday A; Orsy P; Godo M; Mozes M; Kokeny G; Lacza Z; Koller A; Ungvari Z; Gross ML; Benyo Z; Hamar P. 2010. Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice. Am J Physiol Heart Circ Physiol 299(2):H386-95. PubMed: 20511416 MGI: J:163556
Bugnicourt JM; Da Silveira C; Bengrine A; Godefroy O; Baumbach G; Sevestre H; Bode-Boeger SM; Kielstein JT; Massy ZA; Chillon JM. 2011. Chronic renal failure alters endothelial function in cerebral circulation in mice. Am J Physiol Heart Circ Physiol 301(3):H1143-52. PubMed: 21705678 MGI: J:176903
Burgos JS; Ramirez C; Sastre I; Alfaro JM; Valdivieso F. 2005. Herpes simplex virus type 1 infection via the bloodstream with apolipoprotein E dependence in the gonads is influenced by gender. J Virol 79(3):1605-12. PubMed: 15650186 MGI: J:95551
Burleigh ME; Babaev VR; Oates JA; Harris RC; Gautam S; Riendeau D; Marnett LJ; Morrow JD; Fazio S; Linton MF. 2002. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor-deficient mice. Circulation 105(15):1816-23. PubMed: 11956125 MGI: J:103220
Burleigh ME; Babaev VR; Yancey PG; Major AS; McCaleb JL; Oates JA; Morrow JD; Fazio S; Linton MF. 2005. Cyclooxygenase-2 promotes early atherosclerotic lesion formation in ApoE-deficient and C57BL/6 mice. J Mol Cell Cardiol 39(3):443-52. PubMed: 16040051 MGI: J:103979
Burnett MS; Gaydos CA; Madico GE; Glad SM; Paigen B; Quinn TC; Epstein SE. 2001. Atherosclerosis in apoE knockout mice infected with multiple pathogens. J Infect Dis 183(2):226-231. PubMed: 11120928 MGI: J:66879
Bursill CA; Castro ML; Beattie DT; Nakhla S; van der Vorst E; Heather AK; Barter PJ; Rye KA. 2010. High-density lipoproteins suppress chemokines and chemokine receptors in vitro and in vivo. Arterioscler Thromb Vasc Biol 30(9):1773-8. PubMed: 20702809 MGI: J:179548
Burton CA; Patel S; Mundt S; Hassing H; Zhang D; Hermanowski-Vosatka A; Wright SD; Chao YS; Detmers PA; Sparrow CP. 2002. Deficiency in sPLA(2) does not affect HDL levels or atherosclerosis in mice. Biochem Biophys Res Commun 294(1):88-94. PubMed: 12054745 MGI: J:77028
Busch M; Westhofen TC; Koch M; Lutz MB; Zernecke A. 2014. Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice. PLoS One 9(2):e88452. PubMed: 24551105 MGI: J:213070
Butcher MJ; Gjurich BN; Phillips T; Galkina EV. 2012. The IL-17A/IL-17RA axis plays a proatherogenic role via the regulation of aortic myeloid cell recruitment. Circ Res 110(5):675-87. PubMed: 22302786 MGI: J:212669
Buttini M; Masliah E; Yu GQ; Palop JJ; Chang S; Bernardo A; Lin C; Wyss-Coray T; Huang Y; Mucke L. 2010. Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice. Am J Pathol 177(2):563-9. PubMed: 20595630 MGI: J:163384
Buttini M; Orth M; Bellosta S; Akeefe H; Pitas RE; Wyss-Coray T; Mucke L; Mahley RW. 1999. Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration. J Neurosci 19(12):4867-80. PubMed: 10366621 MGI: J:55835
Buttini M; Yu GQ; Shockley K; Huang Y; Jones B; Masliah E; Mallory M; Yeo T; Longo FM; Mucke L. 2002. Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. J Neurosci 22(24):10539-48. PubMed: 12486146 MGI: J:129689
Buzello M; Tornig J; Faulhaber J; Ehmke H; Ritz E; Amann K. 2003. The apolipoprotein e knockout mouse: a model documenting accelerated atherogenesis in uremia. J Am Soc Nephrol 14(2):311-6. PubMed: 12538731 MGI: J:103173
Cabana VG; Feng N; Reardon CA; Lukens J; Webb NR; de Beer FC; Getz GS. 2004. Influence of apoA-I and apoE on the formation of serum amyloid A-containing lipoproteins in vivo and in vitro. J Lipid Res 45(2):317-25. PubMed: 14595002 MGI: J:121045
Cain WJ; Millar JS; Himebauch AS; Tietge UJ; Maugeais C; Usher D; Rader DJ. 2005. Lipoprotein [a] is cleared from the plasma primarily by the liver in a process mediated by apolipoprotein [a]. J Lipid Res 46(12):2681-91. PubMed: 16150825 MGI: J:106146
Cakir Y; Yang Z; Knight CA; Pompilius M; Westbrook D; Bailey SM; Pinkerton KE; Ballinger SW. 2007. Effect of alcohol and tobacco smoke on mtDNA damage and atherogenesis. Free Radic Biol Med 43(9):1279-88. PubMed: 17893041 MGI: J:125300
Caligiuri G; Groyer E; Khallou-Laschet J; Al Haj Zen A; Sainz J; Urbain D; Gaston AT; Lemitre M; Nicoletti A; Lafont A. 2005. Reduced immunoregulatory CD31+ T cells in the blood of atherosclerotic mice with plaque thrombosis. Arterioscler Thromb Vasc Biol 25(8):1659-64. PubMed: 15933243 MGI: J:114337
Caligiuri G; Levy B; Pernow J; Thoren P; Hansson GK. 1999. Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice. Proc Natl Acad Sci U S A 96(12):6920-4. PubMed: 10359814 MGI: J:55973
Caligiuri G; Nicoletti A; Poirier B; Hansson GK. 2002. Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic mice. J Clin Invest 109(6):745-53. PubMed: 11901183 MGI: J:75627
Caligiuri G; Rudling M; Ollivier V; Jacob MP; Michel JB; Hansson GK; Nicoletti A. 2003. Interleukin-10 deficiency increases atherosclerosis, thrombosis, and low-density lipoproteins in apolipoprotein E knockout mice. Mol Med 9(1-2):10-7. PubMed: 12765335 MGI: J:105858
Callegari A; Coons ML; Ricks JL; Yang HL; Gross TS; Huber P; Rosenfeld ME; Scatena M. 2013. Bone marrow- or vessel wall-derived osteoprotegerin is sufficient to reduce atherosclerotic lesion size and vascular calcification. Arterioscler Thromb Vasc Biol 33(11):2491-500. PubMed: 23990207 MGI: J:222218
Callegari A; Liu Y; White CC; Chait A; Gough P; Raines EW; Cox D; Kavanagh TJ; Rosenfeld ME. 2011. Gain and loss of function for glutathione synthesis: impact on advanced atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 31(11):2473-82. PubMed: 21868708 MGI: J:191462
Calleja L; Paris MA; Paul A; Vilella E; Joven J; Jimenez A; Beltran G; Uceda M; Maeda N; Osada J. 1999. Low-cholesterol and high-fat diets reduce atherosclerotic lesion development in ApoE-knockout mice. Arterioscler Thromb Vasc Biol 19(10):2368-75. PubMed: 10521366 MGI: J:59716
Cambon K; Davies HA; Stewart MG. 2000. Synaptic loss is accompanied by an increase in synaptic area in the dentate gyrus of aged human apolipoprotein E4 transgenic mice. Neuroscience 97(4):685-92. PubMed: 10842013 MGI: J:118049
Campagnolo P; Hong X; di Bernardini E; Smyrnias I; Hu Y; Xu Q. 2015. Resveratrol-Induced Vascular Progenitor Differentiation towards Endothelial Lineage via MiR-21/Akt/beta-Catenin Is Protective in Vessel Graft Models. PLoS One 10(5):e0125122. PubMed: 25961718 MGI: J:240375
Campbell IC; Weiss D; Suever JD; Virmani R; Veneziani A; Vito RP; Oshinski JN; Taylor WR. 2013. Biomechanical modeling and morphology analysis indicates plaque rupture due to mechanical failure unlikely in atherosclerosis-prone mice. Am J Physiol Heart Circ Physiol 304(3):H473-86. PubMed: 23203971 MGI: J:194633
Campen MJ; Lund AK; Knuckles TL; Conklin DJ; Bishop B; Young D; Seilkop S; Seagrave J; Reed MD; McDonald JD. 2010. Inhaled diesel emissions alter atherosclerotic plaque composition in ApoE(-/-) mice. Toxicol Appl Pharmacol 242(3):310-7. PubMed: 19891982 MGI: J:157024
Canault M; Peiretti F; Poggi M; Mueller C; Kopp F; Bonardo B; Bastelica D; Nicolay A; Alessi MC; Nalbone G. 2008. Progression of atherosclerosis in ApoE-deficient mice that express distinct molecular forms of TNF-alpha. J Pathol 214(5):574-83. PubMed: 18247429 MGI: J:133510
Cao C; Zhu Y; Chen W; Li L; Qi Y; Wang X; Zhao Y; Wan X; Chen X. 2013. IKKepsilon knockout prevents high fat diet induced arterial atherosclerosis and NF-kappaB signaling in mice. PLoS One 8(5):e64930. PubMed: 23741427 MGI: J:202115
Cao RY; Adams MA; Habenicht AJ; Funk CD. 2007. Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice. Prostaglandins Other Lipid Mediat 84(1-2):34-42. PubMed: 17643886 MGI: J:129321
Cao RY; St Amand T; Li X; Yoon SH; Wang CP; Song H; Maruyama T; Brown PM; Zelt DT; Funk CD. 2012. Prostaglandin Receptor EP4 in Abdominal Aortic Aneurysms. Am J Pathol 181(1):313-21. PubMed: 22595380 MGI: J:185548
Cao Y; Jacobsen NR; Danielsen PH; Lenz AG; Stoeger T; Loft S; Wallin H; Roursgaard M; Mikkelsen L; Moller P. 2014. Vascular effects of multiwalled carbon nanotubes in dyslipidemic ApoE-/- mice and cultured endothelial cells. Toxicol Sci 138(1):104-16. PubMed: 24431218 MGI: J:207491
Carlson GA; Borchelt DR; Dake A; Turner S; Danielson V; Coffin JD; Eckman C; Meiners J; Nilsen SP; Younkin SG; Hsiao KK. 1997. Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice. Hum Mol Genet 6(11):1951-9. PubMed: 9302276 MGI: J:43446
Cartland SP; Erlich JH; Kavurma MM. 2014. TRAIL deficiency contributes to diabetic nephropathy in fat-fed ApoE-/- mice. PLoS One 9(3):e92952. PubMed: 24667560 MGI: J:215054
Cassis LA; Gupte M; Thayer S; Zhang X; Charnigo R; Howatt DA; Rateri DL; Daugherty A. 2009. ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol 296(5):H1660-5. PubMed: 19252100 MGI: J:150893
Castellani LW; Nguyen CN; Charugundla S; Weinstein MM; Doan CX; Blaner WS; Wongsiriroj N; Lusis AJ. 2008. Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance. J Biol Chem 283(17):11633-44. PubMed: 18160395 MGI: J:136532
Castellano JM; Kim J; Stewart FR; Jiang H; DeMattos RB; Patterson BW; Fagan AM; Morris JC; Mawuenyega KG; Cruchaga C; Goate AM; Bales KR; Paul SM; Bateman RJ; Holtzman DM. 2011. Human apoE isoforms differentially regulate brain amyloid-beta peptide clearance. Sci Transl Med 3(89):89ra57. PubMed: 21715678 MGI: J:178363
Catanozi S; Rocha JC; Passarelli M; Guzzo ML; Alves C; Furukawa LN; Nunes VS; Nakandakare ER; Heimann JC; Quintao EC. 2003. Dietary sodium chloride restriction enhances aortic wall lipid storage and raises plasma lipid concentration in LDL receptor knockout mice. J Lipid Res 44(4):727-32. PubMed: 12562870 MGI: J:120709
Cesar L; Suarez SV; Adi J; Adi N; Vazquez-Padron R; Yu H; Ma Q; Goldschmidt-Clermont PJ; Agatston A; Kurlansky P; Webster KA. 2011. An essential role for diet in exercise-mediated protection against dyslipidemia, inflammation and atherosclerosis in ApoE/ mice. PLoS One 6(2):e17263. PubMed: 21359188 MGI: J:171082
Chadjichristos CE; Scheckenbach KE; van Veen TA; Richani Sarieddine MZ; de Wit C; Yang Z; Roth I; Bacchetta M; Viswambharan H; Foglia B; Dudez T; van Kempen MJ; Coenjaerts FE; Miquerol L; Deutsch U; Jongsma HJ; Chanson M; Kwak BR. 2010. Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesion. Circulation 121(1):123-31. PubMed: 20026782 MGI: J:162224
Chamberlain CM; Ang LS; Boivin WA; Cooper DM; Williams SJ; Zhao H; Hendel A; Folkesson M; Swedenborg J; Allard MF; McManus BM; Granville DJ. 2010. Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm. Am J Pathol 176(2):1038-49. PubMed: 20035050 MGI: J:156606
Chamberlain J; Francis S; Brookes Z; Shaw G; Graham D; Alp NJ; Dower S; Crossman DC. 2009. Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS One 4(4):e5073. PubMed: 19347044 MGI: J:148173
Chambliss KL; Barrera J; Umetani M; Umetani J; Kim SH; Madak-Erdogan Z; Huang L; Katzenellenbogen BS; Katzenellenbogen JA; Mineo C; Shaul PW. 2016. Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice. Endocrinology 157(10):3731-3741. PubMed: 27552247 MGI: J:240445
Chambliss KL; Wu Q; Oltmann S; Konaniah ES; Umetani M; Korach KS; Thomas GD; Mineo C; Yuhanna IS; Kim SH; Madak-Erdogan Z; Maggi A; Dineen SP; Roland CL; Hui DY; Brekken RA; Katzenellenbogen JA; Katzenellenbogen BS; Shaul PW. 2010. Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J Clin Invest 120(7):2319-30. PubMed: 20577047 MGI: J:163783
Champagne D; Dupuy JB; Rochford J; Poirier J. 2002. Apolipoprotein E knockout mice display procedural deficits in the Morris water maze: analysis of learning strategies in three versions of the task. Neuroscience 114(3):641-54. PubMed: 12220566 MGI: J:120203
Chandak PG; Obrowsky S; Radovic B; Doddapattar P; Aflaki E; Kratzer A; Doshi LS; Povoden S; Ahammer H; Hoefler G; Levak-Frank S; Kratky D. 2011. Lack of acyl-CoA:diacylglycerol acyltransferase 1 reduces intestinal cholesterol absorption and attenuates atherosclerosis in apolipoprotein E knockout mice. Biochim Biophys Acta 1811(12):1011-20. PubMed: 21924378 MGI: J:180334
Chang JD; Sukhova GK; Libby P; Schvartz E; Lichtenstein AH; Field SJ; Kennedy C; Madhavarapu S; Luo J; Wu D; Cantley LC. 2007. Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosis. Proc Natl Acad Sci U S A 104(19):8077-82. PubMed: 17483449 MGI: J:121582
Chang K; Francis SA; Aikawa E; Figueiredo JL; Kohler RH; McCarthy JR; Weissleder R; Plutzky J; Jaffer FA. 2010. Pioglitazone suppresses inflammation in vivo in murine carotid atherosclerosis: novel detection by dual-target fluorescence molecular imaging. Arterioscler Thromb Vasc Biol 30(10):1933-9. PubMed: 20689078 MGI: J:182106
Chang S; Zhang SH; Maeda N; Borensztajn J. 1994. Hepatic clearance of chylomicron remnants in mice lacking apoprotein E. Biochim Biophys Acta 1215(1-2):205-8. PubMed: 7948005 MGI: J:21599
Chatterjee S; Bedja D; Mishra S; Amuzie C; Avolio A; Kass DA; Berkowitz D; Renehan M. 2014. Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein E-/- mice and rabbits fed a high-fat and -cholesterol diet. Circulation 129(23):2403-13. PubMed: 24710030 MGI: J:222666
Che J; Okigaki M; Takahashi T; Katsume A; Adachi Y; Yamaguchi S; Matsunaga S; Takeda M; Matsui A; Kishita E; Ikeda K; Yamada H; Matsubara H. 2011. Endothelial FGF receptor signaling accelerates atherosclerosis. Am J Physiol Heart Circ Physiol 300(1):H154-61. PubMed: 20952669 MGI: J:168420
Chen J; Green J; Yurdagul A Jr; Albert P; McInnis MC; Orr AW. 2015. alphavbeta3 Integrins Mediate Flow-Induced NF-kappaB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation. Am J Pathol 185(9):2575-89. PubMed: 26212910 MGI: J:226518
Chen J; Kuhlencordt PJ; Astern J; Gyurko R; Huang PL. 2001. Hypertension does not account for the accelerated atherosclerosis and development of aneurysms in male apolipoprotein e/endothelial nitric oxide synthase double knockout mice. Circulation 104(20):2391-4. PubMed: 11705813 MGI: J:103382
Chen PY; Qin L; Baeyens N; Li G; Afolabi T; Budatha M; Tellides G; Schwartz MA; Simons M. 2015. Endothelial-to-mesenchymal transition drives atherosclerosis progression. J Clin Invest 125(12):4514-28. PubMed: 26517696 MGI: J:229400
Chen WY; Cheng BC; Jiang MJ; Hsieh MY; Chang MS. 2006. IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 26(9):2090-5. PubMed: 16778121 MGI: J:127995
Chen X; Zhang H; McAfee S; Zhang C. 2010. The reciprocal relationship between adiponectin and LOX-1 in the regulation of endothelial dysfunction in ApoE knockout mice. Am J Physiol Heart Circ Physiol 299(3):H605-12. PubMed: 20581092 MGI: J:164495
Chen Y; Zhu J; Lum PY; Yang X; Pinto S; MacNeil DJ; Zhang C; Lamb J; Edwards S; Sieberts SK; Leonardson A; Castellini LW; Wang S; Champy MF; Zhang B; Emilsson V; Doss S; Ghazalpour A; Horvath S; Drake TA; Lusis AJ; Schadt EE. 2008. Variations in DNA elucidate molecular networks that cause disease. Nature 452(7186):429-35. PubMed: 18344982 MGI: J:134171
Chen YC; Bui AV; Diesch J; Manasseh R; Hausding C; Rivera J; Haviv I; Agrotis A; Htun NM; Jowett J; Hagemeyer CE; Hannan RD; Bobik A; Peter K. 2013. A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic/therapeutic discoveries using gene and microRNA expression profiling. Circ Res 113(3):252-65. PubMed: 23748430 MGI: J:213398
Chen YX; Zhang M; Cai Y; Zhao Q; Dai W. 2015. The Sirt1 activator SRT1720 attenuates angiotensin II-induced atherosclerosis in apoE(-)/(-) mice through inhibiting vascular inflammatory response. Biochem Biophys Res Commun 465(4):732-8. PubMed: 26296466 MGI: J:232883
Chen Z; Fitzgerald RL; Li G; Davidson NO; Schonfeld G. 2004. Hepatic secretion of apoB-100 is impaired in hypobetalipoproteinemic mice with an apoB-38.9-specifying allele. J Lipid Res 45(1):155-63. PubMed: 13130124 MGI: J:87974
Chen Z; Fitzgerald RL; Saffitz JE; Semenkovich CF; Schonfeld G. 2003. Amino terminal 38.9% of apolipoprotein B-100 is sufficient to support cholesterol-rich lipoprotein production and atherosclerosis. Arterioscler Thromb Vasc Biol 23(4):668-74. PubMed: 12615667 MGI: J:103058
Cheng C; Tempel D; Den Dekker WK; Haasdijk R; Chrifi I; Bos FL; Wagtmans K; van de Kamp EH; Blonden L; Biessen EA; Moll F; Pasterkamp G; Serruys PW; Schulte-Merker S; Duckers HJ. 2011. Ets2 determines the inflammatory state of endothelial cells in advanced atherosclerotic lesions. Circ Res 109(4):382-95. PubMed: 21700929 MGI: J:186601
Cheng C; Tempel D; van Haperen R; de Boer HC; Segers D; Huisman M; van Zonneveld AJ; Leenen PJ; van der Steen A; Serruys PW; de Crom R; Krams R. 2007. Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines. J Clin Invest 117(3):616-26. PubMed: 17304353 MGI: J:120778
Cheng F; Torzewski M; Degreif A; Rossmann H; Canisius A; Lackner KJ. 2013. Impact of glutathione peroxidase-1 deficiency on macrophage foam cell formation and proliferation: implications for atherogenesis. PLoS One 8(8):e72063. PubMed: 23991041 MGI: J:204544
Cheng H; Zhou Y; Holtzman DM; Han X. 2010. Apolipoprotein E mediates sulfatide depletion in animal models of Alzheimer's disease. Neurobiol Aging 31(7):1188-96. PubMed: 18762354 MGI: J:161991
Cherepanova OA; Gomez D; Shankman LS; Swiatlowska P; Williams J; Sarmento OF; Alencar GF; Hess DL; Bevard MH; Greene ES; Murgai M; Turner SD; Geng YJ; Bekiranov S; Connelly JJ; Tomilin A; Owens GK. 2016. Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective. Nat Med 22(6):657-65. PubMed: 27183216 MGI: J:239720
Chereshnev I; Trogan E; Omerhodzic S; Itskovich V; Aguinaldo JG; Fayad ZA; Fisher EA; Reis ED. 2003. Mouse model of heterotopic aortic arch transplantation. J Surg Res 111(2):171-6. PubMed: 12850459 MGI: J:118962
Cheung SH; Kwok WK; To KF; Lau JY. 2014. Anti-atherogenic effect of hydrogen sulfide by over-expression of cystathionine gamma-lyase (CSE) gene. PLoS One 9(11):e113038. PubMed: 25397776 MGI: J:225143
Chevre R; Gonzalez-Granado JM; Megens RT; Sreeramkumar V; Silvestre-Roig C; Molina-Sanchez P; Weber C; Soehnlein O; Hidalgo A; Andres V. 2014. High-resolution imaging of intravascular atherogenic inflammation in live mice. Circ Res 114(5):770-9. PubMed: 24366169 MGI: J:223701
Chew P; Yuen DY; Koh P; Stefanovic N; Febbraio MA; Kola I; Cooper ME; de Haan JB. 2009. Site-specific antiatherogenic effect of the antioxidant ebselen in the diabetic apolipoprotein E-deficient mouse. Arterioscler Thromb Vasc Biol 29(6):823-30. PubMed: 19325139 MGI: J:164044
Chew P; Yuen DY; Stefanovic N; Pete J; Coughlan MT; Jandeleit-Dahm KA; Thomas MC; Rosenfeldt F; Cooper ME; de Haan JB. 2010. Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse. Diabetes 59(12):3198-207. PubMed: 20823099 MGI: J:169335
Chiba T; Han CY; Vaisar T; Shimokado K; Kargi A; Chen MH; Wang S; McDonald TO; O'Brien KD; Heinecke JW; Chait A. 2009. Serum amyloid A3 does not contribute to circulating SAA levels. J Lipid Res 50(7):1353-62. PubMed: 19286646 MGI: J:158176
Cho YL; Hur SM; Kim JY; Kim JH; Lee DK; Choe J; Won MH; Ha KS; Jeoung D; Han S; Ryoo S; Lee H; Min JK; Kwon YG; Kim DH; Kim YM. 2015. Specific activation of insulin-like growth factor-1 receptor by ginsenoside Rg5 promotes angiogenesis and vasorelaxation. J Biol Chem 290(1):467-77. PubMed: 25391655 MGI: J:218394
Choi ET; Collins ET; Marine LA; Uberti MG; Uchida H; Leidenfrost JE; Khan MF; Boc KP; Abendschein DR; Parks WC. 2005. Matrix metalloproteinase-9 modulation by resident arterial cells is responsible for injury-induced accelerated atherosclerotic plaque development in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25(5):1020-5. PubMed: 15746435 MGI: J:110044
Choi J; Forster MJ; McDonald SR; Weintraub ST; Carroll CA; Gracy RW. 2004. Proteomic identification of specific oxidized proteins in ApoE-knockout mice: relevance to Alzheimer's disease. Free Radic Biol Med 36(9):1155-62. PubMed: 15082069 MGI: J:91069
Choy K; Beck K; Png FY; Wu BJ; Leichtweis SB; Thomas SR; Hou JY; Croft KD; Mori TA; Stocker R. 2005. Processes involved in the site-specific effect of probucol on atherosclerosis in apolipoprotein E gene knockout mice. Arterioscler Thromb Vasc Biol 25(8):1684-90. PubMed: 15961704 MGI: J:114329
Christman MA 2nd; Goetz DJ; Dickerson E; McCall KD; Lewis CJ; Benencia F; Silver MJ; Kohn LD; Malgor R. 2008. Wnt5a is expressed in murine and human atherosclerotic lesions. Am J Physiol Heart Circ Physiol 294(6):H2864-70. PubMed: 18456733 MGI: J:136708
Christoffersen C; Benn M; Christensen PM; Gordts PL; Roebroek AJ; Frikke-Schmidt R; Tybjaerg-Hansen A; Dahlback B; Nielsen LB. 2012. The plasma concentration of HDL-associated apoM is influenced by LDL receptor-mediated clearance of apoB-containing particles. J Lipid Res 53(10):2198-204. PubMed: 22826357 MGI: J:188041
Christoffersen C; Pedersen TX; Gordts PL; Roebroek AJ; Dahlback B; Nielsen LB. 2010. Opposing effects of apolipoprotein m on catabolism of apolipoprotein B-containing lipoproteins and atherosclerosis. Circ Res 106(10):1624-34. PubMed: 20360257 MGI: J:172136
Chu A; Ordonez ET; Hellerstein MK. 2006. Measurement of mouse vascular smooth muscle and atheroma cell proliferation by 2H2O incorporation into DNA. Am J Physiol Cell Physiol 291(5):C1014-21. PubMed: 16774990 MGI: J:119869
Chuah MI; Getchell ML. 1999. Metallothionein in olfactory mucosa of Alzheimer's disease patients and apoE-deficient mice. Neuroreport 10(9):1919-24. PubMed: 10501533 MGI: J:59464
Chukkapalli SS; Rivera MF; Velsko IM; Lee JY; Chen H; Zheng D; Bhattacharyya I; Gangula PR; Lucas AR; Kesavalu L. 2014. Invasion of oral and aortic tissues by oral spirochete Treponema denticola in ApoE(-/-) mice causally links periodontal disease and atherosclerosis. Infect Immun 82(5):1959-67. PubMed: 24566627 MGI: J:209887
Chun HJ; Ali ZA; Kojima Y; Kundu RK; Sheikh AY; Agrawal R; Zheng L; Leeper NJ; Pearl NE; Patterson AJ; Anderson JP; Tsao PS; Lenardo MJ; Ashley EA; Quertermous T. 2008. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest 118(10):3343-54. PubMed: 18769630 MGI: J:141167
Chung WS; Verghese PB; Chakraborty C; Joung J; Hyman BT; Ulrich JD; Holtzman DM; Barres BA. 2016. Novel allele-dependent role for APOE in controlling the rate of synapse pruning by astrocytes. Proc Natl Acad Sci U S A 113(36):10186-91. PubMed: 27559087 MGI: J:235583
Chyu KY; Lio WM; Dimayuga PC; Zhou J; Zhao X; Yano J; Trinidad P; Honjo T; Cercek B; Shah PK. 2014. Cholesterol lowering modulates T cell function in vivo and in vitro. PLoS One 9(3):e92095. PubMed: 24647529 MGI: J:215073
Clarke MC; Figg N; Maguire JJ; Davenport AP; Goddard M; Littlewood TD; Bennett MR. 2006. Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nat Med 12(9):1075-80. PubMed: 16892061 MGI: J:115051
Clarke MC; Littlewood TD; Figg N; Maguire JJ; Davenport AP; Goddard M; Bennett MR. 2008. Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration. Circ Res 102(12):1529-38. PubMed: 18497329 MGI: J:151378
Clarke MC; Talib S; Figg NL; Bennett MR. 2010. Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflammation: effects of hyperlipidemia-mediated inhibition of phagocytosis. Circ Res 106(2):363-72. PubMed: 19926874 MGI: J:170062
Claudel T; Leibowitz MD; Fievet C; Tailleux A; Wagner B; Repa JJ; Torpier G; Lobaccaro JM; Paterniti JR; Mangelsdorf DJ; Heyman RA; Auwerx J. 2001. Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor. Proc Natl Acad Sci U S A 98(5):2610-5. PubMed: 11226287 MGI: J:67869
Clee SM; Bissada N; Miao F; Miao L; Marais AD; Henderson HE; Steures P; McManus J; McManus B; LeBoeuf RC; Kastelein JJ; Hayden MR. 2000. Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis J Lipid Res 41(4):521-31. PubMed: 10744772 MGI: J:61561
Coleman PR; Hahn CN; Grimshaw M; Lu Y; Li X; Brautigan PJ; Beck K; Stocker R; Vadas MA; Gamble JR. 2010. Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells. Blood 116(19):4016-24. PubMed: 20664062 MGI: J:166468
Collins RG; Velji R; Guevara NV; Hicks MJ; Chan L; Beaudet AL. 2000. P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 191(1):189-94. PubMed: 10620617 MGI: J:59249
Combadiere C; Potteaux S; Gao JL; Esposito B; Casanova S; Lee EJ; Debre P; Tedgui A; Murphy PM; Mallat Z. 2003. Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice. Circulation 107(7):1009-16. PubMed: 12600915 MGI: J:103047
Comley LH; Fuller HR; Wishart TM; Mutsaers CA; Thomson D; Wright AK; Ribchester RR; Morris GE; Parson SH; Horsburgh K; Gillingwater TH. 2011. ApoE isoform-specific regulation of regeneration in the peripheral nervous system. Hum Mol Genet 20(12):2406-21. PubMed: 21478199 MGI: J:171975
Conde-Knape K; Bensadoun A; Sobel JH; Cohn JS; Shachter NS. 2002. Overexpression of apoC-I in apoE-null mice: severe hypertriglyceridemia due to inhibition of hepatic lipase. J Lipid Res 43(12):2136-45. PubMed: 12454276 MGI: J:80689
Connelly JJ; Cherepanova OA; Doss JF; Karaoli T; Lillard TS; Markunas CA; Nelson S; Wang T; Ellis PD; Langford CF; Haynes C; Seo DM; Goldschmidt-Clermont PJ; Shah SH; Kraus WE; Hauser ER; Gregory SG. 2013. Epigenetic regulation of COL15A1 in smooth muscle cell replicative aging and atherosclerosis. Hum Mol Genet 22(25):5107-20. PubMed: 23912340 MGI: J:203130
Conover CA; Mason MA; Bale LK; Harrington SC; Nyegaard M; Oxvig C; Overgaard MT. 2010. Transgenic overexpression of pregnancy-associated plasma protein-A in murine arterial smooth muscle accelerates atherosclerotic lesion development. Am J Physiol Heart Circ Physiol 299(2):H284-91. PubMed: 20472761 MGI: J:163872
Corey LM; Baker C; Luchtel DL. 2006. Heart-rate variability in the apolipoprotein E knockout transgenic mouse following exposure to Seattle particulate matter. J Toxicol Environ Health A 69(10):953-65. PubMed: 16728373 MGI: J:136496
Cozen AE; Moriwaki H; Kremen M; DeYoung MB; Dichek HL; Slezicki KI; Young SG; Veniant M; Dichek DA. 2004. Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Circulation 109(17):2129-35. PubMed: 15096455 MGI: J:102208
Crauwels HM; Van Hove CE; Holvoet P; Herman AG; Bult H. 2003. Plaque-associated endothelial dysfunction in apolipoprotein E-deficient mice on a regular diet. Effect of human apolipoprotein AI. Cardiovasc Res 59(1):189-99. PubMed: 12829190 MGI: J:132535
Crisby M; Rahman SM; Sylven C; Winblad B; Schultzberg M. 2004. Effects of high cholesterol diet on gliosis in apolipoprotein E knockout mice. Implications for Alzheimer's disease and stroke. Neurosci Lett 369(2):87-92. PubMed: 15450674 MGI: J:107524
Croce K; Gao H; Wang Y; Mooroka T; Sakuma M; Shi C; Sukhova GK; Packard RR; Hogg N; Libby P; Simon DI. 2009. Myeloid-related protein-8/14 is critical for the biological response to vascular injury. Circulation 120(5):427-36. PubMed: 19620505 MGI: J:166419
Cudaback E; Li X; Montine KS; Montine TJ; Keene CD. 2011. Apolipoprotein E isoform-dependent microglia migration. FASEB J 25(6):2082-91. PubMed: 21385991 MGI: J:172879
Cuerrier CM; Chen YX; Tremblay D; Rayner K; McNulty M; Zhao X; Kennedy CR; de BelleRoche J; Pelling AE; O'Brien ER. 2013. Chronic over-expression of heat shock protein 27 attenuates atherogenesis and enhances plaque remodeling: a combined histological and mechanical assessment of aortic lesions. PLoS One 8(2):e55867. PubMed: 23409070 MGI: J:199342
Cuff CA; Kothapalli D; Azonobi I; Chun S; Zhang Y; Belkin R; Yeh C; Secreto A; Assoian RK; Rader DJ; Pure E. 2001. The adhesion receptor CD44 promotes atherosclerosis by mediating inflammatory cell recruitment and vascular cell activation. J Clin Invest 108(7):1031-40. PubMed: 11581304 MGI: J:72315
Curfs DM; Lutgens E; Gijbels MJ; Kockx MM; Daemen MJ; van Schooten FJ. 2004. Chronic exposure to the carcinogenic compound benzo[a]pyrene induces larger and phenotypically different atherosclerotic plaques in ApoE-knockout mice. Am J Pathol 164(1):101-8. PubMed: 14695324 MGI: J:88500
Cyrus T; Pratico D; Zhao L; Witztum JL; Rader DJ; Rokach J; FitzGerald GA; Funk CD. 2001. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation 103(18):2277-82. PubMed: 11342477 MGI: J:103392
Cyrus T; Witztum JL; Rader DJ; Tangirala R; Fazio S; Linton MF; Funk CD. 1999. Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice [see comments] J Clin Invest 103(11):1597-604. PubMed: 10359569 MGI: J:55714
Czapiga M; Colton CA. 2003. Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport. J Neuroimmunol 134(1-2):44-51. PubMed: 12507771 MGI: J:105895
Dai J; Li W; Chang L; Zhang Z; Tang C; Wang N; Zhu Y; Wang X. 2006. Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis. Free Radic Biol Med 41(10):1566-77. PubMed: 17045925 MGI: J:114515
Dai J; Wang X; Feng J; Kong W; Xu Q; Shen X; Wang X. 2008. Regulatory role of thioredoxin in homocysteine-induced monocyte chemoattractant protein-1 secretion in monocytes/macrophages. FEBS Lett 582(28):3893-8. PubMed: 18976655 MGI: J:143777
Dansky HM; Charlton SA; Barlow CB; Tamminen M; Smith JD; Frank JS; Breslow JL. 1999. Apo A-I inhibits foam cell formation in Apo E-deficient mice after monocyte adherence to endothelium. J Clin Invest 104(1):31-9. PubMed: 10393696 MGI: J:115306
Dansky HM; Charlton SA; Sikes JL; Heath SC; Simantov R; Levin LF; Shu P; Moore KJ; Breslow JL; Smith JD. 1999. Genetic background determines the extent of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 19(8):1960-8. PubMed: 10446078 MGI: J:57355
Danzaki K; Matsui Y; Ikesue M; Ohta D; Ito K; Kanayama M; Kurotaki D; Morimoto J; Iwakura Y; Yagita H; Tsutsui H; Uede T. 2012. Interleukin-17A deficiency accelerates unstable atherosclerotic plaque formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 32(2):273-80. PubMed: 22116098 MGI: J:195969
Dart ML; Jankowska-Gan E; Huang G; Roenneburg DA; Keller MR; Torrealba JR; Rhoads A; Kim B; Bobadilla JL; Haynes LD; Wilkes DS; Burlingham WJ; Greenspan DS. 2010. Interleukin-17-dependent autoimmunity to collagen type V in atherosclerosis. Circ Res 107(9):1106-16. PubMed: 20814021 MGI: J:178192
Das R; Ganapathy S; Mahabeleshwar GH; Drumm C; Febbraio M; Jain MK; Plow EF. 2013. Macrophage gene expression and foam cell formation are regulated by plasminogen. Circulation 127(11):1209-18, e1-16. PubMed: 23401155 MGI: J:210423
Daugherty A; Manning MW; Cassis LA. 2000. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 105(11):1605-12. PubMed: 10841519 MGI: J:112053
Daugherty A; Pure E; Delfel-Butteiger D; Chen S; Leferovich J ; Roselaar SE ; Rader DJ. 1997. The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- mice. J Clin Invest 100(6):1575-80. PubMed: 9294126 MGI: J:43047
Davenport P; Tipping PG. 2003. The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Pathol 163(3):1117-25. PubMed: 12937153 MGI: J:85172
Davis HR Jr; Hoos LM; Tetzloff G; Maguire M; Zhu LJ; Graziano MP; Altmann SW. 2007. Deficiency of Niemann-Pick C1 Like 1 prevents atherosclerosis in ApoE-/- mice. Arterioscler Thromb Vasc Biol 27(4):841-9. PubMed: 17218600 MGI: J:135062
Dawson TC; Kuziel WA; Osahar TA; Maeda N. 1999. Absence of CC chemokine receptor-2 reduces atherosclerosis in apolipoprotein E-deficient mice. Atherosclerosis 143(1):205-11. PubMed: 10208497 MGI: J:84393
De Sarno P; Jope RS. 1998. Phosphoinositide hydrolysis activated by muscarinic or glutamatergic, but not adrenergic, receptors is impaired in ApoE-deficient mice and by hydrogen peroxide and peroxynitrite. Exp Neurol 152(1):123-8. PubMed: 9682019 MGI: J:106374
DeMattos RB; Cirrito JR; Parsadanian M; May PC; O'Dell MA; Taylor JW; Harmony JA; Aronow BJ; Bales KR; Paul SM; Holtzman DM. 2004. ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron 41(2):193-202. PubMed: 14741101 MGI: J:107702
Deckert V; Kretz B; Habbout A; Raghay K; Labbe J; Abello N; Desrumaux C; Gautier T; Lemaire-Ewing S; Maquart G; Le Guern N; Masson D; Steinmetz E; Lagrost L. 2013. Development of abdominal aortic aneurysm is decreased in mice with plasma phospholipid transfer protein deficiency. Am J Pathol 183(3):975-86. PubMed: 23830874 MGI: J:200607
Deeb RS; Shen H; Gamss C; Gavrilova T; Summers BD; Kraemer R; Hao G; Gross SS; Laine M; Maeda N; Hajjar DP; Upmacis RK. 2006. Inducible nitric oxide synthase mediates prostaglandin h2 synthase nitration and suppresses eicosanoid production. Am J Pathol 168(1):349-62. PubMed: 16400036 MGI: J:104432
Deguchi JO; Aikawa E; Libby P; Vachon JR; Inada M; Krane SM; Whittaker P; Aikawa M. 2005. Matrix metalloproteinase-13/collagenase-3 deletion promotes collagen accumulation and organization in mouse atherosclerotic plaques. Circulation 112(17):2708-15. PubMed: 16230484 MGI: J:116828
Deguchi JO; Aikawa M; Tung CH; Aikawa E; Kim DE; Ntziachristos V; Weissleder R; Libby P. 2006. Inflammation in atherosclerosis: visualizing matrix metalloproteinase action in macrophages in vivo. Circulation 114(1):55-62. PubMed: 16801460 MGI: J:122883
Dekker RJ; van Thienen JV; Rohlena J; de Jager SC; Elderkamp YW; Seppen J; de Vries CJ; Biessen EA; van Berkel TJ; Pannekoek H; Horrevoets AJ. 2005. Endothelial KLF2 Links Local Arterial Shear Stress Levels to the Expression of Vascular Tone-Regulating Genes. Am J Pathol 167(2):609-18. PubMed: 16049344 MGI: J:99941
Delaney C; Garg SK; Fernandes C; Hoeltzel M; Allen RH; Stabler S; Yung R. 2013. Maternal diet supplemented with methyl-donors protects against atherosclerosis in F1 ApoE(-/-) mice. PLoS One 8(2):e56253. PubMed: 23437105 MGI: J:197194
Deliri H; Meller N; Kadakkal A; Malhotra R; Brewster J; Doran AC; Pei H; Oldham SN; Skaflen MD; Garmey JC; McNamara CA. 2011. Increased 12/15-lipoxygenase enhances cell growth, fibronectin deposition, and neointimal formation in response to carotid injury. Arterioscler Thromb Vasc Biol 31(1):110-6. PubMed: 20947825 MGI: J:184196
Denis M; Marcinkiewicz J; Zaid A; Gauthier D; Poirier S; Lazure C; Seidah NG; Prat A. 2012. Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. Circulation 125(7):894-901. PubMed: 22261195 MGI: J:196628
Deramchia K; Jacobin-Valat MJ; Vallet A; Bazin H; Santarelli X; Sanchez S; Dos Santos P; Franconi JM; Claverol S; Bonetto S; Clofent-Sanchez G. 2012. New human antibody fragments homing to atherosclerotic endothelial and subendothelial tissues: an in vivo phage display targeting human antibodies homing to atherosclerotic tissues. Am J Pathol 180(6):2576-89. PubMed: 22521648 MGI: J:184677
Desurmont C; Caillaud JM; Emmanuel F; Benoit P; Fruchart JC; Castro G; Branellec D; Heard JM; Duverger N. 2000. Complete atherosclerosis regression after human ApoE gene transfer in ApoE-Deficient/Nude mice Arterioscler Thromb Vasc Biol 20(2):435-42. PubMed: 10669641 MGI: J:60479
Detmers PA; Hernandez M; Mudgett J; Hassing H; Burton C; Mundt S; Chun S; Fletcher D; Card DJ; Lisnock J; Weikel R; Bergstrom JD; Shevell DE; Hermanowski-Vosatka A; Sparrow CP; Chao YS; Rader DJ; Wright SD; Pure E. 2000. Deficiency in inducible nitric oxide synthase results in reduced atherosclerosis in apolipoprotein E-deficient mice J Immunol 165(6):3430-5. PubMed: 10975863 MGI: J:64566
Devarajan A; Grijalva VR; Bourquard N; Meriwether D 3rd; Imaizumi S; Shin BC; Devaskar SU; Reddy ST. 2012. Macrophage paraoxonase 2 regulates calcium homeostasis and cell survival under endoplasmic reticulum stress conditions and is sufficient to prevent the development of aggravated atherosclerosis in paraoxonase 2 deficiency/apoE-/- mice on a Western diet. Mol Genet Metab 107(3):416-27. PubMed: 22864055 MGI: J:189668
Dever GJ; Benson R; Wainwright CL; Kennedy S; Spickett CM. 2008. Phospholipid chlorohydrin induces leukocyte adhesion to ApoE(-/-) mouse arteries via upregulation of P-selectin. Free Radic Biol Med 44(3):452-63. PubMed: 18005671 MGI: J:130122
Devlin CM; Leventhal AR; Kuriakose G; Schuchman EH; Williams KJ; Tabas I. 2008. Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression. Arterioscler Thromb Vasc Biol 28(10):1723-30. PubMed: 18669882 MGI: J:148825
Dewi FN; Wood CE; Lampe JW; Hullar MA; Franke AA; Golden DL; Adams MR; Cline JM. 2012. Endogenous and exogenous equol are antiestrogenic in reproductive tissues of apolipoprotein e-null mice. J Nutr 142(10):1829-35. PubMed: 22933749 MGI: J:189967
Dhanesha N; Ahmad A; Prakash P; Doddapattar P; Lentz SR; Chauhan AK. 2015. Genetic Ablation of Extra Domain A of Fibronectin in Hypercholesterolemic Mice Improves Stroke Outcome by Reducing Thrombo-Inflammation. Circulation 132(23):2237-47. PubMed: 26508731 MGI: J:239044
Di Bartolo BA; Cartland SP; Harith HH; Bobryshev YV; Schoppet M; Kavurma MM. 2013. TRAIL-deficiency accelerates vascular calcification in atherosclerosis via modulation of RANKL. PLoS One 8(9):e74211. PubMed: 24040204 MGI: J:207550
Di Bartolo BA; Chan J; Bennett MR; Cartland S; Bao S; Tuch BE; Kavurma MM. 2011. TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe ( -/- ) mice. Diabetologia 54(12):3157-67. PubMed: 21965021 MGI: J:178125
Didangelos A; Mayr U; Monaco C; Mayr M. 2012. Novel role of ADAMTS-5 protein in proteoglycan turnover and lipoprotein retention in atherosclerosis. J Biol Chem 287(23):19341-5. PubMed: 22493487 MGI: J:186210
Diez-Juan A; Andres V. 2001. The growth suppressor p27(Kip1) protects against diet-induced atherosclerosis. FASEB J 15(11):1989-95. PubMed: 11532979 MGI: J:120150
Dimayuga PC; Zhao X; Yano J; Chyu KY. 2006. Changes in immune responses to oxidized LDL epitopes during aging in hypercholesterolemic apoE(-/-) mice. Am J Physiol Regul Integr Comp Physiol 291(6):R1644-50. PubMed: 16825416 MGI: J:115800
Ding L; Biswas S; Morton RE; Smith JD; Hay N; Byzova TV; Febbraio M; Podrez EA. 2012. Akt3 deficiency in macrophages promotes foam cell formation and atherosclerosis in mice. Cell Metab 15(6):861-72. PubMed: 22632897 MGI: J:185203
Dinsmore C; Reiter JF. 2016. Endothelial primary cilia inhibit atherosclerosis. EMBO Rep 17(2):156-66. PubMed: 26769565 MGI: J:230502
Dithmar S; Curcio CA; Le NA; Brown S; Grossniklaus HE. 2000. Ultrastructural changes in Bruch's membrane of apolipoprotein E-deficient mice. Invest Ophthalmol Vis Sci 41(8):2035-42. PubMed: 10892840 MGI: J:63155
Ditiatkovski M; D'Souza W; Kesani R; Chin-Dusting J; de Haan JB; Remaley A; Sviridov D. 2013. An apolipoprotein A-I mimetic peptide designed with a reductionist approach stimulates reverse cholesterol transport and reduces atherosclerosis in mice. PLoS One 8(7):e68802. PubMed: 23874769 MGI: J:204400
Ditiatkovski M; Toh BH; Bobik A. 2006. GM-CSF deficiency reduces macrophage PPAR-gamma expression and aggravates atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 26(10):2337-44. PubMed: 16873730 MGI: J:128049
Do GM; Kwon EY; Kim HJ; Jeon SM; Ha TY; Park T; Choi MS. 2008. Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo E-deficient mice. Biochem Biophys Res Commun 374(1):55-9. PubMed: 18611391 MGI: J:139370
Dodart JC; Bales KR; Johnstone EM; Little SP; Paul SM. 2002. Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice. Brain Res 955(1-2):191-9. PubMed: 12419536 MGI: J:80485
Dodart JC; Mathis C; Bales KR; Paul SM; Ungerer A. 2000. Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene Neuroreport 11(3):603-7. PubMed: 10718322 MGI: J:61265
Dol-Gleizes F; Delesque-Touchard N; Mares AM; Nestor AL; Schaeffer P; Bono F. 2013. A new synthetic FGF receptor antagonist inhibits arteriosclerosis in a mouse vein graft model and atherosclerosis in apolipoprotein E-deficient mice. PLoS One 8(11):e80027. PubMed: 24224032 MGI: J:209320
Dolev I; Michaelson DM. 2004. A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade. Proc Natl Acad Sci U S A 101(38):13909-14. PubMed: 15365176 MGI: J:92619
Dong Y; Zhang M; Wang S; Liang B; Zhao Z; Liu C; Wu M; Choi HC; Lyons TJ; Zou MH. 2010. Activation of AMP-activated protein kinase inhibits oxidized LDL-triggered endoplasmic reticulum stress in vivo. Diabetes 59(6):1386-96. PubMed: 20299472 MGI: J:169360
Doorenbos C; Tsaih SW; Sheehan S; Ishimori N; Navis G; Churchill G; Dipetrillo K; Korstanje R. 2008. Quantitative Trait Loci for Urinary Albumin in Crosses Between C57BL/6J and A/J Inbred Mice in the Presence and Absence of Apoe. Genetics 179(1):693-9. PubMed: 18493081 MGI: J:135073
Doran AC; Lehtinen AB; Meller N; Lipinski MJ; Slayton RP; Oldham SN; Skaflen MD; Yeboah J; Rich SS; Bowden DW; McNamara CA. 2010. Id3 is a novel atheroprotective factor containing a functionally significant single-nucleotide polymorphism associated with intima-media thickness in humans. Circ Res 106(7):1303-11. PubMed: 20185798 MGI: J:171034
Doran AC; Lipinski MJ; Oldham SN; Garmey JC; Campbell KA; Skaflen MD; Cutchins A; Lee DJ; Glover DK; Kelly KA; Galkina EV; Ley K; Witztum JL; Tsimikas S; Bender TP; McNamara CA. 2012. B-cell aortic homing and atheroprotection depend on Id3. Circ Res 110(1):e1-12. PubMed: 22034493 MGI: J:192716
Doring Y; Manthey HD; Drechsler M; Lievens D; Megens RT; Soehnlein O; Busch M; Manca M; Koenen RR; Pelisek J; Daemen MJ; Lutgens E; Zenke M; Binder CJ; Weber C; Zernecke A. 2012. Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. Circulation 125(13):1673-83. PubMed: 22388324 MGI: J:198616
Douglas G; Bendall JK; Crabtree MJ; Tatham AL; Carter EE; Hale AB; Channon KM. 2012. Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE(-)/(-) mice. Cardiovasc Res 94(1):20-9. PubMed: 22287576 MGI: J:196627
Drosatos K; Sanoudou D; Kypreos KE; Kardassis D; Zannis VI. 2007. A dominant negative form of the transcription factor c-Jun affects genes that have opposing effects on lipid homeostasis in mice. J Biol Chem 282(27):19556-64. PubMed: 17456467 MGI: J:123576
Du F; Yu F; Wang Y; Hui Y; Carnevale K; Fu M; Lu H; Fan D. 2014. MicroRNA-155 deficiency results in decreased macrophage inflammation and attenuated atherogenesis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 34(4):759-67. PubMed: 24504735 MGI: J:222908
Du HP; Li J; You SJ; Wang YL; Wang F; Cao YJ; Hu LF; Liu CF. 2016. DNA methylation in cystathionine-gamma-lyase (CSE) gene promoter induced by ox-LDL in macrophages and in apoE knockout mice. Biochem Biophys Res Commun 469(3):776-82. PubMed: 26692478 MGI: J:233167
Duan RS; Chen Z; Dou YC; Concha Quezada H; Nennesmo I; Adem A; Winblad B; Zhu J. 2006. Apolipoprotein E deficiency increased microglial activation/CCR3 expression and hippocampal damage in kainic acid exposed mice. Exp Neurol 202(2):373-80. PubMed: 16919271 MGI: J:144674
Dubeykovskaya Z; Si Y; Chen X; Worthley DL; Renz BW; Urbanska AM; Hayakawa Y; Xu T; Westphalen CB; Dubeykovskiy A; Chen D; Friedman RA; Asfaha S; Nagar K; Tailor Y; Muthupalani S; Fox JG; Kitajewski J; Wang TC. 2016. Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer. Nat Commun 7:10517. PubMed: 26841680 MGI: J:236280
Duewell P; Kono H; Rayner KJ; Sirois CM; Vladimer G; Bauernfeind FG; Abela GS; Franchi L; Nunez G; Schnurr M; Espevik T; Lien E; Fitzgerald KA; Rock KL; Moore KJ; Wright SD; Hornung V; Latz E. 2010. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464(7293):1357-61. PubMed: 20428172 MGI: J:159453
Duka A; Fotakis P; Georgiadou D; Kateifides A; Tzavlaki K; von Eckardstein L; Stratikos E; Kardassis D; Zannis VI. 2013. ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT. J Lipid Res 54(1):107-15. PubMed: 23132909 MGI: J:192256
Dumanis SB; Tesoriero JA; Babus LW; Nguyen MT; Trotter JH; Ladu MJ; Weeber EJ; Turner RS; Xu B; Rebeck GW; Hoe HS. 2009. ApoE4 decreases spine density and dendritic complexity in cortical neurons in vivo. J Neurosci 29(48):15317-22. PubMed: 19955384 MGI: J:155829
Durgin BG; Cherepanova OA; Gomez D; Karaoli T; Alencar GF; Butcher JT; Zhou YQ; Bendeck MP; Isakson BE; Owens GK; Connelly JJ. 2017. Smooth muscle cell-specific deletion of Col15a1 unexpectedly leads to impaired development of advanced atherosclerotic lesions. Am J Physiol Heart Circ Physiol 312(5):H943-H958. PubMed: 28283548 MGI: J:241641
Dutta P; Courties G; Wei Y; Leuschner F; Gorbatov R; Robbins CS; Iwamoto Y; Thompson B; Carlson AL; Heidt T; Majmudar MD; Lasitschka F; Etzrodt M; Waterman P; Waring MT; Chicoine AT; van der Laan AM; Niessen HW; Piek JJ; Rubin BB; Butany J; Stone JR; Katus HA; Murphy SA; Morrow DA; Sabatine MS; Vinegoni C; Moskowitz MA; Pittet MJ; Libby P; Lin CP; Swirski FK; Weissleder R; Nahrendorf M. 2012. Myocardial infarction accelerates atherosclerosis. Nature 487(7407):325-9. PubMed: 22763456 MGI: J:186697
Dutta P; Hoyer FF; Grigoryeva LS; Sager HB; Leuschner F; Courties G; Borodovsky A; Novobrantseva T; Ruda VM; Fitzgerald K; Iwamoto Y; Wojtkiewicz G; Sun Y; Da Silva N; Libby P; Anderson DG; Swirski FK; Weissleder R; Nahrendorf M. 2015. Macrophages retain hematopoietic stem cells in the spleen via VCAM-1. J Exp Med 212(4):497-512. PubMed: 25800955 MGI: J:222435
Duvoisin RM; Pfankuch T; Wilson JM; Grabell J; Chhajlani V; Brown DG; Johnson E; Raber J. 2010. Acute pharmacological modulation of mGluR8 reduces measures of anxiety. Behav Brain Res 212(2):168-173. PubMed: 20385173 MGI: J:160168
Dworschak M; d'Uscio LV; Breukelmann D; Hannon JD. 2005. Increased tolerance to hypoxic metabolic inhibition and reoxygenation of cardiomyocytes from apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 289(1):H160-7. PubMed: 15734885 MGI: J:99888
Ebrahimian T; Simon D; Lemarie CA; Simeone S; Heidari M; Mann KK; Wassmann S; Lehoux S. 2015. Absence of Four-and-a-Half LIM Domain Protein 2 Decreases Atherosclerosis in ApoE-/- Mice. Arterioscler Thromb Vasc Biol 35(5):1190-7. PubMed: 25767273 MGI: J:241334
Eitzman DT; Westrick RJ; Shen Y; Bodary PF; Gu S; Manning SL; Dobies SL; Ginsburg D. 2005. Homozygosity for factor V Leiden leads to enhanced thrombosis and atherosclerosis in mice. Circulation 111(14):1822-5. PubMed: 15809370 MGI: J:109686
Eitzman DT; Westrick RJ; Xu Z; Tyson J; Ginsburg D. 2000. Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Blood 96(13):4212-5. PubMed: 11110693 MGI: J:106740
Elhage R; Arnal JF; Pieraggi MT; Duverger N; Fievet C; Faye JC; Bayard F. 1997. 17 beta-estradiol prevents fatty streak formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 17(11):2679-84. PubMed: 9409242 MGI: J:81001
Elhage R; Clamens S; Reardon-Alulis C; Getz GS; Fievet C; Maret A; Arnal JF; Bayard F. 2000. Loss of atheroprotective effect of estradiol in immunodeficient mice. Endocrinology 141(1):462-5. PubMed: 10614672 MGI: J:59156
Elhage R; Gourdy P; Brouchet L; Jawien J; Fouque MJ; Fievet C; Huc X; Barreira Y; Couloumiers JC; Arnal JF; Bayard F. 2004. Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient mice. Am J Pathol 165(6):2013-8. PubMed: 15579444 MGI: J:94976
Elhage R; Gourdy P; Jawien J; Brouchet L; Castano C; Fievet C; Hansson GK; Arnal JF; Bayard F. 2005. The Atheroprotective Effect of 17{beta}-Estradiol Depends on Complex Interactions in Adaptive Immunity. Am J Pathol 167(1):267-74. PubMed: 15972970 MGI: J:99377
Elhage R; Jawien J; Rudling M; Ljunggren HG; Takeda K; Akira S; Bayard F; Hansson GK. 2003. Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice. Cardiovasc Res 59(1):234-40. PubMed: 12829194 MGI: J:102800
Ellam T; Hameed A; ul Haque R; Muthana M; Wilkie M; Francis SE; Chico TJ. 2014. Vitamin D deficiency and exogenous vitamin D excess similarly increase diffuse atherosclerotic calcification in apolipoprotein E knockout mice. PLoS One 9(2):e88767. PubMed: 24586387 MGI: J:213442
Ellison S; Gabunia K; Kelemen SE; England RN; Scalia R; Richards JM; Orr AW; Traylor JG Jr; Rogers T; Cornwell W; Berglund LM; Goncalves I; Gomez MF; Autieri MV. 2013. Attenuation of experimental atherosclerosis by interleukin-19. Arterioscler Thromb Vasc Biol 33(10):2316-24. PubMed: 23950143 MGI: J:224123
Engel D; Beckers L; Wijnands E; Seijkens T; Lievens D; Drechsler M; Gerdes N; Soehnlein O; Daemen MJ; Stan RV; Biessen EA; Lutgens E. 2011. Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response. FASEB J 25(11):3838-48. PubMed: 21795505 MGI: J:178418
Engel D; Dobrindt U; Tittel A; Peters P; Maurer J; Gutgemann I; Kaissling B; Kuziel W; Jung S; Kurts C. 2006. Tumor necrosis factor alpha- and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance. Infect Immun 74(11):6100-7. PubMed: 16966414 MGI: J:113552
Engelbertsen D; Rattik S; Knutsson A; Bjorkbacka H; Bengtsson E; Nilsson J. 2014. Induction of T helper 2 responses against human apolipoprotein B100 does not affect atherosclerosis in ApoE-/- mice. Cardiovasc Res 103(2):304-12. PubMed: 24866382 MGI: J:230009
Erbilgin A; Civelek M; Romanoski CE; Pan C; Hagopian R; Berliner JA; Lusis AJ. 2013. Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. J Lipid Res 54(7):1894-905. PubMed: 23667179 MGI: J:199587
Ermakova O; Piszczek L; Luciani L; Cavalli FM; Ferreira T; Farley D; Rizzo S; Paolicelli RC; Al-Banchaabouchi M; Nerlov C; Moriggl R; Luscombe NM; Gross C. 2011. Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. EMBO Mol Med 3(1):50-66. PubMed: 21204268 MGI: J:232020
Ermakova O; Salimova E; Piszczek L; Gross C. 2012. Construction and phenotypic analysis of mice carrying a duplication of the major histocompatibility class I (MHC-I) locus. Mamm Genome 23(7-8):443-53. PubMed: 22772436 MGI: J:190754
Esteban V; Mendez-Barbero N; Jimenez-Borreguero LJ; Roque M; Novensa L; Garcia-Redondo AB; Salaices M; Vila L; Arbones ML; Campanero MR; Redondo JM. 2011. Regulator of calcineurin 1 mediates pathological vascular wall remodeling. J Exp Med 208(10):2125-39. PubMed: 21930771 MGI: J:177284
Everett AW; Ernst EJ. 2004. Increased quantal size in transmission at slow but not fast neuromuscular synapses of apolipoprotein E deficient mice. Exp Neurol 185(2):290-6. PubMed: 14736510 MGI: J:87833
Ewing MM; de Vries MR; Nordzell M; Pettersson K; de Boer HC; van Zonneveld AJ; Frostegard J; Jukema JW; Quax PH. 2011. Annexin A5 therapy attenuates vascular inflammation and remodeling and improves endothelial function in mice. Arterioscler Thromb Vasc Biol 31(1):95-101. PubMed: 20947818 MGI: J:184200
Ezra Y; Oron L; Moskovich L; Roses AD; Beni SM; Shohami E; Michaelson DM. 2003. Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury. Neuroscience 121(2):315-25. PubMed: 14521991 MGI: J:132283
Fagan AM; Holtzman DM; Munson G; Mathur T; Schneider D; Chang LK; Getz GS; Reardon CA; Lukens J; Shah JA; LaDu MJ. 1999. Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. J Biol Chem 274(42):30001-7. PubMed: 10514484 MGI: J:58019
Fagan AM; Murphy BA; Patel SN; Kilbridge JF; Mobley WC; Bu G; Holtzman DM. 1998. Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury. Exp Neurol 151(2):314-25. PubMed: 9628766 MGI: J:48287
Fagan AM; Watson M; Parsadanian M; Bales KR; Paul SM; Holtzman DM. 2002. Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease. Neurobiol Dis 9(3):305-18. PubMed: 11950276 MGI: J:127846
Fan D; Yancey PG; Qiu S; Ding L; Weeber EJ; Linton MF; Fazio S. 2008. Self-association of human PCSK9 correlates with its LDLR-degrading activity. Biochemistry 47(6):1631-9. PubMed: 18197702 MGI: J:132491
Fan J; Stukas S; Wong C; Chan J; May S; Devalle N; Hirsch-Reinshagen V; Wilkinson A; Oda MN; Wellington CL. 2011. An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia. J Lipid Res 52(9):1605-16. PubMed: 21705806 MGI: J:175557
Fan YY; Ramos KS; Chapkin RS. 2001. Dietary gamma-linolenic acid suppresses aortic smooth muscle cell proliferation and modifies atherosclerotic lesions in apolipoprotein E knockout mice. J Nutr 131(6):1675-81. PubMed: 11385052 MGI: J:69821
Fang C; Wen G; Zhang L; Lin L; Moore A; Wu S; Ye S; Xiao Q. 2013. An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo. Cardiovasc Res 99(1):146-55. PubMed: 23512982 MGI: J:211445
Fang G; Song D; Ye X; Mao SZ; Liu G; Liu SF. 2012. Chronic intermittent hypoxia exposure induces atherosclerosis in ApoE knockout mice: role of NF-kappaB p50. Am J Pathol 181(5):1530-9. PubMed: 22940439 MGI: J:190021
Fang P; Zhang D; Cheng Z; Yan C; Jiang X; Kruger WD; Meng S; Arning E; Bottiglieri T; Choi ET; Han Y; Yang XF; Wang H. 2014. Hyperhomocysteinemia potentiates hyperglycemia-induced inflammatory monocyte differentiation and atherosclerosis. Diabetes 63(12):4275-90. PubMed: 25008174 MGI: J:230146
Farese RVJr; Veniant MM; Cham CM; Flynn LM; Pierotti V; Loring JF; Traber M; Ruland S; Stokowski RS; Huszar D; Young SG. 1996. Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc Natl Acad Sci U S A 93(13):6393-8. PubMed: 8692825 MGI: J:33830
Farris SD; Hu JH; Krishnan R; Emery I; Chu T; Du L; Kremen M; Dichek HL; Gold E; Ramsey SA; Dichek DA. 2011. Mechanisms of urokinase plasminogen activator (uPA)-mediated atherosclerosis: role of the uPA receptor and S100A8/A9 proteins. J Biol Chem 286(25):22665-77. PubMed: 21536666 MGI: J:174810
Fazio S; Babaev VR; Burleigh ME; Major AS; Hasty AH; Linton MF. 2002. Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice. J Lipid Res 43(10):1602-9. PubMed: 12364544 MGI: J:79439
Feaver RE; Gelfand BD; Wang C; Schwartz MA; Blackman BR. 2010. Atheroprone hemodynamics regulate fibronectin deposition to create positive feedback that sustains endothelial inflammation. Circ Res 106(11):1703-11. PubMed: 20378855 MGI: J:172705
Febbraio M; Podrez EA; Smith JD; Hajjar DP; Hazen SL; Hoff HF; Sharma K; Silverstein RL. 2000. Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in mice [see comments] J Clin Invest 105(8):1049-56. PubMed: 10772649 MGI: J:61672
Feig JE; Rong JX; Shamir R; Sanson M; Vengrenyuk Y; Liu J; Rayner K; Moore K; Garabedian M; Fisher EA. 2011. HDL promotes rapid atherosclerosis regression in mice and alters inflammatory properties of plaque monocyte-derived cells. Proc Natl Acad Sci U S A 108(17):7166-71. PubMed: 21482781 MGI: J:171343
Feil S; Fehrenbacher B; Lukowski R; Essmann F; Schulze-Osthoff K; Schaller M; Feil R. 2014. Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circ Res 115(7):662-7. PubMed: 25070003 MGI: J:234898
Feng J; Zhang Z; Kong W; Liu B; Xu Q; Wang X. 2009. Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-/- mice. Cardiovasc Res 84(1):155-63. PubMed: 19502284 MGI: J:172487
Feng X; Li H; Rumbin AA; Wang X; La Cava A; Brechtelsbauer K; Castellani LW; Witztum JL; Lusis AJ; Tsao BP. 2007. ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia. J Lipid Res 48(4):794-805. PubMed: 17259598 MGI: J:121671
Ferguson S; Mouzon B; Kayihan G; Wood M; Poon F; Doore S; Mathura V; Humphrey J; O'Steen B; Hayes R; Roses A; Mullan M; Crawford F. 2010. Apolipoprotein E genotype and oxidative stress response to traumatic brain injury. Neuroscience 168(3):811-9. PubMed: 20105454 MGI: J:161501
Fernandez-Hernando C; Ackah E; Yu J; Suarez Y; Murata T; Iwakiri Y; Prendergast J; Miao RQ; Birnbaum MJ; Sessa WC. 2007. Loss of akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metab 6(6):446-57. PubMed: 18054314 MGI: J:130443
Fernandez-Hernando C; Yu J; Suarez Y; Rahner C; Davalos A; Lasuncion MA; Sessa WC. 2009. Genetic evidence supporting a critical role of endothelial caveolin-1 during the progression of atherosclerosis. Cell Metab 10(1):48-54. PubMed: 19583953 MGI: J:152421
Fernandez-Robredo P; Recalde S; Arnaiz G; Salinas-Alaman A; Sadaba LM; Moreno-Orduna M; Garcia-Layana A. 2009. Effect of zeaxanthin and antioxidant supplementation on vascular endothelial growth factor (VEGF) expression in apolipoprotein-E deficient mice. Curr Eye Res 34(7):543-52. PubMed: 19899967 MGI: J:155309
Ferre N; Martinez-Clemente M; Lopez-Parra M; Gonzalez-Periz A; Horrillo R; Planaguma A; Camps J; Joven J; Tres A; Guardiola F; Bataller R; Arroyo V; Claria J. 2009. Increased susceptibility to exacerbated liver injury in hypercholesterolemic ApoE-deficient mice: potential involvement of oxysterols. Am J Physiol Gastrointest Liver Physiol 296(3):G553-62. PubMed: 19136384 MGI: J:146541
Fetterman JL; Pompilius M; Westbrook DG; Uyeminami D; Brown J; Pinkerton KE; Ballinger SW. 2013. Developmental exposure to second-hand smoke increases adult atherogenesis and alters mitochondrial DNA copy number and deletions in apoE(-/-) mice. PLoS One 8(6):e66835. PubMed: 23825571 MGI: J:204347
Figueiredo JL; Aikawa M; Zheng C; Aaron J; Lax L; Libby P; de Lima Filho JL; Gruener S; Fingerle J; Haap W; Hartmann G; Aikawa E. 2015. Selective cathepsin s inhibition attenuates atherosclerosis in apolipoprotein e-deficient mice with chronic renal disease. Am J Pathol 185(4):1156-66. PubMed: 25680278 MGI: J:220168
Foo SY; Heller ER; Wykrzykowska J; Sullivan CJ; Manning-Tobin JJ; Moore KJ; Gerszten RE; Rosenzweig A. 2009. Vascular effects of a low-carbohydrate high-protein diet. Proc Natl Acad Sci U S A 106(36):15418-23. PubMed: 19706393 MGI: J:153097
Fornasa G; Clement M; Groyer E; Gaston AT; Khallou-Laschet J; Morvan M; Guedj K; Kaveri SV; Tedgui A; Michel JB; Nicoletti A; Caligiuri G. 2012. A CD31-derived peptide prevents angiotensin II-induced atherosclerosis progression and aneurysm formation. Cardiovasc Res 94(1):30-7. PubMed: 22293851 MGI: J:196625
Forte TM; Subbanagounder G; Berliner JA; Blanche PJ; Clermont AO; Jia Z; Oda MN; Krauss RM; Bielicki JK. 2002. Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible mice. J Lipid Res 43(3):477-85. PubMed: 11893784 MGI: J:75568
Foss CA; Bedja D; Mease RC; Wang H; Kass DA; Chatterjee S; Pomper MG. 2015. Molecular imaging of inflammation in the ApoE -/- mouse model of atherosclerosis with IodoDPA. Biochem Biophys Res Commun 461(1):70-5. PubMed: 25858322 MGI: J:228393
Foteinos G; Hu Y; Xiao Q; Metzler B; Xu Q. 2008. Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice. Circulation 117(14):1856-63. PubMed: 18378610 MGI: J:153300
Fougerat A; Gayral S; Gourdy P; Schambourg A; Ruckle T; Schwarz MK; Rommel C; Hirsch E; Arnal JF; Salles JP; Perret B; Breton-Douillon M; Wymann MP; Laffargue M. 2008. Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes. Circulation 117(10):1310-7. PubMed: 18268153 MGI: J:148451
Frank PG; Lee H; Park DS; Tandon NN; Scherer PE; Lisanti MP. 2004. Genetic ablation of caveolin-1 confers protection against atherosclerosis. Arterioscler Thromb Vasc Biol 24(1):98-105. PubMed: 14563650 MGI: J:101788
Freigang S; Ampenberger F; Spohn G; Heer S; Shamshiev AT; Kisielow J; Hersberger M; Yamamoto M; Bachmann MF; Kopf M. 2011. Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis. Eur J Immunol 41(7):2040-51. PubMed: 21484785 MGI: J:177309
Freigang S; Ampenberger F; Weiss A; Kanneganti TD; Iwakura Y; Hersberger M; Kopf M. 2013. Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis. Nat Immunol 14(10):1045-53. PubMed: 23995233 MGI: J:208219
Friedrich EB; Clever YP; Wassmann S; Werner N; Bohm M; Nickenig G. 2006. Role of integrin-linked kinase in vascular smooth muscle cells: regulation by statins and angiotensin II. Biochem Biophys Res Commun 349(3):883-9. PubMed: 16962068 MGI: J:113091
Frutkin AD; Otsuka G; Stempien-Otero A; Sesti C; Du L; Jaffe M; Dichek HL; Pennington CJ; Edwards DR; Nieves-Cintron M; Minter D; Preusch M; Hu JH; Marie JC; Dichek DA. 2009. TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol 29(9):1251-7. PubMed: 19325140 MGI: J:167820
Fryer JD; Simmons K; Parsadanian M; Bales KR; Paul SM; Sullivan PM; Holtzman DM. 2005. Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J Neurosci 25(11):2803-10. PubMed: 15772340 MGI: J:98636
Fryer JD; Taylor JW; DeMattos RB; Bales KR; Paul SM; Parsadanian M; Holtzman DM. 2003. Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice. J Neurosci 23(21):7889-96. PubMed: 12944519 MGI: J:85307
Fu C; He J; Li C; Shyy JY; Zhu Y. 2010. Cholesterol increases adhesion of monocytes to endothelium by moving adhesion molecules out of caveolae. Biochim Biophys Acta 1801(7):702-10. PubMed: 20382259 MGI: J:165374
Fu T; Borensztajn J. 2006. Simvastatin causes the formation of cholesterol-rich remnants in mice lacking apoE. Biochem Biophys Res Commun 341(4):1172-6. PubMed: 16460674 MGI: J:105757
Fu T; Kozarsky KF; Borensztajn J. 2003. Overexpression of SR-BI by adenoviral vector reverses the fibrateinduced hypercholesterolemia of apolipoprotein E-deficient mice. J Biol Chem 278(52):52559-63. PubMed: 14570884 MGI: J:87086
Fu Y; Mukhamedova N; Ip S; D'Souza W; Henley KJ; DiTommaso T; Kesani R; Ditiatkovski M; Jones L; Lane RM; Jennings G; Smyth IM; Kile BT; Sviridov D. 2013. ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis. Cell Metab 18(2):225-38. PubMed: 23931754 MGI: J:200990
Fukuda D; Sata M; Ishizaka N; Nagai R. 2008. Critical role of bone marrow angiotensin II type 1 receptor in the pathogenesis of atherosclerosis in apolipoprotein E deficient mice. Arterioscler Thromb Vasc Biol 28(1):90-6. PubMed: 17962627 MGI: J:159821
Fukumoto Y; Deguchi JO; Libby P; Rabkin-Aikawa E; Sakata Y; Chin MT; Hill CC; Lawler PR; Varo N; Schoen FJ; Krane SM; Aikawa M. 2004. Genetically determined resistance to collagenase action augments interstitial collagen accumulation in atherosclerotic plaques. Circulation 110(14):1953-9. PubMed: 15451791 MGI: J:146712
Fullerton SM; Shirman GA; Strittmatter WJ; Matthew WD. 2001. Impairment of the blood-nerve and blood-brain barriers in apolipoprotein e knockout mice. Exp Neurol 169(1):13-22. PubMed: 11312553 MGI: J:69455
Fullerton SM; Strittmatter WJ; Matthew WD. 1998. Peripheral sensory nerve defects in apolipoprotein E knockout mice. Exp Neurol 153(1):156-63. PubMed: 9743578 MGI: J:106368
Furbee JW Jr; Francone O; Parks JS. 2002. In vivo contribution of LCAT to apolipoprotein B lipoprotein cholesteryl esters in LDL receptor and apolipoprotein E knockout mice. J Lipid Res 43(3):428-37. PubMed: 11893779 MGI: J:75567
Furbee JW Jr; Sawyer JK; Parks JS. 2002. Lecithin:cholesterol acyltransferase deficiency increases atherosclerosis in the low density lipoprotein receptor and apolipoprotein E knockout mice. J Biol Chem 277(5):3511-9. PubMed: 11719520 MGI: J:74315
Fuster JJ; Gonzalez-Navarro H; Vinue A; Molina-Sanchez P; Andres-Manzano MJ; Nakayama KI; Nakayama K; Diez-Juan A; Bernad A; Rodriguez C; Martinez-Gonzalez J; Andres V. 2011. Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism. Arterioscler Thromb Vasc Biol 31(11):2455-63. PubMed: 21885849 MGI: J:191458
Gabas-Rivera C; Barranquero C; Martinez-Beamonte R; Navarro MA; Surra JC; Osada J. 2014. Dietary squalene increases high density lipoprotein-cholesterol and paraoxonase 1 and decreases oxidative stress in mice. PLoS One 9(8):e104224. PubMed: 25117703 MGI: J:223156
Galan M; Varona S; Orriols M; Rodriguez JA; Aguilo S; Dilme J; Camacho M; Martinez-Gonzalez J; Rodriguez C. 2016. Induction of histone deacetylases (HDACs) in human abdominal aortic aneurysm: therapeutic potential of HDAC inhibitors. Dis Model Mech 9(5):541-52. PubMed: 26989193 MGI: J:232499
Galkina E; Harry BL; Ludwig A; Liehn EA; Sanders JM; Bruce A; Weber C; Ley K. 2007. CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wall. Circulation 116(16):1801-11. PubMed: 17909108 MGI: J:139833
Galkina E; Kadl A; Sanders J; Varughese D; Sarembock IJ; Ley K. 2006. Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent. J Exp Med 203(5):1273-82. PubMed: 16682495 MGI: J:124135
Galkina EV; Butcher M; Keller SR; Goff M; Bruce A; Pei H; Sarembock IJ; Sanders JM; Nagelin MH; Srinivasan S; Kulkarni RN; Hedrick CC; Lattanzio FA; Dobrian AD; Nadler JL; Ley K. 2012. Accelerated atherosclerosis in Apoe-/- mice heterozygous for the insulin receptor and the insulin receptor substrate-1. Arterioscler Thromb Vasc Biol 32(2):247-56. PubMed: 22199371 MGI: J:195961
Gallardo G; Schluter OM; Sudhof TC. 2008. A molecular pathway of neurodegeneration linking alpha-synuclein to ApoE and Abeta peptides. Nat Neurosci 11(3):301-8. PubMed: 18297066 MGI: J:131733
Gandhi C; Khan MM; Lentz SR; Chauhan AK. 2012. ADAMTS13 reduces vascular inflammation and the development of early atherosclerosis in mice. Blood 119(10):2385-91. PubMed: 22123843 MGI: J:182469
Gao J; Ishigaki Y; Yamada T; Kondo K; Yamaguchi S; Imai J; Uno K; Hasegawa Y; Sawada S; Ishihara H; Oyadomari S; Mori M; Oka Y; Katagiri H. 2011. Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses. Circulation 124(7):830-9. PubMed: 21810656 MGI: J:189392
Gao J; Katagiri H; Ishigaki Y; Yamada T; Ogihara T; Imai J; Uno K; Hasegawa Y; Kanzaki M; Yamamoto TT; Ishibashi S; Oka Y. 2007. Involvement of apolipoprotein E in excess fat accumulation and insulin resistance. Diabetes 56(1):24-33. PubMed: 17192461 MGI: J:121950
Gao Q; Jiang Y; Ma T; Zhu F; Gao F; Zhang P; Guo C; Wang Q; Wang X; Ma C; Zhang Y; Chen W; Zhang L. 2010. A critical function of Th17 proinflammatory cells in the development of atherosclerotic plaque in mice. J Immunol 185(10):5820-7. PubMed: 20952673 MGI: J:165788
Garcia RA; Search DJ; Lupisella JA; Ostrowski J; Guan B; Chen J; Yang WP; Truong A; He A; Zhang R; Yan M; Hellings SE; Gargalovic PS; Ryan CS; Watson LM; Langish RA; Shipkova PA; Carson NL; Taylor JR; Yang R; Psaltis GC; Harrity TW; Robl JA; Gordon DA. 2013. 11beta-hydroxysteroid dehydrogenase type 1 gene knockout attenuates atherosclerosis and in vivo foam cell formation in hyperlipidemic apoE(-)/(-) mice. PLoS One 8(2):e53192. PubMed: 23383297 MGI: J:199430
Gareus R; Kotsaki E; Xanthoulea S; van der Made I; Gijbels MJ; Kardakaris R; Polykratis A; Kollias G; de Winther MP; Pasparakis M. 2008. Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab 8(5):372-83. PubMed: 19046569 MGI: J:143751
Gates AC; Bernal-Mizrachi C; Chinault SL; Feng C; Schneider JG; Coleman T; Malone JP; Townsend RR; Chakravarthy MV; Semenkovich CF. 2007. Respiratory uncoupling in skeletal muscle delays death and diminishes age-related disease. Cell Metab 6(6):497-505. PubMed: 18054318 MGI: J:130440
Gaudreault N; Kumar N; Posada JM; Stephens KB; Reyes de Mochel NS; Eberle D; Olivas VR; Kim RY; Harms MJ; Johnson S; Messina LM; Rapp JH; Raffai RL. 2012. ApoE suppresses atherosclerosis by reducing lipid accumulation in circulating monocytes and the expression of inflammatory molecules on monocytes and vascular endothelium. Arterioscler Thromb Vasc Biol 32(2):264-72. PubMed: 22053073 MGI: J:195610
Gavrila D; Li WG; McCormick ML; Thomas M; Daugherty A; Cassis LA; Miller FJ Jr; Oberley LW; Dellsperger KC; Weintraub NL. 2005. Vitamin E inhibits abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25(8):1671-7. PubMed: 15933246 MGI: J:114336
Gayral S; Garnotel R; Castaing-Berthou A; Blaise S; Fougerat A; Berge E; Montheil A; Malet N; Wymann MP; Maurice P; Debelle L; Martiny L; Martinez LO; Pshezhetsky AV; Duca L; Laffargue M. 2014. Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kgamma pathway. Cardiovasc Res 102(1):118-27. PubMed: 24357053 MGI: J:229142
Ge S; Hertel B; Koltsova EK; Sorensen-Zender I; Kielstein JT; Ley K; Haller H; von Vietinghoff S. 2013. Increased atherosclerotic lesion formation and vascular leukocyte accumulation in renal impairment are mediated by interleukin-17A. Circ Res 113(8):965-74. PubMed: 23908345 MGI: J:213467
Gelfand BD; Meller J; Pryor AW; Kahn M; Bortz PD; Wamhoff BR; Blackman BR. 2011. Hemodynamic activation of beta-catenin and T-cell-specific transcription factor signaling in vascular endothelium regulates fibronectin expression. Arterioscler Thromb Vasc Biol 31(7):1625-33. PubMed: 21527747 MGI: J:191469
Georgopoulos S; McKee A; Kan HY; Zannis VI. 2002. Generation and characterization of two transgenic mouse lines expressing human ApoE2 in neurons and glial cells. Biochemistry 41(30):9293-301. PubMed: 12135350 MGI: J:78003
Getz GS; Reardon CA. 2016. ApoE knockout and knockin mice: the history of their contribution to the understanding of atherogenesis. J Lipid Res 57(5):758-66. PubMed: 27015743 MGI: J:231754
Ghazalpour A; Doss S; Zhang B; Wang S; Plaisier C; Castellanos R; Brozell A; Schadt EE; Drake TA; Lusis AJ; Horvath S. 2006. Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet 2(8):e130. PubMed: 16934000 MGI: J:115983
Ghosh J; Das S; Guha R; Ghosh D; Naskar K; Das A; Roy S. 2012. Hyperlipidemia offers protection against Leishmania donovani infection: role of membrane cholesterol. J Lipid Res 53(12):2560-72. PubMed: 23060454 MGI: J:190995
Ghoshal S; Loftin CD. 2012. Cyclooxygenase-2 inhibition attenuates abdominal aortic aneurysm progression in hyperlipidemic mice. PLoS One 7(11):e44369. PubMed: 23209546 MGI: J:194782
Giunti S; Calkin AC; Forbes JM; Allen TJ; Thomas MC; Cooper ME; Jandeleit-Dahm KA. 2010. The pleiotropic actions of rosuvastatin confer renal benefits in the diabetic Apo-E knockout mouse. Am J Physiol Renal Physiol 299(3):F528-35. PubMed: 20554645 MGI: J:163553
Glaros EN; Kim WS; Quinn CM; Jessup W; Rye KA; Garner B. 2008. Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice. J Lipid Res 49(2):324-31. PubMed: 17978313 MGI: J:131877
Glaros EN; Kim WS; Rye KA; Shayman JA; Garner B. 2008. Reduction of plasma glycosphingolipid levels has no impact on atherosclerosis in apolipoprotein E-null mice. J Lipid Res 49(8):1677-81. PubMed: 18467744 MGI: J:138447
Godschalk RW; Albrecht C; Curfs DM; Schins RP; Bartsch H; van Schooten FJ; Nair J. 2007. Decreased levels of lipid peroxidation-induced DNA damage in the onset of atherogenesis in apolipoprotein E deficient mice. Mutat Res 621(1-2):87-94. PubMed: 17418875 MGI: J:123175
Goeritzer M; Schlager S; Radovic B; Madreiter CT; Rainer S; Thomas G; Lord CC; Sacks J; Brown AL; Vujic N; Obrowsky S; Sachdev V; Kolb D; Chandak PG; Graier WF; Sattler W; Brown JM; Kratky D. 2014. Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis. J Lipid Res 55(12):2562-75. PubMed: 25316883 MGI: J:217163
Goettsch C; Rauner M; Pacyna N; Hempel U; Bornstein SR; Hofbauer LC. 2011. miR-125b Regulates Calcification of Vascular Smooth Muscle Cells. Am J Pathol 179(4):1594-600. PubMed: 21806957 MGI: J:176306
Gold ES; Ramsey SA; Sartain MJ; Selinummi J; Podolsky I; Rodriguez DJ; Moritz RL; Aderem A. 2012. ATF3 protects against atherosclerosis by suppressing 25-hydroxycholesterol-induced lipid body formation. J Exp Med 209(4):807-17. PubMed: 22473958 MGI: J:183850
Goldstein LB; Vitek MP; Dawson H; Bullman S. 2000. Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse. Neuroscience 99(4):705-10. PubMed: 10974433 MGI: J:119167
Gomez M; Sanz-Gonzalez SM; Abu Nabah YN; Lamana A; Sanchez-Madrid F; Andres V. 2009. Atherosclerosis development in apolipoprotein E-null mice deficient for CD69. Cardiovasc Res 81(1):197-205. PubMed: 18703531 MGI: J:162209
Gonzales JC; Gordts PL; Foley EM; Esko JD. 2013. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans. J Clin Invest 123(6):2742-51. PubMed: 23676495 MGI: J:201440
Gonzalez-Navarro H; Nong Z; Amar MJ; Shamburek RD; Najib-Fruchart J; Paigen BJ; Brewer HB Jr; Santamarina-Fojo S. 2004. The ligand-binding function of hepatic lipase modulates the development of atherosclerosis in transgenic mice. J Biol Chem 279(44):45312-21. PubMed: 15304509 MGI: J:94495
Goodrum JF; Bouldin TW; Zhang SH; Maeda N; Popko B. 1995. Nerve regeneration and cholesterol reutilization occur in the absence of apolipoproteins E and A-I in mice. J Neurochem 64(1):408-16. PubMed: 7798939 MGI: J:22362
Goossens P; Gijbels MJ; Zernecke A; Eijgelaar W; Vergouwe MN; van der Made I; Vanderlocht J; Beckers L; Buurman WA; Daemen MJ; Kalinke U; Weber C; Lutgens E; de Winther MP. 2010. Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. Cell Metab 12(2):142-53. PubMed: 20674859 MGI: J:163078
Gordts PL; Reekmans S; Lauwers A; Van Dongen A; Verbeek L; Roebroek AJ. 2009. Inactivation of the LRP1 intracellular NPxYxxL motif in LDLR-deficient mice enhances postprandial dyslipidemia and atherosclerosis. Arterioscler Thromb Vasc Biol 29(9):1258-64. PubMed: 19667105 MGI: J:167801
Gorenne I; Kumar S; Gray K; Figg N; Yu H; Mercer J; Bennett M. 2013. Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. Circulation 127(3):386-96. PubMed: 23224247 MGI: J:210140
Gough PJ; Gomez IG; Wille PT; Raines EW. 2006. Macrophage expression of active MMP-9 induces acute plaque disruption in apoE-deficient mice. J Clin Invest 116(1):59-69. PubMed: 16374516 MGI: J:105266
Gourdy P; Schambourg A; Filipe C; Douin-Echinard V; Garmy-Susini B; Calippe B; Terce F; Bayard F; Arnal JF. 2007. Transforming growth factor activity is a key determinant for the effect of estradiol on fatty streak deposit in hypercholesterolemic mice. Arterioscler Thromb Vasc Biol 27(10):2214-21. PubMed: 17690314 MGI: J:134877
Grainger DJ; Reckless J; McKilligin E. 2004. Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice. J Immunol 173(10):6366-75. PubMed: 15528376 MGI: J:94282
Gray SP; Di Marco E; Okabe J; Szyndralewiez C; Heitz F; Montezano AC; de Haan JB; Koulis C; El-Osta A; Andrews KL; Chin-Dusting JP; Touyz RM; Wingler K; Cooper ME; Schmidt HH; Jandeleit-Dahm KA. 2013. NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis. Circulation 127(18):1888-902. PubMed: 23564668 MGI: J:211396
Grewal N; Thornton GM; Behzad H; Sharma A; Lu A; Zhang P; Reid WD; Granville Alex Scott DJ. 2014. Accumulation of oxidized LDL in the tendon tissues of C57BL/6 or apolipoprotein E knock-out mice that consume a high fat diet: potential impact on tendon health. PLoS One 9(12):e114214. PubMed: 25502628 MGI: J:225197
Grootendorst J; Bour A; Vogel E; Kelche C; Sullivan PM; Dodart JC; Bales K; Mathis C. 2005. Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. Behav Brain Res 159(1):1-14. PubMed: 15794991 MGI: J:97643
Gross S; Tilly P; Hentsch D; Vonesch JL; Fabre JE. 2007. Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors. J Exp Med 204(2):311-20. PubMed: 17242161 MGI: J:125376
Guedj K; Khallou-Laschet J; Clement M; Morvan M; Gaston AT; Fornasa G; Dai J; Gervais-Taurel M; Eberl G; Michel JB; Caligiuri G; Nicoletti A. 2014. M1 macrophages act as LTbetaR-independent lymphoid tissue inducer cells during atherosclerosis-related lymphoid neogenesis. Cardiovasc Res 101(3):434-43. PubMed: 24272771 MGI: J:220062
Guo GL; Santamarina-Fojo S; Akiyama TE; Amar MJ; Paigen BJ; Brewer B Jr; Gonzalez FJ. 2006. Effects of FXR in foam-cell formation and atherosclerosis development. Biochim Biophys Acta 1761(12):1401-9. PubMed: 17110163 MGI: J:118172
Guo Y; Fan Y; Zhang J; Lomberk GA; Zhou Z; Sun L; Mathison AJ; Garcia-Barrio MT; Zhang J; Zeng L; Li L; Pennathur S; Willer CJ; Rader DJ; Urrutia R; Chen YE. 2015. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production. J Clin Invest 125(10):3819-30. PubMed: 26368306 MGI: J:226403
Guo Y; Zhang C; Du X; Nair U; Yoo TJ. 2005. Morphological and functional alterations of the cochlea in apolipoprotein E gene deficient mice. Hear Res 208(1-2):54-67. PubMed: 16051453 MGI: J:101576
Guo Z; Mitchell-Raymundo F; Yang H; Ikeno Y; Nelson J; Diaz V; Richardson A; Reddick R. 2002. Dietary restriction reduces atherosclerosis and oxidative stress in the aorta of apolipoprotein E-deficient mice. Mech Ageing Dev 123(8):1121-31. PubMed: 12044962 MGI: J:76930
Guo Z; Ran Q; Roberts LJ 2nd; Zhou L; Richardson A; Sharan C; Wu D; Yang H. 2008. Suppression of atherogenesis by overexpression of glutathione peroxidase-4 in apolipoprotein E-deficient mice. Free Radic Biol Med 44(3):343-52. PubMed: 18215741 MGI: J:130157
Gustavsson C; Agardh CD; Zetterqvist AV; Nilsson J; Agardh E; Gomez MF. 2010. Vascular cellular adhesion molecule-1 (VCAM-1) expression in mice retinal vessels is affected by both hyperglycemia and hyperlipidemia. PLoS One 5(9):e12699. PubMed: 20856927 MGI: J:165118
Haefliger JA; Martin D; Favre D; Petremand Y; Mazzolai L; Abderrahmani A; Meda P; Waeber G; Allagnat F. 2013. Reduction of connexin36 content by ICER-1 contributes to insulin-secreting cells apoptosis induced by oxidized LDL particles. PLoS One 8(1):e55198. PubMed: 23383107 MGI: J:195912
Hafezi-Moghadam A; Thomas KL; Wagner DD. 2007. ApoE deficiency leads to a progressive age-dependent blood-brain barrier leakage. Am J Physiol Cell Physiol 292(4):C1256-62. PubMed: 16870825 MGI: J:125887
Hag AM; Pedersen SF; Christoffersen C; Binderup T; Jensen MM; Jorgensen JT; Skovgaard D; Ripa RS; Kjaer A. 2012. (18)F-FDG PET imaging of murine atherosclerosis: association with gene expression of key molecular markers. PLoS One 7(11):e50908. PubMed: 23226424 MGI: J:194777
Hagensen MK; Shim J; Falk E; Bentzon JF. 2011. Flanking recipient vasculature, not circulating progenitor cells, contributes to endothelium and smooth muscle in murine allograft vasculopathy. Arterioscler Thromb Vasc Biol 31(4):808-13. PubMed: 21233450 MGI: J:184171
Hagensen MK; Shim J; Thim T; Falk E; Bentzon JF. 2010. Circulating endothelial progenitor cells do not contribute to plaque endothelium in murine atherosclerosis. Circulation 121(7):898-905. PubMed: 20142446 MGI: J:170440
Haghighat A; Weiss D; Whalin MK; Cowan DP; Taylor WR. 2007. Granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor exacerbate atherosclerosis in apolipoprotein E-deficient mice. Circulation 115(15):2049-54. PubMed: 17404156 MGI: J:135370
Hameed AG; Arnold ND; Chamberlain J; Pickworth JA; Paiva C; Dawson S; Cross S; Long L; Zhao L; Morrell NW; Crossman DC; Newman CM; Kiely DG; Francis SE; Lawrie A. 2012. Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension. J Exp Med 209(11):1919-35. PubMed: 23071256 MGI: J:190896
Hamzah J; Kotamraju VR; Seo JW; Agemy L; Fogal V; Mahakian LM; Peters D; Roth L; Gagnon MK; Ferrara KW; Ruoslahti E. 2011. Specific penetration and accumulation of a homing peptide within atherosclerotic plaques of apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 108(17):7154-9. PubMed: 21482787 MGI: J:171341
Han JH; Oh TJ; Lee G; Maeng HJ; Lee DH; Kim KM; Choi SH; Jang HC; Lee HS; Park KS; Kim YB; Lim S. 2017. The beneficial effects of empagliflozin, an SGLT2 inhibitor, on atherosclerosis in ApoE -/- mice fed a western diet. Diabetologia 60(2):364-376. PubMed: 27866224 MGI: J:238722
Han L; Tang MX; Ti Y; Wang ZH; Wang J; Ding WY; Wang H; Zhang Y; Zhang W; Zhong M. 2013. Overexpressing STAMP2 improves insulin resistance in diabetic ApoE(-)/(-)/LDLR(-)/(-) mice via macrophage polarization shift in adipose tissues. PLoS One 8(11):e78903. PubMed: 24236066 MGI: J:209316
Han SH; Chung SY. 2000. Marked hippocampal neuronal damage without motor deficits after mild concussive-like brain injury in apolipoprotein E-deficient mice Ann N Y Acad Sci 903:357-65. PubMed: 10818526 MGI: J:62422
Han X; Cheng H; Fryer JD; Fagan AM; Holtzman DM. 2003. Novel role for apolipoprotein E in the central nervous system. Modulation of sulfatide content. J Biol Chem 278(10):8043-51. PubMed: 12501252 MGI: J:131491
Han X; Holtzman DM; McKeel DW Jr. 2001. Plasmalogen deficiency in early Alzheimer's disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry. J Neurochem 77(4):1168-80. PubMed: 11359882 MGI: J:69528
Hanna RN; Shaked I; Hubbeling HG; Punt JA; Wu R; Herrley E; Zaugg C; Pei H; Geissmann F; Ley K; Hedrick CC. 2012. NR4A1 (Nur77) deletion polarizes macrophages toward an inflammatory phenotype and increases atherosclerosis. Circ Res 110(3):416-27. PubMed: 22194622 MGI: J:192704
Hanniman EA; Lambert G; McCarthy TC; Sinal CJ. 2005. Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice. J Lipid Res 46(12):2595-604. PubMed: 16186601 MGI: J:106149
Hans CP; Feng Y; Naura AS; Zerfaoui M; Rezk BM; Xia H; Kaye AD; Matrougui K; Lazartigues E; Boulares AH. 2009. Protective effects of PARP-1 knockout on dyslipidemia-induced autonomic and vascular dysfunction in ApoE mice: effects on eNOS and oxidative stress. PLoS One 4(10):e7430. PubMed: 19823587 MGI: J:154098
Hansmann G; Wagner RA; Schellong S; Perez VA; Urashima T; Wang L; Sheikh AY; Suen RS; Stewart DJ; Rabinovitch M. 2007. Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Circulation 115(10):1275-84. PubMed: 17339547 MGI: J:132327
Hansmann G; de Jesus Perez VA; Alastalo TP; Alvira CM; Guignabert C; Bekker JM; Schellong S; Urashima T; Wang L; Morrell NW; Rabinovitch M. 2008. An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. J Clin Invest 118(5):1846-57. PubMed: 18382765 MGI: J:136168
Hanssen NM; Brouwers O; Gijbels MJ; Wouters K; Wijnands E; Cleutjens JP; De Mey JG; Miyata T; Biessen EA; Stehouwer CD; Schalkwijk CG. 2014. Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE-/- mice with or without diabetes. Cardiovasc Res 104(1):160-70. PubMed: 25139743 MGI: J:230222
Hao M; Head WS; Gunawardana SC; Hasty AH; Piston DW. 2007. Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction. Diabetes 56(9):2328-38. PubMed: 17575085 MGI: J:126584
Harada N; Ito K; Hosoya T; Mimura J; Maruyama A; Noguchi N; Yagami KI; Morito N; Takahashi S; Maher JM; Yamamoto M; Itoh K. 2012. Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation. Free Radic Biol Med 53(12):2256-2262. PubMed: 23051009 MGI: J:193780
Harja E; Bu DX; Hudson BI; Chang JS; Shen X; Hallam K; Kalea AZ; Lu Y; Rosario RH; Oruganti S; Nikolla Z; Belov D; Lalla E; Ramasamy R; Yan SF; Schmidt AM. 2008. Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE-/- mice. J Clin Invest 118(1):183-94. PubMed: 18079965 MGI: J:130844
Harja E; Bucciarelli LG; Lu Y; Stern DM; Zou YS; Schmidt AM; Yan SF. 2004. Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammation. Circ Res 94(3):333-9. PubMed: 14670837 MGI: J:96665
Harja E; Chang JS; Lu Y; Leitges M; Zou YS; Schmidt AM; Yan SF. 2009. Mice deficient in PKCbeta and apolipoprotein E display decreased atherosclerosis. FASEB J 23(4):1081-91. PubMed: 19036858 MGI: J:147225
Harrington SC; Simari RD; Conover CA. 2007. Genetic deletion of pregnancy-associated plasma protein-A is associated with resistance to atherosclerotic lesion development in apolipoprotein E-deficient mice challenged with a high-fat diet. Circ Res 100(12):1696-702. PubMed: 17510462 MGI: J:137790
Harris FM; Brecht WJ; Xu Q; Mahley RW; Huang Y. 2004. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem 279(43):44795-801. PubMed: 15322121 MGI: J:93984
Harrison CB; Selemidis S; Guida E; King PT; Sobey CG; Drummond GR. 2012. NOX2beta: A novel splice variant of NOX2 that regulates NADPH oxidase activity in macrophages. PLoS One 7(10):e48326. PubMed: 23118986 MGI: J:192279
Harrison M; Smith E; Ross E; Krams R; Segers D; Buckley CD; Nash GB; Rainger GE. 2013. The role of platelet-endothelial cell adhesion molecule-1 in atheroma formation varies depending on the site-specific hemodynamic environment. Arterioscler Thromb Vasc Biol 33(4):694-701. PubMed: 23372062 MGI: J:217979
Harry BL; Sanders JM; Feaver RE; Lansey M; Deem TL; Zarbock A; Bruce AC; Pryor AW; Gelfand BD; Blackman BR; Schwartz MA; Ley K. 2008. Endothelial cell PECAM-1 promotes atherosclerotic lesions in areas of disturbed flow in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 28(11):2003-8. PubMed: 18688018 MGI: J:148824
Hartley CJ; Reddy AK; Madala S; Martin-McNulty B; Vergona R; Sullivan ME; Halks-Miller M; Taffet GE; Michael LH; Entman ML; Wang YX. 2000. Hemodynamic changes in apolipoprotein E-knockout mice. Am J Physiol Heart Circ Physiol 279(5):H2326-34. PubMed: 11045969 MGI: J:108154
Hartman RE; Laurer H; Longhi L; Bales KR; Paul SM; McIntosh TK; Holtzman DM. 2002. Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease. J Neurosci 22(23):10083-7. PubMed: 12451108 MGI: J:133058
Hartman RE; Wozniak DF; Nardi A; Olney JW; Sartorius L; Holtzman DM. 2001. Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology. Exp Neurol 170(2):326-44. PubMed: 11476599 MGI: J:71062
Hartmann P; Zhou Z; Natarelli L; Wei Y; Nazari-Jahantigh M; Zhu M; Grommes J; Steffens S; Weber C; Schober A. 2016. Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nat Commun 7:10521. PubMed: 26837267 MGI: J:236287
Hashimoto T; Kihara M; Imai N; Yoshida S; Shimoyamada H; Yasuzaki H; Ishida J; Toya Y; Kiuchi Y; Hirawa N; Tamura K; Yazawa T; Kitamura H; Fukamizu A; Umemura S. 2007. Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis. Am J Pathol 171(5):1705-12. PubMed: 17884970 MGI: J:126802
Hatcher JP; Virley D; Hadingham SJ; Roberts J; Hunter AJ; Parsons AA. 2002. The behavioural effect of middle cerebral artery occlusion on apolipoprotein-E deficient mice. Behav Brain Res 131(1-2):139-49. PubMed: 11844581 MGI: J:96228
Hayashi C; Papadopoulos G; Gudino CV; Weinberg EO; Barth KR; Madrigal AG; Chen Y; Ning H; LaValley M; Gibson FC 3rd; Hamilton JA; Genco CA. 2012. Protective role for TLR4 signaling in atherosclerosis progression as revealed by infection with a common oral pathogen. J Immunol 189(7):3681-8. PubMed: 22956579 MGI: J:190543
Hayashi H; Campenot RB; Vance DE; Vance JE. 2009. Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin. J Biol Chem 284(43):29605-13. PubMed: 19717566 MGI: J:156971
He C; Zhu H; Zhang W; Okon I; Wang Q; Li H; Le YZ; Xie Z. 2013. 7-Ketocholesterol Induces Autophagy in Vascular Smooth Muscle Cells through Nox4 and Atg4B. Am J Pathol 183(2):626-37. PubMed: 23770348 MGI: J:198718
Hechler B; Freund M; Ravanat C; Magnenat S; Cazenave JP; Gachet C. 2008. Reduced atherosclerotic lesions in P2Y1/apolipoprotein E double-knockout mice: the contribution of non-hematopoietic-derived P2Y1 receptors. Circulation 118(7):754-63. PubMed: 18663083 MGI: J:158117
Heidt T; Sager HB; Courties G; Dutta P; Iwamoto Y; Zaltsman A; von Zur Muhlen C; Bode C; Fricchione GL; Denninger J; Lin CP; Vinegoni C; Libby P; Swirski FK; Weissleder R; Nahrendorf M. 2014. Chronic variable stress activates hematopoietic stem cells. Nat Med 20(7):754-8. PubMed: 24952646 MGI: J:227608
Hemdahl AL; Falk E; Thoren P; Hansson GK. 2004. Thrombin inhibitor reduces myocardial infarction in apoE-/- x LDLR-/- mice. Am J Physiol Heart Circ Physiol 287(2):H872-7. PubMed: 15031124 MGI: J:95598
Hermanowski-Vosatka A; Balkovec JM; Cheng K; Chen HY; Hernandez M; Koo GC; Le Grand CB; Li Z; Metzger JM; Mundt SS; Noonan H; Nunes CN; Olson SH; Pikounis B; Ren N; Robertson N; Schaeffer JM; Shah K; Springer MS; Strack AM; Strowski M; Wu K; Wu T; Xiao J; Zhang BB; Wright SD; Thieringer R. 2005. 11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice. J Exp Med 202(4):517-27. PubMed: 16103409 MGI: J:100504
Hernandez-Vargas P; Ortiz-Munoz G; Lopez-Franco O; Suzuki Y; Gallego-Delgado J; Sanjuan G; Lazaro A; Lopez-Parra V; Ortega L; Egido J; Gomez-Guerrero C. 2006. Fcgamma receptor deficiency confers protection against atherosclerosis in apolipoprotein E knockout mice. Circ Res 99(11):1188-96. PubMed: 17053192 MGI: J:129087
Hiebert PR; Boivin WA; Abraham T; Pazooki S; Zhao H; Granville DJ. 2011. Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice. Exp Gerontol 46(6):489-99. PubMed: 21316440 MGI: J:186959
Hiebert PR; Boivin WA; Zhao H; McManus BM; Granville DJ. 2013. Perforin and granzyme B have separate and distinct roles during atherosclerotic plaque development in apolipoprotein E knockout mice. PLoS One 8(10):e78939. PubMed: 24205352 MGI: J:209223
Higashimori M; Tatro JB; Moore KJ; Mendelsohn ME; Galper JB; Beasley D. 2011. Role of toll-like receptor 4 in intimal foam cell accumulation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 31(1):50-7. PubMed: 20966403 MGI: J:184191
Hilgendorf I; Theurl I; Gerhardt LM; Robbins CS; Weber GF; Gonen A; Iwamoto Y; Degousee N; Holderried TA; Winter C; Zirlik A; Lin HY; Sukhova GK; Butany J; Rubin BB; Witztum JL; Libby P; Nahrendorf M; Weissleder R; Swirski FK. 2014. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation 129(16):1677-87. PubMed: 24488984 MGI: J:221696
Hinder LM; Vincent AM; Hayes JM; McLean LL; Feldman EL. 2013. Apolipoprotein E knockout as the basis for mouse models of dyslipidemia-induced neuropathy. Exp Neurol 239:102-10. PubMed: 23059459 MGI: J:196993
Hirasawa H; Tanaka S; Sakai A; Tsutsui M; Shimokawa H; Miyata H; Moriwaki S; Niida S; Ito M; Nakamura T. 2007. ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells. J Bone Miner Res 22(7):1020-30. PubMed: 17388726 MGI: J:137540
Hirsch-Reinshagen V; Zhou S; Burgess BL; Bernier L; McIsaac SA; Chan JY; Tansley GH; Cohn JS; Hayden MR; Wellington CL. 2004. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J Biol Chem 279(39):41197-207. PubMed: 15269218 MGI: J:93331
Hirschfield GM; Gallimore JR; Kahan MC; Hutchinson WL; Sabin CA; Benson GM; Dhillon AP; Tennent GA; Pepys MB. 2005. Transgenic human C-reactive protein is not proatherogenic in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 102(23):8309-14. PubMed: 15919817 MGI: J:99730
Hodgin JB; Knowles JW; Kim HS; Smithies O; Maeda N. 2002. Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. J Clin Invest 109(4):541-8. PubMed: 11854327 MGI: J:74702
Hoekstra M; Frodermann V; van den Aardweg T; van der Sluis RJ; Kuiper J. 2013. Leukocytosis and enhanced susceptibility to endotoxemia but not atherosclerosis in adrenalectomized APOE knockout mice. PLoS One 8(11):e80441. PubMed: 24265824 MGI: J:209659
Hoekstra M; Van Eck M. 2016. HDL is redundant for adrenal steroidogenesis in LDLR knockout mice with a human-like lipoprotein profile. J Lipid Res 57(4):631-7. PubMed: 26891738 MGI: J:231607
Hofmann Bowman MA; Gawdzik J; Bukhari U; Husain AN; Toth PT; Kim G; Earley J; McNally EM. 2011. S100A12 in vascular smooth muscle accelerates vascular calcification in apolipoprotein E-null mice by activating an osteogenic gene regulatory program. Arterioscler Thromb Vasc Biol 31(2):337-44. PubMed: 20966394 MGI: J:184194
Hofmann MA; Lalla E; Lu Y; Gleason MR; Wolf BM; Tanji N; Ferran LJ Jr; Kohl B; Rao V; Kisiel W; Stern DM; Schmidt AM. 2001. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. J Clin Invest 107(6):675-83. PubMed: 11254667 MGI: J:120549
Hofmann SM; Perez-Tilve D; Greer TM; Coburn BA; Grant E; Basford JE; Tschop MH; Hui DY. 2008. Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. Diabetes 57(1):5-12. PubMed: 17914034 MGI: J:132417
Holdt LM; von Delft A; Nicolaou A; Baumann S; Kostrzewa M; Thiery J; Teupser D. 2013. Quantitative trait loci mapping of the mouse plasma proteome (pQTL). Genetics 193(2):601-8. PubMed: 23172855 MGI: J:195244
Holm TM; Braun A; Trigatti BL; Brugnara C; Sakamoto M; Krieger M; Andrews NC. 2002. Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. Blood 99(5):1817-24. PubMed: 11861300 MGI: J:75090
Holtzman DM; Bales KR; Tenkova T; Fagan AM; Parsadanian M; Sartorius LJ; Mackey B; Olney J; McKeel D; Wozniak D; Paul SM. 2000. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 97(6):2892-7. PubMed: 10694577 MGI: J:61176
Holtzman DM; Bales KR; Wu S; Bhat P; Parsadanian M; Fagan AM; Chang LK; Sun Y; Paul SM. 1999. Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease. J Clin Invest 103(6):R15-R21. PubMed: 10079115 MGI: J:53613
Holtzman DM; Fagan AM; Mackey B; Tenkova T; Sartorius L; Paul SM; Bales K; Ashe KH; Irizarry MC; Hyman BT. 2000. Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model. Ann Neurol 47(6):739-47. PubMed: 10852539 MGI: J:113061
Holvoet P; Danloy S; Deridder E; Lox M; Bernar H; Dhoest A; Collen D. 1998. Substitution of the carboxyl-terminal domain of apo AI with apo AII sequences restores the potential of HDL to reduce the progression of atherosclerosis in apo E knockout mice. J Clin Invest 102(2):379-85. PubMed: 9664079 MGI: J:115147
Homeister JW; Daugherty A; Lowe JB. 2004. Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 24(10):1897-903. PubMed: 15308551 MGI: J:102212
Hong C; Bradley MN; Rong X; Wang X; Wagner A; Grijalva V; Castellani LW; Salazar J; Realegeno S; Boyadjian R; Fogelman AM; Van Lenten BJ; Reddy ST; Lusis AJ; Tangirala RK; Tontonoz P. 2012. LXRalpha is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice. J Lipid Res 53(6):1126-33. PubMed: 22454476 MGI: J:184910
Honjo T; Chyu KY; Dimayuga PC; Lio WM; Yano J; Trinidad P; Zhao X; Zhou J; Cercek B; Shah PK. 2015. Immunization with an ApoB-100 Related Peptide Vaccine Attenuates Angiotensin-II Induced Hypertension and Renal Fibrosis in Mice. PLoS One 10(6):e0131731. PubMed: 26121471 MGI: J:233882
Hopkins PC; Huang Y; McGuire JG; Pitas RE. 2002. Evidence for differential effects of apoE3 and apoE4 on HDL metabolism. J Lipid Res 43(11):1881-9. PubMed: 12401887 MGI: J:123999
Horsburgh K; Kelly S; McCulloch J; Higgins GA; Roses AD; Nicoll JA. 1999. Increased neuronal damage in apolipoprotein E-deficient mice following global ischaemia. Neuroreport 10(4):837-41. PubMed: 10208557 MGI: J:54423
Horsburgh K; McCulloch J; Nilsen M; Roses AD; Nicoll JA. 2000. Increased neuronal damage and apoE immunoreactivity in human apolipoprotein E, E4 isoform-specific, transgenic mice after global cerebral ischaemia. Eur J Neurosci 12(12):4309-17. PubMed: 11122341 MGI: J:129722
Hoshii Y; Kawano H; Cui D; Takeda T; Gondo T; Takahashi M; Kogishi K ; Higuchi K ; Ishihara T. 1997. Amyloid A protein amyloidosis induced in apolipoprotein-E-deficient mice. Am J Pathol 151(4):911-7. PubMed: 9327723 MGI: J:43190
Hoving S; Heeneman S; Gijbels MJ; te Poele JA; Bolla M; Pol JF; Simons MY; Russell NS; Daemen MJ; Stewart FA. 2010. NO-donating aspirin and aspirin partially inhibit age-related atherosclerosis but not radiation-induced atherosclerosis in ApoE null mice. PLoS One 5(9):e12874. PubMed: 20877628 MGI: J:165109
Hoyer FF; Steinmetz M; Zimmer S; Becker A; Lutjohann D; Buchalla R; Zimmer A; Nickenig G. 2011. Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo. J Mol Cell Cardiol 51(6):1007-14. PubMed: 21884703 MGI: J:178500
Hu JH; Du L; Chu T; Otsuka G; Dronadula N; Jaffe M; Gill SE; Parks WC; Dichek DA. 2010. Overexpression of urokinase by plaque macrophages causes histological features of plaque rupture and increases vascular matrix metalloproteinase activity in aged apolipoprotein e-null mice. Circulation 121(14):1637-44. PubMed: 20351234 MGI: J:172629
Huang LH; Melton EM; Li H; Sohn P; Rogers MA; Mulligan-Kehoe MJ; Fiering SN; Hickey WF; Chang CC; Chang TY. 2016. Myeloid Acyl-CoA:Cholesterol Acyltransferase 1 Deficiency Reduces Lesion Macrophage Content and Suppresses Atherosclerosis Progression. J Biol Chem 291(12):6232-44. PubMed: 26801614 MGI: J:231221
Huang M; Pang X; Karalis K; Theoharides TC. 2003. Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice. Cardiovasc Res 59(1):241-9. PubMed: 12829195 MGI: J:102798
Huang MS; Lu J; Ivanov Y; Sage AP; Tseng W; Demer LL; Tintut Y. 2008. Hyperlipidemia impairs osteoanabolic effects of PTH. J Bone Miner Res 23(10):1672-9. PubMed: 18505371 MGI: J:153411
Huang Q; Qin L; Dai S; Zhang H; Pasula S; Zhou H; Chen H; Min W. 2013. AIP1 suppresses atherosclerosis by limiting hyperlipidemia-induced inflammation and vascular endothelial dysfunction. Arterioscler Thromb Vasc Biol 33(4):795-804. PubMed: 23413429 MGI: J:217971
Huang Y; Liu XQ; Rall SC Jr; Taylor JM; von Eckardstein A; Assmann G; Mahley RW. 1998. Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J Biol Chem 273(41):26388-93. PubMed: 9756870 MGI: J:115206
Huang Y; Rall SC Jr; Mahley RW. 1997. Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler Thromb Vasc Biol 17(11):2817-24. PubMed: 9409260 MGI: J:45728
Huang ZH; Reardon CA; Mazzone T. 2006. Endogenous ApoE expression modulates adipocyte triglyceride content and turnover. Diabetes 55(12):3394-402. PubMed: 17130485 MGI: J:121013
Huang ZH; Reardon CA; Subbaiah PV; Getz GS; Mazzone T. 2013. ApoE derived from adipose tissue does not suppress atherosclerosis or correct hyperlipidemia in apoE knockout mice. J Lipid Res 54(1):202-13. PubMed: 23071294 MGI: J:190990
Huber SA; Sakkinen P; Conze D; Hardin N; Tracy R. 1999. Interleukin-6 exacerbates early atherosclerosis in mice. Arterioscler Thromb Vasc Biol 19(10):2364-7. PubMed: 10521365 MGI: J:103386
Hudson BI; Bucciarelli LG; Wendt T; Sakaguchi T; Lalla E; Qu W; Lu Y; Lee L; Stern DM; Naka Y; Ramasamy R; Yan SD; Yan SF; D'Agati V; Schmidt AM. 2003. Blockade of receptor for advanced glycation endproducts: a new target for therapeutic intervention in diabetic complications and inflammatory disorders. Arch Biochem Biophys 419(1):80-8. PubMed: 14568011 MGI: J:86419
Hunter JM; Cirrito JR; Restivo JL; Kinley RD; Sullivan PM; Holtzman DM; Koger D; Delong C; Lin S; Zhao L; Liu F; Bales K; Paul SM. 2012. Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. Brain Res 1467:120-32. PubMed: 22682924 MGI: J:186434
Huo Y; Schober A; Forlow SB; Smith DF; Hyman MC; Jung S; Littman DR; Weber C; Ley K. 2003. Circulating activated platelets exacerbate atherosclerosis in mice deficient in apolipoprotein E. Nat Med 9(1):61-7. PubMed: 12483207 MGI: J:81164
Hussain A; Luong M; Pooley A; Nathan BP. 2013. Isoform-specific effects of apoE on neurite outgrowth in olfactory epithelium culture. J Biomed Sci 20:49. PubMed: 23845000 MGI: J:239196
Hyvarinen K; Tuomainen AM; Laitinen S; Alfthan G; Salminen I; Leinonen M; Saikku P; Kovanen PT; Jauhiainen M; Pussinen PJ. 2013. The effect of proatherogenic pathogens on adipose tissue transcriptome and fatty acid distribution in apolipoprotein E-deficient mice. BMC Genomics 14:709. PubMed: 24131481 MGI: J:206533
Hyvarinen K; Tuomainen AM; Laitinen S; Bykov IL; Tormakangas L; Lindros K; Kakela R; Alfthan G; Salminen I; Jauhiainen M; Kovanen PT; Leinonen M; Saikku P; Pussinen PJ. 2009. Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice. Infect Immun 77(8):3442-9. PubMed: 19451238 MGI: J:151250
Igbavboa U; Avdulov NA; Chochina SV; Wood WG. 1997. Transbilayer distribution of cholesterol is modified in brain synaptic plasma membranes of knockout mice deficient in the low-density lipoprotein receptor, apolipoprotein E, or both proteins. J Neurochem 69(4):1661-7. PubMed: 9326295 MGI: J:43043
Ihara Y; Egashira K; Nakano K; Ohtani K; Kubo M; Koga J; Iwai M; Horiuchi M; Gang Z; Yamagishi S; Sunagawa K. 2007. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. J Mol Cell Cardiol 43(4):455-64. PubMed: 17761193 MGI: J:126372
Ii M; Takeshita K; Ibusuki K; Luedemann C; Wecker A; Eaton E; Thorne T; Asahara T; Liao JK; Losordo DW. 2010. Notch signaling regulates endothelial progenitor cell activity during recovery from arterial injury in hypercholesterolemic mice. Circulation 121(9):1104-12. PubMed: 20176991 MGI: J:170438
Imai Y; Shindo T; Maemura K; Sata M; Saito Y; Kurihara Y; Akishita M; Osuga J; Ishibashi S; Tobe K; Morita H; Oh-hashi Y; Suzuki T; Maekawa H; Kangawa K; Minamino N; Yazaki Y; Nagai R; Kurihara H. 2002. Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression. Arterioscler Thromb Vasc Biol 22(8):1310-5. PubMed: 12171793 MGI: J:103212
Imaizumi S; Grijalva V; Priceman S; Wu L; Su F; Farias-Eisner R; Hama S; Navab M; Fogelman AM; Reddy ST. 2010. Mitogen-activated protein kinase phosphatase-1 deficiency decreases atherosclerosis in apolipoprotein E null mice by reducing monocyte chemoattractant protein-1 levels. Mol Genet Metab 101(1):66-75. PubMed: 20619710 MGI: J:164607
Inoue K; Arai Y; Kurihara H; Kita T; Sawamura T. 2005. Overexpression of lectin-like oxidized low-density lipoprotein receptor-1 induces intramyocardial vasculopathy in apolipoprotein E-null mice. Circ Res 97(2):176-84. PubMed: 15961718 MGI: J:111393
Iqbal J; Macdonald LJ; Low L; Seckl JR; Yau CW; Walker BR; Hadoke PW. 2012. Contribution of endogenous glucocorticoids and their intravascular metabolism by 11beta-HSDs to postangioplasty neointimal proliferation in mice. Endocrinology 153(12):5896-905. PubMed: 23125311 MGI: J:192833
Iqbal J; Queiroz J; Li Y; Jiang XC; Ron D; Hussain MM. 2012. Increased intestinal lipid absorption caused by Ire1beta deficiency contributes to hyperlipidemia and atherosclerosis in apolipoprotein E-deficient mice. Circ Res 110(12):1575-84. PubMed: 22556338 MGI: J:212657
Isenberg JS; Hyodo F; Pappan LK; Abu-Asab M; Tsokos M; Krishna MC; Frazier WA; Roberts DD. 2007. Blocking thrombospondin-1/CD47 signaling alleviates deleterious effects of aging on tissue responses to ischemia. Arterioscler Thromb Vasc Biol 27(12):2582-8. PubMed: 17916772 MGI: J:147523
Ishibashi M; Masson D; Westerterp M; Wang N; Sayers S; Li R; Welch CL; Tall AR. 2010. Reduced VLDL clearance in Apoe(-/-)Npc1(-/-) mice is associated with increased Pcsk9 and Idol expression and decreased hepatic LDL-receptor levels. J Lipid Res 51(9):2655-63. PubMed: 20562239 MGI: J:164461
Ishibashi S; Herz J; Maeda N; Goldstein JL; Brown MS. 1994. The two-receptor model of lipoprotein clearance: tests of the hypothesis in knockout mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins. Proc Natl Acad Sci U S A 91(10):4431-5. PubMed: 8183926 MGI: J:18138
Ishibashi S; Perrey S; Chen Z; Osuga Ji; Shimada M; Ohashi K; Harada K; Yazaki Y; Yamada N. 1996. Role of the low density lipoprotein (LDL) receptor pathway in the metabolism of chylomicron remnants. A quantitative study in knockout mice lacking the LDL receptor, apolipoprotein E, or both. J Biol Chem 271(37):22422-7. PubMed: 8798405 MGI: J:35377
Ishida T; Choi SY; Kundu RK; Spin J; Yamashita T; Hirata K; Kojima Y; Yokoyama M; Cooper AD; Quertermous T. 2004. Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. J Biol Chem 279(43):45085-92. PubMed: 15304490 MGI: J:93987
Ishigaki Y; Oikawa S; Suzuki T; Usui S; Magoori K; Kim DH; Suzuki H; Sasaki J; Sasano H; Okazaki M; Toyota T; Saito T; Yamamoto TT. 2000. Virus-mediated transduction of apolipoprotein E (ApoE)-sendai develops lipoprotein glomerulopathy in ApoE-deficient mice J Biol Chem 275(40):31269-73. PubMed: 10903326 MGI: J:65016
Ishimori N; Iwabuchi K; Fujii S; Watano K; Iwabuchi C; Ato M; Chiba H; Tanaka S; Kitabatake A; Onoe K. 2001. Mixed allogeneic chimerism with wild-type strains ameliorates atherosclerosis in apolipoprotein E-deficient mice. J Leukoc Biol 69(5):732-40. PubMed: 11358981 MGI: J:69647
Isoda K; Sawada S; Ishigami N; Matsuki T; Miyazaki K; Kusuhara M; Iwakura Y; Ohsuzu F. 2004. Lack of interleukin-1 receptor antagonist modulates plaque composition in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 24(6):1068-73. PubMed: 15059807 MGI: J:102337
Ivanovski O; Szumilak D; Nguyen-Khoa T; Ruellan N; Phan O; Lacour B; Descamps-Latscha B; Drueke TB; Massy ZA. 2005. The antioxidant N-acetylcysteine prevents accelerated atherosclerosis in uremic apolipoprotein E knockout mice. Kidney Int 67(6):2288-94. PubMed: 15882270 MGI: J:110116
Iwai M; Chen R; Li Z; Shiuchi T; Suzuki J; Ide A; Tsuda M; Okumura M; Min LJ; Mogi M; Horiuchi M. 2005. Deletion of angiotensin II type 2 receptor exaggerated atherosclerosis in apolipoprotein E-null mice. Circulation 112(11):1636-43. PubMed: 16145000 MGI: J:116799
Iwai M; Kanno H; Senba I; Nakaoka H; Moritani T; Horiuchi M. 2011. Irbesartan increased PPARgamma activity in vivo in white adipose tissue of atherosclerotic mice and improved adipose tissue dysfunction. Biochem Biophys Res Commun 406(1):123-6. PubMed: 21296052 MGI: J:170925
Jacobi J; Maas R; Cardounel AJ; Arend M; Pope AJ; Cordasic N; Heusinger-Ribeiro J; Atzler D; Strobel J; Schwedhelm E; Boger RH; Hilgers KF. 2010. Dimethylarginine dimethylaminohydrolase overexpression ameliorates atherosclerosis in apolipoprotein E-deficient mice by lowering asymmetric dimethylarginine. Am J Pathol 176(5):2559-70. PubMed: 20348244 MGI: J:160760
Jain S; Yoon SY; Leung L; Knoferle J; Huang Y. 2013. Cellular source-specific effects of apolipoprotein (apo) E4 on dendrite arborization and dendritic spine development. PLoS One 8(3):e59478. PubMed: 23527202 MGI: J:200182
Jansen F; Yang X; Franklin BS; Hoelscher M; Schmitz T; Bedorf J; Nickenig G; Werner N. 2013. High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation. Cardiovasc Res 98(1):94-106. PubMed: 23341580 MGI: J:210428
Jawien J; Gajda M; Olszanecki R; Korbut R. 2007. BAY x 1005 attenuates atherosclerosis in apoE/LDLR - double knockout mice. J Physiol Pharmacol 58(3):583-8. PubMed: 17928652 MGI: J:130080
Jenner AM; Lim WL; Ng MP; Wenk MR; Shui G; Sharman MJ; Gandy SE; Martins RN. 2010. The effect of APOE genotype on brain levels of oxysterols in young and old human APOE epsilon2, epsilon3 and epsilon4 knock-in mice. Neuroscience 169(1):109-15. PubMed: 20416362 MGI: J:165367
Ji Y; Gong Y; Gan W; Beach T; Holtzman DM; Wisniewski T. 2003. Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients. Neuroscience 122(2):305-15. PubMed: 14614898 MGI: J:126171
Jia C; Xiong M; Wang P; Cui J; Du X; Yang Q; Wang W; Chen Y; Zhang T. 2014. Notoginsenoside R1 attenuates atherosclerotic lesions in ApoE deficient mouse model. PLoS One 9(6):e99849. PubMed: 24933211 MGI: J:218860
Jiang XC; Beyer TP; Li Z; Liu J; Quan W; Schmidt RJ; Zhang Y; Bensch WR; Eacho PI; Cao G. 2003. Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expression. J Biol Chem 278(49):49072-8. PubMed: 12947111 MGI: J:86766
Jiang XC; Tall AR; Qin S; Lin M; Schneider M; Lalanne F; Deckert V; Desrumaux C; Athias A; Witztum JL; Lagrost L. 2002. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem 277(35):31850-6. PubMed: 12105225 MGI: J:120468
Jin SY; Tohyama J; Bauer RC; Cao NN; Rader DJ; Zheng XL. 2012. Genetic ablation of Adamts13 gene dramatically accelerates the formation of early atherosclerosis in a murine model. Arterioscler Thromb Vasc Biol 32(8):1817-23. PubMed: 22652598 MGI: J:201491
Johansson ME; Hagg U; Wikstrom J; Wickman A; Bergstrom G; Gan LM. 2005. Haemodynamically significant plaque formation and regional endothelial dysfunction in cholesterol-fed ApoE-/- mice. Clin Sci (Lond) 108(6):531-8. PubMed: 15675896 MGI: J:109794
Johnstone SR; Kroncke BM; Straub AC; Best AK; Dunn CA; Mitchell LA; Peskova Y; Nakamoto RK; Koval M; Lo CW; Lampe PD; Columbus L; Isakson BE. 2012. MAPK phosphorylation of connexin 43 promotes binding of cyclin E and smooth muscle cell proliferation. Circ Res 111(2):201-11. PubMed: 22652908 MGI: J:212895
Johnstone SR; Ross J; Rizzo MJ; Straub AC; Lampe PD; Leitinger N; Isakson BE. 2009. Oxidized phospholipid species promote in vivo differential cx43 phosphorylation and vascular smooth muscle cell proliferation. Am J Pathol 175(2):916-24. PubMed: 19608875 MGI: J:150954
Joseph SB; McKilligin E; Pei L; Watson MA; Collins AR; Laffitte BA; Chen M; Noh G; Goodman J; Hagger GN; Tran J; Tippin TK; Wang X; Lusis AJ; Hsueh WA; Law RE; Collins JL; Willson TM; Tontonoz P. 2002. Synthetic LXR ligand inhibits the development of atherosclerosis in mice. Proc Natl Acad Sci U S A 99(11):7604-9. PubMed: 12032330 MGI: J:76860
Joyce CW; Amar MJ; Lambert G; Vaisman BL; Paigen B; Najib-Fruchart J; Hoyt RF Jr; Neufeld ED; Remaley AT; Fredrickson DS; Brewer HB Jr; Santamarina-Fojo S. 2002. The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice. Proc Natl Acad Sci U S A 99(1):407-12. PubMed: 11752403 MGI: J:73704
Judkins CP; Diep H; Broughton BR; Mast AE; Hooker EU; Miller AA; Selemidis S; Dusting GJ; Sobey CG; Drummond GR. 2010. Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice. Am J Physiol Heart Circ Physiol 298(1):H24-32. PubMed: 19837950 MGI: J:158487
Jun JY; Ma Z; Segar L. 2011. Spontaneously diabetic Ins2(+/Akita):apoE-deficient mice exhibit exaggerated hypercholesterolemia and atherosclerosis. Am J Physiol Endocrinol Metab 301(1):E145-54. PubMed: 21447785 MGI: J:182074
Kamari Y; Shaish A; Shemesh S; Vax E; Grosskopf I; Dotan S; White M; Voronov E; Dinarello CA; Apte RN; Harats D. 2011. Reduced atherosclerosis and inflammatory cytokines in apolipoprotein-E-deficient mice lacking bone marrow-derived interleukin-1alpha. Biochem Biophys Res Commun 405(2):197-203. PubMed: 21219852 MGI: J:168581
Kampschulte M; Stockl C; Langheinrich AC; Althohn U; Bohle RM; Krombach GA; Stieger P; Churin Y; Kremer S; Dierkes C; Rath T; Roeb E; Roderfeld M. 2014. Western diet in ApoE-LDLR double-deficient mouse model of atherosclerosis leads to hepatic steatosis, fibrosis, and tumorigenesis. Lab Invest 94(11):1273-82. PubMed: 25199052 MGI: J:216362
Kanellakis P; Agrotis A; Kyaw TS; Koulis C; Ahrens I; Mori S; Takahashi HK; Liu K; Peter K; Nishibori M; Bobik A. 2011. High-mobility group box protein 1 neutralization reduces development of diet-induced atherosclerosis in apolipoprotein e-deficient mice. Arterioscler Thromb Vasc Biol 31(2):313-9. PubMed: 21088249 MGI: J:184183
Kanthi Y; Hyman MC; Liao H; Baek AE; Visovatti SH; Sutton NR; Goonewardena SN; Neral MK; Jo H; Pinsky DJ. 2015. Flow-dependent expression of ectonucleotide tri(di)phosphohydrolase-1 and suppression of atherosclerosis. J Clin Invest 125(8):3027-36. PubMed: 26121751 MGI: J:224535
Karackattu SL; Picard MH; Krieger M. 2005. Lymphocytes are not required for the rapid onset of coronary heart disease in scavenger receptor class B type I/apolipoprotein E double knockout mice. Arterioscler Thromb Vasc Biol 25(4):803-8. PubMed: 15692099 MGI: J:110023
Karackattu SL; Trigatti B; Krieger M. 2006. Hepatic lipase deficiency delays atherosclerosis, myocardial infarction, and cardiac dysfunction and extends lifespan in SR-BI/apolipoprotein E double knockout mice. Arterioscler Thromb Vasc Biol 26(3):548-54. PubMed: 16397139 MGI: J:127979
Karagiannides I; Abdou R; Tzortzopoulou A; Voshol PJ; Kypreos KE. 2008. Apolipoprotein E predisposes to obesity and related metabolic dysfunctions in mice. FEBS J 275(19):4796-809. PubMed: 18754772 MGI: J:142460
Karavia EA; Papachristou DJ; Kotsikogianni I; Giopanou I; Kypreos KE. 2011. Deficiency in apolipoprotein E has a protective effect on diet-induced nonalcoholic fatty liver disease in mice. FEBS J 278(17):3119-29. PubMed: 21740524 MGI: J:190789
Kardakaris R; Gareus R; Xanthoulea S; Pasparakis M. 2011. Endothelial and macrophage-specific deficiency of P38alpha MAPK does not affect the pathogenesis of atherosclerosis in ApoE-/- mice. PLoS One 6(6):e21055. PubMed: 21695272 MGI: J:174787
Karra R; Vemullapalli S; Dong C; Herderick EE; Song X; Slosek K; Nevins JR; West M; Goldschmidt-Clermont PJ; Seo D. 2005. Molecular evidence for arterial repair in atherosclerosis. Proc Natl Acad Sci U S A 102(46):16789-94. PubMed: 16275914 MGI: J:103741
Kasahara K; Tanoue T; Yamashita T; Yodoi K; Matsumoto T; Emoto T; Mizoguchi T; Hayashi T; Kitano N; Sasaki N; Atarashi K; Honda K; Hirata KI. 2017. Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis. J Lipid Res 58(3):519-528. PubMed: 28130274 MGI: J:239684
Katsouri L; Georgopoulos S. 2011. Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model. PLoS One 6(7):e21880. PubMed: 21755005 MGI: J:174945
Kauser K; da Cunha V; Fitch R; Mallari C; Rubanyi GM. 2000. Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 278(5):H1679-85. PubMed: 10775149 MGI: J:62352
Kawahito H; Yamada H; Irie D; Kato T; Akakabe Y; Kishida S; Takata H; Wakana N; Ogata T; Ikeda K; Ueyama T; Matoba S; Mori Y; Matsubara H. 2013. Periaortic adipose tissue-specific activation of the renin-angiotensin system contributes to atherosclerosis development in uninephrectomized apoE-/- mice. Am J Physiol Heart Circ Physiol 305(5):H667-75. PubMed: 23812390 MGI: J:202269
Kawase R; Ohama T; Matsuyama A; Matsuwaki T; Okada T; Yamashita T; Yuasa-Kawase M; Nakaoka H; Nakatani K; Inagaki M; Tsubakio-Yamamoto K; Masuda D; Nakagawa-Toyama Y; Nishida M; Ohmoto Y; Nishihara M; Komuro I; Yamashita S. 2013. Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice. Cardiovasc Res 100(1):125-33. PubMed: 23847387 MGI: J:219323
Kayashima Y; Makhanova NA; Matsuki K; Tomita H; Bennett BJ; Maeda N. 2015. Identification of aortic arch-specific quantitative trait loci for atherosclerosis by an intercross of DBA/2J and 129S6 apolipoprotein E-deficient mice. PLoS One 10(2):e0117478. PubMed: 25689165 MGI: J:229127
Kayashima Y; Tomita H; Zhilicheva S; Kim S; Kim HS; Bennett BJ; Maeda N. 2014. Quantitative trait loci affecting atherosclerosis at the aortic root identified in an intercross between DBA2J and 129S6 apolipoprotein E-null mice. PLoS One 9(2):e88274. PubMed: 24586312 MGI: J:208464
Keller JN; Lauderback CM; Butterfield DA; Kindy MS; Yu J; Markesbery WR. 2000. Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice. J Neurochem 74(4):1579-86. PubMed: 10737615 MGI: J:61167
Kennedy DJ; Kuchibhotla S; Westfall KM; Silverstein RL; Morton RE; Febbraio M. 2011. A CD36-dependent pathway enhances macrophage and adipose tissue inflammation and impairs insulin signalling. Cardiovasc Res 89(3):604-13. PubMed: 21088116 MGI: J:186882
Khallou-Laschet J; Caligiuri G; Groyer E; Tupin E; Gaston AT; Poirier B; Kronenberg M; Cohen JL; Klatzmann D; Kaveri SV; Nicoletti A. 2006. The proatherogenic role of T cells requires cell division and is dependent on the stage of the disease. Arterioscler Thromb Vasc Biol 26(2):353-8. PubMed: 16322528 MGI: J:127968
Kim CW; Kumar S; Son DJ; Jang IH; Griendling KK; Jo H. 2014. Prevention of abdominal aortic aneurysm by anti-microRNA-712 or anti-microRNA-205 in angiotensin II-infused mice. Arterioscler Thromb Vasc Biol 34(7):1412-21. PubMed: 24812324 MGI: J:223602
Kim E; Tolhurst AT; Qin LY; Chen XY; Febbraio M; Cho S. 2008. CD36/fatty acid translocase, an inflammatory mediator, is involved in hyperlipidemia-induced exacerbation in ischemic brain injury. J Neurosci 28(18):4661-70. PubMed: 18448643 MGI: J:134972
Kim TW; Febbraio M; Robinet P; Dugar B; Greene D; Cerny A; Latz E; Gilmour R; Staschke K; Chisolm G; Fox PL; Dicorleto PE; Smith JD; Li X. 2011. The Critical Role of IL-1 Receptor-Associated Kinase 4-Mediated NF-{kappa}B Activation in Modified Low-Density Lipoprotein-Induced Inflammatory Gene Expression and Atherosclerosis. J Immunol 186(5):2871-80. PubMed: 21278342 MGI: J:169384
Kimura T; Tse K; McArdle S; Gerhardt T; Miller J; Mikulski Z; Sidney J; Sette A; Wolf D; Ley K. 2017. Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells. Am J Physiol Heart Circ Physiol 312(4):H781-H790. PubMed: 28087520 MGI: J:240967
Kindy MS; Rader DJ. 1998. Reduction in amyloid A amyloid formation in apolipoprotein-E-deficient mice [see comments] Am J Pathol 152(5):1387-95. PubMed: 9588907 MGI: J:47401
King SM; McNamee RA; Houng AK; Patel R; Brands M; Reed GL. 2009. Platelet dense-granule secretion plays a critical role in thrombosis and subsequent vascular remodeling in atherosclerotic mice. Circulation 120(9):785-91. PubMed: 19687360 MGI: J:167109
King VL; Cassis LA; Daugherty A. 2007. Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in mice. Am J Pathol 171(6):2040-7. PubMed: 18055554 MGI: J:128948
King VL; Lin AY; Kristo F; Anderson TJ; Ahluwalia N; Hardy GJ; Owens AP 3rd; Howatt DA; Shen D; Tager AM; Luster AD; Daugherty A; Gerszten RE. 2009. Interferon-gamma and the interferon-inducible chemokine CXCL10 protect against aneurysm formation and rupture. Circulation 119(3):426-35. PubMed: 19139386 MGI: J:166204
Kinoshita H; Matsumura T; Ishii N; Fukuda K; Senokuchi T; Motoshima H; Kondo T; Taketa K; Kawasaki S; Hanatani S; Takeya M; Nishikawa T; Araki E. 2013. Apocynin suppresses the progression of atherosclerosis in apoE-deficient mice by inactivation of macrophages. Biochem Biophys Res Commun 431(2):124-30. PubMed: 23318172 MGI: J:198069
Kipari T; Hadoke PW; Iqbal J; Man TY; Miller E; Coutinho AE; Zhang Z; Sullivan KM; Mitic T; Livingstone DE; Schrecker C; Samuel K; White CI; Bouhlel MA; Chinetti-Gbaguidi G; Staels B; Andrew R; Walker BR; Savill JS; Chapman KE; Seckl JR. 2013. 11beta-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis. FASEB J 27(4):1519-31. PubMed: 23303209 MGI: J:197640
Kirii H; Niwa T; Yamada Y; Wada H; Saito K; Iwakura Y; Asano M; Moriwaki H; Seishima M. 2003. Lack of interleukin-1beta decreases the severity of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 23(4):656-60. PubMed: 12615675 MGI: J:103057
Kirk EA; Heinecke JW; LeBoeuf RC. 2001. Iron overload diminishes atherosclerosis in apoE-deficient mice. J Clin Invest 107(12):1545-53. PubMed: 11413162 MGI: J:70613
Kirkby NS; Lundberg MH; Wright WR; Warner TD; Paul-Clark MJ; Mitchell JA. 2014. COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks. PLoS One 9(6):e98165. PubMed: 24887395 MGI: J:218136
Kiss RS; You Z; Genest J Jr; Behm DJ; Giaid A. 2011. Urotensin II differentially regulates macrophage and hepatic cholesterol homeostasis. Peptides 32(5):956-63. PubMed: 21376094 MGI: J:214289
Kisucka J; Chauhan AK; Zhao BQ; Patten IS; Yesilaltay A; Krieger M; Wagner DD. 2009. Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis. Blood 113(23):6015-22. PubMed: 19349621 MGI: J:149496
Kitamoto S; Egashira K; Ichiki T; Han X; McCurdy S; Sakuda S; Sunagawa K; Boisvert WA. 2013. Chitinase inhibition promotes atherosclerosis in hyperlipidemic mice. Am J Pathol 183(1):313-25. PubMed: 23685110 MGI: J:199001
Kitayama J; Faraci FM; Lentz SR; Heistad DD. 2007. Cerebral vascular dysfunction during hypercholesterolemia. Stroke 38(7):2136-41. PubMed: 17525390 MGI: J:148665
Klement H; St Croix B; Milsom C; May L; Guo Q; Yu JL; Klement P; Rak J. 2007. Atherosclerosis and vascular aging as modifiers of tumor progression, angiogenesis, and responsiveness to therapy. Am J Pathol 171(4):1342-51. PubMed: 17823292 MGI: J:125516
Knaapen AM; Curfs DM; Pachen DM; Gottschalk RW; de Winther MP; Daemen MJ; Van Schooten FJ. 2007. The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis. Mutat Res 621(1-2):31-41. PubMed: 17376491 MGI: J:123179
Knowles JW; Reddick RL; Jennette JC; Shesely EG; Smithies O; Maeda N. 2000. Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment. J Clin Invest 105(4):451-8. PubMed: 10683374 MGI: J:60670
Ko KW; Corry DB; Brayton CF; Paul A; Chan L. 2009. Extravascular inflammation does not increase atherosclerosis in apoE-deficient mice. Biochem Biophys Res Commun 384(1):93-9. PubMed: 19393222 MGI: J:150604
Ko KW; Paul A; Ma K; Li L; Chan L. 2005. Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res 46(12):2586-94. PubMed: 16199802 MGI: J:106132
Koistinaho M; Kettunen MI; Holtzman DM; Kauppinen RA; Higgins LS; Koistinaho J. 2002. Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility. Stroke 33(7):1905-10. PubMed: 12105373 MGI: J:133156
Koistinaho M; Lin S; Wu X; Esterman M; Koger D; Hanson J; Higgs R; Liu F; Malkani S; Bales KR; Paul SM. 2004. Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides. Nat Med 10(7):719-26. PubMed: 15195085 MGI: J:91799
Kojima Y; Kundu RK; Cox CM; Leeper NJ; Anderson JA; Chun HJ; Ali ZA; Ashley EA; Krieg PA; Quertermous T. 2010. Upregulation of the apelin-APJ pathway promotes neointima formation in the carotid ligation model in mouse. Cardiovasc Res 87(1):156-65. PubMed: 20176814 MGI: J:175875
Kojima Y; Volkmer JP; McKenna K; Civelek M; Lusis AJ; Miller CL; Direnzo D; Nanda V; Ye J; Connolly AJ; Schadt EE; Quertermous T; Betancur P; Maegdefessel L; Matic LP; Hedin U; Weissman IL; Leeper NJ. 2016. CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis. Nature 536(7614):86-90. PubMed: 27437576 MGI: J:236630
Kolbus D; Ljungcrantz I; Soderberg I; Alm R; Bjorkbacka H; Nilsson J; Fredrikson GN. 2012. TAP1-deficiency does not alter atherosclerosis development in Apoe-/- mice. PLoS One 7(3):e33932. PubMed: 22479479 MGI: J:224200
Koltsova EK; Garcia Z; Chodaczek G; Landau M; McArdle S; Scott SR; von Vietinghoff S; Galkina E; Miller YI; Acton ST; Ley K. 2012. Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosis. J Clin Invest 122(9):3114-26. PubMed: 22886300 MGI: J:191432
Kotti T; Head DD; McKenna CE; Russell DW. 2008. Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. Proc Natl Acad Sci U S A 105(32):11394-9. PubMed: 18685105 MGI: J:140342
Koupenova M; Johnston-Cox H; Vezeridis A; Gavras H; Yang D; Zannis V; Ravid K. 2012. A2b adenosine receptor regulates hyperlipidemia and atherosclerosis. Circulation 125(2):354-63. PubMed: 22144568 MGI: J:193794
Kraemer R; Baker PJ; Kent KC; Ye Y; Han JJ; Tejada R; Silane M; Upmacis R; Deeb R; Chen Y; Levine DM; Hempstead B. 2005. Decreased neurotrophin TrkB receptor expression reduces lesion size in the apolipoprotein E-null mutant mouse. Circulation 112(23):3644-53. PubMed: 16330706 MGI: J:116881
Kramann R; Goettsch C; Wongboonsin J; Iwata H; Schneider RK; Kuppe C; Kaesler N; Chang-Panesso M; Machado FG; Gratwohl S; Madhurima K; Hutcheson JD; Jain S; Aikawa E; Humphreys BD. 2016. Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease. Cell Stem Cell 19(5):628-642. PubMed: 27618218 MGI: J:238999
Kramer CD; Weinberg EO; Gower AC; He X; Mekasha S; Slocum C; Beaulieu LM; Wetzler L; Alekseyev Y; Gibson FC 3rd; Freedman JE; Ingalls RR; Genco CA. 2014. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics 15:1176. PubMed: 25540039 MGI: J:221502
Krebs P; Scandella E; Bolinger B; Engeler D; Miller S; Ludewig B. 2007. Chronic immune reactivity against persisting microbial antigen in the vasculature exacerbates atherosclerotic lesion formation. Arterioscler Thromb Vasc Biol 27(10):2206-13. PubMed: 17656668 MGI: J:134893
Kremen M; Krishnan R; Emery I; Hu JH; Slezicki KI; Wu A; Qian K; Du L; Plawman A; Stempien-Otero A; Dichek DA. 2008. Plasminogen mediates the atherogenic effects of macrophage-expressed urokinase and accelerates atherosclerosis in apoE-knockout mice. Proc Natl Acad Sci U S A 105(44):17109-14. PubMed: 18957535 MGI: J:144061
Krohn R; Raffetseder U; Bot I; Zernecke A; Shagdarsuren E; Liehn EA; van Santbrink PJ; Nelson PJ; Biessen EA; Mertens PR; Weber C. 2007. Y-box binding protein-1 controls CC chemokine ligand-5 (CCL5) expression in smooth muscle cells and contributes to neointima formation in atherosclerosis-prone mice. Circulation 116(16):1812-20. PubMed: 17893273 MGI: J:139837
Kruit JK; Kremer PH; Dai L; Tang R; Ruddle P; de Haan W; Brunham LR; Verchere CB; Hayden MR. 2010. Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice. Diabetologia 53(6):1110-9. PubMed: 20229095 MGI: J:159879
Krzywkowski P; Ghribi O; Gagne J; Chabot C; Kar S; Rochford J; Massicotte G; Poirier J. 1999. Cholinergic systems and long-term potentiation in memory-impaired apolipoprotein E-deficient mice. Neuroscience 92(4):1273-86. PubMed: 10426483 MGI: J:110875
Ku CS; Pham TX; Park Y; Kim B; Shin MS; Kang I; Lee J. 2013. Edible blue-green algae reduce the production of pro-inflammatory cytokines by inhibiting NF-kappaB pathway in macrophages and splenocytes. Biochim Biophys Acta 1830(4):2981-8. PubMed: 23357040 MGI: J:199038
Kudchodkar B; Jones H; Simecka J; Dory L. 2008. Hyperbaric oxygen treatment attenuates the pro-inflammatory and immune responses in apolipoprotein E knockout mice. Clin Immunol 128(3):435-41. PubMed: 18595776 MGI: J:138706
Kuhlencordt PJ; Chen J; Han F; Astern J; Huang PL. 2001. Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice. Circulation 103(25):3099-104. PubMed: 11425775 MGI: J:103350
Kuhlencordt PJ; Gyurko R; Han F; Scherrer-Crosbie M; Aretz TH; Hajjar R; Picard MH; Huang PL. 2001. Accelerated atherosclerosis, aortic aneurysm formation, and ischemic heart disease in apolipoprotein E/endothelial nitric oxide synthase double-knockout mice. Circulation 104(4):448-54. PubMed: 11468208 MGI: J:103306
Kuijpers MJ; van der Meijden PE; Feijge MA; Mattheij NJ; May F; Govers-Riemslag J; Meijers JC; Heemskerk JW; Renne T; Cosemans JM. 2014. Factor XII regulates the pathological process of thrombus formation on ruptured plaques. Arterioscler Thromb Vasc Biol 34(8):1674-80. PubMed: 24855058 MGI: J:223896
Kumarathasan P; Vincent R; Blais E; Saravanamuthu A; Gupta P; Wyatt H; Mitchel R; Hannan M; Trivedi A; Whitman S. 2013. Cardiovascular changes in atherosclerotic ApoE-deficient mice exposed to Co60 (gamma) radiation. PLoS One 8(6):e65486. PubMed: 23840332 MGI: J:204334
Kunieda T; Minamino T; Nishi J; Tateno K; Oyama T; Katsuno T; Miyauchi H; Orimo M; Okada S; Takamura M; Nagai T; Kaneko S; Komuro I. 2006. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 114(9):953-60. PubMed: 16908765 MGI: J:125247
Kunjathoor VV; Chiu DS; O'Brien KD; LeBoeuf RC. 2002. Accumulation of biglycan and perlecan, but not versican, in lesions of murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 22(3):462-8. PubMed: 11884291 MGI: J:103309
Kushiyama A; Okubo H; Sakoda H; Kikuchi T; Fujishiro M; Sato H; Kushiyama S; Iwashita M; Nishimura F; Fukushima T; Nakatsu Y; Kamata H; Kawazu S; Higashi Y; Kurihara H; Asano T. 2012. Xanthine oxidoreductase is involved in macrophage foam cell formation and atherosclerosis development. Arterioscler Thromb Vasc Biol 32(2):291-8. PubMed: 22095983 MGI: J:195970
Kuszczyk MA; Sanchez S; Pankiewicz J; Kim J; Duszczyk M; Guridi M; Asuni AA; Sullivan PM; Holtzman DM; Sadowski MJ. 2013. Blocking the Interaction between Apolipoprotein E and Abeta Reduces Intraneuronal Accumulation of Abeta and Inhibits Synaptic Degeneration. Am J Pathol 182(5):1750-68. PubMed: 23499462 MGI: J:195341
Kwon DH; Eom GH; Ko JH; Shin S; Joung H; Choe N; Nam YS; Min HK; Kook T; Yoon S; Kang W; Kim YS; Kim HS; Choi H; Koh JT; Kim N; Ahn Y; Cho HJ; Lee IK; Park DH; Suk K; Seo SB; Wissing ER; Mendrysa SM; Nam KI; Kook H. 2016. MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification. Nat Commun 7:10492. PubMed: 26832969 MGI: J:236289
Kyaw T; Cui P; Tay C; Kanellakis P; Hosseini H; Liu E; Rolink AG; Tipping P; Bobik A; Toh BH. 2013. BAFF receptor mAb treatment ameliorates development and progression of atherosclerosis in hyperlipidemic ApoE(-/-) mice. PLoS One 8(4):e60430. PubMed: 23560095 MGI: J:200154
Kyaw T; Tay C; Hosseini H; Kanellakis P; Gadowski T; MacKay F; Tipping P; Bobik A; Toh BH. 2012. Depletion of B2 but not B1a B cells in BAFF receptor-deficient ApoE mice attenuates atherosclerosis by potently ameliorating arterial inflammation. PLoS One 7(1):e29371. PubMed: 22238605 MGI: J:223906
Kypreos KE. 2008. ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia. Biochemistry 47(39):10491-502. PubMed: 18767813 MGI: J:141173
Kypreos KE; Li X; van Dijk KW; Havekes LM; Zannis VI. 2003. Molecular mechanisms of type III hyperlipoproteinemia: The contribution of the carboxy-terminal domain of ApoE can account for the dyslipidemia that is associated with the E2/E2 phenotype. Biochemistry 42(33):9841-53. PubMed: 12924933 MGI: J:115687
Kypreos KE; Zannis VI. 2007. Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT. Biochem J 403(2):359-67. PubMed: 17206937 MGI: J:121679
Kypreos KE; Zannis VI. 2006. LDL receptor deficiency or apoE mutations prevent remnant clearance and induce hypertriglyceridemia in mice. J Lipid Res 47(3):521-9. PubMed: 16339113 MGI: J:107556
Lambert G; Sakai N; Vaisman BL; Neufeld EB; Marteyn B; Chan CC; Paigen B; Lupia E; Thomas A; Striker LJ; Blanchette-Mackie J; Csako G; Brady JN; Costello R; Striker GE; Remaley AT; Brewer HB Jr; Santamarina-Fojo S. 2001. Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice. J Biol Chem 276(18):15090-8. PubMed: 11278414 MGI: J:69299
Lammers B; Zhao Y; Hoekstra M; Hildebrand RB; Ye D; Meurs I; Van Berkel TJ; Van Eck M. 2011. Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE. PLoS One 6(10):e26095. PubMed: 22022523 MGI: J:178098
Lampropoulou A; Zannis VI; Kypreos KE. 2012. Pharmacodynamic and pharmacokinetic analysis of apoE4 [L261A, W264A, F265A, L268A, V269A], a recombinant apolipoprotein E variant with improved biological properties. Biochem Pharmacol 84(11):1451-8. PubMed: 22985620 MGI: J:193572
Landsman L; Bar-On L; Zernecke A; Kim KW; Krauthgamer R; Shagdarsuren E; Lira SA; Weissman IL; Weber C; Jung S. 2009. CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival. Blood 113(4):963-72. PubMed: 18971423 MGI: J:145036
Langheinrich AC; Michniewicz A; Sedding DG; Walker G; Beighley PE; Rau WS; Bohle RM; Ritman EL. 2006. Correlation of vasa vasorum neovascularization and plaque progression in aortas of apolipoprotein E(-/-)/low-density lipoprotein(-/-) double knockout mice. Arterioscler Thromb Vasc Biol 26(2):347-52. PubMed: 16293797 MGI: J:127960
Laskowitz DT; Lee DM; Schmechel D; Staats HF. 2000. Altered immune responses in apolipoprotein E-deficient mice. J Lipid Res 41(4):613-20. PubMed: 10744782 MGI: J:61564
Laufs U; Wassmann S; Czech T; Munzel T; Eisenhauer M; Bohm M; Nickenig G. 2005. Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis. Arterioscler Thromb Vasc Biol 25(4):809-14. PubMed: 15692095 MGI: J:110022
Law A; Gauthier S; Quirion R. 2003. Alteration of nitric oxide synthase activity in young and aged apolipoprotein E-deficient mice. Neurobiol Aging 24(1):187-90. PubMed: 12493565 MGI: J:119319
Lawrie A; Hameed AG; Chamberlain J; Arnold N; Kennerley A; Hopkinson K; Pickworth J; Kiely DG; Crossman DC; Francis SE. 2011. Paigen diet-fed apolipoprotein e knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner. Am J Pathol 179(4):1693-705. PubMed: 21835155 MGI: J:176302
Laxton RC; Hu Y; Duchene J; Zhang F; Zhang Z; Leung KY; Xiao Q; Scotland RS; Hodgkinson CP; Smith K; Willeit J; Lopez-Otin C; Simpson IA; Kiechl S; Ahluwalia A; Xu Q; Ye S. 2009. A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res 105(9):921-9. PubMed: 19745165 MGI: J:169956
Layne MD; Patel A; Chen YH; Rebel VI; Carvajal IM; Pellacani A; Ith B; Zhao D; Schreiber BM; Yet SF; Lee ME; Storch J; Perrella MA. 2001. Role of macrophage-expressed adipocyte fatty acid binding protein in the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J 15(14):2733-5. PubMed: 11606480 MGI: J:73162
Le Guezennec X; Brichkina A; Huang YF; Kostromina E; Han W; Bulavin DV. 2012. Wip1-dependent regulation of autophagy, obesity, and atherosclerosis. Cell Metab 16(1):68-80. PubMed: 22768840 MGI: J:187401
Le Lay S; Kurzchalia TV. 2005. Getting rid of caveolins: phenotypes of caveolin-deficient animals. Biochim Biophys Acta 1746(3):322-33. PubMed: 16019085 MGI: J:104846
Lee EC; Desai U; Gololobov G; Hong S; Feng X; Yu XC; Gay J; Wilganowski N; Gao C; Du LL; Chen J; Hu Y; Zhao S; Kirkpatrick L; Schneider M; Zambrowicz BP; Landes G; Powell DR; Sonnenburg WK. 2009. Identification of a new functional domain in angiopoietin-like 3 (ANGPTL3) and angiopoietin-like 4 (ANGPTL4) involved in binding and inhibition of lipoprotein lipase (LPL). J Biol Chem 284(20):13735-45. PubMed: 19318355 MGI: J:149912
Lee GL; Wu JY; Yeh CC; Kuo CC. 2016. TLR4 induces CREB-mediated IL-6 production via upregulation of F-spondin to promote vascular smooth muscle cell migration. Biochem Biophys Res Commun 473(4):1205-10. PubMed: 27091427 MGI: J:235171
Lee HT; Chiu LL; Lee TS; Tsai HL; Chau LY. 2003. Dietary iron restriction increases plaque stability in apolipoprotein-e-deficient mice. J Biomed Sci 10(5):510-7. PubMed: 12928591 MGI: J:103069
Lee K; Saidel GM; Penn MS. 2008. Permeability change of arterial endothelium is an age-dependent function of lesion size in apolipoprotein E-null mice. Am J Physiol Heart Circ Physiol 295(6):H2273-9. PubMed: 18835923 MGI: J:143304
Lee SJ; Grosskopf I; Choi SY; Cooper AD. 2004. Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158->Cys), and E3-Leiden. J Lipid Res 45(12):2199-210. PubMed: 15466367 MGI: J:94176
Lee TS; Shiao MS; Pan CC; Chau LY. 1999. Iron-deficient diet reduces atherosclerotic lesions in apoE-deficient mice. Circulation 99(9):1222-9. PubMed: 10069791 MGI: J:103204
Lee TS; Yen HC; Pan CC; Chau LY. 1999. The role of interleukin 12 in the development of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 19(3):734-42. PubMed: 10073981 MGI: J:53839
Lei L; Li H; Yan F; Xiao Y. 2013. Hyperlipidemia impaired innate immune response to periodontal pathogen porphyromonas gingivalis in apolipoprotein E knockout mice. PLoS One 8(8):e71849. PubMed: 23977160 MGI: J:205837
Leidenfrost JE; Khan MF; Boc KP; Villa BR; Collins ET; Parks WC; Abendschein DR; Choi ET. 2003. A model of primary atherosclerosis and post-angioplasty restenosis in mice. Am J Pathol 163(2):773-8. PubMed: 12875996 MGI: J:113609
Leighty RE; Nilsson LN; Potter H; Costa DA; Low MA; Bales KR; Paul SM; Arendash GW. 2004. Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition. Behav Brain Res 153(1):107-21. PubMed: 15219712 MGI: J:91238
Lemaire M; Lemarie CA; Flores Molina M; Guilbert C; Lehoux S; Mann KK. 2014. Genetic deletion of LXRalpha prevents arsenic-enhanced atherosclerosis, but not arsenic-altered plaque composition. Toxicol Sci 142(2):477-88. PubMed: 25273567 MGI: J:227826
Lemaitre V; Soloway PD; D'Armiento J. 2003. Increased medial degradation with pseudo-aneurysm formation in apolipoprotein E-knockout mice deficient in tissue inhibitor of metalloproteinases-1. Circulation 107(2):333-8. PubMed: 12538437 MGI: J:103082
Leucker TM; Nomura Y; Kim JH; Bhatta A; Wang V; Wecker A; Jandu S; Santhanam L; Berkowitz D; Romer L; Pandey D. 2017. Cystathionine gamma-lyase protects vascular endothelium: a role for inhibition of histone deacetylase 6. Am J Physiol Heart Circ Physiol 312(4):H711-H720. PubMed: 28188215 MGI: J:241222
Leuschner F; Panizzi P; Chico-Calero I; Lee WW; Ueno T; Cortez-Retamozo V; Waterman P; Gorbatov R; Marinelli B; Iwamoto Y; Chudnovskiy A; Figueiredo JL; Sosnovik DE; Pittet MJ; Swirski FK; Weissleder R; Nahrendorf M. 2010. Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res 107(11):1364-73. PubMed: 20930148 MGI: J:178180
Levi O; Dolev I; Belinson H; Michaelson DM. 2007. Intraneuronal amyloid-beta plays a role in mediating the synergistic pathological effects of apoE4 and environmental stimulation. J Neurochem 103(3):1031-40. PubMed: 17666042 MGI: J:126660
Levi O; Jongen-Relo AL; Feldon J; Roses AD; Michaelson DM. 2003. ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory. Neurobiol Dis 13(3):273-82. PubMed: 12901842 MGI: J:131475
Levi O; Lutjohann D; Devir A; von Bergmann K; Hartmann T; Michaelson DM. 2005. Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation. J Neurochem 95(4):987-97. PubMed: 16190879 MGI: J:102888
Levi O; Michaelson DM. 2007. Environmental enrichment stimulates neurogenesis in apolipoprotein E3 and neuronal apoptosis in apolipoprotein E4 transgenic mice. J Neurochem 100(1):202-10. PubMed: 17074063 MGI: J:118697
Levy AP; Levy JE; Kalet-Litman S; Miller-Lotan R; Levy NS; Asaf R; Guetta J; Yang C; Purushothaman KR; Fuster V; Moreno PR. 2007. Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque. Arterioscler Thromb Vasc Biol 27(1):134-40. PubMed: 17068284 MGI: J:134942
Lewis DR; Petersen LK; York AW; Zablocki KR; Joseph LB; Kholodovych V; Prud'homme RK; Uhrich KE; Moghe PV. 2015. Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo. Proc Natl Acad Sci U S A 112(9):2693-8. PubMed: 25691739 MGI: J:220164
Lewis P; Stefanovic N; Pete J; Calkin AC; Giunti S; Thallas-Bonke V; Jandeleit-Dahm KA; Allen TJ; Kola I; Cooper ME; de Haan JB. 2007. Lack of the antioxidant enzyme glutathione peroxidase-1 accelerates atherosclerosis in diabetic apolipoprotein E-deficient mice. Circulation 115(16):2178-87. PubMed: 17420349 MGI: J:135907
Lewis RD; Perry MJ; Guschina IA; Jackson CL; Morgan BP; Hughes TR. 2011. CD55 Deficiency Protects against Atherosclerosis in ApoE-Deficient Mice via C3a Modulation of Lipid Metabolism. Am J Pathol 179(4):1601-7. PubMed: 21816131 MGI: J:176305
Li G; Bien-Ly N; Andrews-Zwilling Y; Xu Q; Bernardo A; Ring K; Halabisky B; Deng C; Mahley RW; Huang Y. 2009. GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell 5(6):634-45. PubMed: 19951691 MGI: J:155879
Li G; Sanders JM; Bevard MH; Sun Z; Chumley JW; Galkina EV; Ley K; Sarembock IJ. 2008. CD40 Ligand Promotes Mac-1 Expression, Leukocyte Recruitment, and Neointima Formation after Vascular Injury. Am J Pathol 172(4):1141-52. PubMed: 18349125 MGI: J:133345
Li G; Sanders JM; Phan ET; Ley K; Sarembock IJ. 2005. Arterial macrophages and regenerating endothelial cells express p-selectin in atherosclerosis-prone apolipoprotein e-deficient mice. Am J Pathol 167(6):1511-8. PubMed: 16314466 MGI: J:103660
Li J; Zhang P; Li T; Liu Y; Zhu Q; Chen T; Liu T; Huang C; Zhang J; Zhang Y; Guo Y. 2015. CTRP9 enhances carotid plaque stability by reducing pro-inflammatory cytokines in macrophages. Biochem Biophys Res Commun 458(4):890-5. PubMed: 25701788 MGI: J:220478
Li MW; Mian MO; Barhoumi T; Rehman A; Mann K; Paradis P; Schiffrin EL. 2013. Endothelin-1 overexpression exacerbates atherosclerosis and induces aortic aneurysms in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 33(10):2306-15. PubMed: 23887640 MGI: J:222228
Li Q; Li Y; Zhang Z; Gilbert TR; Matsumoto AH; Dobrin SE; Shi W. 2008. Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice. Stroke 39(1):166-73. PubMed: 18048852 MGI: J:129301
Li Q; Park K; Li C; Rask-Madsen C; Mima A; Qi W; Mizutani K; Huang P; King GL. 2013. Induction of vascular insulin resistance and endothelin-1 expression and acceleration of atherosclerosis by the overexpression of protein kinase C-beta isoform in the endothelium. Circ Res 113(4):418-27. PubMed: 23759514 MGI: J:213396
Li R; Mittelstein D; Lee J; Fang K; Majumdar R; Tintut Y; Demer LL; Hsiai TK. 2012. A dynamic model of calcific nodule destabilization in response to monocyte- and oxidized lipid-induced matrix metalloproteinases. Am J Physiol Cell Physiol 302(4):C658-65. PubMed: 22031601 MGI: J:180622
Li X; Zhu M; Penfold ME; Koenen RR; Thiemann A; Heyll K; Akhtar S; Koyadan S; Wu Z; Gremse F; Kiessling F; van Zandvoort M; Schall TJ; Weber C; Schober A. 2014. Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue. Circulation 129(11):1244-53. PubMed: 24374972 MGI: J:219310
Li XA; Guo L; Dressman JL; Asmis R; Smart EJ. 2005. A novel ligand-independent apoptotic pathway induced by scavenger receptor class B, type I and suppressed by endothelial nitric-oxide synthase and high density lipoprotein. J Biol Chem 280(19):19087-96. PubMed: 15749707 MGI: J:99934
Li XN; Song J; Zhang L; LeMaire SA; Hou X; Zhang C; Coselli JS; Chen L; Wang XL; Zhang Y; Shen YH. 2009. Activation of the AMPK-FOXO3 pathway reduces fatty acid-induced increase in intracellular reactive oxygen species by upregulating thioredoxin. Diabetes 58(10):2246-57. PubMed: 19592618 MGI: J:154396
Li Z; Park TS; Li Y; Pan X; Iqbal J; Lu D; Tang W; Yu L; Goldberg IJ; Hussain MM; Jiang XC. 2009. Serine palmitoyltransferase (SPT) deficient mice absorb less cholesterol. Biochim Biophys Acta 1791(4):297-306. PubMed: 19416652 MGI: J:148766
Liao D; Tan H; Hui R; Li Z; Jiang X; Gaubatz J; Yang F; Durante W; Chan L; Schafer AI; Pownall HJ; Yang X; Wang H. 2006. Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res 99(6):598-606. PubMed: 16931800 MGI: J:125063
Lievens D; Zernecke A; Seijkens T; Soehnlein O; Beckers L; Munnix IC; Wijnands E; Goossens P; van Kruchten R; Thevissen L; Boon L; Flavell RA; Noelle RJ; Gerdes N; Biessen EA; Daemen MJ; Heemskerk JW; Weber C; Lutgens E. 2010. Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood 116(20):4317-27. PubMed: 20705757 MGI: J:166644
Lim HY; Rutkowski JM; Helft J; Reddy ST; Swartz MA; Randolph GJ; Angeli V. 2009. Hypercholesterolemic mice exhibit lymphatic vessel dysfunction and degeneration. Am J Pathol 175(3):1328-37. PubMed: 19679879 MGI: J:152800
Lim HY; Thiam CH; Yeo KP; Bisoendial R; Hii CS; McGrath KC; Tan KW; Heather A; Alexander JS; Angeli V. 2013. Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL. Cell Metab 17(5):671-84. PubMed: 23663736 MGI: J:199273
Lim RS; Kratzer A; Barry NP; Miyazaki-Anzai S; Miyazaki M; Mantulin WW; Levi M; Potma EO; Tromberg BJ. 2010. Multimodal CARS microscopy determination of the impact of diet on macrophage infiltration and lipid accumulation on plaque formation in ApoE-deficient mice. J Lipid Res 51(7):1729-37. PubMed: 20208058 MGI: J:162831
Lim RS; Suhalim JL; Miyazaki-Anzai S; Miyazaki M; Levi M; Potma EO; Tromberg BJ. 2011. Identification of cholesterol crystals in plaques of atherosclerotic mice using hyperspectral CARS imaging. J Lipid Res 52(12):2177-86. PubMed: 21949051 MGI: J:178544
Lin J; Li H; Yang M; Ren J; Huang Z; Han F; Huang J; Ma J; Zhang D; Zhang Z; Wu J; Huang D; Qiao M; Jin G; Wu Q; Huang Y; Du J; Han J. 2013. A role of RIP3-mediated macrophage necrosis in atherosclerosis development. Cell Rep 3(1):200-10. PubMed: 23333278 MGI: J:196325
Lin WL; Chang CF; Shi CS; Shi GY; Wu HL. 2013. Recombinant lectin-like domain of thrombomodulin suppresses vascular inflammation by reducing leukocyte recruitment via interacting with Lewis Y on endothelial cells. Arterioscler Thromb Vasc Biol 33(10):2366-73. PubMed: 23950139 MGI: J:224124
Lin YW; Liu PS; Adhikari N; Hall JL; Wei LN. 2015. RIP140 contributes to foam cell formation and atherosclerosis by regulating cholesterol homeostasis in macrophages. J Mol Cell Cardiol 79:287-94. PubMed: 25528964 MGI: J:225768
Lin Z; Pan X; Wu F; Ye D; Zhang Y; Wang Y; Jin L; Lian Q; Huang Y; Ding H; Triggle C; Wang K; Li X; Xu A. 2015. Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. Circulation 131(21):1861-71. PubMed: 25794851 MGI: J:234319
Lindgren A; Levin M; Rodrigo Blomqvist S; Wikstrom J; Ahnmark A; Mogensen C; Bottcher G; Bohlooly-Y M; Boren J; Gan LM; Linden D. 2013. Adiponectin receptor 2 deficiency results in reduced atherosclerosis in the brachiocephalic artery in apolipoprotein E deficient mice. PLoS One 8(11):e80330. PubMed: 24324556 MGI: J:209743
Lipinski MJ; Perry HM; Doran AC; Oldham SN; McNamara CA. 2011. Comment on 'Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis'. J Immunol 186(1):4; author reply 6. PubMed: 21172871 MGI: J:167993
Lipskaia L; Keuylian Z; Blirando K; Mougenot N; Jacquet A; Rouxel C; Sghairi H; Elaib Z; Blaise R; Adnot S; Hajjar RJ; Chemaly ER; Limon I; Bobe R. 2014. Expression of sarco (endo) plasmic reticulum calcium ATPase (SERCA) system in normal mouse cardiovascular tissues, heart failure and atherosclerosis. Biochim Biophys Acta 1843(11):2705-18. PubMed: 25110346 MGI: J:218468
Liu C; Wang Q; Guo H; Xia M; Yuan Q; Hu Y; Zhu H; Hou M; Ma J; Tang Z; Ling W. 2008. Plasma S-adenosylhomocysteine is a better biomarker of atherosclerosis than homocysteine in apolipoprotein E-deficient mice fed high dietary methionine. J Nutr 138(2):311-5. PubMed: 18203897 MGI: J:133409
Liu J; Lu H; Howatt DA; Balakrishnan A; Moorleghen JJ; Sorci-Thomas M; Cassis LA; Daugherty A. 2015. Associations of ApoAI and ApoB-containing lipoproteins with AngII-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol 35(8):1826-34. PubMed: 26044581 MGI: J:241810
Liu P; Yu YR; Spencer JA; Johnson AE; Vallanat CT; Fong AM; Patterson C; Patel DD. 2008. CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden. Arterioscler Thromb Vasc Biol 28(2):243-50. PubMed: 18079406 MGI: J:147667
Liu S; Li J; Chen MH; Liu Z; Shi W. 2015. Variation in Type 2 Diabetes-Related Phenotypes among Apolipoprotein E-Deficient Mouse Strains. PLoS One 10(5):e0120935. PubMed: 25946019 MGI: J:224436
Liu S; Shen H; Xu M; Liu O; Zhao L; Liu S; Guo Z; Du J. 2010. FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model. Am J Physiol Endocrinol Metab 299(3):E351-63. PubMed: 20530739 MGI: J:170034
Liu Z; Luo H; Zhang L; Huang Y; Liu B; Ma K; Feng J; Xie J; Zheng J; Hu J; Zhan S; Zhu Y; Xu Q; Kong W; Wang X. 2012. Hyperhomocysteinemia exaggerates adventitial inflammation and angiotensin II-induced abdominal aortic aneurysm in mice. Circ Res 111(10):1261-73. PubMed: 22912384 MGI: J:212627
Liuba P; Karnani P; Pesonen E; Paakkari I; Forslid A; Johansson L; Persson K; Wadstrom T; Laurini R. 2000. Endothelial dysfunction after repeated Chlamydia pneumoniae infection in apolipoprotein E-knockout mice. Circulation 102(9):1039-44. PubMed: 10961970 MGI: J:103191
Lizarbe TR; Tarin C; Gomez M; Lavin B; Aracil E; Orte LM; Zaragoza C. 2009. Nitric Oxide Induces the Progression of Abdominal Aortic Aneurysms through the Matrix Metalloproteinase Inducer EMMPRIN. Am J Pathol :. PubMed: 19779140 MGI: J:152751
Lloyd DJ; McCormick J; Helmering J; Kim KW; Wang M; Fordstrom P; Kaufman SA; Lindberg RA; Veniant MM. 2008. Generation and characterization of two novel mouse models exhibiting the phenotypes of the metabolic syndrome: Apob48-/-Lepob/ob mice devoid of ApoE or Ldlr. Am J Physiol Endocrinol Metab 294(3):E496-505. PubMed: 18160459 MGI: J:133453
Lopes J; Adiguzel E; Gu S; Liu SL; Hou G; Heximer S; Assoian RK; Bendeck MP. 2013. Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis. Am J Pathol 182(6):2241-53. PubMed: 23567639 MGI: J:198531
Lowbeer C; Forsberg AM; Tokuno S; Hemdahl AL; Gustafsson SA; Valen G. 2004. Cardiac troponin T content in heart and skeletal muscle and in blood samples from ApoE/LDL receptor double knockout mice. Clin Chim Acta 344(1-2):73-8. PubMed: 15149873 MGI: J:105262
Lu KY; Ching LC; Su KH; Yu YB; Kou YR; Hsiao SH; Huang YC; Chen CY; Cheng LC; Pan CC; Lee TS. 2010. Erythropoietin suppresses the formation of macrophage foam cells: role of liver X receptor alpha. Circulation 121(16):1828-37. PubMed: 20385932 MGI: J:172626
Lu Y; Zhang L; Liao X; Sangwung P; Prosdocimo DA; Zhou G; Votruba AR; Brian L; Han YJ; Gao H; Wang Y; Shimizu K; Weinert-Stein K; Khrestian M; Simon DI; Freedman NJ; Jain MK. 2013. Kruppel-like factor 15 is critical for vascular inflammation. J Clin Invest 123(10):4232-41. PubMed: 23999430 MGI: J:203920
Luchtefeld M; Schunkert H; Stoll M; Selle T; Lorier R; Grote K; Sagebiel C; Jagavelu K; Tietge UJ; Assmus U; Streetz K; Hengstenberg C; Fischer M; Mayer B; Maresso K; El Mokhtari NE; Schreiber S; Muller W; Bavendiek U; Grothusen C; Drexler H; Trautwein C; Broeckel U; Schieffer B. 2007. Signal transducer of inflammation gp130 modulates atherosclerosis in mice and man. J Exp Med 204(8):1935-44. PubMed: 17664290 MGI: J:125950
Ludewig B; Freigang S; Jaggi M; Kurrer MO; Pei YC; Vlk L; Odermatt B; Zinkernagel RM; Hengartner H. 2000. Linking immune-mediated arterial inflammation and cholesterol-induced atherosclerosis in a transgenic mouse model Proc Natl Acad Sci U S A 97(23):12752-7. PubMed: 11050173 MGI: J:65803
Ludewig B; Jaggi M; Dumrese T; Brduscha-Riem K; Odermatt B; Hengartner H; Zinkernagel RM. 2001. Hypercholesterolemia exacerbates virus-induced immunopathologic liver disease via suppression of antiviral cytotoxic T cell responses. J Immunol 166(5):3369-76. PubMed: 11207293 MGI: J:126478
Lund G; Andersson L; Lauria M; Lindholm M; Fraga MF; Villar-Garea A; Ballestar E; Esteller M; Zaina S. 2004. DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E. J Biol Chem 279(28):29147-54. PubMed: 15131116 MGI: J:91688
Luo MJ; Thieringer R; Springer MS; Wright SD; Hermanowski-Vosatka A; Plump A; Balkovec JM; Cheng K; Ding GJ; Kawka DW; Koo GC; Grand CB; Luo Q; Maletic MM; Malkowitz L; Shah K; Singer I; Waddell ST; Wu KK; Yuan J; Zhu J; Stepaniants S; Yang X; Lum PY; Wang IM. 2013. 11beta-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature. Physiol Genomics 45(1):47-57. PubMed: 23170035 MGI: J:195245
Luo W; Wang H; Guo C; Wang J; Kwak J; Bahrou KL; Eitzman DT. 2012. Haploinsufficiency of E-selectin ligand-1 is associated with reduced atherosclerotic plaque macrophage content while complete deficiency leads to early embryonic lethality in mice. Atherosclerosis 224(2):363-7. PubMed: 22939356 MGI: J:226586
Luo X; Xiao Y; Song F; Yang Y; Xia M; Ling W. 2012. Increased plasma S-adenosyl-homocysteine levels induce the proliferation and migration of VSMCs through an oxidative stress-ERK1/2 pathway in apoE(-/-) mice. Cardiovasc Res 95(2):241-50. PubMed: 22492673 MGI: J:202578
Lutgens E; Faber B; Schapira K; Evelo CT; van Haaften R; Heeneman S; Cleutjens KB; Bijnens AP; Beckers L; Porter JG; Mackay CR; Rennert P; Bailly V; Jarpe M; Dolinski B; Koteliansky V; de Fougerolles T; Daemen MJ. 2005. Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody. Circulation 111(25):3443-52. PubMed: 15967845 MGI: J:114617
Lutgens E; Gorelik L; Daemen MJ; de Muinck ED; Grewal IS; Koteliansky VE; Flavell RA. 1999. Requirement for CD154 in the progression of atherosclerosis. Nat Med 5(11):1313-6. PubMed: 10546000 MGI: J:124002
Lutgens E; Lievens D; Beckers L; Wijnands E; Soehnlein O; Zernecke A; Seijkens T; Engel D; Cleutjens J; Keller AM; Naik SH; Boon L; Oufella HA; Mallat Z; Ahonen CL; Noelle RJ; de Winther MP; Daemen MJ; Biessen EA; Weber C. 2010. Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med 207(2):391-404. PubMed: 20100871 MGI: J:157760
Lutgens E; Lutgens SP; Faber BC; Heeneman S; Gijbels MM; de Winther MP; Frederik P; van der Made I; Daugherty A; Sijbers AM; Fisher A; Long CJ; Saftig P; Black D; Daemen MJ; Cleutjens KB. 2006. Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation. Circulation 113(1):98-107. PubMed: 16365196 MGI: J:121514
Lutgens SP; Kisters N; Lutgens E; van Haaften RI; Evelo CT; de Winther MP; Saftig P; Daemen MJ; Heeneman S; Cleutjens KB. 2006. Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic. J Pathol 210(3):334-43. PubMed: 16972305 MGI: J:115163
Luttun A; Lupu F; Storkebaum E; Hoylaerts MF; Moons L; Crawley J; Bono F; Poole AR; Tipping P; Herbert JM; Collen D; Carmeliet P. 2002. Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 22(3):499-505. PubMed: 11884297 MGI: J:102938
Ma L; Zhong J; Zhao Z; Luo Z; Ma S; Sun J; He H; Zhu T; Liu D; Zhu Z; Tepel M. 2011. Activation of TRPV1 reduces vascular lipid accumulation and attenuates atherosclerosis. Cardiovasc Res 92(3):504-13. PubMed: 21908651 MGI: J:191700
Ma Y; Ashraf MZ; Podrez EA. 2010. Scavenger receptor BI modulates platelet reactivity and thrombosis in dyslipidemia. Blood 116(11):1932-41. PubMed: 20508162 MGI: J:164537
Ma Y; Malbon CC; Williams DL; Thorngate FE. 2008. Altered gene expression in early atherosclerosis is blocked by low level apolipoprotein E. PLoS One 3(6):e2503. PubMed: 18560564 MGI: J:137210
Ma Z; Choudhury A; Kang SA; Monestier M; Cohen PL; Eisenberg RA. 2008. Accelerated atherosclerosis in ApoE deficient lupus mouse models. Clin Immunol 127(2):168-75. PubMed: 18325838 MGI: J:133606
Madan M; Amar S. 2008. Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS One 3(9):e3204. PubMed: 18787704 MGI: J:143937
Madenspacher JH; Azzam KM; Gong W; Gowdy KM; Vitek MP; Laskowitz DT; Remaley AT; Wang JM; Fessler MB. 2012. Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity. J Biol Chem 287(52):43730-40. PubMed: 23118226 MGI: J:193759
Madhur MS; Funt SA; Li L; Vinh A; Chen W; Lob HE; Iwakura Y; Blinder Y; Rahman A; Quyyumi AA; Harrison DG. 2011. Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient mice. Arterioscler Thromb Vasc Biol 31(7):1565-72. PubMed: 21474820 MGI: J:191474
Magoori K; Kang MJ; Ito MR; Kakuuchi H; Ioka RX; Kamataki A; Kim DH; Asaba H; Iwasaki S; Takei YA; Sasaki M; Usui S; Okazaki M; Takahashi S; Ono M; Nose M; Sakai J; Fujino T; Yamamoto TT. 2003. Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E. J Biol Chem 278(13):11331-6. PubMed: 12509421 MGI: J:82582
Maguire JJ; Wiley KE; Kuc RE; Stoneman VE; Bennett MR; Davenport AP. 2006. Endothelin-mediated vasoconstriction in early atherosclerosis is markedly increased in ApoE-/- mouse but prevented by atorvastatin. Exp Biol Med (Maywood) 231(6):806-12. PubMed: 16741003 MGI: J:135718
Magwenzi S; Woodward C; Wraith KS; Aburima A; Raslan Z; Jones H; McNeil C; Wheatcroft S; Yuldasheva N; Febbriao M; Kearney M; Naseem KM. 2015. Oxidized LDL activates blood platelets through CD36/NOX2-mediated inhibition of the cGMP/protein kinase G signaling cascade. Blood 125(17):2693-703. PubMed: 25710879 MGI: J:222020
Maiellaro-Rafferty K; Weiss D; Joseph G; Wan W; Gleason RL; Taylor WR. 2011. Catalase overexpression in aortic smooth muscle prevents pathological mechanical changes underlying abdominal aortic aneurysm formation. Am J Physiol Heart Circ Physiol 301(2):H355-62. PubMed: 21551275 MGI: J:174894
Maimaitiyiming H; Clemons K; Zhou Q; Norman H; Wang S. 2015. Thrombospondin1 deficiency attenuates obesity-associated microvascular complications in ApoE-/- mice. PLoS One 10(3):e0121403. PubMed: 25803585 MGI: J:229182
Maiseyeu A; Badgeley MA; Kampfrath T; Mihai G; Deiuliis JA; Liu C; Sun Q; Parthasarathy S; Simon DI; Croce K; Rajagopalan S. 2012. In vivo targeting of inflammation-associated myeloid-related protein 8/14 via gadolinium immunonanoparticles. Arterioscler Thromb Vasc Biol 32(4):962-70. PubMed: 22308043 MGI: J:195954
Maitra U; Davis S; Reilly CM; Li L. 2009. Differential regulation of Foxp3 and IL-17 expression in CD4 T helper cells by IRAK-1. J Immunol 182(9):5763-9. PubMed: 19380824 MGI: J:147704
Major AS; Dove DE; Ishiguro H; Su YR; Brown AM; Liu L; Carter KJ; Linton MF; Fazio S. 2001. Increased cholesterol efflux in apolipoprotein AI (ApoAI)-producing macrophages as a mechanism for reduced atherosclerosis in ApoAI((-/-)) mice. Arterioscler Thromb Vasc Biol 21(11):1790-5. PubMed: 11701467 MGI: J:107390
Makowski L; Boord JB; Maeda K; Babaev VR; Uysal KT; Morgan MA; Parker RA; Suttles J; Fazio S; Hotamisligil GS; Linton MF. 2001. Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis. Nat Med 7(6):699-705. PubMed: 11385507 MGI: J:69989
Mallat Z; Gojova A; Marchiol-Fournigault C; Esposito B; Kamate C; Merval R; Fradelizi D; Tedgui A. 2001. Inhibition of transforming growth factor-beta signaling accelerates atherosclerosis and induces an unstable plaque phenotype in mice. Circ Res 89(10):930-4. PubMed: 11701621 MGI: J:115410
Mallavia B; Oguiza A; Lopez-Franco O; Recio C; Ortiz-Munoz G; Lazaro I; Lopez-Parra V; Egido J; Gomez-Guerrero C. 2013. Gene Deficiency in Activating Fcgamma Receptors Influences the Macrophage Phenotypic Balance and Reduces Atherosclerosis in Mice. PLoS One 8(6):e66754. PubMed: 23805273 MGI: J:204205
Malloy SI; Altenburg MK; Knouff C; Lanningham-Foster L; Parks JS; Maeda N. 2004. Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3. Arterioscler Thromb Vasc Biol 24(1):91-7. PubMed: 12969990 MGI: J:146721
Manelli AM; Bulfinch LC; Sullivan PM; LaDu MJ. 2007. Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. Neurobiol Aging 28(8):1139-47. PubMed: 16837105 MGI: J:123898
Mani S; Li H; Untereiner A; Wu L; Yang G; Austin RC; Dickhout JG; Lhotak S; Meng QH; Wang R. 2013. Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis. Circulation 127(25):2523-34. PubMed: 23704252 MGI: J:211386
Manichaikul A; Wang Q; Shi YL; Zhang Z; Leitinger N; Shi W. 2011. Characterization of Ath29, a major mouse atherosclerosis susceptibility locus, and identification of Rcn2 as a novel regulator of cytokine expression. Am J Physiol Heart Circ Physiol 301(3):H1056-61. PubMed: 21666121 MGI: J:176926
Manka D; Collins RG; Ley K; Beaudet AL; Sarembock IJ. 2001. Absence of p-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in apolipoprotein e-deficient mice. Circulation 103(7):1000-5. PubMed: 11181476 MGI: J:103301
Manning-Tobin JJ; Moore KJ; Seimon TA; Bell SA; Sharuk M; Alvarez-Leite JI; de Winther MP; Tabas I; Freeman MW. 2009. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol 29(1):19-26. PubMed: 18948635 MGI: J:159787
Marneros AG; Keene DR; Hansen U; Fukai N; Moulton K; Goletz PL; Moiseyev G; Pawlyk BS; Halfter W; Dong S; Shibata M; Li T; Crouch RK; Bruckner P; Olsen BR. 2004. Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J 23(1):89-99. PubMed: 14685281 MGI: J:87454
Martens GW; Arikan MC; Lee J; Ren F; Vallerskog T; Kornfeld H. 2008. Hypercholesterolemia impairs immunity to tuberculosis. Infect Immun 76(8):3464-72. PubMed: 18505807 MGI: J:139394
Martinez HG; Quinones MP; Jimenez F; Estrada CA; Clark K; Muscogiuri G; Sorice G; Musi N; Reddick RL; Ahuja SS. 2011. Critical role of chemokine (C-C motif) receptor 2 (CCR2) in the KKAy + Apoe -/- mouse model of the metabolic syndrome. Diabetologia 54(10):2660-8. PubMed: 21779871 MGI: J:177084
Martinez-Hervas S; Vinue A; Nunez L; Andres-Blasco I; Piqueras L; Real JT; Ascaso JF; Burks DJ; Sanz MJ; Gonzalez-Navarro H. 2014. Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis. Cardiovasc Res 103(2):324-36. PubMed: 24788416 MGI: J:229852
Martinez-Miguel P; Raoch V; Zaragoza C; Valdivielso JM; Rodriguez-Puyol M; Rodriguez-Puyol D; Lopez-Ongil S. 2009. Endothelin-converting enzyme-1 increases in atherosclerotic mice: potential role of oxidized low density lipoproteins. J Lipid Res 50(3):364-75. PubMed: 18997155 MGI: J:149087
Massaro D; Massaro GD. 2008. Apoetm1Unc mice have impaired alveologenesis, low lung function, and rapid loss of lung function. Am J Physiol Lung Cell Mol Physiol 294(5):L991-7. PubMed: 18344414 MGI: J:136630
Massberg S; Brand K; Gruner S; Page S; Muller E; Muller I; Bergmeier W; Richter T; Lorenz M; Konrad I; Nieswandt B; Gawaz M. 2002. A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. J Exp Med 196(7):887-96. PubMed: 12370251 MGI: J:112015
Massberg S; Gruner S; Konrad I; Garcia Arguinzonis MI; Eigenthaler M; Hemler K; Kersting J; Schulz C; Muller I; Besta F; Nieswandt B; Heinzmann U; Walter U; Gawaz M. 2004. Enhanced in vivo platelet adhesion in vasodilator-stimulated phosphoprotein (VASP)-deficient mice. Blood 103(1):136-42. PubMed: 12933589 MGI: J:87218
Massberg S; Schurzinger K; Lorenz M; Konrad I; Schulz C; Plesnila N; Kennerknecht E; Rudelius M; Sauer S; Braun S; Kremmer E; Emambokus NR; Frampton J; Gawaz M. 2005. Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb. Circulation 112(8):1180-8. PubMed: 16103235 MGI: J:116803
Massy ZA; Ivanovski O; Nguyen-Khoa T; Angulo J; Szumilak D; Mothu N; Phan O; Daudon M; Lacour B; Drueke TB; Muntzel MS. 2005. Uremia accelerates both atherosclerosis and arterial calcification in apolipoprotein E knockout mice. J Am Soc Nephrol 16(1):109-16. PubMed: 15563564 MGI: J:110084
Mato M; Ookawara S; Mashiko T; Sakamoto A; Mato TK; Maeda N; Kodama T. 1999. Regional difference of lipid distribution in brain of apolipoprotein E deficient mice. Anat Rec 256(2):165-76. PubMed: 10486514 MGI: J:57869
Matsui Y; Rittling SR; Okamoto H; Inobe M; Jia N; Shimizu T; Akino M; Sugawara T; Morimoto J; Kimura C; Kon S; Denhardt D; Kitabatake A; Uede T. 2003. Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 23(6):1029-34. PubMed: 12730087 MGI: J:103051
Matsumoto T; D'uscio LV; Eguchi D; Akiyama M; Smith LA; Katusic ZS. 2003. Protective effect of chronic vitamin C treatment on endothelial function of apolipoprotein E-deficient mouse carotid artery. J Pharmacol Exp Ther 306(1):103-8. PubMed: 12660308 MGI: J:124738
Matsuo M; Campenot RB; Vance DE; Ueda K; Vance JE. 2011. Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins. Biochim Biophys Acta 1811(1):31-8. PubMed: 21040802 MGI: J:170292
Matsushima Y; Hayashi S; Tachibana M. 1999. Spontaneously hyperlipidemic (SHL) mice: Japanese wild mice with apolipoprotein E deficiency. Mamm Genome 10(4):352-7. PubMed: 10087291 MGI: J:54051
Matter CM; Ma L; von Lukowicz T; Meier P; Lohmann C; Zhang D; Kilic U; Hofmann E; Ha SW; Hersberger M; Hermann DM; Luscher TF. 2006. Increased balloon-induced inflammation, proliferation, and neointima formation in apolipoprotein E (ApoE) knockout mice. Stroke 37(10):2625-32. PubMed: 16946151 MGI: J:135932
Matthews RT; Beal MF. 1996. Increased 3-nitrotyrosine in brains of Apo E-deficient mice. Brain Res 718(1-2):181-4. PubMed: 8773783 MGI: J:33429
Maugeais C; Tietge UJ; Tsukamoto K; Glick JM; Rader DJ. 2000. Hepatic apolipoprotein E expression promotes very low density lipoprotein-apolipoprotein B production in vivo in mice. J Lipid Res 41(10):1673-9. PubMed: 11013310 MGI: J:120029
Mayr M; Zampetaki A; Sidibe A; Mayr U; Yin X; De Souza AI; Chung YL; Madhu B; Quax PH; Hu Y; Griffiths JR; Xu Q. 2008. Proteomic and metabolomic analysis of smooth muscle cells derived from the arterial media and adventitial progenitors of apolipoprotein E-deficient mice. Circ Res 102(9):1046-56. PubMed: 18388323 MGI: J:149025
McAlpine CS; Bowes AJ; Khan MI; Shi Y; Werstuck GH. 2012. Endoplasmic reticulum stress and glycogen synthase kinase-3beta activation in apolipoprotein E-deficient mouse models of accelerated atherosclerosis. Arterioscler Thromb Vasc Biol 32(1):82-91. PubMed: 21998135 MGI: J:195980
McAlpine CS; Werstuck GH. 2014. Protein kinase R-like endoplasmic reticulum kinase and glycogen synthase kinase-3alpha/beta regulate foam cell formation. J Lipid Res 55(11):2320-33. PubMed: 25183803 MGI: J:216137
McDaniel B; Sheng H; Warner DS; Hedlund LW; Benveniste H. 2001. Tracking brain volume changes in C57BL/6J and ApoE-deficient mice in a model of neurodegeneration: a 5-week longitudinal micro-MRI study. Neuroimage 14(6):1244-55. PubMed: 11707081 MGI: J:103030
McGillicuddy CJ; Carrier MJ; Weinberg PD. 2001. Distribution of lipid deposits around aortic branches of mice lacking LDL receptors and apolipoprotein E. Arterioscler Thromb Vasc Biol 21(7):1220-5. PubMed: 11451755 MGI: J:103203
McKittrick IB; Bogaert Y; Nadeau K; Snell-Bergeon J; Hull A; Jiang T; Wang X; Levi M; Moulton KS. 2011. Urinary matrix metalloproteinase activities: biomarkers for plaque angiogenesis and nephropathy in diabetes. Am J Physiol Renal Physiol 301(6):F1326-33. PubMed: 21921021 MGI: J:180023
Mees B; Recalde A; Loinard C; Tempel D; Godinho M; Vilar J; van Haperen R; Levy B; de Crom R; Silvestre JS. 2011. Endothelial nitric oxide synthase overexpression restores the efficiency of bone marrow mononuclear cell-based therapy. Am J Pathol 178(1):55-60. PubMed: 21224043 MGI: J:168239
Mencarelli A; Renga B; Distrutti E; Fiorucci S. 2009. Antiatherosclerotic effect of farnesoid X receptor. Am J Physiol Heart Circ Physiol 296(2):H272-81. PubMed: 19028791 MGI: J:146332
Mendez-Barbero N; Esteban V; Villahoz S; Escolano A; Urso K; Alfranca A; Rodriguez C; Sanchez SA; Osawa T; Andres V; Martinez-Gonzalez J; Minami T; Redondo JM; Campanero MR. 2013. A major role for RCAN1 in atherosclerosis progression. EMBO Mol Med 5(12):1901-17. PubMed: 24127415 MGI: J:229224
Meng L; Jin W; Wang X. 2015. RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality. Proc Natl Acad Sci U S A 112(35):11007-12. PubMed: 26283397 MGI: J:226708
Meng L; Jin W; Wang Y; Huang H; Li J; Zhang C. 2016. RIP3-dependent necrosis induced inflammation exacerbates atherosclerosis. Biochem Biophys Res Commun 473(2):497-502. PubMed: 26995086 MGI: J:234815
Mercer J; Figg N; Stoneman V; Braganza D; Bennett MR. 2005. Endogenous p53 protects vascular smooth muscle cells from apoptosis and reduces atherosclerosis in ApoE knockout mice. Circ Res 96(6):667-74. PubMed: 15746445 MGI: J:107632
Mercer JR; Cheng KK; Figg N; Gorenne I; Mahmoudi M; Griffin J; Vidal-Puig A; Logan A; Murphy MP; Bennett M. 2010. DNA damage links mitochondrial dysfunction to atherosclerosis and the metabolic syndrome. Circ Res 107(8):1021-31. PubMed: 20705925 MGI: J:178198
Merched AJ; Chan L. 2004. Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis. Circulation 110(25):3830-41. PubMed: 15596565 MGI: J:112845
Mercier N; Kiviniemi TO; Saraste A; Miiluniemi M; Silvola J; Jalkanen S; Yegutkin GG. 2012. Impaired ATP-induced coronary blood flow and diminished aortic NTPDase activity precede lesion formation in apolipoprotein E-deficient mice. Am J Pathol 180(1):419-28. PubMed: 22074736 MGI: J:180156
Merhi-Soussi F; Kwak BR; Magne D; Chadjichristos C; Berti M; Pelli G; James RW; Mach F; Gabay C. 2005. Interleukin-1 plays a major role in vascular inflammation and atherosclerosis in male apolipoprotein E-knockout mice. Cardiovasc Res 66(3):583-93. PubMed: 15914123 MGI: J:132570
Merkel M; Velez-Carrasco W; Hudgins LC; Breslow JL. 2001. Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice. Proc Natl Acad Sci U S A 98(23):13294-9. PubMed: 11606787 MGI: J:72580
Mezdour H; Jones R; Dengremont C; Castro G; Maeda N. 1997. Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient mice. J Biol Chem 272(21):13570-5. PubMed: 9153204 MGI: J:40434
Miao J; Vitek MP; Xu F; Previti ML; Davis J; Van Nostrand WE. 2005. Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. J Neurosci 25(27):6271-7. PubMed: 16000616 MGI: J:99430
Michelsen KS; Wong MH; Shah PK; Zhang W; Yano J; Doherty TM; Akira S; Rajavashisth TB; Arditi M. 2004. Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein E. Proc Natl Acad Sci U S A 101(29):10679-84. PubMed: 15249654 MGI: J:91481
Mihara K; Spansier M; Rooseboom M; Smit MJ; Dokter W. 2007. Functional replacement of murine CXCR2 by its human homologue in the development of atherosclerosis in LDLR knockout mice. Biol Pharm Bull 30(7):1231-6. PubMed: 17603159 MGI: J:124372
Mikael LG; Wang XL; Wu Q; Jiang H; Maclean KN; Rozen R. 2009. Hyperhomocysteinemia is associated with hypertriglyceridemia in mice with methylenetetrahydrofolate reductase deficiency. Mol Genet Metab 98(1-2):187-94. PubMed: 19560954 MGI: J:152562
Minahk C; Kim KW; Nelson R; Trigatti B; Lehner R; Vance DE. 2008. Conversion of low density lipoprotein-associated phosphatidylcholine to triacylglycerol by primary hepatocytes. J Biol Chem 283(10):6449-58. PubMed: 18175806 MGI: J:133757
Miriyala S; Gongora Nieto MC; Mingone C; Smith D; Dikalov S; Harrison DG; Jo H. 2006. Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation. Circulation 113(24):2818-25. PubMed: 16769910 MGI: J:122442
Mishima T; Iwabuchi K; Fujii S; Tanaka SY; Ogura H; Watano-Miyata K; Ishimori N; Andoh Y; Nakai Y; Iwabuchi C; Ato M; Kitabatake A; Tsutsui H; Onoe K. 2008. Allograft inflammatory factor-1 augments macrophage phagocytotic activity and accelerates the progression of atherosclerosis in ApoE-/- mice. Int J Mol Med 21(2):181-7. PubMed: 18204784 MGI: J:149040
Mishra S; Bedja D; Amuzie C; Avolio A; Chatterjee S. 2015. Prevention of cardiac hypertrophy by the use of a glycosphingolipid synthesis inhibitor in ApoE-/- mice. Biochem Biophys Res Commun 465(1):159-64. PubMed: 26253472 MGI: J:232889
Mitchell C; Mignon A; Guidotti JE; Besnard S; Fabre M; Duverger N; Parlier D; Tedgui A; Kahn A; Gilgenkrantz H. 2000. Therapeutic liver repopulation in a mouse model of hypercholesterolemia Hum Mol Genet 9(11):1597-602. PubMed: 10861286 MGI: J:63199
Mitchell PL; Karakach TK; Currie DL; McLeod RS. 2012. t-10, c-12 CLA dietary supplementation inhibits atherosclerotic lesion development despite adverse cardiovascular and hepatic metabolic marker profiles. PLoS One 7(12):e52634. PubMed: 23285120 MGI: J:195756
Miura Y; Chiba T; Tomita I; Koizumi H; Miura S; Umegaki K; Hara Y; Ikeda M; Tomita T. 2001. Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice. J Nutr 131(1):27-32. PubMed: 11208934 MGI: J:66898
Miyamoto T; Yumoto H; Takahashi Y; Davey M; Gibson FC 3rd; Genco CA. 2006. Pathogen-accelerated atherosclerosis occurs early after exposure and can be prevented via immunization. Infect Immun 74(2):1376-80. PubMed: 16428788 MGI: J:105066
Miyazaki T; Taketomi Y; Takimoto M; Lei XF; Arita S; Kim-Kaneyama JR; Arata S; Ohata H; Ota H; Murakami M; Miyazaki A. 2011. m-Calpain induction in vascular endothelial cells on human and mouse atheromas and its roles in VE-cadherin disorganization and atherosclerosis. Circulation 124(23):2522-32. PubMed: 22064597 MGI: J:193805
Moazed TC; Campbell LA; Rosenfeld ME; Grayston JT; Kuo CC. 1999. Chlamydia pneumoniae infection accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. J Infect Dis 180(1):238-41. PubMed: 10353889 MGI: J:120562
Moghadasian MH; McManus BM; Nguyen LB; Shefer S; Nadji M; Godin DV; Green TJ; Hill J; Yang Y; Scudamore CH; Frohlich JJ. 2001. Pathophysiology of apolipoprotein E deficiency in mice: relevance to apo E-related disorders in humans. FASEB J 15(14):2623-30. PubMed: 11726538 MGI: J:73202
Moghadasian MH; Nguyen LB; Shefer S; McManus BM; Frohlich JJ. 1999. Histologic, hematologic, and biochemical characteristics of apo E-deficient mice: effects of dietary cholesterol and phytosterols. Lab Invest 79(3):355-64. PubMed: 10092072 MGI: J:120513
Molenaar TJ; Twisk J; de Haas SA; Peterse N; Vogelaar BJ; van Leeuwen SH; Michon IN; van Berkel TJ; Kuiper J; Biessen EA. 2003. P-selectin as a candidate target in atherosclerosis. Biochem Pharmacol 66(5):859-66. PubMed: 12948867 MGI: J:115693
Molica F; Matter CM; Burger F; Pelli G; Lenglet S; Zimmer A; Pacher P; Steffens S. 2012. Cannabinoid receptor CB2 protects against balloon-induced neointima formation. Am J Physiol Heart Circ Physiol 302(5):H1064-74. PubMed: 22227125 MGI: J:185015
Montano EN; Boullier A; Almazan F; Binder CJ; Witztum JL; Hartvigsen K. 2013. Development and application of a nonradioactive binding assay of oxidized low-density lipoprotein to macrophage scavenger receptors. J Lipid Res 54(11):3206-14. PubMed: 23997238 MGI: J:203430
Montine TJ; Montine KS; Olson SJ; Graham DG; Roberts LJ 2nd; Morrow JD; Linton MF; Fazio S; Swift LL. 1999. Increased cerebral cortical lipid peroxidation and abnormal phospholipids in aged homozygous apoE-deficient C57BL/6J mice. Exp Neurol 158(1):234-41. PubMed: 10448437 MGI: J:56409
Moore KJ; Kunjathoor VV; Koehn SL; Manning JJ; Tseng AA; Silver JM; McKee M; Freeman MW. 2005. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest 115(8):2192-201. PubMed: 16075060 MGI: J:100226
Moore ZW; Hui DY. 2005. Apolipoprotein E inhibition of vascular hyperplasia and neointima formation requires inducible nitric oxide synthase. J Lipid Res 46(10):2083-90. PubMed: 16061951 MGI: J:104724
Moos MP; John N; Grabner R; Nossmann S; Gunther B; Vollandt R; Funk CD; Kaiser B; Habenicht AJ. 2005. The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 25(11):2386-91. PubMed: 16179593 MGI: J:116852
Morais RL; Hilzendeger AM; Visniauskas B; Todiras M; Alenina N; Mori MA; Araujo RC; Nakaie CR; Chagas JR; Carmona AK; Bader M; Pesquero JB. 2017. High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism. Am J Physiol Heart Circ Physiol 312(3):H437-H445. PubMed: 27940965 MGI: J:239954
Moran CS; Jose RJ; Biros E; Golledge J. 2014. Osteoprotegerin deficiency limits angiotensin II-induced aortic dilatation and rupture in the apolipoprotein E-knockout mouse. Arterioscler Thromb Vasc Biol 34(12):2609-16. PubMed: 25301844 MGI: J:230464
Morel S; Braunersreuther V; Chanson M; Bouis D; Rochemont V; Foglia B; Pelli G; Sutter E; Pinsky DJ; Mach F; Kwak BR. 2014. Endothelial Cx40 limits myocardial ischaemia/reperfusion injury in mice. Cardiovasc Res 102(2):329-37. PubMed: 24639196 MGI: J:229808
Morgan S; Yamanouchi D; Harberg C; Wang Q; Keller M; Si Y; Burlingham W; Seedial S; Lengfeld J; Liu B. 2012. Elevated protein kinase C-delta contributes to aneurysm pathogenesis through stimulation of apoptosis and inflammatory signaling. Arterioscler Thromb Vasc Biol 32(10):2493-502. PubMed: 22879584 MGI: J:207882
Morgantini C; Imaizumi S; Grijalva V; Navab M; Fogelman AM; Reddy ST. 2010. Apolipoprotein A-I mimetic peptides prevent atherosclerosis development and reduce plaque inflammation in a murine model of diabetes. Diabetes 59(12):3223-8. PubMed: 20826564 MGI: J:169334
Moriwaki H; Stempien-Otero A; Kremen M; Cozen AE; Dichek DA. 2004. Overexpression of urokinase by macrophages or deficiency of plasminogen activator inhibitor type 1 causes cardiac fibrosis in mice. Circ Res 95(6):637-44. PubMed: 15297377 MGI: J:101486
Mortensen MB; Kjolby M; Gunnersen S; Larsen JV; Palmfeldt J; Falk E; Nykjaer A; Bentzon JF. 2014. Targeting sortilin in immune cells reduces proinflammatory cytokines and atherosclerosis. J Clin Invest 124(12):5317-22. PubMed: 25401472 MGI: J:219379
Mortimer BC; Beveridge DJ; Martins IJ; Redgrave TG. 1995. Intracellular localization and metabolism of chylomicron remnants in the livers of low density lipoprotein receptor-deficient mice and apoE-deficient mice. Evidence for slow metabolism via an alternative apoE-dependent pathway. J Biol Chem 270(48):28767-76. PubMed: 7499399 MGI: J:29909
Mueller CF; Wassmann K; Widder JD; Wassmann S; Chen CH; Keuler B; Kudin A; Kunz WS; Nickenig G. 2008. Multidrug resistance protein-1 affects oxidative stress, endothelial dysfunction, and atherogenesis via leukotriene C4 export. Circulation 117(22):2912-8. PubMed: 18506003 MGI: J:155084
Mukhamedova N; D'Souza W; Low H; Kesani R; Chimini G; Sviridov D. 2011. Global functional knockdown of ATP binding cassette transporter A1 stimulates development of atherosclerosis in apoE K/O mice. Biochem Biophys Res Commun 412(3):446-9. PubMed: 21839726 MGI: J:176065
Murphy AJ; Akhtari M; Tolani S; Pagler T; Bijl N; Kuo CL; Wang M; Sanson M; Abramowicz S; Welch C; Bochem AE; Kuivenhoven JA; Yvan-Charvet L; Tall AR. 2011. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J Clin Invest 121(10):4138-49. PubMed: 21968112 MGI: J:178453
Nachtigal M; Ghaffar A; Mayer EP. 2008. Galectin-3 gene inactivation reduces atherosclerotic lesions and adventitial inflammation in ApoE-deficient mice. Am J Pathol 172(1):247-55. PubMed: 18156214 MGI: J:130923
Nagarajan S; Burris RL; Stewart BW; Wilkerson JE; Badger TM. 2008. Dietary soy protein isolate ameliorates atherosclerotic lesions in apolipoprotein E-deficient mice potentially by inhibiting monocyte chemoattractant protein-1 expression. J Nutr 138(2):332-7. PubMed: 18203900 MGI: J:133406
Nahid MA; Rivera M; Lucas A; Chan EK; Kesavalu L. 2011. Polymicrobial Infection with Periodontal Pathogens Specifically Enhances MicroRNA miR-146a in ApoE-/- Mice during Experimental Periodontal Disease. Infect Immun 79(4):1597-605. PubMed: 21263019 MGI: J:170951
Naiki Y; Sorrentino R; Wong MH; Michelsen KS; Shimada K; Chen S; Yilmaz A; Slepenkin A; Schroder NW; Crother TR; Bulut Y; Doherty TM; Bradley M; Shaposhnik Z; Peterson EM; Tontonoz P; Shah PK; Arditi M. 2008. TLR/MyD88 and liver X receptor alpha signaling pathways reciprocally control Chlamydia pneumoniae-induced acceleration of atherosclerosis. J Immunol 181(10):7176-85. PubMed: 18981139 MGI: J:140936
Najafi AH; Aghili N; Tilan JU; Andrews JA; Peng X; Lassance-Soares RM; Sood S; Alderman LO; Abe K; Li L; Kolodgie FD; Virmani R; Zukowska Z; Epstein SE; Burnett MS. 2013. A new murine model of stress-induced complex atherosclerotic lesions. Dis Model Mech 6(2):323-31. PubMed: 23324329 MGI: J:195064
Nakai Y; Iwabuchi K; Fujii S; Ishimori N; Dashtsoodol N; Watano K; Mishima T; Iwabuchi C; Tanaka S; Bezbradica JS; Nakayama T; Taniguchi M; Miyake S; Yamamura T; Kitabatake A; Joyce S; Van Kaer L; Onoe K. 2004. Natural killer T cells accelerate atherogenesis in mice. Blood 104(7):2051-9. PubMed: 15113755 MGI: J:93754
Nakamuta M; Taniguchi S; Ishida BY; Kobayashi K; Chan L. 1998. Phenotype interaction of apobec-1 and CETP, LDLR, and apoE gene expression in mice: role of apoB mRNA editing in lipoprotein phenotype expression. Arterioscler Thromb Vasc Biol 18(5):747-55. PubMed: 9598833 MGI: J:48202
Nakata Y; Maeda N. 2002. Vulnerable atherosclerotic plaque morphology in apolipoprotein E-deficient mice unable to make ascorbic Acid. Circulation 105(12):1485-90. PubMed: 11914259 MGI: J:103232
Nam D; Ni CW; Rezvan A; Suo J; Budzyn K; Llanos A; Harrison D; Giddens D; Jo H. 2009. Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis. Am J Physiol Heart Circ Physiol 297(4):H1535-43. PubMed: 19684185 MGI: J:154332
Namjoshi DR; Martin G; Donkin J; Wilkinson A; Stukas S; Fan J; Carr M; Tabarestani S; Wuerth K; Hancock RE; Wellington CL. 2013. The liver X receptor agonist GW3965 improves recovery from mild repetitive traumatic brain injury in mice partly through apolipoprotein E. PLoS One 8(1):e53529. PubMed: 23349715 MGI: J:195849
Narasimha AJ; Watanabe J; Ishikawa TO; Priceman SJ; Wu L; Herschman HR; Reddy ST. 2010. Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol 30(2):260-8. PubMed: 19926832 MGI: J:172108
Nashed B; Yeganeh B; HayGlass KT; Moghadasian MH. 2005. Antiatherogenic effects of dietary plant sterols are associated with inhibition of proinflammatory cytokine production in Apo E-KO mice. J Nutr 135(10):2438-44. PubMed: 16177209 MGI: J:106647
Nathan BP; Gairhe S; Nwosu I; Clark S; Struble RG. 2010. Reconstitution of the olfactory epithelium following injury in apoE-deficient mice. Exp Neurol 226(1):40-6. PubMed: 20696162 MGI: J:166650
Nathan BP; Nisar R; Short J; Randall S; Grissom E; Griffin G; Switzer PV; Struble RG. 2005. Delayed olfactory nerve regeneration in ApoE-deficient mice. Brain Res 1041(1):87-94. PubMed: 15804503 MGI: J:97427
Nathan BP; Yost J; Litherland MT; Struble RG; Switzer PV. 2004. Olfactory function in apoE knockout mice. Behav Brain Res 150(1-2):1-7. PubMed: 15033273 MGI: J:89344
Naura AS; Hans CP; Zerfaoui M; Errami Y; Ju J; Kim H; Matrougui K; Kim JG; Boulares AH. 2009. High-fat diet induces lung remodeling in ApoE-deficient mice: an association with an increase in circulatory and lung inflammatory factors. Lab Invest 89(11):1243-51. PubMed: 19752857 MGI: J:153736
Nawrocki AR; Hofmann SM; Teupser D; Basford JE; Durand JL; Jelicks LA; Woo CW; Kuriakose G; Factor SM; Tanowitz HB; Hui DY; Tabas I; Scherer PE. 2010. Lack of association between adiponectin levels and atherosclerosis in mice. Arterioscler Thromb Vasc Biol 30(6):1159-65. PubMed: 20299691 MGI: J:180866
Nazari-Jahantigh M; Wei Y; Noels H; Akhtar S; Zhou Z; Koenen RR; Heyll K; Gremse F; Kiessling F; Grommes J; Weber C; Schober A. 2012. MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Invest 122(11):4190-202. PubMed: 23041630 MGI: J:193560
Ng DS; Maguire GF; Wylie J; Ravandi A; Xuan W; Ahmed Z; Eskandarian M; Kuksis A; Connelly PW. 2002. Oxidative stress is markedly elevated in lecithin:cholesterol acyltransferase-deficient mice and is paradoxically reversed in the apolipoprotein E knockout background in association with a reduction in atherosclerosis. J Biol Chem 277(14):11715-20. PubMed: 11809774 MGI: J:124830
Ng HP; Burris RL; Nagarajan S. 2011. Attenuated atherosclerotic lesions in apoE-Fcgamma-chain-deficient hyperlipidemic mouse model is associated with inhibition of Th17 cells and promotion of regulatory T cells. J Immunol 187(11):6082-93. PubMed: 22043015 MGI: J:179719
Ng HP; Zhu X; Harmon EY; Lennartz MR; Nagarajan S. 2015. Reduced Atherosclerosis in apoE-inhibitory FcgammaRIIb-Deficient Mice Is Associated With Increased Anti-Inflammatory Responses by T Cells and Macrophages. Arterioscler Thromb Vasc Biol 35(5):1101-12. PubMed: 25792447 MGI: J:241629
Ngalame NN; Micciche AF; Feil ME; States JC. 2013. Delayed temporal increase of hepatic Hsp70 in ApoE knockout mice after prenatal arsenic exposure. Toxicol Sci 131(1):225-33. PubMed: 22956628 MGI: J:192764
Nguyen AD; Itoh S; Jeney V; Yanagisawa H; Fujimoto M; Ushio-Fukai M; Fukai T. 2004. Fibulin-5 is a novel binding protein for extracellular superoxide dismutase. Circ Res 95(11):1067-74. PubMed: 15528465 MGI: J:103848
Nicoletti A; Kaveri S; Caligiuri G; Bariety J; Hansson GK. 1998. Immunoglobulin treatment reduces atherosclerosis in apo E knockout mice. J Clin Invest 102(5):910-8. PubMed: 9727059 MGI: J:49660
Nie P; Li D; Hu L; Jin S; Yu Y; Cai Z; Shao Q; Shen J; Yi J; Xiao H; Shen L; He B. 2014. Atorvastatin improves plaque stability in ApoE-knockout mice by regulating chemokines and chemokine receptors. PLoS One 9(5):e97009. PubMed: 24816562 MGI: J:217362
Niebauer J; Maxwell AJ; Lin PS; Wang D; Tsao PS; Cooke JP. 2003. NOS inhibition accelerates atherogenesis: reversal by exercise. Am J Physiol Heart Circ Physiol 285(2):H535-40. PubMed: 12598230 MGI: J:84828
Nigro P; Abe J; Woo CH; Satoh K; McClain C; O'Dell MR; Lee H; Lim JH; Li JD; Heo KS; Fujiwara K; Berk BC. 2010. PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5. Blood 116(11):1971-9. PubMed: 20538799 MGI: J:164515
Nigro P; Satoh K; O'Dell MR; Soe NN; Cui Z; Mohan A; Abe J; Alexis JD; Sparks JD; Berk BC. 2011. Cyclophilin A is an inflammatory mediator that promotes atherosclerosis in apolipoprotein E-deficient mice. J Exp Med 208(1):53-66. PubMed: 21173104 MGI: J:176860
Nikolov IG; Joki N; Nguyen-Khoa T; Ivanovski O; Phan O; Lacour B; Drueke TB; Massy ZA; Dos Reis LM; Jorgetti V; Lafage-Proust MH. 2010. Chronic kidney disease bone and mineral disorder (CKD-MBD) in apolipoprotein E-deficient mice with chronic renal failure. Bone 47(1):156-63. PubMed: 20406703 MGI: J:162029
Nilsson LN; Arendash GW; Leighty RE; Costa DA; Low MA; Garcia MF; Cracciolo JR; Rojiani A; Wu X; Bales KR; Paul SM; Potter H. 2004. Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation. Neurobiol Aging 25(9):1153-67. PubMed: 15312961 MGI: J:102326
Nilsson-Ohman J; Fredrikson GN; Nilsson-Berglund LM; Gustavsson C; Bengtsson E; Smith ML; Agardh CD; Agardh E; Jovinge S; Gomez MF; Nilsson J. 2009. Tumor necrosis factor-alpha does not mediate diabetes-induced vascular inflammation in mice. Arterioscler Thromb Vasc Biol 29(10):1465-70. PubMed: 19755528 MGI: J:167795
Nishitsuji K; Hosono T; Nakamura T; Bu G; Michikawa M. 2011. Apolipoprotein E Regulates the Integrity of Tight Junctions in an Isoform-dependent Manner in an in Vitro Blood-Brain Barrier Model. J Biol Chem 286(20):17536-42. PubMed: 21471207 MGI: J:172669
Nobili E; Salvado MD; Folkersen L; Castiglioni L; Kastrup J; Wetterholm A; Tremoli E; Hansson GK; Sironi L; Haeggstrom JZ; Gabrielsen A. 2012. Cysteinyl leukotriene signaling aggravates myocardial hypoxia in experimental atherosclerotic heart disease. PLoS One 7(7):e41786. PubMed: 22848603 MGI: J:189697
Nofer JR; Brodde M; Herminghaus G; Seedorf U; Assmann G; Kehrel BE. 2006. Normal platelet reactivity in apolipoprotein E (apo E)-deficient mouse. Platelets 17(7):498-500. PubMed: 17074727 MGI: J:136476
Nong Z; Gonzalez-Navarro H; Amar M; Freeman L; Knapper C; Neufeld EB; Paigen BJ; Hoyt RF; Fruchart-Najib J; Santamarina-Fojo S. 2003. Hepatic lipase expression in macrophages contributes to atherosclerosis in apoE-deficient and LCAT-transgenic mice. J Clin Invest 112(3):367-78. PubMed: 12897204 MGI: J:84922
Norata GD; Marchesi P; Pulakazhi Venu VK; Pasqualini F; Anselmo A; Moalli F; Pizzitola I; Garlanda C; Mantovani A; Catapano AL. 2009. Deficiency of the long pentraxin PTX3 promotes vascular inflammation and atherosclerosis. Circulation 120(8):699-708. PubMed: 19667236 MGI: J:167113
Norata GD; Venu VK; Callegari E; Paloschi V; Catapano AL. 2012. Effect of Tie-2 conditional deletion of BDNF on atherosclerosis in the ApoE null mutant mouse. Biochim Biophys Acta 1822(6):927-35. PubMed: 22386878 MGI: J:184993
Nwosu I; Gairhe S; Struble RG; Nathan BP. 2008. Impact of apoE deficiency during synaptic remodeling in the mouse olfactory bulb. Neurosci Lett 441(3):282-5. PubMed: 18621483 MGI: J:138855
O'Brien KD; McDonald TO; Kunjathoor V; Eng K; Knopp EA; Lewis K; Lopez R; Kirk EA; Chait A; Wight TN; deBeer FC; LeBoeuf RC. 2005. Serum amyloid A and lipoprotein retention in murine models of atherosclerosis. Arterioscler Thromb Vasc Biol 25(4):785-90. PubMed: 15692094 MGI: J:110024
Oguiza A; Recio C; Lazaro I; Mallavia B; Blanco J; Egido J; Gomez-Guerrero C. 2015. Peptide-based inhibition of IkappaB kinase/nuclear factor-kappaB pathway protects against diabetes-associated nephropathy and atherosclerosis in a mouse model of type 1 diabetes. Diabetologia 58(7):1656-67. PubMed: 25982245 MGI: J:224789
Ohashi M; Runge MS; Faraci FM; Heistad DD. 2006. MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 26(10):2331-6. PubMed: 16873728 MGI: J:128050
Ohkubo N; Lee YD; Morishima A; Terashima T; Kikkawa S; Tohyama M; Sakanaka M; Tanaka J; Maeda N; Vitek MP; Mitsuda N. 2003. Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. FASEB J 17(2):295-7. PubMed: 12490540 MGI: J:110630
Ohman MK; Shen Y; Obimba CI; Wright AP; Warnock M; Lawrence DA; Eitzman DT. 2008. Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation 117(6):798-805. PubMed: 18212290 MGI: J:145083
Ohman MK; Wright AP; Wickenheiser KJ; Luo W; Russo HM; Eitzman DT. 2010. Monocyte chemoattractant protein-1 deficiency protects against visceral fat-induced atherosclerosis. Arterioscler Thromb Vasc Biol 30(6):1151-8. PubMed: 20299683 MGI: J:180870
Ohsawa I; Nishimaki K; Murakami Y; Suzuki Y; Ishikawa M; Ohta S. 2008. Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity. J Neurosci 28(24):6239-49. PubMed: 18550766 MGI: J:137374
Ohsawa I; Nishimaki K; Yamagata K; Ishikawa M; Ohta S. 2008. Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys Res Commun 377(4):1195-8. PubMed: 18996093 MGI: J:143175
Okamoto Y; Folco EJ; Minami M; Wara AK; Feinberg MW; Sukhova GK; Colvin RA; Kihara S; Funahashi T; Luster AD; Libby P. 2008. Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res 102(2):218-25. PubMed: 17991878 MGI: J:145595
Okazaki H; Igarashi M; Nishi M; Sekiya M; Tajima M; Takase S; Takanashi M; Ohta K; Tamura Y; Okazaki S; Yahagi N; Ohashi K; Amemiya-Kudo M; Nakagawa Y; Nagai R; Kadowaki T; Osuga J; Ishibashi S. 2008. Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages. J Biol Chem 283(48):33357-64. PubMed: 18782767 MGI: J:143389
Okoro EU; Zhao Y; Guo Z; Zhou L; Lin X; Yang H. 2012. Apolipoprotein E4 is deficient in inducing macrophage ABCA1 expression and stimulating the Sp1 signaling pathway. PLoS One 7(9):e44430. PubMed: 22984509 MGI: J:225086
Olofsson PS; Soderstrom LA; Wagsater D; Sheikine Y; Ocaya P; Lang F; Rabu C; Chen L; Rudling M; Aukrust P; Hedin U; Paulsson-Berne G; Sirsjo A; Hansson GK. 2008. CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic mice. Circulation 117(10):1292-301. PubMed: 18285570 MGI: J:148448
Omodaka K; Nishiguchi KM; Yasuda M; Tanaka Y; Sato K; Nakamura O; Maruyama K; Nakazawa T. 2014. Neuroprotective effect against axonal damage-induced retinal ganglion cell death in apolipoprotein E-deficient mice through the suppression of kainate receptor signaling. Brain Res 1586:203-12. PubMed: 25160129 MGI: J:215375
Ong JM; Zorapapel NC; Aoki AM; Brown DJ; Nesburn AB; Rich KA; Kenney CM. 2003. Impaired electroretinogram (ERG) response in apolipoprotein E-deficient mice. Curr Eye Res 27(1):15-24. PubMed: 12868005 MGI: J:84688
Ong JM; Zorapapel NC; Rich KA; Wagstaff RE; Lambert RW; Rosenberg SE; Moghaddas F; Pirouzmanesh A; Aoki AM; Kenney MC. 2001. Effects of cholesterol and apolipoprotein E on retinal abnormalities in ApoE-deficient mice. Invest Ophthalmol Vis Sci 42(8):1891-900. PubMed: 11431458 MGI: J:70245
Ophir G; Meilin S; Efrati M; Chapman J; Karussis D; Roses A; Michaelson DM. 2003. Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice. Neurobiol Dis 12(1):56-64. PubMed: 12609489 MGI: J:126223
Osada N; Kosuge Y; Kihara T; Ishige K; Ito Y. 2009. Apolipoprotein E-deficient mice are more vulnerable to ER stress after transient forebrain ischemia. Neurochem Int 54(7):403-9. PubMed: 19428781 MGI: J:150590
Osako MK; Nakagami H; Koibuchi N; Shimizu H; Nakagami F; Koriyama H; Shimamura M; Miyake T; Rakugi H; Morishita R. 2010. Estrogen inhibits vascular calcification via vascular RANKL system: common mechanism of osteoporosis and vascular calcification. Circ Res 107(4):466-75. PubMed: 20595654 MGI: J:175029
Osako MK; Nakagami H; Shimamura M; Koriyama H; Nakagami F; Shimizu H; Miyake T; Yoshizumi M; Rakugi H; Morishita R. 2013. Cross-talk of receptor activator of nuclear factor-kappaB ligand signaling with renin-angiotensin system in vascular calcification. Arterioscler Thromb Vasc Biol 33(6):1287-96. PubMed: 23580147 MGI: J:218869
Ostos MA; Recalde D; Zakin MM; Scott-Algara D. 2002. Implication of natural killer T cells in atherosclerosis development during a LPS-induced chronic inflammation. FEBS Lett 519(1-3):23-9. PubMed: 12023012 MGI: J:109189
Osuga J; Yagyu H; Ohashi K; Harada K; Yazaki Y; Yamada N; Ishibashi S. 1997. Effects of apo E deficiency on plasma lipid levels in mice lacking APOBEC-1. Biochem Biophys Res Commun 236(2):375-8. PubMed: 9240444 MGI: J:41982
Otero-Losada M; Cao G; Mc Loughlin S; Rodriguez-Granillo G; Ottaviano G; Milei J. 2014. Rate of atherosclerosis progression in ApoE-/- mice long after discontinuation of cola beverage drinking. PLoS One 9(3):e89838. PubMed: 24670925 MGI: J:215051
Oumouna-Benachour K; Hans CP; Suzuki Y; Naura A; Datta R; Belmadani S; Fallon K; Woods C; Boulares AH. 2007. Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death. Circulation 115(18):2442-50. PubMed: 17438151 MGI: J:137119
Ovchinnikova O; Robertson AK; Wagsater D; Folco EJ; Hyry M; Myllyharju J; Eriksson P; Libby P; Hansson GK. 2009. T-cell activation leads to reduced collagen maturation in atherosclerotic plaques of Apoe(-/-) mice. Am J Pathol 174(2):693-700. PubMed: 19131590 MGI: J:144195
Owiny JR; Strandberg JD. 2000. Cholesterol granulomas in mice deficient in apolipoprotein E Contemp Topics 39(6):57-58. MGI: J:66450
Ozaki M; Kawashima S; Yamashita T; Hirase T; Namiki M; Inoue N; Hirata K; Yasui H; Sakurai H; Yoshida Y; Masada M; Yokoyama M. 2002. Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice. J Clin Invest 110(3):331-40. PubMed: 12163452 MGI: J:118410
Pan S; White TA; Witt TA; Chiriac A; Mueske CS; Simari RD. 2009. Vascular-directed tissue factor pathway inhibitor overexpression regulates plasma cholesterol and reduces atherosclerotic plaque development. Circ Res 105(7):713-20, 8 p following 720. PubMed: 19713537 MGI: J:169961
Panjwani N; Mulvihill EE; Longuet C; Yusta B; Campbell JE; Brown TJ; Streutker C; Holland D; Cao X; Baggio LL; Drucker DJ. 2013. GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. Endocrinology 154(1):127-39. PubMed: 23183176 MGI: J:194207
Parkin SL; Pritchett JP; Grimsditch DC; Bruckdorfer KR; Sahota PK; Lloyd A; Overend P; Benson GM. 2004. Circulating levels of the chemokines JE and KC in female C3H apolipoprotein-E-deficient and C57BL apolipoprotein-E-deficient mice as potential markers of atherosclerosis development. Biochem Soc Trans 32(Pt 1):128-30. PubMed: 14748730 MGI: J:101865
Parks BW; Srivastava R; Yu S; Kabarowski JH. 2009. ApoE-dependent modulation of HDL and atherosclerosis by G2A in LDL receptor-deficient mice independent of bone marrow-derived cells. Arterioscler Thromb Vasc Biol 29(4):539-47. PubMed: 19164809 MGI: J:159778
Pascual-Garcia M; Carbo JM; Leon T; Matalonga J; Out R; Van Berkel T; Sarrias MR; Lozano F; Celada A; Valledor AF. 2011. Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4. J Immunol 186(8):4656-67. PubMed: 21398609 MGI: J:172455
Paszty C; Maeda N; Verstuyft J; Rubin EM. 1994. Apolipoprotein AI transgene corrects apolipoprotein E deficiency-induced atherosclerosis in mice. J Clin Invest 94(2):899-903. PubMed: 8040345 MGI: J:111180
Patel J; McNeill E; Douglas G; Hale AB; de Bono J; Lee R; Iqbal AJ; Regan-Komito D; Stylianou E; Greaves DR; Channon KM. 2015. RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling. Nat Commun 6:6614. PubMed: 25782711 MGI: J:221876
Patel MN; Bernard WG; Milev NB; Cawthorn WP; Figg N; Hart D; Prieur X; Virtue S; Hegyi K; Bonnafous S; Bailly-Maitre B; Chu Y; Griffin JL; Mallat Z; Considine RV; Tran A; Gual P; Takeuchi O; Akira S; Vidal-Puig A; Bennett MR; Sethi JK. 2015. Hematopoietic IKBKE limits the chronicity of inflammasome priming and metaflammation. Proc Natl Acad Sci U S A 112(2):506-11. PubMed: 25540417 MGI: J:218376
Patel S; Thelander EM; Hernandez M; Montenegro J; Hassing H; Burton C; Mundt S; Hermanowski-Vosatka A; Wright SD; Chao YS; Detmers PA. 2001. ApoE(-/-) mice develop atherosclerosis in the absence of complement component C5. Biochem Biophys Res Commun 286(1):164-70. PubMed: 11485323 MGI: J:71193
Patrick CB; Krzywkowski P; Ramassamy C; Poirier J; Rapoport SI; Murphy EJ. 2000. Phospholipase A2 activity is decreased selectively in the hippocampus of aged apolipoprotein E deficient mice. Neurosci Lett 288(3):211-4. PubMed: 10889345 MGI: J:108022
Paul A; Chang BH; Li L; Yechoor VK; Chan L. 2008. Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis. Circ Res 102(12):1492-501. PubMed: 18483409 MGI: J:151382
Paul A; Ko KW; Li L; Yechoor V; McCrory MA; Szalai AJ; Chan L. 2004. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation 109(5):647-55. PubMed: 14744975 MGI: J:127913
Paulsson G; Zhou X; Tornquist E; Hansson GK. 2000. Oligoclonal T cell expansions in atherosclerotic lesions of apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 20(1):10-7. PubMed: 10634795 MGI: J:60057
Pedersen TX; Madsen M; Junker N; Christoffersen C; Vikesa J; Bro S; Hultgardh-Nilsson A; Nielsen LB. 2013. Osteopontin deficiency dampens the pro-atherogenic effect of uraemia. Cardiovasc Res 98(3):352-9. PubMed: 23455547 MGI: J:211447
Pejnovic N; Vratimos A; Lee SH; Popadic D; Takeda K; Akira S; Chan WL. 2009. Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet. Mol Immunol 47(1):37-45. PubMed: 19201478 MGI: J:155263
Peluzio MC; Miguel E Jr; Drumond TC; Cesar GC; Santiago HC; Teixeira MM; Vieira EC; Arantes RM; Alvarez-Leite JI. 2003. Monocyte chemoattractant protein-1 involvement in the alpha-tocopherol-induced reduction of atherosclerotic lesions in apolipoprotein E knockout mice. Br J Nutr 90(1):3-11. PubMed: 12844369 MGI: J:106130
Pendse AA; Johnson LA; Kim HS; McNair M; Nipp CT; Wilhelm C; Maeda N. 2012. Pro- and antiatherogenic effects of a dominant-negative P465L mutation of peroxisome proliferator-activated receptor-gamma in apolipoprotein E-Null mice. Arterioscler Thromb Vasc Biol 32(6):1436-44. PubMed: 22539598 MGI: J:197088
Perrella MA; Pellacani A; Layne MD; Patel A; Zhao D; Schreiber BM; Storch J; Feinberg MW; Hsieh CM; Haber E; Lee ME. 2001. Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. FASEB J 15(10):1774-6. PubMed: 11481226 MGI: J:70693
Perry HM; Oldham SN; Fahl SP; Que X; Gonen A; Harmon DB; Tsimikas S; Witztum JL; Bender TP; McNamara CA. 2013. Helix-loop-helix factor inhibitor of differentiation 3 regulates interleukin-5 expression and B-1a B cell proliferation. Arterioscler Thromb Vasc Biol 33(12):2771-9. PubMed: 24115031 MGI: J:222211
Persson L; Boren J; Nicoletti A; Hansson GK; Pekna M. 2005. Immunoglobulin treatment reduces atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice via the complement system. Clin Exp Immunol 142(3):441-5. PubMed: 16297155 MGI: J:107602
Persson L; Boren J; Robertson AK; Wallenius V; Hansson GK; Pekna M. 2004. Lack of complement factor C3, but not factor B, increases hyperlipidemia and atherosclerosis in apolipoprotein E-/- low-density lipoprotein receptor-/- mice. Arterioscler Thromb Vasc Biol 24(6):1062-7. PubMed: 15059809 MGI: J:102339
Petit-Turcotte C; Aumont N; Blain JF; Poirier J. 2007. Apolipoprotein E receptors and amyloid expression are modulated in an apolipoprotein E-dependent fashion in response to hippocampal deafferentation in rodent. Neuroscience 150(1):58-63. PubMed: 17935896 MGI: J:130789
Petrovan RJ; Yuan Y; Curtiss LK. 2008. Expression of the Lystbeige mutation is atheroprotective in chow-fed apolipoprotein E-deficient mice. J Lipid Res 49(2):429-37. PubMed: 17982137 MGI: J:131876
Pfankuch T; Rizk A; Olsen R; Poage C; Raber J. 2005. Role of circulating androgen levels in effects of apoE4 on cognitive function. Brain Res 1053(1-2):88-96. PubMed: 16054121 MGI: J:100285
Piedrahita JA; Zhang SH; Hagaman JR; Oliver PM; Maeda N. 1992. Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. Proc Natl Acad Sci U S A 89(10):4471-5. PubMed: 1584779 MGI: J:1050
Podrez EA; Byzova TV; Febbraio M; Salomon RG; Ma Y; Valiyaveettil M; Poliakov E; Sun M; Finton PJ; Curtis BR; Chen J; Zhang R; Silverstein RL; Hazen SL. 2007. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nat Med 13(9):1086-95. PubMed: 17721545 MGI: J:125153
Poeckel D; Zemski Berry KA; Murphy RC; Funk CD. 2009. Dual 12/15- and 5-lipoxygenase deficiency in macrophages alters arachidonic acid metabolism and attenuates peritonitis and atherosclerosis in apoe knock-out mice. J Biol Chem 284(31):21077-89. PubMed: 19509298 MGI: J:153174
Pola R; Gaetani E; Flex A; Aprahamian T; Proia AS; Bosch-Marce M; Smith RC; Pola P. 2003. Peripheral nerve ischemia: apolipoprotein E deficiency results in impaired functional recovery and reduction of associated intraneural angiogenic response. Exp Neurol 184(1):264-73. PubMed: 14637097 MGI: J:118461
Ponnuswamy P; Ostermeier E; Schrottle A; Chen J; Huang PL; Ertl G; Nieswandt B; Kuhlencordt PJ. 2009. Oxidative stress and compartment of gene expression determine proatherosclerotic effects of inducible nitric oxide synthase. Am J Pathol 174(6):2400-10. PubMed: 19465644 MGI: J:148912
Ponnuswamy P; Schrottle A; Ostermeier E; Gruner S; Huang PL; Ertl G; Hoffmann U; Nieswandt B; Kuhlencordt PJ. 2012. eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. PLoS One 7(1):e30193. PubMed: 22291917 MGI: J:224062
Popko B; Goodrum JF; Bouldin TW; Zhang SH; Maeda N. 1993. Nerve regeneration occurs in the absence of apolipoprotein E in mice. J Neurochem 60(3):1155-8. PubMed: 8436967 MGI: J:115371
Postea O; Vasina EM; Cauwenberghs S; Projahn D; Liehn EA; Lievens D; Theelen W; Kramp BK; Butoi ED; Soehnlein O; Heemskerk JW; Ludwig A; Weber C; Koenen RR. 2012. Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia. Arterioscler Thromb Vasc Biol 32(5):1186-93. PubMed: 22383701 MGI: J:196930
Potteaux S; Gautier EL; Hutchison SB; van Rooijen N; Rader DJ; Thomas MJ; Sorci-Thomas MG; Randolph GJ. 2011. Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regression. J Clin Invest 121(5):2025-36. PubMed: 21505265 MGI: J:173940
Poupel L; Boissonnas A; Hermand P; Dorgham K; Guyon E; Auvynet C; Charles FS; Lesnik P; Deterre P; Combadiere C. 2013. Pharmacological inhibition of the chemokine receptor, CX3CR1, reduces atherosclerosis in mice. Arterioscler Thromb Vasc Biol 33(10):2297-305. PubMed: 23887641 MGI: J:222227
Pourcet B; Feig JE; Vengrenyuk Y; Hobbs AJ; Kepka-Lenhart D; Garabedian MJ; Morris SM Jr; Fisher EA; Pineda-Torra I. 2011. LXRalpha regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8. Circ Res 109(5):492-501. PubMed: 21757649 MGI: J:186595
Powell DR; Gay JP; Wilganowski N; Doree D; Savelieva KV; Lanthorn TH; Read R; Vogel P; Hansen GM; Brommage R; Ding ZM; Desai U; Zambrowicz B. 2015. Diacylglycerol Lipase alpha Knockout Mice Demonstrate Metabolic and Behavioral Phenotypes Similar to Those of Cannabinoid Receptor 1 Knockout Mice. Front Endocrinol (Lausanne) 6:86. PubMed: 26082754 MGI: J:233545
Pratico D; Cyrus T; Li H; FitzGerald GA. 2000. Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis Blood 96(12):3823-6. PubMed: 11090066 MGI: J:66258
Pratico D; Rokach J; Tangirala RK. 1999. Brains of aged apolipoprotein E-deficient mice have increased levels of F2-isoprostanes, in vivo markers of lipid peroxidation. J Neurochem 73(2):736-41. PubMed: 10428071 MGI: J:111985
Prins PA; Hill MF; Airey D; Nwosu S; Perati PR; Tavori H; F Linton M; Kon V; Fazio S; Sampson UK. 2014. Angiotensin-induced abdominal aortic aneurysms in hypercholesterolemic mice: role of serum cholesterol and temporal effects of exposure. PLoS One 9(1):e84517. PubMed: 24465413 MGI: J:212302
Proctor BM; Ren J; Chen Z; Schneider JG; Coleman T; Lupu TS; Semenkovich CF; Muslin AJ. 2007. Grb2 is required for atherosclerotic lesion formation. Arterioscler Thromb Vasc Biol 27(6):1361-7. PubMed: 17363695 MGI: J:134913
Puolivali J; Pradier L; Riekkinen P Jr. 2000. Impaired recovery of noradrenaline levels in apolipoprotein E-deficient mice after N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine lesion Neuroscience 95(2):353-8. PubMed: 10658614 MGI: J:60513
Qi J; Yang P; Yi B; Huo Y; Chen M; Zhang J; Sun J. 2015. Heat shock protein 90 inhibition by 17-DMAG attenuates abdominal aortic aneurysm formation in mice. Am J Physiol Heart Circ Physiol 308(8):H841-52. PubMed: 25637544 MGI: J:220745
Qiao JH; Tripathi J; Mishra NK; Cai Y; Tripathi S; Wang XP; Imes S ; Fishbein MC ; Clinton SK ; Libby P ; Lusis AJ ; Rajavashisth TB. 1997. Role of macrophage colony-stimulating factor in atherosclerosis: studies of osteopetrotic mice. Am J Pathol 150(5):1687-99. PubMed: 9137093 MGI: J:40136
Qiao X; Cummins DJ; Paul SM. 2001. Neuroinflammation-induced acceleration of amyloid deposition in the APPV717F transgenic mouse. Eur J Neurosci 14(3):474-82. PubMed: 11553297 MGI: J:128174
Qin Z; Itoh S; Jeney V; Ushio-Fukai M; Fukai T. 2006. Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress. FASEB J 20(2):334-6. PubMed: 16371425 MGI: J:105736
Qing H; Liu Y; Zhao Y; Aono J; Jones KL; Heywood EB; Howatt D; Binkley CM; Daugherty A; Liang Y; Bruemmer D. 2014. Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic stem cells accelerates atherosclerosis. Stem Cells 32(9):2419-29. PubMed: 24806827 MGI: J:216777
Quillard T; Araujo HA; Franck G; Tesmenitsky Y; Libby P. 2014. Matrix metalloproteinase-13 predominates over matrix metalloproteinase-8 as the functional interstitial collagenase in mouse atheromata. Arterioscler Thromb Vasc Biol 34(6):1179-86. PubMed: 24723558 MGI: J:223611
Qureshi AA; Salser WA; Parmar R; Emeson EE. 2001. Novel tocotrienols of rice bran inhibit atherosclerotic lesions in C57BL/6 ApoE-deficient mice. J Nutr 131(10):2606-18. PubMed: 11584079 MGI: J:72067
Raber J; Akana SF; Bhatnagar S; Dallman MF; Wong D; Mucke L. 2000. Hypothalamic-pituitary-adrenal dysfunction in Apoe(-/-) mice: possible role in behavioral and metabolic alterations. J Neurosci 20(5):2064-71. PubMed: 10684907 MGI: J:60585
Raber J; Bongers G; LeFevour A; Buttini M; Mucke L. 2002. Androgens protect against apolipoprotein E4-induced cognitive deficits. J Neurosci 22(12):5204-9. PubMed: 12077215 MGI: J:109059
Raber J; Wong D; Buttini M; Orth M; Bellosta S; Pitas RE; Mahley RW; Mucke L. 1998. Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females. Proc Natl Acad Sci U S A 95(18):10914-9. PubMed: 9724804 MGI: J:100975
Raber J; Wong D; Yu GQ; Buttini M; Mahley RW; Pitas RE; Mucke L. 2000. Apolipoprotein E and cognitive performance. Nature 404(6776):352-4. PubMed: 10746713 MGI: J:129695
Rafatian N; Karunakaran D; Rayner KJ; Leenen FH; Milne RW; Whitman SC. 2013. Cathepsin G deficiency decreases complexity of atherosclerotic lesions in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 305(8):H1141-8. PubMed: 23934850 MGI: J:202861
Rahaman SO; Lennon DJ; Febbraio M; Podrez EA; Hazen SL; Silverstein RL. 2006. A CD36-dependent signaling cascade is necessary for macrophage foam cell formation. Cell Metab 4(3):211-21. PubMed: 16950138 MGI: J:129743
Rahaman SO; Swat W; Febbraio M; Silverstein RL. 2011. Vav family Rho guanine nucleotide exchange factors regulate CD36-mediated macrophage foam cell formation. J Biol Chem 286(9):7010-7. PubMed: 21209086 MGI: J:170538
Rahman A; Akterin S; Flores-Morales A; Crisby M; Kivipelto M; Schultzberg M; Cedazo-Minguez A. 2005. High cholesterol diet induces tau hyperphosphorylation in apolipoprotein E deficient mice. FEBS Lett 579(28):6411-6. PubMed: 16288750 MGI: J:103774
Rahman SM; Van Dam AM; Schultzberg M; Crisby M. 2005. High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice. J Neuroimmunol 169(1-2):59-67. PubMed: 16198427 MGI: J:106397
Raife TJ; Dwyre DM; Stevens JW; Erger RA; Leo L; Wilson KM; Fernandez JA; Wilder J; Kim HS; Griffin JH; Maeda N; Lentz SR. 2011. Human thrombomodulin knock-in mice reveal differential effects of human thrombomodulin on thrombosis and atherosclerosis. Arterioscler Thromb Vasc Biol 31(11):2509-17. PubMed: 21885846 MGI: J:191461
Raizman JE; Chen YX; Seibert T; Hibbert B; Cuerrier CM; Salari S; Zhao X; Hu T; Shi C; Ma X; Simard T; Caravaggio J; Rayner K; Bowdish D; Moore K; O'Brien ER. 2013. Heat shock protein-27 attenuates foam cell formation and atherogenesis by down-regulating scavenger receptor-A expression via NF-kappaB signaling. Biochim Biophys Acta 1831(12):1721-8. PubMed: 23939398 MGI: J:204093
Raj T; Kanellakis P; Pomilio G; Jennings G; Bobik A; Agrotis A. 2006. Inhibition of fibroblast growth factor receptor signaling attenuates atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 26(8):1845-51. PubMed: 16709940 MGI: J:127978
Rajwani A; Ezzat V; Smith J; Yuldasheva NY; Duncan ER; Gage M; Cubbon RM; Kahn MB; Imrie H; Abbas A; Viswambharan H; Aziz A; Sukumar P; Vidal-Puig A; Sethi JK; Xuan S; Shah AM; Grant PJ; Porter KE; Kearney MT; Wheatcroft SB. 2012. Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis. Diabetes 61(4):915-24. PubMed: 22357965 MGI: J:196733
Ramassamy C; Averill D; Beffert U; Theroux L; Lussier-Cacan S; Cohn JS; Christen Y; Schoofs A; Davignon J; Poirier J. 2000. Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain. Neurobiol Dis 7(1):23-37. PubMed: 10671320 MGI: J:60765
Ramassamy C; Krzywkowski P; Averill D; Lussier-Cacan S; Theroux L; Christen Y; Davignon J; Poirier J. 2001. Impact of apoE deficiency on oxidative insults and antioxidant levels in the brain. Brain Res Mol Brain Res 86(1-2):76-83. PubMed: 11165374 MGI: J:67204
Ramos CL; Huo Y; Jung U; Ghosh S; Manka DR; Sarembock IJ; Ley K. 1999. Direct demonstration of P-selectin- and VCAM-1-dependent mononuclear cell rolling in early atherosclerotic lesions of apolipoprotein E-deficient mice. Circ Res 84(11):1237-44. PubMed: 10364560 MGI: J:55953
Rask-Madsen C; Buonomo E; Li Q; Park K; Clermont AC; Yerokun O; Rekhter M; King GL. 2012. Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol 32(5):1124-31. PubMed: 22426129 MGI: J:196925
Rask-Madsen C; Li Q; Freund B; Feather D; Abramov R; Wu IH; Chen K; Yamamoto-Hiraoka J; Goldenbogen J; Sotiropoulos KB; Clermont A; Geraldes P; Dall'Osso C; Wagers AJ; Huang PL; Rekhter M; Scalia R; Kahn CR; King GL. 2010. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab 11(5):379-89. PubMed: 20444418 MGI: J:160928
Rateri DL; Howatt DA; Moorleghen JJ; Charnigo R; Cassis LA; Daugherty A. 2011. Prolonged infusion of angiotensin II in apoE(-/-) mice promotes macrophage recruitment with continued expansion of abdominal aortic aneurysm. Am J Pathol 179(3):1542-8. PubMed: 21763672 MGI: J:176318
Rattazzi M; Bennett BJ; Bea F; Kirk EA; Ricks JL; Speer M; Schwartz SM; Giachelli CM; Rosenfeld ME. 2005. Calcification of advanced atherosclerotic lesions in the innominate arteries of ApoE-deficient mice: potential role of chondrocyte-like cells. Arterioscler Thromb Vasc Biol 25(7):1420-5. PubMed: 15845913 MGI: J:114224
Raveendran VV; Kassel KM; Smith DD; Luyendyk JP; Williams KJ; Cherian R; Reed GA; Flynn CA; Csanaky IL; Lickteig AL; Pratt-Hyatt MJ; Klaassen CD; Dileepan KN. 2014. H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice. Am J Physiol Gastrointest Liver Physiol 307(2):G219-28. PubMed: 24852568 MGI: J:221719
Rayner K; Chen YX; McNulty M; Simard T; Zhao X; Wells DJ; de Belleroche J; O'Brien ER. 2008. Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A. Circ Res 103(2):133-41. PubMed: 18566345 MGI: J:151372
Reardon CA; Blachowicz L; White T; Cabana V; Wang Y; Lukens J; Bluestone J; Getz GS. 2001. Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 21(6):1011-6. PubMed: 11397712 MGI: J:103188
Reardon CA; Miller ER; Blachowicz L; Lukens J; Binder CJ; Witztum JL; Getz GS. 2004. Autoantibodies to OxLDL fail to alter the clearance of injected OxLDL in apolipoprotein E-deficient mice. J Lipid Res 45(7):1347-54. PubMed: 15102879 MGI: J:90652
Recio C; Oguiza A; Lazaro I; Mallavia B; Egido J; Gomez-Guerrero C. 2014. Suppressor of cytokine signaling 1-derived peptide inhibits Janus kinase/signal transducers and activators of transcription pathway and improves inflammation and atherosclerosis in diabetic mice. Arterioscler Thromb Vasc Biol 34(9):1953-60. PubMed: 25012131 MGI: J:227174
Reddick RL; Zhang SH; Maeda N. 1994. Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression [published erratum appears in Arterioscler Thromb 1994 May;14(5):839] Arterioscler Thromb 14(1):141-7. PubMed: 8274470 MGI: J:28538
Reddy ST; Nguyen JT; Grijalva V; Hough G; Hama S; Navab M; Fogelman AM. 2004. Potential role for mitogen-activated protein kinase phosphatase-1 in the development of atherosclerotic lesions in mouse models. Arterioscler Thromb Vasc Biol 24(9):1676-81. PubMed: 15242861 MGI: J:102220
Reeve JL; Stenson-Cox C; O'Doherty A; Porn-Ares I; Ares M; O'Brien T; Samali A. 2007. OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/- mice aortas. Biochem Biophys Res Commun 356(3):681-6. PubMed: 17374365 MGI: J:121476
Reich EE; Montine KS; Gross MD; Roberts LJ 2nd; Swift LL; Morrow JD; Montine TJ. 2001. Interactions between apolipoprotein E gene and dietary alpha-tocopherol influence cerebral oxidative damage in aged mice. J Neurosci 21(16):5993-9. PubMed: 11487622 MGI: J:123803
Reifenberg K; Cheng F; Orning C; Crain J; Kupper I; Wiese E; Protschka M; Blessing M; Lackner KJ; Torzewski M. 2012. Overexpression of TGF-ss1 in macrophages reduces and stabilizes atherosclerotic plaques in ApoE-deficient mice. PLoS One 7(7):e40990. PubMed: 22829904 MGI: J:189586
Reifenberg K; Cheng F; Twardowski L; Kupper I; Wiese E; Bollmann F; Kleinert H; Blessing M; Lackner KJ; Torzewski M. 2013. T cell-specific overexpression of TGFss1 fails to influence atherosclerosis in ApoE-deficient mice. PLoS One 8(12):e81444. PubMed: 24339930 MGI: J:209736
Reifenberg K; Lehr HA; Baskal D; Wiese E; Schaefer SC; Black S; Samols D; Torzewski M; Lackner KJ; Husmann M; Blettner M; Bhakdi S. 2005. Role of C-reactive protein in atherogenesis: can the apolipoprotein E knockout mouse provide the answer? Arterioscler Thromb Vasc Biol 25(8):1641-6. PubMed: 15920030 MGI: J:114340
Reis ED; Roque M; Dansky H; Fallon JT; Badimon JJ; Cordon-Cardo C; Shiff SJ; Fisher EA. 2000. Sulindac inhibits neointimal formation after arterial injury in wild-type and apolipoprotein E-deficient mice Proc Natl Acad Sci U S A 97(23):12764-9. PubMed: 11027305 MGI: J:65802
Rekhter M; Staschke K; Estridge T; Rutherford P; Jackson N; Gifford-Moore D; Foxworthy P; Reidy C; Huang XD; Kalbfleisch M; Hui K; Kuo MS; Gilmour R; Vlahos CJ. 2008. Genetic ablation of IRAK4 kinase activity inhibits vascular lesion formation. Biochem Biophys Res Commun 367(3):642-8. PubMed: 18190779 MGI: J:131296
Revermann M; Schloss M; Barbosa-Sicard E; Mieth A; Liebner S; Morisseau C; Geisslinger G; Schermuly RT; Fleming I; Hammock BD; Brandes RP. 2010. Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice. Arterioscler Thromb Vasc Biol 30(5):909-14. PubMed: 20224052 MGI: J:175818
Richez C; Richards RJ; Duffau P; Weitzner Z; Andry CD; Rifkin IR; Aprahamian T. 2013. The effect of mycophenolate mofetil on disease development in the gld.apoE (-/-) mouse model of accelerated atherosclerosis and systemic lupus erythematosus. PLoS One 8(4):e61042. PubMed: 23577189 MGI: J:200141
Rivera MF; Lee JY; Aneja M; Goswami V; Liu L; Velsko IM; Chukkapalli SS; Bhattacharyya I; Chen H; Lucas AR; Kesavalu LN. 2013. Polymicrobial infection with major periodontal pathogens induced periodontal disease and aortic atherosclerosis in hyperlipidemic ApoE(null) mice. PLoS One 8(2):e57178. PubMed: 23451182 MGI: J:199329
Rizk-Jackson A; Robertson J; Raber J. 2008. Tfm-AR modulates the effects of ApoE4 on cognition. J Neurochem 105(1):63-7. PubMed: 18039320 MGI: J:135450
Robbins CS; Chudnovskiy A; Rauch PJ; Figueiredo JL; Iwamoto Y; Gorbatov R; Etzrodt M; Weber GF; Ueno T; van Rooijen N; Mulligan-Kehoe MJ; Libby P; Nahrendorf M; Pittet MJ; Weissleder R; Swirski FK. 2012. Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation 125(2):364-74. PubMed: 22144566 MGI: J:193795
Robbins CS; Hilgendorf I; Weber GF; Theurl I; Iwamoto Y; Figueiredo JL; Gorbatov R; Sukhova GK; Gerhardt LM; Smyth D; Zavitz CC; Shikatani EA; Parsons M; van Rooijen N; Lin HY; Husain M; Libby P; Nahrendorf M; Weissleder R; Swirski FK. 2013. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med 19(9):1166-72. PubMed: 23933982 MGI: J:201890
Robertson AK; Rudling M; Zhou X; Gorelik L; Flavell RA; Hansson GK. 2003. Disruption of TGF-beta signaling in T cells accelerates atherosclerosis. J Clin Invest 112(9):1342-50. PubMed: 14568988 MGI: J:86532
Robertson J; Curley J; Kaye J; Quinn J; Pfankuch T; Raber J. 2005. apoE isoforms and measures of anxiety in probable AD patients and Apoe-/- mice. Neurobiol Aging 26(5):637-43. PubMed: 15708438 MGI: J:101973
Robertson TA; Dutton NS; Martins RN; Taddei K; Papadimitriou JM. 2000. Comparison of astrocytic and myocytic metabolic dysregulation in apolipoprotein E deficient and human apolipoprotein E transgenic mice. Neuroscience 98(2):353-9. PubMed: 10854768 MGI: J:119594
Rocha VZ; Folco EJ; Sukhova G; Shimizu K; Gotsman I; Vernon AH; Libby P. 2008. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res 103(5):467-76. PubMed: 18658050 MGI: J:152646
Rodriguez JJ; Olabarria M; Chvatal A; Verkhratsky A. 2009. Astroglia in dementia and Alzheimer's disease. Cell Death Differ 16(3):378-85. PubMed: 19057621 MGI: J:158080
Rohwedder I; Montanez E; Beckmann K; Bengtsson E; Duner P; Nilsson J; Soehnlein O; Fassler R. 2012. Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation. EMBO Mol Med 4(7):564-76. PubMed: 22514136 MGI: J:231132
Roselaar SE; Kakkanathu PX; Daugherty A. 1996. Lymphocyte populations in atherosclerotic lesions of apoE -/- and LDL receptor -/- mice. Decreasing density with disease progression. Arterioscler Thromb Vasc Biol 16(8):1013-8. PubMed: 8696940 MGI: J:111962
Rosenfeld ME; Polinsky P; Virmani R; Kauser K; Rubanyi G; Schwartz SM. 2000. Advanced atherosclerotic lesions in the innominate artery of the ApoE knockout mouse. Arterioscler Thromb Vasc Biol 20(12):2587-92. PubMed: 11116057 MGI: J:102940
Rossignol P; Luttun A; Martin-Ventura JL; Lupu F; Carmeliet P; Collen D; Angles-Cano E; Lijnen HR. 2006. Plasminogen activation: a mediator of vascular smooth muscle cell apoptosis in atherosclerotic plaques. J Thromb Haemost 4(3):664-70. PubMed: 16460449 MGI: J:135792
Roth Flach RJ; Skoura A; Matevossian A; Danai LV; Zheng W; Cortes C; Bhattacharya SK; Aouadi M; Hagan N; Yawe JC; Vangala P; Menendez LG; Cooper MP; Fitzgibbons TP; Buckbinder L; Czech MP. 2015. Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis. Nat Commun 6:8995. PubMed: 26688060 MGI: J:239995
Rotzius P; Soehnlein O; Kenne E; Lindbom L; Nystrom K; Thams S; Eriksson EE. 2009. ApoE(-/-)/lysozyme M(EGFP/EGFP) mice as a versatile model to study monocyte and neutrophil trafficking in atherosclerosis. Atherosclerosis 202(1):111-8. PubMed: 18508059 MGI: J:191563
Rouis M; Adamy C; Duverger N; Lesnik P; Horellou P; Moreau M; Emmanuel F; Caillaud JM; Laplaud PM; Dachet C; Chapman MJ. 1999. Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinase-1 reduces atherosclerotic lesions in apolipoprotein E-deficient mice. Circulation 100(5):533-40. PubMed: 10430768 MGI: J:57414
Rousselet E; Marcinkiewicz J; Kriz J; Zhou A; Hatten ME; Prat A; Seidah NG. 2011. PCSK9 reduces the protein levels of the LDL receptor in mouse brain during development and after ischemic stroke. J Lipid Res 52(7):1383-91. PubMed: 21518694 MGI: J:174826
Rowlan JS; Li Q; Manichaikul A; Wang Q; Matsumoto AH; Shi W. 2013. Atherosclerosis susceptibility Loci identified in an extremely atherosclerosis-resistant mouse strain. J Am Heart Assoc 2(4):e000260. PubMed: 23938286 MGI: J:237473
Rowlan JS; Zhang Z; Wang Q; Fang Y; Shi W. 2013. New quantitative trait loci for carotid atherosclerosis identified in an intercross derived from apolipoprotein E-deficient mouse strains. Physiol Genomics 45(8):332-42. PubMed: 23463770 MGI: J:197549
Rozenberg I; Sluka SH; Rohrer L; Hofmann J; Becher B; Akhmedov A; Soliz J; Mocharla P; Boren J; Johansen P; Steffel J; Watanabe T; Luscher TF; Tanner FC. 2010. Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins. Arterioscler Thromb Vasc Biol 30(5):923-30. PubMed: 20203300 MGI: J:175819
Rozenberg O; Rosenblat M; Coleman R; Shih DM; Aviram M. 2003. Paraoxonase (PON1) deficiency is associated with increased macrophage oxidative stress: studies in PON1-knockout mice. Free Radic Biol Med 34(6):774-84. PubMed: 12633754 MGI: J:82696
Rozenberg O; Shiner M; Aviram M; Hayek T. 2008. Paraoxonase 1 (PON1) attenuates diabetes development in mice through its antioxidative properties. Free Radic Biol Med 44(11):1951-9. PubMed: 18358245 MGI: J:136069
Ruby MA; Nomura DK; Hudak CS; Mangravite LM; Chiu S; Casida JE; Krauss RM. 2008. Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins. Proc Natl Acad Sci U S A 105(38):14561-6. PubMed: 18794527 MGI: J:142587
Rudolf M; Mohi A; Dettbarn MC; Miura Y; Aherrahrou Z; Ranjbar M; Mutus B; Knobloch JK. 2014. Detection of esterified cholesterol in murine Bruch's membrane wholemounts with a perfringolysin O-based cholesterol marker. Invest Ophthalmol Vis Sci 55(8):4759-67. PubMed: 24985479 MGI: J:230152
Saederup N; Cardona AE; Croft K; Mizutani M; Cotleur AC; Tsou CL; Ransohoff RM; Charo IF. 2010. Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice. PLoS One 5(10):e13693. PubMed: 21060874 MGI: J:166664
Saederup N; Chan L; Lira SA; Charo IF. 2008. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesis. Circulation 117(13):1642-8. PubMed: 18165355 MGI: J:153310
Sag D; Cekic C; Wu R; Linden J; Hedrick CC. 2015. The cholesterol transporter ABCG1 links cholesterol homeostasis and tumour immunity. Nat Commun 6:6354. PubMed: 25724068 MGI: J:221785
Sager HB; Heidt T; Hulsmans M; Dutta P; Courties G; Sebas M; Wojtkiewicz GR; Tricot B; Iwamoto Y; Sun Y; Weissleder R; Libby P; Swirski FK; Nahrendorf M. 2015. Targeting Interleukin-1beta Reduces Leukocyte Production After Acute Myocardial Infarction. Circulation 132(20):1880-90. PubMed: 26358260 MGI: J:239050
Saito T; Hasegawa Y; Ishigaki Y; Yamada T; Gao J; Imai J; Uno K; Kaneko K; Ogihara T; Shimosawa T; Asano T; Fujita T; Oka Y; Katagiri H. 2013. Importance of endothelial NF-kappaB signalling in vascular remodelling and aortic aneurysm formation. Cardiovasc Res 97(1):106-14. PubMed: 23015640 MGI: J:210070
Sakamoto S; Tsuruda T; Hatakeyama K; Imamura T; Asada Y; Kitamura K. 2014. Impact of age-dependent adventitia inflammation on structural alteration of abdominal aorta in hyperlipidemic mice. PLoS One 9(8):e105739. PubMed: 25153991 MGI: J:223273
Sales VL; Sukhova GK; Lopez-Ilasaca MA; Libby P; Dzau VJ; Pratt RE. 2005. Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. Circulation 112(21):3328-36. PubMed: 16286588 MGI: J:116912
Salguero G; Schuett H; Jagielska J; Schley R; Tallone E; Luchtefeld M; Drexler H; Muller W; Grote K; Schieffer B. 2009. Hepatocyte gp130 deficiency reduces vascular remodeling after carotid artery ligation. Hypertension 54(5):1035-42. PubMed: 19805641 MGI: J:166312
Samokhin AO; Buhling F; Theissig F; Bromme D. 2010. ApoE-deficient mice on cholate-containing high-fat diet reveal a pathology similar to lung sarcoidosis. Am J Pathol 176(3):1148-56. PubMed: 20093498 MGI: J:158353
Samson T; van Buul JD; Kroon J; Welch C; Bakker EN; Matlung HL; van den Berg TK; Sharek L; Doerschuk C; Hahn K; Burridge K. 2013. The guanine-nucleotide exchange factor SGEF plays a crucial role in the formation of atherosclerosis. PLoS One 8(1):e55202. PubMed: 23372835 MGI: J:195919
Samyn H; Moerland M; van Gent T; van Haperen R; van Tol A; de Crom R. 2009. Reduction of HDL levels lowers plasma PLTP and affects its distribution among lipoproteins in mice. Biochim Biophys Acta 1791(8):790-6. PubMed: 19422933 MGI: J:153479
Sandberg WJ; Halvorsen B; Yndestad A; Smith C; Otterdal K; Brosstad FR; Froland SS; Olofsson PS; Damas JK; Gullestad L; Hansson GK; Oie E; Aukrust P. 2009. Inflammatory interaction between LIGHT and proteinase-activated receptor-2 in endothelial cells: potential role in atherogenesis. Circ Res 104(1):60-8. PubMed: 19023130 MGI: J:156437
Sanz-Gonzalez SM; Barquin L; Garcia-Cao I; Roque M; Gonzalez JM; Fuster JJ; Castells MT; Flores JM; Serrano M; Andres V. 2007. Increased p53 gene dosage reduces neointimal thickening induced by mechanical injury but has no effect on native atherosclerosis. Cardiovasc Res 75(4):803-12. PubMed: 17570351 MGI: J:162732
Sastre C; Fernandez-Laso V; Madrigal-Matute J; Munoz-Garcia B; Moreno JA; Pastor-Vargas C; Llamas-Granda P; Burkly LC; Egido J; Martin-Ventura JL; Blanco-Colio LM. 2014. Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice. J Cell Mol Med 18(4):721-34. PubMed: 24479820 MGI: J:225250
Sastre C; Rubio-Navarro A; Buendia I; Gomez-Guerrero C; Blanco J; Mas S; Egido J; Blanco-Colio LM; Ortiz A; Moreno JA. 2013. Hyperlipidemia-associated renal damage decreases Klotho expression in kidneys from ApoE knockout mice. PLoS One 8(12):e83713. PubMed: 24386260 MGI: J:209843
Satoh K; Nigro P; Matoba T; O'Dell MR; Cui Z; Shi X; Mohan A; Yan C; Abe J; Illig KA; Berk BC. 2009. Cyclophilin A enhances vascular oxidative stress and the development of angiotensin II-induced aortic aneurysms. Nat Med 15(6):649-56. PubMed: 19430489 MGI: J:151171
Satoh K; Nigro P; Zeidan A; Soe NN; Jaffre F; Oikawa M; O'Dell MR; Cui Z; Menon P; Lu Y; Mohan A; Yan C; Blaxall BC; Berk BC. 2011. Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 31(5):1116-23. PubMed: 21330604 MGI: J:191491
Sayin VI; Khan OM; Pehlivanoglu LE; Staffas A; Ibrahim MX; Asplund A; Agren P; Nilton A; Bergstrom G; Bergo MO; Boren J; Lindahl P. 2014. Loss of one copy of Zfp148 reduces lesional macrophage proliferation and atherosclerosis in mice by activating p53. Circ Res 115(9):781-9. PubMed: 25212213 MGI: J:226877
Schapira K; Lutgens E; de Fougerolles A; Sprague A; Roemen A; Gardner H; Koteliansky V; Daemen M; Heeneman S. 2005. Genetic deletion or antibody blockade of alpha1beta1 integrin induces a stable plaque phenotype in ApoE-/- mice. Arterioscler Thromb Vasc Biol 25(9):1917-24. PubMed: 15976328 MGI: J:114326
Schieffer B; Selle T; Hilfiker A; Hilfiker-Kleiner D; Grote K; Tietge UJ; Trautwein C; Luchtefeld M; Schmittkamp C; Heeneman S; Daemen MJ; Drexler H. 2004. Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis. Circulation 110(22):3493-500. PubMed: 15557373 MGI: J:103918
Schierwagen R; Maybuchen L; Hittatiya K; Klein S; Uschner FE; Braga TT; Franklin BS; Nickenig G; Strassburg CP; Plat J; Sauerbruch T; Latz E; Lutjohann D; Zimmer S; Trebicka J. 2016. Statins improve NASH via inhibition of RhoA and Ras. Am J Physiol Gastrointest Liver Physiol 311(4):G724-G733. PubMed: 27634010 MGI: J:240513
Schilling AF; Schinke T; Munch C; Gebauer M; Niemeier A; Priemel M; Streichert T; Rueger JM; Amling M. 2005. Increased bone formation in mice lacking apolipoprotein E. J Bone Miner Res 20(2):274-82. PubMed: 15647822 MGI: J:111209
Schneider DJ; Hayes M; Wadsworth M; Taatjes H; Rincon M; Taatjes DJ; Sobel BE. 2004. Attenuation of neointimal vascular smooth muscle cellularity in atheroma by plasminogen activator inhibitor type 1 (PAI-1). J Histochem Cytochem 52(8):1091-9. PubMed: 15258185 MGI: J:136411
Schneider JG; Finck BN; Ren J; Standley KN; Takagi M; Maclean KH; Bernal-Mizrachi C; Muslin AJ; Kastan MB; Semenkovich CF. 2006. ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. Cell Metab 4(5):377-89. PubMed: 17084711 MGI: J:129761
Schober A; Nazari-Jahantigh M; Wei Y; Bidzhekov K; Gremse F; Grommes J; Megens RT; Heyll K; Noels H; Hristov M; Wang S; Kiessling F; Olson EN; Weber C. 2014. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med 20(4):368-76. PubMed: 24584117 MGI: J:210259
Schober A; Zernecke A; Liehn EA; von Hundelshausen P; Knarren S; Kuziel WA; Weber C. 2004. Crucial role of the CCL2/CCR2 axis in neointimal hyperplasia after arterial injury in hyperlipidemic mice involves early monocyte recruitment and CCL2 presentation on platelets. Circ Res 95(11):1125-33. PubMed: 15528472 MGI: J:103847
Schober JM; Chen N; Grzeszkiewicz TM; Jovanovic I; Emeson EE; Ugarova TP; Ye RD; Lau LF; Lam SC. 2002. Identification of integrin alpha(M)beta(2) as an adhesion receptor on peripheral blood monocytes for Cyr61 (CCN1) and connective tissue growth factor (CCN2): immediate-early gene products expressed in atherosclerotic lesions. Blood 99(12):4457-65. PubMed: 12036876 MGI: J:77053
Schreyer SA; Vick C; Lystig TC; Mystkowski P; LeBoeuf RC. 2002. LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice. Am J Physiol Endocrinol Metab 282(1):E207-14. PubMed: 11739102 MGI: J:75609
Schroder K; Vecchione C; Jung O; Schreiber JG; Shiri-Sverdlov R; van Gorp PJ; Busse R; Brandes RP. 2006. Xanthine oxidase inhibitor tungsten prevents the development of atherosclerosis in ApoE knockout mice fed a Western-type diet. Free Radic Biol Med 41(9):1353-60. PubMed: 17023262 MGI: J:114514
Schroeter MR; Leifheit-Nestler M; Hubert A; Schumann B; Gluckermann R; Eschholz N; Kruger N; Lutz S; Hasenfuss G; Konstantinides S; Schafer K. 2013. Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains. Cardiovasc Res 99(3):555-65. PubMed: 23723060 MGI: J:218655
Schulte S; Sukhova GK; Libby P. 2008. Genetically programmed biases in Th1 and th2 immune responses modulate atherogenesis. Am J Pathol 172(6):1500-8. PubMed: 18467709 MGI: J:136186
Schurmann C; Gremse F; Jo H; Kiessling F; Brandes RP. 2015. Micro-CT Technique Is Well Suited for Documentation of Remodeling Processes in Murine Carotid Arteries. PLoS One 10(6):e0130374. PubMed: 26086218 MGI: J:237797
Schwedler SB; Amann K; Wernicke K; Krebs A; Nauck M; Wanner C; Potempa LA; Galle J. 2005. Native C-reactive protein increases whereas modified C-reactive protein reduces atherosclerosis in apolipoprotein E-knockout mice. Circulation 112(7):1016-23. PubMed: 16087790 MGI: J:116864
Scott NJ; Cameron VA; Raudsepp S; Lewis LK; Simpson ER; Richards AM; Ellmers LJ. 2012. Generation and characterization of a mouse model of the metabolic syndrome: apolipoprotein E and aromatase double knockout mice. Am J Physiol Endocrinol Metab 302(5):E576-84. PubMed: 22185842 MGI: J:184647
Secchiero P; Candido R; Corallini F; Zacchigna S; Toffoli B; Rimondi E; Fabris B; Giacca M; Zauli G. 2006. Systemic tumor necrosis factor-related apoptosis-inducing ligand delivery shows antiatherosclerotic activity in apolipoprotein E-null diabetic mice. Circulation 114(14):1522-30. PubMed: 17000905 MGI: J:126407
Secchiero P; Corallini F; Pandolfi A; Consoli A; Candido R; Fabris B; Celeghini C; Capitani S; Zauli G. 2006. An increased osteoprotegerin serum release characterizes the early onset of diabetes mellitus and may contribute to endothelial cell dysfunction. Am J Pathol 169(6):2236-44. PubMed: 17148684 MGI: J:116226
Seehaus S; Shahzad K; Kashif M; Vinnikov IA; Schiller M; Wang H; Madhusudhan T; Eckstein V; Bierhaus A; Bea F; Blessing E; Weiler H; Frommhold D; Nawroth PP; Isermann B. 2009. Hypercoagulability inhibits monocyte transendothelial migration through protease-activated receptor-1-, phospholipase-Cbeta-, phosphoinositide 3-kinase-, and nitric oxide-dependent signaling in monocytes and promotes plaque stability. Circulation 120(9):774-84. PubMed: 19687358 MGI: J:167110
Segedy AK; Pyle AL; Li B; Zhang Y; Babaev VR; Jat P; Fazio S; Atkinson JB; Linton MF; Young PP. 2014. Identification of small proline-rich repeat protein 3 as a novel atheroprotective factor that promotes adaptive Akt signaling in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 34(12):2527-36. PubMed: 25278290 MGI: J:230470
Seitz A; Gourevitch D; Zhang XM; Clark L; Chen P; Kragol M; Levenkova N; Rux J; Samulewicz S; Heber-Katz E. 2005. Sense and antisense transcripts of the apolipoprotein E gene in normal and ApoE knockout mice, their expression after spinal cord injury and corresponding human transcripts. Hum Mol Genet 14(18):2661-70. PubMed: 16091415 MGI: J:103504
Sekiya M; Osuga J; Nagashima S; Ohshiro T; Igarashi M; Okazaki H; Takahashi M; Tazoe F; Wada T; Ohta K; Takanashi M; Kumagai M; Nishi M; Takase S; Yahagi N; Yagyu H; Ohashi K; Nagai R; Kadowaki T; Furukawa Y; Ishibashi S. 2009. Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis. Cell Metab 10(3):219-28. PubMed: 19723498 MGI: J:152385
Seno T; Hamaguchi M; Ashihara E; Kohno M; Ishino H; Yamamoto A; Kadoya M; Nakamura K; Murakami K; Matoba S; Maekawa T; Kawahito Y. 2011. 15-deoxy-Delta(1)(2),(1) prostaglandin J reduces the formation of atherosclerotic lesions in apolipoprotein E knockout mice. PLoS One 6(10):e25541. PubMed: 22003398 MGI: J:179609
Sentman ML; Brannstrom T; Westerlund S; Laukkanen MO; Yla-Herttuala S; Basu S; Marklund SL. 2001. Extracellular superoxide dismutase deficiency and atherosclerosis in mice. Arterioscler Thromb Vasc Biol 21(9):1477-82. PubMed: 11557675 MGI: J:103233
Shah PK; Nilsson J; Kaul S; Fishbein MC; Ageland H; Hamsten A; Johansson J; Karpe F; Cercek B. 1998. Effects of recombinant apolipoprotein A-I(Milano) on aortic atherosclerosis in apolipoprotein E-deficient mice. Circulation 97(8):780-5. PubMed: 9498542 MGI: J:47056
Shami A; Gustafsson R; Kalamajski S; Krams R; Segers D; Rauch U; Roos G; Nilsson J; Oldberg A; Hultgardh-Nilsson A. 2013. Fibromodulin deficiency reduces low-density lipoprotein accumulation in atherosclerotic plaques in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol 33(2):354-61. PubMed: 23202368 MGI: J:216908
Shamshiev AT; Ampenberger F; Ernst B; Rohrer L; Marsland BJ; Kopf M. 2007. Dyslipidemia inhibits Toll-like receptor-induced activation of CD8alpha-negative dendritic cells and protective Th1 type immunity. J Exp Med 204(2):441-52. PubMed: 17296788 MGI: J:125366
Shankman LS; Gomez D; Cherepanova OA; Salmon M; Alencar GF; Haskins RM; Swiatlowska P; Newman AA; Greene ES; Straub AC; Isakson B; Randolph GJ; Owens GK. 2015. KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med 21(6):628-37. PubMed: 25985364 MGI: J:228450
Shea TB; Rogers E; Ashline D; Ortiz D; Sheu MS. 2002. Apolipoprotein E deficiency promotes increased oxidative stress and compensatory increases in antioxidants in brain tissue. Free Radic Biol Med 33(8):1115-20. PubMed: 12374623 MGI: J:118781
Sheedy FJ; Grebe A; Rayner KJ; Kalantari P; Ramkhelawon B; Carpenter SB; Becker CE; Ediriweera HN; Mullick AE; Golenbock DT; Stuart LM; Latz E; Fitzgerald KA; Moore KJ. 2013. CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol 14(8):812-20. PubMed: 23812099 MGI: J:205721
Sheikine Y; Deodato B; Olofsson PS; Soderstrom LA; Lundberg AM; Bodin I; Rudling M; Theodorsson E; Hansson GK. 2010. Activation of VPAC1 receptors aggravates early atherosclerosis in hypercholesterolemic apolipoprotein E-deficient mice. Biochem Biophys Res Commun 402(3):471-6. PubMed: 20951679 MGI: J:166459
Shen J; Chandrasekharan UM; Ashraf MZ; Long E; Morton RE; Liu Y; Smith JD; DiCorleto PE. 2010. Lack of mitogen-activated protein kinase phosphatase-1 protects ApoE-null mice against atherosclerosis. Circ Res 106(5):902-10. PubMed: 20093631 MGI: J:170868
Shi W; Pei H; Fischer JJ; James JC; Angle JF; Matsumoto AH; Helm GA; Sarembock IJ. 2004. Neointimal formation in two apolipoprotein E-deficient mouse strains with different atherosclerosis susceptibility. J Lipid Res 45(11):2008-14. PubMed: 15314103 MGI: J:94175
Shi W; Wang X; Wong J; Hedrick CC; Wong H; Castellani LW; Lusis AJ. 2004. Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice. Biochem Biophys Res Commun 317(1):223-9. PubMed: 15047172 MGI: J:88891
Shih DM; Xia YR; Wang XP; Miller E; Castellani LW; Subbanagounder G; Cheroutre H; Faull KF; Berliner JA; Witztum JL; Lusis AJ. 2000. Combined serum paraoxonase knockout/apolipoprotein E knockout mice exhibit increased lipoprotein oxidation and atherosclerosis. J Biol Chem 275(23):17527-35. PubMed: 10748217 MGI: J:62750
Shih DM; Xia YR; Wang XP; Wang SS; Bourquard N; Fogelman AM; Lusis AJ; Reddy ST. 2007. Decreased obesity and atherosclerosis in human paraoxonase 3 transgenic mice. Circ Res 100(8):1200-7. PubMed: 17379834 MGI: J:135375
Shim J; Handberg A; Ostergren C; Falk E; Bentzon JF. 2011. Genetic susceptibility of the arterial wall is an important determinant of atherosclerosis in C57BL/6 and FVB/N mouse strains. Arterioscler Thromb Vasc Biol 31(8):1814-20. PubMed: 21571684 MGI: J:191861
Shin HK; Oka F; Kim JH; Atochin D; Huang PL; Ayata C. 2014. Endothelial dysfunction abrogates the efficacy of normobaric hyperoxia in stroke. J Neurosci 34(46):15200-7. PubMed: 25392489 MGI: J:217406
Shinohara M; Yamashita T; Tawa H; Takeda M; Sasaki N; Takaya T; Toh R; Takeuchi A; Ohigashi T; Shinohara K; Kawashima S; Yokoyama M; Hirata K; Momose A. 2008. Atherosclerotic plaque imaging using phase-contrast X-ray computed tomography. Am J Physiol Heart Circ Physiol 294(2):H1094-100. PubMed: 18083896 MGI: J:132318
Shinozaki S; Chiba T; Kokame K; Miyata T; Kaneko E; Shimokado K. 2013. A deficiency of Herp, an endoplasmic reticulum stress protein, suppresses atherosclerosis in ApoE knockout mice by attenuating inflammatory responses. PLoS One 8(10):e75249. PubMed: 24204574 MGI: J:209190
Silva AR; Aguilar EC; Alvarez-Leite JI; da Silva RF; Arantes RM; Bader M; Alenina N; Pelli G; Lenglet S; Galan K; Montecucco F; Mach F; Santos SH; Santos RA. 2013. Mas receptor deficiency is associated with worsening of lipid profile and severe hepatic steatosis in ApoE knockout mice. Am J Physiol Regul Integr Comp Physiol :. PubMed: 24089374 MGI: J:201802
Sims-Robinson C; Bakeman A; Glasser R; Boggs J; Pacut C; Feldman EL. 2016. The role of endoplasmic reticulum stress in hippocampal insulin resistance. Exp Neurol 277:261-7. PubMed: 26775176 MGI: J:229542
Singaraja RR; Fievet C; Castro G; James ER; Hennuyer N; Clee SM; Bissada N; Choy JC; Fruchart JC; McManus BM; Staels B; Hayden MR. 2002. Increased ABCA1 activity protects against atherosclerosis. J Clin Invest 110(1):35-42. PubMed: 12093886 MGI: J:77473
Singh NK; Kotla S; Dyukova E; Traylor JG Jr; Orr AW; Chernoff J; Marion TN; Rao GN. 2015. Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice. Nat Commun 6:7450. PubMed: 26104863 MGI: J:223014
Sinningen K; Rauner M; Goettsch C; Al-Fakhri N; Schoppet M; Hofbauer LC. 2013. Monocytic expression of osteoclast-associated receptor (OSCAR) is induced in atherosclerotic mice and regulated by oxidized low-density lipoprotein in vitro. Biochem Biophys Res Commun 437(2):314-8. PubMed: 23817038 MGI: J:205322
Siu KL; Cai H. 2014. Circulating tetrahydrobiopterin as a novel biomarker for abdominal aortic aneurysm. Am J Physiol Heart Circ Physiol 307(11):H1559-64. PubMed: 25260610 MGI: J:220800
Siu KL; Miao XN; Cai H. 2014. Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E null mice. PLoS One 9(2):e88899. PubMed: 24558445 MGI: J:213350
Sjoland H; Eitzman DT; Gordon D; Westrick R; Nabel EG; Ginsburg D. 2000. Atherosclerosis progression in LDL receptor-deficient and apolipoprotein E-deficient mice is independent of genetic alterations in plasminogen activator inhibitor-1. Arterioscler Thromb Vasc Biol 20(3):846-52. PubMed: 10712412 MGI: J:61287
Skoura A; Michaud J; Im DS; Thangada S; Xiong Y; Smith JD; Hla T. 2011. Sphingosine-1-phosphate receptor-2 function in myeloid cells regulates vascular inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol 31(1):81-5. PubMed: 20947824 MGI: J:184197
Smedlund KB; Birnbaumer L; Vazquez G. 2015. Increased size and cellularity of advanced atherosclerotic lesions in mice with endothelial overexpression of the human TRPC3 channel. Proc Natl Acad Sci U S A 112(17):E2201-6. PubMed: 25870279 MGI: J:221111
Smith DD; Tan X; Raveendran VV; Tawfik O; Stechschulte DJ; Dileepan KN. 2012. Mast cell deficiency attenuates progression of atherosclerosis and hepatic steatosis in apolipoprotein E-null mice. Am J Physiol Heart Circ Physiol 302(12):H2612-21. PubMed: 22505639 MGI: J:188087
Smith E; Prasad KM; Butcher M; Dobrian A; Kolls JK; Ley K; Galkina E. 2010. Blockade of interleukin-17A results in reduced atherosclerosis in apolipoprotein E-deficient mice. Circulation 121(15):1746-55. PubMed: 20368519 MGI: J:172628
Smith R; Petersen A; Bates GP; Brundin P; Li JY. 2005. Depletion of rabphilin 3A in a transgenic mouse model (R6/1) of Huntington's disease, a possible culprit in synaptic dysfunction. Neurobiol Dis 20(3):673-84. PubMed: 15967669 MGI: J:104634
Smook ML; van Leeuwen M; Heeringa P; Damoiseaux JG; Theunissen R; Daemen MJ; Lutgens E; Cohen Tervaert JW. 2008. Anti-oxLDL antibody isotype levels, as potential markers for progressive atherosclerosis in APOE and APOECD40L mice. Clin Exp Immunol 154(2):264-9. PubMed: 18778362 MGI: J:142416
So JS; Hur KY; Tarrio M; Ruda V; Frank-Kamenetsky M; Fitzgerald K; Koteliansky V; Lichtman AH; Iwawaki T; Glimcher LH; Lee AH. 2012. Silencing of lipid metabolism genes through IRE1alpha-mediated mRNA decay lowers plasma lipids in mice. Cell Metab 16(4):487-99. PubMed: 23040070 MGI: J:190921
Sobel BE; Schneider DJ; Lee YH; Pratley RE. 2006. Insulin resistance increases PAI-1 in the heart. Biochem Biophys Res Commun 346(1):102-7. PubMed: 16750510 MGI: J:110785
Soehnlein O; Wantha S; Simsekyilmaz S; Doring Y; Megens RT; Mause SF; Drechsler M; Smeets R; Weinandy S; Schreiber F; Gries T; Jockenhoevel S; Moller M; Vijayan S; van Zandvoort MA; Agerberth B; Pham CT; Gallo RL; Hackeng TM; Liehn EA; Zernecke A; Klee D; Weber C. 2011. Neutrophil-derived cathelicidin protects from neointimal hyperplasia. Sci Transl Med 3(103):103ra98. PubMed: 21974936 MGI: J:178318
Soh J; Iqbal J; Queiroz J; Fernandez-Hernando C; Hussain MM. 2013. MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Nat Med 19(7):892-900. PubMed: 23749231 MGI: J:199837
Solca C; Pandit B; Yu H; Tint GS; Patel SB. 2007. Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse. Mol Genet Metab 91(1):7-14. PubMed: 17197219 MGI: J:121454
Sommerville LJ; Kelemen SE; Autieri MV. 2008. Increased smooth muscle cell activation and neointima formation in response to injury in AIF-1 transgenic mice. Arterioscler Thromb Vasc Biol 28(1):47-53. PubMed: 17991871 MGI: J:147519
Son DJ; Kim SY; Han SS; Kim CW; Kumar S; Park BS; Lee SE; Yun YP; Jo H; Park YH. 2012. Piperlongumine inhibits atherosclerotic plaque formation and vascular smooth muscle cell proliferation by suppressing PDGF receptor signaling. Biochem Biophys Res Commun 427(2):349-54. PubMed: 22995306 MGI: J:190097
Sontag TJ; Carnemolla R; Vaisar T; Reardon CA; Getz GS. 2012. Naturally occurring variant of mouse apolipoprotein A-I alters the lipid and HDL association properties of the protein. J Lipid Res 53(5):951-63. PubMed: 22402133 MGI: J:184879
Sontag TJ; Chellan B; Bhanvadia CV; Getz GS; Reardon CA. 2015. Alginic acid cell entrapment: a novel method for measuring in vivo macrophage cholesterol homeostasis. J Lipid Res 56(2):470-83. PubMed: 25465389 MGI: J:219836
Sontag TJ; Krishack PA; Lukens JR; Bhanvadia CV; Getz GS; Reardon CA. 2014. Apolipoprotein A-I protection against atherosclerosis is dependent on genetic background. Arterioscler Thromb Vasc Biol 34(2):262-9. PubMed: 24334873 MGI: J:222825
Sontag TJ; Reardon CA. 2014. Polymorphisms of mouse apolipoprotein A-II alter its physical and functional nature. PLoS One 9(2):e88705. PubMed: 24520415 MGI: J:212949
Soro-Paavonen A; Watson AM; Li J; Paavonen K; Koitka A; Calkin AC; Barit D; Coughlan MT; Drew BG; Lancaster GI; Thomas M; Forbes JM; Nawroth PP; Bierhaus A; Cooper ME; Jandeleit-Dahm KA. 2008. Receptor for advanced glycation end products (RAGE) deficiency attenuates the development of atherosclerosis in diabetes. Diabetes 57(9):2461-9. PubMed: 18511846 MGI: J:141808
Sorrentino R; Yilmaz A; Schubert K; Crother TR; Pinto A; Shimada K; Arditi M; Chen S. 2015. A single infection with Chlamydia pneumoniae is sufficient to exacerbate atherosclerosis in ApoE deficient mice. Cell Immunol 294(1):25-32. PubMed: 25666507 MGI: J:223831
Soto I; Graham LC; Richter HJ; Simeone SN; Radell JE; Grabowska W; Funkhouser WK; Howell MC; Howell GR. 2015. APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction. PLoS Biol 13(10):e1002279. PubMed: 26512759 MGI: J:226383
Spin JM; Hsu M; Azuma J; Tedesco MM; Dyer JS; Maegdefessel L; Dalman RL; Tsao PS. 2011. Transcriptional Profiling and Network Analysis of the Murine Angiotensin II-Induced Abdominal Aortic Aneurysm. Physiol Genomics :. PubMed: 21712436 MGI: J:174621
Srivastava S; Vladykovskaya E; Barski OA; Spite M; Kaiserova K; Petrash JM; Chung SS; Hunt G; Dawn B; Bhatnagar A. 2009. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. Circ Res 105(8):793-802. PubMed: 19729598 MGI: J:169958
Srivastava S; Vladykovskaya EN; Haberzettl P; Sithu SD; D'Souza SE; States JC. 2009. Arsenic exacerbates atherosclerotic lesion formation and inflammation in ApoE-/- mice. Toxicol Appl Pharmacol 241(1):90-100. PubMed: 19682479 MGI: J:153899
Staprans I; Pan XM; Rapp JH; Grunfeld C; Feingold KR. 2000. Oxidized cholesterol in the diet accelerates the development of atherosclerosis in LDL receptor- and apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 20(3):708-14. PubMed: 10712395 MGI: J:103278
Stevens HY; Melchior B; Bell KS; Yun S; Yeh JC; Frangos JA. 2008. PECAM-1 is a critical mediator of atherosclerosis. Dis Model Mech 1(2-3):175-81. PubMed: 19048083 MGI: J:142083
Stewart CR; Stuart LM; Wilkinson K; van Gils JM; Deng J; Halle A; Rayner KJ; Boyer L; Zhong R; Frazier WA; Lacy-Hulbert A; Khoury JE; Golenbock DT; Moore KJ. 2010. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol 11(2):155-61. PubMed: 20037584 MGI: J:158401
Stewart FA; Heeneman S; Te Poele J; Kruse J; Russell NS; Gijbels M; Daemen M. 2006. Ionizing radiation accelerates the development of atherosclerotic lesions in ApoE-/- mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage. Am J Pathol 168(2):649-58. PubMed: 16436678 MGI: J:143858
Stolla M; Pelisek J; von Bruhl ML; Schafer A; Barocke V; Heider P; Lorenz M; Tirniceriu A; Steinhart A; Bauersachs J; Bray PF; Massberg S; Schulz C. 2012. Fractalkine is expressed in early and advanced atherosclerotic lesions and supports monocyte recruitment via CX3CR1. PLoS One 7(8):e43572. PubMed: 22916279 MGI: J:191688
Stoneman V; Braganza D; Figg N; Mercer J; Lang R; Goddard M; Bennett M. 2007. Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques. Circ Res 100(6):884-93. PubMed: 17322176 MGI: J:133717
Strack AM; Carballo-Jane E; Wang SP; Xue J; Ping X; McNamara LA; Thankappan A; Price O; Wolff M; Wu TJ; Kawka D; Mariano M; Burton C; Chang CH; Chen J; Menke J; Luell S; Zycband EI; Tong X; Raubertas R; Sparrow CP; Hubbard B; Woods J; O'Neill G; Waters MG; Sitlani A. 2013. Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis. J Lipid Res 54(1):177-88. PubMed: 23103473 MGI: J:192168
Strawbridge RJ; Hilding A; Silveira A; Osterholm C; Sennblad B; McLeod O; Tsikrika P; Foroogh F; Tremoli E; Baldassarre D; Veglia F; Rauramaa R; Smit AJ; Giral P; Kurl S; Mannarino E; Grossi E; Syvanen AC; Humphries SE; de Faire U; Ostenson CG; Maegdefessel L; Hamsten A; Backlund A. 2016. Soluble CD93 Is Involved in Metabolic Dysregulation but Does Not Influence Carotid Intima-Media Thickness. Diabetes 65(10):2888-99. PubMed: 27659228 MGI: J:240507
Strom A; Olin AI; Aspberg A; Hultgardh-Nilsson A. 2006. Fibulin-2 is present in murine vascular lesions and is important for smooth muscle cell migration. Cardiovasc Res 69(3):755-63. PubMed: 16409997 MGI: J:105710
Su YR; Dove DE; Major AS; Hasty AH; Boone B; Linton MF; Fazio S. 2005. Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1. Circulation 111(18):2373-81. PubMed: 15851589 MGI: J:111648
Su Z; Li Y; James JC; Matsumoto AH; Helm GA; Lusis AJ; Shi W. 2006. Genetic linkage of hyperglycemia, body weight and serum amyloid-P in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice. Hum Mol Genet 15(10):1650-8. PubMed: 16595606 MGI: J:108422
Su Z; Li Y; James JC; McDuffie M; Matsumoto AH; Helm GA; Weber JL; Lusis AJ; Shi W. 2006. Quantitative Trait Locus Analysis of Atherosclerosis in an Intercross Between C57BL/6 and C3H Mice Carrying the Mutant Apolipoprotein E Gene. Genetics 172(3):1799-807. PubMed: 16387874 MGI: J:106521
Suarna C; Wu BJ; Choy K; Mori T; Croft K; Cynshi O; Stocker R. 2006. Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency. Free Radic Biol Med 41(5):722-30. PubMed: 16895792 MGI: J:111987
Subbaiah PV; Jiang XC; Belikova NA; Aizezi B; Huang ZH; Reardon CA. 2012. Regulation of plasma cholesterol esterification by sphingomyelin: Effect of physiological variations of plasma sphingomyelin on lecithin-cholesterol acyltransferase activity. Biochim Biophys Acta 1821(6):908-13. PubMed: 22370449 MGI: J:185003
Subbarao K; Jala VR; Mathis S; Suttles J; Zacharias W; Ahamed J; Ali H; Tseng MT; Haribabu B. 2004. Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Arterioscler Thromb Vasc Biol 24(2):369-75. PubMed: 14656734 MGI: J:102012
Suen RS; Rampersad SN; Stewart DJ; Courtman DW. 2011. Differential roles of endothelin-1 in angiotensin II-induced atherosclerosis and aortic aneurysms in apolipoprotein E-null mice. Am J Pathol 179(3):1549-59. PubMed: 21718678 MGI: J:176329
Sugita M; Sugita H; Kaneki M. 2007. Farnesyltransferase inhibitor, manumycin a, prevents atherosclerosis development and reduces oxidative stress in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 27(6):1390-5. PubMed: 17363690 MGI: J:135085
Sui Y; Xu J; Rios-Pilier J; Zhou C. 2011. Deficiency of PXR decreases atherosclerosis in apoE-deficient mice. J Lipid Res 52(9):1652-9. PubMed: 21685500 MGI: J:175563
Sukhanov S; Higashi Y; Shai SY; Blackstock C; Galvez S; Vaughn C; Titterington J; Delafontaine P. 2011. Differential requirement for nitric oxide in IGF-1-induced anti-apoptotic, anti-oxidant and anti-atherosclerotic effects. FEBS Lett 585(19):3065-72. PubMed: 21872589 MGI: J:176427
Sukhova GK; Wang B; Libby P; Pan JH; Zhang Y; Grubb A; Fang K; Chapman HA; Shi GP. 2005. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res 96(3):368-75. PubMed: 15653570 MGI: J:106879
Sullivan PM; Mace BE; Maeda N; Schmechel DE. 2004. Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice. Neuroscience 124(4):725-33. PubMed: 15026113 MGI: J:89986
Sun C; Wu MH; Lee ES; Yuan SY. 2012. A disintegrin and metalloproteinase 15 contributes to atherosclerosis by mediating endothelial barrier dysfunction via Src family kinase activity. Arterioscler Thromb Vasc Biol 32(10):2444-51. PubMed: 22904271 MGI: J:201476
Sun C; Wu MH; Yuan SY. 2011. Nonmuscle myosin light-chain kinase deficiency attenuates atherosclerosis in apolipoprotein E-deficient mice via reduced endothelial barrier dysfunction and monocyte migration. Circulation 124(1):48-57. PubMed: 21670231 MGI: J:186297
Sun Y; Byon CH; Yuan K; Chen J; Mao X; Heath JM; Javed A; Zhang K; Anderson PG; Chen Y. 2012. Smooth muscle cell-specific runx2 deficiency inhibits vascular calcification. Circ Res 111(5):543-52. PubMed: 22773442 MGI: J:212649
Sussan TE; Jun J; Thimmulappa R; Bedja D; Antero M; Gabrielson KL; Polotsky VY; Biswal S. 2008. Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice. PLoS One 3(11):e3791. PubMed: 19023427 MGI: J:143903
Suzuki H; Kurihara Y; Takeya M; Kamada N; Kataoka M; Jishage K ; Ueda O ; Sakaguchi H ; Higashi T ; Suzuki T ; Takashima Y ; Kawabe Y ; Cynshi O ; Wada Y ; Honda M ; Kurihara H ; Aburatani H ; Doi T ; Matsumoto A ; Azuma S ; Noda T ; Toyoda Y ; Itakura H; Yazaki Y ; Kodama T ; et al. 1997. A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infection. Nature 386(6622):292-6. PubMed: 9069289 MGI: J:39079
Swirski FK; Libby P; Aikawa E; Alcaide P; Luscinskas FW; Weissleder R; Pittet MJ. 2007. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest 117(1):195-205. PubMed: 17200719 MGI: J:117447
Tabibiazar R; Wagner RA; Spin JM; Ashley EA; Narasimhan B; Rubin EM; Efron B; Tsao PS; Tibshirani R; Quertermous T. 2005. Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease. Arterioscler Thromb Vasc Biol 25(2):302-8. PubMed: 15550693 MGI: J:109803
Tacke F; Alvarez D; Kaplan TJ; Jakubzick C; Spanbroek R; Llodra J; Garin A; Liu J; Mack M; van Rooijen N; Lira SA; Habenicht AJ; Randolph GJ. 2007. Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaques. J Clin Invest 117(1):185-94. PubMed: 17200718 MGI: J:117437
Tahara S; Morooka T; Wang Z; Bezerra HG; Rollins AM; Simon DI; Costa MA. 2012. Intravascular optical coherence tomography detection of atherosclerosis and inflammation in murine aorta. Arterioscler Thromb Vasc Biol 32(5):1150-7. PubMed: 22308042 MGI: J:196941
Taibi F; Metzinger-Le Meuth V; M'Baya-Moutoula E; Djelouat Ms; Louvet L; Bugnicourt JM; Poirot S; Bengrine A; Chillon JM; Massy ZA; Metzinger L. 2014. Possible involvement of microRNAs in vascular damage in experimental chronic kidney disease. Biochim Biophys Acta 1842(1):88-98. PubMed: 24140891 MGI: J:210044
Takaoka N; Campbell LA; Lee A; Rosenfeld ME; Kuo CC. 2008. Chlamydia pneumoniae infection increases adherence of mouse macrophages to mouse endothelial cells in vitro and to aortas ex vivo. Infect Immun 76(2):510-4. PubMed: 18070891 MGI: J:130335
Takeda M; Yamashita T; Sasaki N; Nakajima K; Kita T; Shinohara M; Ishida T; Hirata K. 2010. Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions. Arterioscler Thromb Vasc Biol 30(12):2495-503. PubMed: 20930170 MGI: J:183142
Takeda S; Hashimoto T; Roe AD; Hori Y; Spires-Jones TL; Hyman BT. 2013. Brain interstitial oligomeric amyloid beta increases with age and is resistant to clearance from brain in a mouse model of Alzheimer's disease. FASEB J 27(8):3239-48. PubMed: 23640054 MGI: J:203564
Taketa K; Matsumura T; Yano M; Ishii N; Senokuchi T; Motoshima H; Murata Y; Kim-Mitsuyama S; Kawada T; Itabe H; Takeya M; Nishikawa T; Tsuruzoe K; Araki E. 2008. Oxidized low density lipoprotein activates peroxisome proliferator-activated receptor-alpha (PPARalpha) and PPARgamma through MAPK-dependent COX-2 expression in macrophages. J Biol Chem 283(15):9852-62. PubMed: 18208815 MGI: J:135237
Talasila A; Yu H; Ackers-Johnson M; Bot M; van Berkel T; Bennett MR; Bot I; Sinha S. 2013. Myocardin regulates vascular response to injury through miR-24/-29a and platelet-derived growth factor receptor-beta. Arterioscler Thromb Vasc Biol 33(10):2355-65. PubMed: 23825366 MGI: J:222230
Taleb S; Romain M; Ramkhelawon B; Uyttenhove C; Pasterkamp G; Herbin O; Esposito B; Perez N; Yasukawa H; Van Snick J; Yoshimura A; Tedgui A; Mallat Z. 2009. Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis. J Exp Med 206(10):2067-77. PubMed: 19737863 MGI: J:153361
Tam SP; Ancsin JB; Tan R; Kisilevsky R. 2005. Peptides derived from serum amyloid A prevent, and reverse, aortic lipid lesions in apoE-/- mice. J Lipid Res 46(10):2091-101. PubMed: 16061946 MGI: J:104723
Tamura Y; Osuga J; Adachi H; Tozawa R; Takanezawa Y; Ohashi K; Yahagi N; Sekiya M; Okazaki H; Tomita S; Iizuka Y; Koizumi H; Inaba T; Yagyu H; Kamada N; Suzuki H; Shimano H; Kadowaki T; Tsujimoto M; Arai H; Yamada N; Ishibashi S. 2004. Scavenger receptor expressed by endothelial cells I (SREC-I) mediates the uptake of acetylated low density lipoproteins by macrophages stimulated with lipopolysaccharide. J Biol Chem 279(30):30938-44. PubMed: 15145948 MGI: J:91911
Tan SM; Sharma A; Yuen DY; Stefanovic N; Krippner G; Mugesh G; Chai Z; de Haan JB. 2013. The modified selenenyl amide, M-hydroxy ebselen, attenuates diabetic nephropathy and diabetes-associated atherosclerosis in ApoE/GPx1 double knockout mice. PLoS One 8(7):e69193. PubMed: 23874911 MGI: J:204391
Tanaka R; Miwa Y; Mou K; Tomikawa M; Eguchi N; Urade Y; Takahashi-Yanaga F; Morimoto S; Wake N; Sasaguri T. 2009. Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice. Biochem Biophys Res Commun 378(4):851-6. PubMed: 19070593 MGI: J:142908
Tang M; Cyrus T; Yao Y; Vocun L; Pratico D. 2005. Involvement of thromboxane receptor in the proatherogenic effect of isoprostane F2alpha-III: evidence from apolipoprotein E- and LDL receptor-deficient mice. Circulation 112(18):2867-74. PubMed: 16267259 MGI: J:116835
Tangirala RK; Bischoff ED; Joseph SB; Wagner BL; Walczak R; Laffitte BA; Daige CL; Thomas D; Heyman RA; Mangelsdorf DJ; Wang X; Lusis AJ; Tontonoz P; Schulman IG. 2002. Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Proc Natl Acad Sci U S A 99(18):11896-901. PubMed: 12193651 MGI: J:125452
Taniyama Y; Fuse H; Satomi T; Tozawa R; Yasuhara Y; Shimakawa K; Shibata S; Hattori M; Nakata M; Taketomi S. 2005. Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun 330(1):104-10. PubMed: 15781238 MGI: J:97471
Tavori H; Fan D; Giunzioni I; Zhu L; Linton MF; Fogo AB; Fazio S. 2014. Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice. J Lipid Res 55(10):2073-81. PubMed: 25183802 MGI: J:216138
Tchantchou F; Graves M; Shea TB. 2006. Expression and activity of methionine cycle genes are altered following folate and vitamin E deficiency under oxidative challenge: modulation by apolipoprotein E-deficiency. Nutr Neurosci 9(1-2):17-24. PubMed: 16910166 MGI: J:135845
Tenger C; Zhou X. 2003. Apolipoprotein E modulates immune activation by acting on the antigen-presenting cell. Immunology 109(3):392-7. PubMed: 12807485 MGI: J:84130
Tennert C; Teupser D; Mueller MA; Wilfert W; Renner-Muller I; Stein O; Stein Y; Sippel AE; Wolf E; Thiery J. 2007. Effect of macrophage ApoE on atherosclerosis in LDL-receptor deficient mice. Biochem Biophys Res Commun 361(3):574-9. PubMed: 17669363 MGI: J:124271
Terasawa Y; Ladha Z; Leonard SW; Morrow JD; Newland D; Sanan D; Packer L; Traber MG; Farese RV Jr. 2000. Increased atherosclerosis in hyperlipidemic mice deficient in alpha -tocopherol transfer protein and vitamin E Proc Natl Acad Sci U S A 97(25):13830-4. PubMed: 11095717 MGI: J:66419
Tesanovic S; Vinh A; Gaspari TA; Casley D; Widdop RE. 2010. Vasoprotective and atheroprotective effects of angiotensin (1-7) in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 30(8):1606-13. PubMed: 20448208 MGI: J:179559
Teter B; Harris-White ME; Frautschy SA; Cole GM. 1999. Role of apolipoprotein E and estrogen in mossy fiber sprouting in hippocampal slice cultures. Neuroscience 91(3):1009-16. PubMed: 10391478 MGI: J:119607
Teupser D; Pavlides S; Tan M; Gutierrez-Ramos JC; Kolbeck R; Breslow JL. 2004. Major reduction of atherosclerosis in fractalkine (CX3CL1)-deficient mice is at the brachiocephalic artery, not the aortic root. Proc Natl Acad Sci U S A 101(51):17795-800. PubMed: 15596719 MGI: J:95279
Teupser D; Weber O; Rao TN; Sass K; Thiery J; Fehling HJ. 2011. No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice. J Biol Chem 286(8):6272-9. PubMed: 21149301 MGI: J:170409
Theilmeier G; De Geest B; Van Veldhoven PP; Stengel D; Michiels C; Lox M; Landeloos M; Chapman MJ; Ninio E; Collen D; Himpens B; Holvoet P. 2000. HDL-associated PAF-AH reduces endothelial adhesiveness in apoE-/- mice. FASEB J 14(13):2032-9. PubMed: 11023987 MGI: J:119589
Theurl M; Schgoer W; Albrecht-Schgoer K; Lener D; Wolf D; Wolf M; Demetz E; Tymoszuk P; Tancevski I; Fischer-Colbrie R; Franz WM; Marschang P; Kirchmair R. 2015. Secretoneurin gene therapy improves hind limb and cardiac ischaemia in Apo E(-)/(-) mice without influencing systemic atherosclerosis. Cardiovasc Res 105(1):96-106. PubMed: 25377726 MGI: J:230301
Thirunavukkarasu S; Khan NS; Song CY; Ghafoor HU; Brand DD; Gonzalez FJ; Malik KU. 2016. Cytochrome P450 1B1 Contributes to the Development of Angiotensin II-Induced Aortic Aneurysm in Male Apoe(-/-) Mice. Am J Pathol 186(8):2204-19. PubMed: 27301358 MGI: J:234289
Thomas M; Gavrila D; McCormick ML; Miller FJ Jr; Daugherty A; Cassis LA; Dellsperger KC; Weintraub NL. 2006. Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Circulation 114(5):404-13. PubMed: 16864727 MGI: J:123854
Thorngate FE; Rudel LL; Walzem RL; Williams DL. 2000. Low levels of extrahepatic nonmacrophage ApoE inhibit atherosclerosis without correcting hypercholesterolemia in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 20(8):1939-45. PubMed: 10938015 MGI: J:130658
Thorngate FE; Strockbine PA; Erickson SK; Williams DL. 2002. Altered adrenal gland cholesterol metabolism in the apoE-deficient mouse. J Lipid Res 43(11):1920-6. PubMed: 12401891 MGI: J:123997
Thorngate FE; Yancey PG; Kellner-Weibel G; Rudel LL; Rothblat GH; Williams DL. 2003. Testing the role of apoA-I, HDL, and cholesterol efflux in the atheroprotective action of low-level apoE expression. J Lipid Res 44(12):2331-8. PubMed: 12951361 MGI: J:193807
Tian J; Pei H; James JC; Li Y; Matsumoto AH; Helm GA; Shi W. 2005. Circulating adhesion molecules in apoE-deficient mouse strains with different atherosclerosis susceptibility. Biochem Biophys Res Commun 329(3):1102-7. PubMed: 15752767 MGI: J:97395
Tian XY; Ganeshan K; Hong C; Nguyen KD; Qiu Y; Kim J; Tangirala RK; Tontonoz P; Chawla A. 2016. Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance. Cell Metab 23(1):165-78. PubMed: 26549485 MGI: J:232743
Tie G; Yan J; Khair L; Messina JA; Deng A; Kang J; Fazzio T; Messina LM. 2017. Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and gammadelta T Cells from Hematopoietic Stem Cells. Cancer Res 77(9):2351-2362. PubMed: 28249902 MGI: J:242169
Tiebel O; Oka K; Robinson K; Sullivan M; Martinez J; Nakamuta M; Ishimura-Oka K; Chan L. 1999. Mouse very low-density lipoprotein receptor (VLDLR): gene structure, tissue-specific expression and dietary and developmental regulation. Atherosclerosis 145(2):239-51. PubMed: 10488949 MGI: J:59491
Tikellis C; Pickering RJ; Tsorotes D; Huet O; Cooper ME; Jandeleit-Dahm K; Thomas MC. 2014. Dicarbonyl stress in the absence of hyperglycemia increases endothelial inflammation and atherogenesis similar to that observed in diabetes. Diabetes 63(11):3915-25. PubMed: 24812427 MGI: J:229837
Tilley RE; Pedersen B; Pawlinski R; Sato Y; Erlich JH; Shen Y; Day S; Huang Y; Eitzman DT; Boisvert WA; Curtiss LK; Fay WP; Mackman N. 2006. Atherosclerosis in mice is not affected by a reduction in tissue factor expression. Arterioscler Thromb Vasc Biol 26(3):555-62. PubMed: 16385085 MGI: J:127980
Tirziu D; Moodie KL; Zhuang ZW; Singer K; Helisch A; Dunn JF; Li W; Singh J; Simons M. 2005. Delayed arteriogenesis in hypercholesterolemic mice. Circulation 112(16):2501-9. PubMed: 16230502 MGI: J:116827
To AW; Ribe EM; Chuang TT; Schroeder JE; Lovestone S. 2011. The epsilon3 and epsilon4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice. PLoS One 6(2):e16991. PubMed: 21347323 MGI: J:171093
To K; Agrotis A; Besra G; Bobik A; Toh BH. 2009. NKT cell subsets mediate differential proatherogenic effects in ApoE-/- mice. Arterioscler Thromb Vasc Biol 29(5):671-7. PubMed: 19251589 MGI: J:161832
Tokuno S; Hinokiyama K; Tokuno K; Lowbeer C; Hansson LO; Valen G. 2002. Spontaneous ischemic events in the brain and heart adapt the hearts of severely atherosclerotic mice to ischemia. Arterioscler Thromb Vasc Biol 22(6):995-1001. PubMed: 12067910 MGI: J:102937
Tomita H; Zhilicheva S; Kim S; Maeda N. 2010. Aortic arch curvature and atherosclerosis have overlapping quantitative trait loci in a cross between 129S6/SvEvTac and C57BL/6J apolipoprotein E-null mice. Circ Res 106(6):1052-60. PubMed: 20133902 MGI: J:170863
Tomiyama-Hanayama M; Rakugi H; Kohara M; Mima T; Adachi Y; Ohishi M; Katsuya T; Hoshida Y; Aozasa K; Ogihara T; Nishimoto N. 2009. Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice. Am J Physiol Renal Physiol 297(3):F679-84. PubMed: 19570877 MGI: J:152197
Tordjman K; Bernal-Mizrachi C; Zemany L; Weng S; Feng C; Zhang F; Leone TC; Coleman T; Kelly DP; Semenkovich CF. 2001. PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. J Clin Invest 107(8):1025-34. PubMed: 11306606 MGI: J:68880
Torzewski M; Ochsenhirt V; Kleschyov AL; Oelze M; Daiber A; Li H; Rossmann H; Tsimikas S; Reifenberg K; Cheng F; Lehr HA; Blankenberg S; Forstermann U; Munzel T; Lackner KJ. 2007. Deficiency of glutathione peroxidase-1 accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 27(4):850-7. PubMed: 17255533 MGI: J:135067
Tous M; Ferre N; Rull A; Marsillach J; Coll B; Alonso-Villaverde C; Camps J; Joven J. 2006. Dietary cholesterol and differential monocyte chemoattractant protein-1 gene expression in aorta and liver of apo E-deficient mice. Biochem Biophys Res Commun 340(4):1078-84. PubMed: 16403442 MGI: J:105001
Tous M; Ferre N; Vilella E; Riu F; Camps J; Joven J. 2004. Circulating blood cells modulate the atherosclerotic process in apolipoprotein E-deficient mice. Metabolism 53(1):95-100. PubMed: 14681849 MGI: J:87089
Tous M; Ribas V; Ferre N; Escola-Gil JC; Blanco-Vaca F; Alonso-Villaverde C; Coll B; Camps J; Joven J. 2005. Turpentine-induced inflammation reduces the hepatic expression of the multiple drug resistance gene, the plasma cholesterol concentration and the development of atherosclerosis in apolipoprotein E deficient mice. Biochim Biophys Acta 1733(2-3):192-8. PubMed: 15863366 MGI: J:99060
Toyama K; Wulff H; Chandy KG; Azam P; Raman G; Saito T; Fujiwara Y; Mattson DL; Das S; Melvin JE; Pratt PF; Hatoum OA; Gutterman DD; Harder DR; Miura H. 2008. The intermediate-conductance calcium-activated potassium channel KCa3.1 contributes to atherogenesis in mice and humans. J Clin Invest 118(9):3025-37. PubMed: 18688283 MGI: J:140971
Trieu VN; Uckun FM. 2000. Apolipoprotein E and apolipoprotein D expression in a murine model of singlet oxygen-induced cerebral stroke. Biochem Biophys Res Commun 268(3):835-41. PubMed: 10679292 MGI: J:60716
Trigatti B; Rayburn H; Vinals M; Braun A; Miettinen H; Penman M; Hertz M; Schrenzel M; Amigo L; Rigotti A; Krieger M. 1999. Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiology. Proc Natl Acad Sci U S A 96(16):9322-7. PubMed: 10430941 MGI: J:105226
Trigueros-Motos L; Gonzalez-Granado JM; Cheung C; Fernandez P; Sanchez-Cabo F; Dopazo A; Sinha S; Andres V. 2013. Embryological-origin-dependent differences in homeobox expression in adult aorta: role in regional phenotypic variability and regulation of NF-kappaB activity. Arterioscler Thromb Vasc Biol 33(6):1248-56. PubMed: 23448971 MGI: J:217964
Tse J; Martin-McNaulty B; Halks-Miller M; Kauser K; DelVecchio V; Vergona R; Sullivan ME; Rubanyi GM. 1999. Accelerated atherosclerosis and premature calcified cartilaginous metaplasia in the aorta of diabetic male Apo E knockout mice can be prevented by chronic treatment with 17 beta-estradiol. Atherosclerosis 144(2):303-13. PubMed: 10407491 MGI: J:56238
Tsubakimoto Y; Yamada H; Yokoi H; Kishida S; Takata H; Kawahito H; Matsui A; Urao N; Nozawa Y; Hirai H; Imanishi J; Ashihara E; Maekawa T; Takahashi T; Okigaki M; Matsubara H. 2009. Bone marrow angiotensin AT1 receptor regulates differentiation of monocyte lineage progenitors from hematopoietic stem cells. Arterioscler Thromb Vasc Biol 29(10):1529-36. PubMed: 19628784 MGI: J:167806
Tsukamoto K; Mani DR; Shi J; Zhang S; Haagensen DE; Otsuka F; Guan J; Smith JD; Weng W; Liao R; Kolodgie FD; Virmani R; Krieger M. 2013. Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. Proc Natl Acad Sci U S A 110(42):17023-8. PubMed: 24082102 MGI: J:201999
Tsukamoto K; Tangirala R; Chun SH; Pure E; Rader DJ. 1999. Rapid regression of atherosclerosis induced by liver-directed gene transfer of ApoE in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 19(9):2162-70. PubMed: 10479659 MGI: J:59495
Tsukano H; Gotoh T; Endo M; Miyata K; Tazume H; Kadomatsu T; Yano M; Iwawaki T; Kohno K; Araki K; Mizuta H; Oike Y. 2010. The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes to the instability of atherosclerotic plaques. Arterioscler Thromb Vasc Biol 30(10):1925-32. PubMed: 20651282 MGI: J:182109
Tucka J; Yu H; Gray K; Figg N; Maguire J; Lam B; Bennett M; Littlewood T. 2014. Akt1 regulates vascular smooth muscle cell apoptosis through FoxO3a and Apaf1 and protects against arterial remodeling and atherosclerosis. Arterioscler Thromb Vasc Biol 34(11):2421-8. PubMed: 25234814 MGI: J:230474
Tufanli O; Telkoparan Akillilar P; Acosta-Alvear D; Kocaturk B; Onat UI; Hamid SM; Cimen I; Walter P; Weber C; Erbay E. 2017. Targeting IRE1 with small molecules counteracts progression of atherosclerosis. Proc Natl Acad Sci U S A 114(8):E1395-E1404. PubMed: 28137856 MGI: J:240941
Tupin E; Nicoletti A; Elhage R; Rudling M; Ljunggren HG; Hansson GK; Berne GP. 2004. CD1d-dependent activation of NKT cells aggravates atherosclerosis. J Exp Med 199(3):417-22. PubMed: 14744994 MGI: J:90471
Uchida HA; Poduri A; Subramanian V; Cassis LA; Daugherty A. 2011. Urokinase-type plasminogen activator deficiency in bone marrow-derived cells augments rupture of angiotensin II-induced abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 31(12):2845-52. PubMed: 21868698 MGI: J:191466
Uchiyama R; Hasegawa H; Kameda Y; Ueda K; Kobayashi Y; Komuro I; Takano H. 2012. Role of regulatory T cells in atheroprotective effects of granulocyte colony-stimulating factor. J Mol Cell Cardiol 52(5):1038-47. PubMed: 22285481 MGI: J:183696
Umetani M; Ghosh P; Ishikawa T; Umetani J; Ahmed M; Mineo C; Shaul PW. 2014. The cholesterol metabolite 27-hydroxycholesterol promotes atherosclerosis via proinflammatory processes mediated by estrogen receptor alpha. Cell Metab 20(1):172-82. PubMed: 24954418 MGI: J:215482
Upmacis RK; Crabtree MJ; Deeb RS; Shen H; Lane PB; Benguigui LE; Maeda N; Hajjar DP; Gross SS. 2007. Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase. Am J Physiol Heart Circ Physiol 293(5):H2878-87. PubMed: 17766468 MGI: J:132084
Usui F; Kimura H; Ohshiro T; Tatsumi K; Kawashima A; Nishiyama A; Iwakura Y; Ishibashi S; Takahashi M. 2012. Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice. Biochem Biophys Res Commun 420(1):72-7. PubMed: 22402284 MGI: J:182584
Usui F; Shirasuna K; Kimura H; Tatsumi K; Kawashima A; Karasawa T; Hida S; Sagara J; Taniguchi S; Takahashi M. 2012. Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice. Biochem Biophys Res Commun 425(2):162-8. PubMed: 22819845 MGI: J:187166
Vaessen SF; Dallinga-Thie GM; Ross CJ; Splint LJ; Castellani LW; Rensen PC; Hayden MR; Schaap FG; Kuivenhoven JA. 2009. Plasma apolipoprotein AV levels in mice are positively associated with plasma triglyceride levels. J Lipid Res 50(5):880-4. PubMed: 19141870 MGI: J:149639
Vaisman BL; Andrews KL; Khong SM; Wood KC; Moore XL; Fu Y; Kepka-Lenhart DM; Morris SM Jr; Remaley AT; Chin-Dusting JP. 2012. Selective endothelial overexpression of arginase II induces endothelial dysfunction and hypertension and enhances atherosclerosis in mice. PLoS One 7(7):e39487. PubMed: 22829869 MGI: J:189591
Van Herck JL; De Meyer GR; Martinet W; Van Hove CE; Foubert K; Theunis MH; Apers S; Bult H; Vrints CJ; Herman AG. 2009. Impaired fibrillin-1 function promotes features of plaque instability in apolipoprotein E-deficient mice. Circulation 120(24):2478-87. PubMed: 19948973 MGI: J:168127
VanderLaan PA; Reardon CA; Thisted RA; Getz GS. 2009. VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice. J Lipid Res 50(3):376-85. PubMed: 18957695 MGI: J:149089
Vatassery GT; Quach HT; Smith WE; Kuskowski M. 2008. Deletion of apolipoprotein E gene modifies the rate of depletion of alpha tocopherol (vitamin E) from mice brains. Biochim Biophys Acta 1782(6):414-20. PubMed: 18395016 MGI: J:136773
Vatassery GT; Quach HT; Smith WE; Santacruz KS; Roy S. 2007. Apolipoprotein e deficiency leads to altered brain uptake of alpha tocopherol injected into lateral cerebral ventricles. Biochim Biophys Acta 1772(7):797-803. PubMed: 17560088 MGI: J:124803
Vedantham S; Noh H; Ananthakrishnan R; Son N; Hallam K; Hu Y; Yu S; Shen X; Rosario R; Lu Y; Ravindranath T; Drosatos K; Huggins LA; Schmidt AM; Goldberg IJ; Ramasamy R. 2011. Human aldose reductase expression accelerates atherosclerosis in diabetic apolipoprotein E-/- mice. Arterioscler Thromb Vasc Biol 31(8):1805-13. PubMed: 21636809 MGI: J:191855
Vedantham S; Thiagarajan D; Ananthakrishnan R; Wang L; Rosario R; Zou YS; Goldberg I; Yan SF; Schmidt AM; Ramasamy R. 2014. Aldose reductase drives hyperacetylation of Egr-1 in hyperglycemia and consequent upregulation of proinflammatory and prothrombotic signals. Diabetes 63(2):761-74. PubMed: 24186862 MGI: J:209006
Veillard NR; Steffens S; Pelli G; Lu B; Kwak BR; Gerard C; Charo IF; Mach F. 2005. Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo. Circulation 112(6):870-8. PubMed: 16061736 MGI: J:116866
Velsko IM; Chukkapalli SS; Rivera MF; Lee JY; Chen H; Zheng D; Bhattacharyya I; Gangula PR; Lucas AR; Kesavalu L. 2014. Active invasion of oral and aortic tissues by Porphyromonas gingivalis in mice causally links periodontitis and atherosclerosis. PLoS One 9(5):e97811. PubMed: 24836175 MGI: J:216336
Vendrov AE; Hakim ZS; Madamanchi NR; Rojas M; Madamanchi C; Runge MS. 2007. Atherosclerosis is attenuated by limiting superoxide generation in both macrophages and vessel wall cells. Arterioscler Thromb Vasc Biol 27(12):2714-21. PubMed: 17823367 MGI: J:147527
Vendrov AE; Madamanchi NR; Niu XL; Molnar KC; Runge M; Szyndralewiez C; Page P; Runge MS. 2010. NADPH oxidases regulate CD44 and hyaluronic acid expression in thrombin-treated vascular smooth muscle cells and in atherosclerosis. J Biol Chem 285(34):26545-57. PubMed: 20558727 MGI: J:166188
Veniant MM; Pierotti V; Newland D; Cham CM; Sanan DA; Walzem RL ; Young SG. 1997. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. J Clin Invest 100(1):180-8. PubMed: 9202070 MGI: J:41510
Veniant MM; Sullivan MA; Kim SK; Ambroziak P; Chu A; Wilson MD; Hellerstein MK; Rudel LL; Walzem RL; Young SG. 2000. Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100 J Clin Invest 106(12):1501-10. PubMed: 11120757 MGI: J:66424
Verdeguer F; Castro C; Kubicek M; Pla D; Vila-Caballer M; Vinue A; Civeira F; Pocovi M; Calvete JJ; Andres V. 2007. Complement regulation in murine and human hypercholesterolemia and role in the control of macrophage and smooth muscle cell proliferation. Cardiovasc Res 76(2):340-50. PubMed: 17673191 MGI: J:162728
Vickers KC; Landstreet SR; Levin MG; Shoucri BM; Toth CL; Taylor RC; Palmisano BT; Tabet F; Cui HL; Rye KA; Sethupathy P; Remaley AT. 2014. MicroRNA-223 coordinates cholesterol homeostasis. Proc Natl Acad Sci U S A 111(40):14518-23. PubMed: 25246565 MGI: J:216464
Vidal J; Bruce Verchere C; Andrikopoulos S; Wang F; Hull RL; Cnop M; Olin KL; LeBoeuf RC; O'Brien KD; Chait A; Kahn SE. 2003. The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice. Diabetologia 46(1):71-9. PubMed: 12637985 MGI: J:82403
Vikramadithyan RK; Kako Y; Chen G; Hu Y; Arikawa-Hirasawa E; Yamada Y; Goldberg IJ. 2004. Atherosclerosis in perlecan heterozygous mice. J Lipid Res 45(10):1806-12. PubMed: 15258195 MGI: J:93619
Villa-Bellosta R; Hamczyk MR; Andres V. 2016. Alternatively activated macrophages exhibit an anticalcifying activity dependent on extracellular ATP/pyrophosphate metabolism. Am J Physiol Cell Physiol 310(10):C788-99. PubMed: 26936458 MGI: J:235692
Virtue A; Johnson C; Lopez-Pastrana J; Shao Y; Fu H; Li X; Li YF; Yin Y; Mai J; Rizzo V; Tordoff M; Bagi Z; Shan H; Jiang X; Wang H; Yang XF. 2017. MicroRNA-155 Deficiency Leads to Decreased Atherosclerosis, Increased White Adipose Tissue Obesity, and Non-alcoholic Fatty Liver Disease: A NOVEL MOUSE MODEL OF OBESITY PARADOX. J Biol Chem 292(4):1267-1287. PubMed: 27856635 MGI: J:239243
Vitek MP; Brown CM; Colton CA. 2009. APOE genotype-specific differences in the innate immune response. Neurobiol Aging 30(9):1350-60. PubMed: 18155324 MGI: J:152961
Vliegen I; Duijvestijn A; Grauls G; Herngreen S; Bruggeman C; Stassen F. 2004. Cytomegalovirus infection aggravates atherogenesis in apoE knockout mice by both local and systemic immune activation. Microbes Infect 6(1):17-24. PubMed: 14738889 MGI: J:105285
Vu DM; Tai A; Tatro JB; Karas RH; Huber BT; Beasley D. 2014. gammadeltaT cells are prevalent in the proximal aorta and drive nascent atherosclerotic lesion progression and neutrophilia in hypercholesterolemic mice. PLoS One 9(10):e109416. PubMed: 25313857 MGI: J:223560
Wahrle SE; Jiang H; Parsadanian M; Kim J; Li A; Knoten A; Jain S; Hirsch-Reinshagen V; Wellington CL; Bales KR; Paul SM; Holtzman DM. 2008. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest 118(2):671-82. PubMed: 18202749 MGI: J:131400
Walker LC; Parker CA; Lipinski WJ; Callahan MJ; Carroll RT; Gandy SE ; Smith JD ; Jucker M ; Bisgaier CL. 1997. Cerebral lipid deposition in aged apolipoprotein-E-deficient mice. Am J Pathol 151(5):1371-7. PubMed: 9358763 MGI: J:43846
Wan JB; Huang LL; Rong R; Tan R; Wang J; Kang JX. 2010. Endogenously decreasing tissue n-6/n-3 fatty acid ratio reduces atherosclerotic lesions in apolipoprotein E-deficient mice by inhibiting systemic and vascular inflammation. Arterioscler Thromb Vasc Biol 30(12):2487-94. PubMed: 20705919 MGI: J:182105
Wan W; Lim JK; Lionakis MS; Rivollier A; McDermott DH; Kelsall BL; Farber JM; Murphy PM. 2011. Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient mice. Circ Res 109(4):374-81. PubMed: 21680896 MGI: J:186603
Wan W; Lionakis MS; Liu Q; Roffe E; Murphy PM. 2013. Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice. Cardiovasc Res 97(3):580-8. PubMed: 23180724 MGI: J:210283
Wang H; Jiang X; Yang F; Gaubatz JW; Ma L; Magera MJ; Yang X; Berger PB; Durante W; Pownall HJ; Schafer AI. 2003. Hyperhomocysteinemia accelerates atherosclerosis in cystathionine beta-synthase and apolipoprotein E double knock-out mice with and without dietary perturbation. Blood 101(10):3901-7. PubMed: 12506016 MGI: J:83449
Wang H; Zhang W; Tang R; Hebbel RP; Kowalska MA; Zhang C; Marth JD; Fukuda M; Zhu C; Huo Y. 2009. Core2 1-6-N-glucosaminyltransferase-I deficiency protects injured arteries from neointima formation in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 29(7):1053-9. PubMed: 19372458 MGI: J:167819
Wang H; Zhang W; Tang R; Zhu C; Bucher C; Blazar BR; Geng JG; Zhang C; Linden J; Wu C; Huo Y. 2010. Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 30(5):915-22. PubMed: 20167656 MGI: J:175821
Wang J; Cheng X; Xiang MX; Alanne-Kinnunen M; Wang JA; Chen H; He A; Sun X; Lin Y; Tang TT; Tu X; Sjoberg S; Sukhova GK; Liao YH; Conrad DH; Yu L; Kawakami T; Kovanen PT; Libby P; Shi GP. 2011. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest 121(9):3564-77. PubMed: 21821913 MGI: J:178258
Wang J; Lindholt JS; Sukhova GK; Shi MA; Xia M; Chen H; Xiang M; He A; Wang Y; Xiong N; Libby P; Wang JA; Shi GP. 2014. IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms. EMBO Mol Med 6(7):952-69. PubMed: 24963147 MGI: J:232287
Wang J; Sun C; Gerdes N; Liu C; Liao M; Liu J; Shi MA; He A; Zhou Y; Sukhova GK; Chen H; Cheng XW; Kuzuya M; Murohara T; Zhang J; Cheng X; Jiang M; Shull GE; Rogers S; Yang CL; Ke Q; Jelen S; Bindels R; Ellison DH; Jarolim P; Libby P; Shi GP. 2015. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med 21(7):820-6. PubMed: 26099046 MGI: J:224865
Wang J; Uryga AK; Reinhold J; Figg N; Baker L; Finigan A; Gray K; Kumar S; Clarke M; Bennett M. 2015. Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability. Circulation 132(20):1909-19. PubMed: 26416809 MGI: J:239047
Wang J; Xian X; Huang W; Chen L; Wu L; Zhu Y; Fan J; Ross C; Hayden MR; Liu G. 2007. Expression of LPL in endothelial-intact artery results in lipid deposition and vascular cell adhesion molecule-1 upregulation in both LPL and ApoE-deficient mice. Arterioscler Thromb Vasc Biol 27(1):197-203. PubMed: 17038632 MGI: J:134943
Wang KY; Tanimoto A; Guo X; Yamada S; Shimajiri S; Murata Y; Ding Y; Tsutsui M; Kato S; Watanabe T; Ohtsu H; Hirano K; Kohno K; Sasaguri Y. 2011. Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level. Arterioscler Thromb Vasc Biol 31(4):800-7. PubMed: 21273563 MGI: J:184163
Wang L; Li H; Zhang J; Lu W; Zhao J; Su L; Zhao B; Zhang Y; Zhang S; Miao J. 2013. Phosphatidylethanolamine binding protein 1 in vacular endothelial cell autophagy and atherosclerosis. J Physiol 591(Pt 20):5005-15. PubMed: 23959677 MGI: J:215850
Wang L; Yin J; Nickles HT; Ranke H; Tabuchi A; Hoffmann J; Tabeling C; Barbosa-Sicard E; Chanson M; Kwak BR; Shin HS; Wu S; Isakson BE; Witzenrath M; de Wit C; Fleming I; Kuppe H; Kuebler WM. 2012. Hypoxic pulmonary vasoconstriction requires connexin 40-mediated endothelial signal conduction. J Clin Invest 122(11):4218-30. PubMed: 23093775 MGI: J:194012
Wang P; Xu TY; Guan YF; Zhao Y; Li ZY; Lan XH; Wang X; Yang PY; Kang ZM; Vanhoutte PM; Miao CY. 2014. Vascular smooth muscle cell apoptosis is an early trigger for hypothyroid atherosclerosis. Cardiovasc Res 102(3):448-59. PubMed: 24604622 MGI: J:229495
Wang Q; Grainger AT; Manichaikul A; Farber E; Onengut-Gumuscu S; Shi W. 2015. Genetic linkage of hyperglycemia and dyslipidemia in an intercross between BALB/cJ and SM/J Apoe-deficient mouse strains. BMC Genet 16:133. PubMed: 26555648 MGI: J:228273
Wang S; Yehya N; Schadt EE; Wang H; Drake TA; Lusis AJ. 2006. Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity. PLoS Genet 2(2):e15. PubMed: 16462940 MGI: J:115779
Wang SS; Martin LJ; Schadt EE; Meng H; Wang X; Zhao W; Ingram-Drake L; Nebohacova M; Mehrabian M; Drake TA; Lusis AJ. 2009. Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circ Cardiovasc Genet 2(6):573-82. PubMed: 20031637 MGI: J:182797
Wang SS; Schadt EE; Wang H; Wang X; Ingram-Drake L; Shi W; Drake TA; Lusis AJ. 2007. Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression data. Circ Res 101(3):e11-30. PubMed: 17641228 MGI: J:140288
Wang WJ; Baez JM; Maurer R; Dansky HM; Cohen DE. 2006. Homozygous disruption of Pctp modulates atherosclerosis in apolipoprotein E-deficient mice. J Lipid Res 47(11):2400-7. PubMed: 16940277 MGI: J:147028
Wang WY; Zhang J; Wu WY; Li J; Ma YL; Chen WH; Yan H; Wang K; Xu WW; Shen JH; Wang YP. 2011. Inhibition of Lipoprotein-Associated Phospholipase A2 Ameliorates Inflammation and Decreases Atherosclerotic Plaque Formation in ApoE-Deficient Mice. PLoS One 6(8):e23425. PubMed: 21909350 MGI: J:176134
Wang Y; Ait-Oufella H; Herbin O; Bonnin P; Ramkhelawon B; Taleb S; Huang J; Offenstadt G; Combadiere C; Renia L; Johnson JL; Tharaux PL; Tedgui A; Mallat Z. 2010. TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. J Clin Invest 120(2):422-32. PubMed: 20101093 MGI: J:156667
Wang Y; Gusarova V; Banfi S; Gromada J; Cohen JC; Hobbs HH. 2015. Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion. J Lipid Res 56(7):1296-307. PubMed: 25954050 MGI: J:224940
Wang Y; Kim NS; Haince JF; Kang HC; David KK; Andrabi SA; Poirier GG; Dawson VL; Dawson TM. 2011. Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci Signal 4(167):ra20. PubMed: 21467298 MGI: J:186001
Wang Y; Lu H; Huang Z; Lin H; Lei Z; Chen X; Tang M; Gao F; Dong M; Li R; Lin L. 2014. Apolipoprotein E-knockout mice on high-fat diet show autoimmune injury on kidney and aorta. Biochem Biophys Res Commun 450(1):788-93. PubMed: 24953693 MGI: J:220051
Wang YX; Halks-Miller M; Vergona R; Sullivan ME; Fitch R; Mallari C; Martin-McNulty B; da Cunha V; Freay A; Rubanyi GM; Kauser K. 2000. Increased aortic stiffness assessed by pulse wave velocity in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 278(2):H428-34. PubMed: 10666072 MGI: J:60364
Wang Z; Klipfell E; Bennett BJ; Koeth R; Levison BS; Dugar B; Feldstein AE; Britt EB; Fu X; Chung YM; Wu Y; Schauer P; Smith JD; Allayee H; Tang WH; DiDonato JA; Lusis AJ; Hazen SL. 2011. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 472(7341):57-63. PubMed: 21475195 MGI: J:170985
Wang Z; Liu B; Wang P; Dong X; Fernandez-Hernando C; Li Z; Hla T; Li Z; Claffey K; Smith JD; Wu D. 2008. Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice. J Clin Invest 118(1):195-204. PubMed: 18079968 MGI: J:130826
Wang Z; Roberts AB; Buffa JA; Levison BS; Zhu W; Org E; Gu X; Huang Y; Zamanian-Daryoush M; Culley MK; DiDonato AJ; Fu X; Hazen JE; Krajcik D; DiDonato JA; Lusis AJ; Hazen SL. 2015. Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. Cell 163(7):1585-95. PubMed: 26687352 MGI: J:227980
Wang ZH; Shang YY; Zhang S; Zhong M; Wang XP; Deng JT; Pan J; Zhang Y; Zhang W. 2012. Silence of TRIB3 suppresses atherosclerosis and stabilizes plaques in diabetic ApoE-/-/LDL receptor-/- mice. Diabetes 61(2):463-73. PubMed: 22275087 MGI: J:196759
Wanschel A; Seibert T; Hewing B; Ramkhelawon B; Ray TD; van Gils JM; Rayner KJ; Feig JE; O'Brien ER; Fisher EA; Moore KJ. 2013. Neuroimmune guidance cue Semaphorin 3E is expressed in atherosclerotic plaques and regulates macrophage retention. Arterioscler Thromb Vasc Biol 33(5):886-93. PubMed: 23430613 MGI: J:217969
Warnatsch A; Ioannou M; Wang Q; Papayannopoulos V. 2015. Inflammation. Neutrophil extracellular traps license macrophages for cytokine production in atherosclerosis. Science 349(6245):316-20. PubMed: 26185250 MGI: J:225899
Wassmann S; Czech T; van Eickels M; Fleming I; Bohm M; Nickenig G. 2004. Inhibition of diet-induced atherosclerosis and endothelial dysfunction in apolipoprotein E/angiotensin II type 1A receptor double-knockout mice. Circulation 110(19):3062-7. PubMed: 15277329 MGI: J:103721
Wassmann S; Werner N; Czech T; Nickenig G. 2006. Improvement of endothelial function by systemic transfusion of vascular progenitor cells. Circ Res 99(8):e74-83. PubMed: 16990568 MGI: J:126502
Watson AM; Gray SP; Jiaze L; Soro-Paavonen A; Wong B; Cooper ME; Bierhaus A; Pickering R; Tikellis C; Tsorotes D; Thomas MC; Jandeleit-Dahm KA. 2012. Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice. Diabetes 61(8):2105-13. PubMed: 22698914 MGI: J:208530
Watson AM; Olukman M; Koulis C; Tu Y; Samijono D; Yuen D; Lee C; Behm DJ; Cooper ME; Jandeleit-Dahm KA; Calkin AC; Allen TJ. 2013. Urotensin II receptor antagonism confers vasoprotective effects in diabetes associated atherosclerosis: studies in humans and in a mouse model of diabetes. Diabetologia 56(5):1155-65. PubMed: 23344731 MGI: J:196412
Watson AM; Soro-Paavonen A; Sheehy K; Li J; Calkin AC; Koitka A; Rajan SN; Brasacchio D; Allen TJ; Cooper ME; Thomas MC; Jandeleit-Dahm KJ. 2011. Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice. Diabetologia 54(3):681-9. PubMed: 21161164 MGI: J:170363
Weber C; Meiler S; Doring Y; Koch M; Drechsler M; Megens RT; Rowinska Z; Bidzhekov K; Fecher C; Ribechini E; van Zandvoort MA; Binder CJ; Jelinek I; Hristov M; Boon L; Jung S; Korn T; Lutz MB; Forster I; Zenke M; Hieronymus T; Junt T; Zernecke A. 2011. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest 121(7):2898-910. PubMed: 21633167 MGI: J:175665
Wei Y; Nazari-Jahantigh M; Chan L; Zhu M; Heyll K; Corbalan-Campos J; Hartmann P; Thiemann A; Weber C; Schober A. 2013. The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis. Circulation 127(15):1609-19. PubMed: 23513069 MGI: J:211443
Wei Y; Zhu M; Corbalan-Campos J; Heyll K; Weber C; Schober A. 2015. Regulation of Csf1r and Bcl6 in macrophages mediates the stage-specific effects of microRNA-155 on atherosclerosis. Arterioscler Thromb Vasc Biol 35(4):796-803. PubMed: 25810298 MGI: J:241626
Welch CL; Sun Y; Arey BJ; Lemaitre V; Sharma N; Ishibashi M; Sayers S; Li R; Gorelik A; Pleskac N; Collins-Fletcher K; Yasuda Y; Bromme D; D'Armiento JM; Ogletree ML; Tall AR. 2007. Spontaneous atherothrombosis and medial degradation in Apoe-/-, Npc1-/- mice. Circulation 116(21):2444-52. PubMed: 17984379 MGI: J:142987
Wen L; Chen Z; Zhang F; Cui X; Sun W; Geary GG; Wang Y; Johnson DA; Zhu Y; Chien S; Shyy JY. 2013. Ca2+/calmodulin-dependent protein kinase kinase beta phosphorylation of Sirtuin 1 in endothelium is atheroprotective. Proc Natl Acad Sci U S A 110(26):E2420-7. PubMed: 23754392 MGI: J:197976
Wen M; Segerer S; Dantas M; Brown PA; Hudkins KL; Goodpaster T; Kirk E; LeBoeuf RC; Alpers CE. 2002. Renal injury in apolipoprotein E-deficient mice. Lab Invest 82(8):999-1006. PubMed: 12177238 MGI: J:125978
Weng S; Sprague JE; Oh J; Riek AE; Chin K; Garcia M; Bernal-Mizrachi C. 2013. Vitamin D deficiency induces high blood pressure and accelerates atherosclerosis in mice. PLoS One 8(1):e54625. PubMed: 23349943 MGI: J:195839
Weng S; Zemany L; Standley KN; Novack DV; La Regina M; Bernal-Mizrachi C; Coleman T; Semenkovich CF. 2003. Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic mice. Proc Natl Acad Sci U S A 100(11):6730-5. PubMed: 12746502 MGI: J:83615
West LE; Steiner T; Judge HM; Francis SE; Storey RF. 2014. Vessel wall, not platelet, P2Y12 potentiates early atherogenesis. Cardiovasc Res 102(3):429-35. PubMed: 24510394 MGI: J:229344
Westerterp M; Berbee JF; Pires NM; van Mierlo GJ; Kleemann R; Romijn JA; Havekes LM; Rensen PC. 2007. Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice. Circulation 116(19):2173-81. PubMed: 17967778 MGI: J:142992
Westerterp M; Gourion-Arsiquaud S; Murphy AJ; Shih A; Cremers S; Levine RL; Tall AR; Yvan-Charvet L. 2012. Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell 11(2):195-206. PubMed: 22862945 MGI: J:190966
Westrick RJ; Bodary PF; Xu Z; Shen YC; Broze GJ; Eitzman DT. 2001. Deficiency of tissue factor pathway inhibitor promotes atherosclerosis and thrombosis in mice. Circulation 103(25):3044-6. PubMed: 11425765 MGI: J:103352
Whitman SC; Ravisankar P; Daugherty A. 2002. Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gamma. Circ Res 90(2):E34-8. PubMed: 11834721 MGI: J:109710
Wigren M; Bengtsson D; Duner P; Olofsson K; Bjorkbacka H; Bengtsson E; Fredrikson GN; Nilsson J. 2009. Atheroprotective effects of Alum are associated with capture of oxidized LDL antigens and activation of regulatory T cells. Circ Res 104(12):e62-70. PubMed: 19478203 MGI: J:164756
Wildhagen KC; Schrijver R; Beckers L; ten Cate H; Reutelingsperger CP; Lutgens E; Nicolaes GA. 2014. Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis. PLoS One 9(7):e101446. PubMed: 25032959 MGI: J:219029
Wilhelmson AS; Bourghardt-Fagman J; Gogos JA; Fogelstrand P; Tivesten A. 2011. Catechol-O-methyltransferase is dispensable for vascular protection by estradiol in mouse models of atherosclerosis and neointima formation. Endocrinology 152(12):4683-90. PubMed: 22009725 MGI: J:179074
Willner EL; Tow B; Buhman KK; Wilson M; Sanan DA; Rudel LL; Farese RV Jr. 2003. Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice. Proc Natl Acad Sci U S A 100(3):1262-7. PubMed: 12538880 MGI: J:81836
Wilson KM; McCaw RB; Leo L; Arning E; Lhotak S; Bottiglieri T; Austin RC; Lentz SR. 2007. Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 27(1):233-40. PubMed: 17082485 MGI: J:147558
Wilson PG; Thompson JC; Webb NR; de Beer FC; King VL; Tannock LR. 2008. Serum amyloid A, but not C-reactive protein, stimulates vascular proteoglycan synthesis in a pro-atherogenic manner. Am J Pathol 173(6):1902-10. PubMed: 18974302 MGI: J:143924
Wilund KR; Rosenblat M; Chung HR; Volkova N; Kaplan M; Woods JA; Aviram M. 2009. Macrophages from alpha 7 nicotinic acetylcholine receptor knockout mice demonstrate increased cholesterol accumulation and decreased cellular paraoxonase expression: a possible link between the nervous system and atherosclerosis development. Biochem Biophys Res Commun 390(1):148-54. PubMed: 19785985 MGI: J:155229
Witting PK; Pettersson K; Ostlund-Lindqvist AM; Westerlund C; Eriksson AW; Stocker R. 1999. Inhibition by a coantioxidant of aortic lipoprotein lipid peroxidation and atherosclerosis in apolipoprotein E and low density lipoprotein receptor gene double knockout mice. FASEB J 13(6):667-75. PubMed: 10094927 MGI: J:54037
Wolfsgruber W; Feil S; Brummer S; Kuppinger O; Hofmann F; Feil R. 2003. A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells. Proc Natl Acad Sci U S A 100(23):13519-24. PubMed: 14597716 MGI: J:128779
Wong CW; Christen T; Roth I; Chadjichristos CE; Derouette JP; Foglia BF; Chanson M; Goodenough DA; Kwak BR. 2006. Connexin37 protects against atherosclerosis by regulating monocyte adhesion. Nat Med 12(8):950-4. PubMed: 16862155 MGI: J:111966
Woollard KJ; Lumsden NG; Andrews KL; Aprico A; Harris E; Irvine JC; Jefferis AM; Fang L; Kanellakis P; Bobik A; Chin-Dusting JP. 2014. Raised soluble P-selectin moderately accelerates atherosclerotic plaque progression. PLoS One 9(5):e97422. PubMed: 24846287 MGI: J:216323
Woollett LA; Osono Y; Herz J; Dietschy JM. 1995. Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse. Proc Natl Acad Sci U S A 92(26):12500-4. PubMed: 8618929 MGI: J:30297
Wright SD; Burton C; Hernandez M; Hassing H; Montenegro J; Mundt S; Patel S; Card DJ; Hermanowski-Vosatka A; Bergstrom JD; Sparrow CP; Detmers PA; Chao YS. 2000. Infectious agents are not necessary for murine atherogenesis. J Exp Med 191(8):1437-42. PubMed: 10770809 MGI: J:61722
Wu BJ; Kathir K; Witting PK; Beck K; Choy K; Li C; Croft KD; Mori TA; Tanous D; Adams MR; Lau AK; Stocker R. 2006. Antioxidants protect from atherosclerosis by a heme oxygenase-1 pathway that is independent of free radical scavenging. J Exp Med 203(4):1117-27. PubMed: 16606673 MGI: J:123780
Wu C; He S; Peng Y; Kushwaha KK; Lin J; Dong J; Wang B; Lin J; Shan S; Liu J; Huang K; Li D. 2014. TSLPR deficiency attenuates atherosclerotic lesion development associated with the inhibition of TH17 cells and the promotion of regulator T cells in ApoE-deficient mice. J Mol Cell Cardiol 76:33-45. PubMed: 25117469 MGI: J:225621
Wu D; Sharan C; Yang H; Goodwin JS; Zhou L; Grabowski GA; Du H; Guo Z. 2007. Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages. J Lipid Res 48(12):2571-8. PubMed: 17720994 MGI: J:129977
Wu D; Yang H; Xiang W; Zhou L; Shi M; Julies G; Laplante JM; Ballard BR; Guo Z. 2005. Heterozygous mutation of ataxia-telangiectasia mutated gene aggravates hypercholesterolemia in apoE-deficient mice. J Lipid Res 46(7):1380-7. PubMed: 15863839 MGI: J:100500
Wu H; Gower RM; Wang H; Perrard XY; Ma R; Bullard DC; Burns AR; Paul A; Smith CW; Simon SI; Ballantyne CM. 2009. Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation 119(20):2708-17. PubMed: 19433759 MGI: J:166427
Wu JH; Goswami R; Cai X; Exum ST; Huang X; Zhang L; Brian L; Premont RT; Peppel K; Freedman NJ. 2006. Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2. J Biol Chem 281(49):37758-72. PubMed: 17018529 MGI: J:117638
Wu JH; Zhang L; Fanaroff AC; Cai X; Sharma KC; Brian L; Exum ST; Shenoy SK; Peppel K; Freedman NJ. 2012. G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. Arterioscler Thromb Vasc Biol 32(2):308-16. PubMed: 22095977 MGI: J:195972
Wu S; Mar-Heyming R; Dugum EZ; Kolaitis NA; Qi H; Pajukanta P; Castellani LW; Lusis AJ; Drake TA. 2009. Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice. Hum Mol Genet :. PubMed: 19995791 MGI: J:155867
Wu X; Kang J; Xie C; Burris R; Ferguson ME; Badger TM; Nagarajan S. 2010. Dietary blueberries attenuate atherosclerosis in apolipoprotein E-deficient mice by upregulating antioxidant enzyme expression. J Nutr 140(9):1628-32. PubMed: 20660283 MGI: J:163618
Wuttge DM; Eriksson P; Sirsjo A; Hansson GK; Stemme S. 2001. Expression of interleukin-15 in mouse and human atherosclerotic lesions. Am J Pathol 159(2):417-23. PubMed: 11485899 MGI: J:70860
Xia M; Guerra N; Sukhova GK; Yang K; Miller CK; Shi GP; Raulet DH; Xiong N. 2011. Immune activation resulting from NKG2D/ligand interaction promotes atherosclerosis. Circulation 124(25):2933-43. PubMed: 22104546 MGI: J:193798
Xian X; Ding Y; Zhang L; Wang Y; McNutt MA; Ross C; Hayden MR; Deng X; Liu G. 2009. Enhanced atherothrombotic formation after oxidative injury by FeCl3 to the common carotid artery in severe combined hyperlipidemic mice. Biochem Biophys Res Commun 385(4):563-9. PubMed: 19481534 MGI: J:151434
Xiao J; Angsana J; Wen J; Smith SV; Park PW; Ford ML; Haller CA; Chaikof EL. 2012. Syndecan-1 displays a protective role in aortic aneurysm formation by modulating T cell-mediated responses. Arterioscler Thromb Vasc Biol 32(2):386-96. PubMed: 22173227 MGI: J:195964
Xiao N; Yin M; Zhang L; Qu X; Du H; Sun X; Mao L; Ren G; Zhang C; Geng Y; An L; Pan J. 2009. Tumor necrosis factor-alpha deficiency retards early fatty-streak lesion by influencing the expression of inflammatory factors in apoE-null mice. Mol Genet Metab 96(4):239-44. PubMed: 19157944 MGI: J:146902
Xiao Q; Zhang F; Grassia G; Hu Y; Zhang Z; Xing Q; Yin X; Maddaluno M; Drung B; Schmidt B; Maffia P; Ialenti A; Mayr M; Xu Q; Ye S. 2014. Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation. Arterioscler Thromb Vasc Biol 34(1):90-8. PubMed: 24158518 MGI: J:222835
Xiao Q; Zhang F; Lin L; Fang C; Wen G; Tsai TN; Pu X; Sims D; Zhang Z; Yin X; Thomaszewski B; Schmidt B; Mayr M; Suzuki K; Xu Q; Ye S. 2013. Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions. Circ Res 112(1):35-47. PubMed: 23071158 MGI: J:212875
Xie C; Burns DK; Turley SD; Dietschy JM. 2000. Cholesterol is sequestered in the brains of mice with Niemann-Pick type C disease but turnover is increased. J Neuropathol Exp Neurol 59(12):1106-17. PubMed: 11138930 MGI: J:104996
Xie P; Zeng X; Xiao J; Sun B; Yang D. 2014. Transgenic CGI-58 expression in macrophages alleviates the atherosclerotic lesion development in ApoE knockout mice. Biochim Biophys Acta 1841(12):1683-90. PubMed: 25178844 MGI: J:230478
Xiong S; Salazar G; Patrushev N; Ma M; Forouzandeh F; Hilenski L; Alexander RW. 2013. Peroxisome proliferator-activated receptor gamma coactivator-1alpha is a central negative regulator of vascular senescence. Arterioscler Thromb Vasc Biol 33(5):988-98. PubMed: 23430617 MGI: J:217966
Xu F; Ji J; Li L; Chen R; Hu WC. 2007. Adventitial fibroblasts are activated in the early stages of atherosclerosis in the apolipoprotein E knockout mouse. Biochem Biophys Res Commun 352(3):681-8. PubMed: 17141183 MGI: J:116614
Xu L; Dai Perrard X; Perrard JL; Yang D; Xiao X; Teng BB; Simon SI; Ballantyne CM; Wu H. 2015. Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia. Arterioscler Thromb Vasc Biol 35(8):1787-97. PubMed: 26112011 MGI: J:241910
Xu PT; Schmechel D; Rothrock-Christian T; Burkhart DS; Qiu HL; Popko B; Sullivan P; Maeda N; Saunders AM; Roses AD; Gilbert JR. 1996. Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. Neurobiol Dis 3(3):229-45. PubMed: 8980023 MGI: J:109197
Xu YY; Du F; Meng B; Xie GH; Cao J; Fan D; Yu H. 2015. Hepatic overexpression of methionine sulfoxide reductase A reduces atherosclerosis in apolipoprotein E-deficient mice. J Lipid Res 56(10):1891-900. PubMed: 26318157 MGI: J:226165
Xu ZE; Chen Y; Huang A; Varghese Z; Moorhead JF; Yan F; Powis SH; Li Q; Ruan XZ. 2011. Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice. Am J Physiol Renal Physiol 301(4):F713-22. PubMed: 21795641 MGI: J:176272
Yagyu H; Ishibashi S; Chen Z; Osuga J; Okazaki M; Perrey S; Kitamine T; Shimada M; Ohashi K; Harada K; Shionoiri F; Yahagi N; Gotoda T; Yazaki Y; Yamada N. 1999. Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice. J Lipid Res 40(9):1677-85. PubMed: 10484615 MGI: J:57257
Yagyu H; Kitamine T; Osuga J; Tozawa R; Chen Z; Kaji Y; Oka T; Perrey S; Tamura Y; Ohashi K; Okazaki H; Yahagi N; Shionoiri F; Iizuka Y; Harada K; Shimano H; Yamashita H; Gotoda T; Yamada N; Ishibashi S. 2000. Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemia. J Biol Chem 275(28):21324-30. PubMed: 10777503 MGI: J:63468
Yamada S; Ding Y; Tanimoto A; Wang KY; Guo X; Li Z; Tasaki T; Nabesima A; Murata Y; Shimajiri S; Kohno K; Ichijo H; Sasaguri Y. 2011. Apoptosis signal-regulating kinase 1 deficiency accelerates hyperlipidemia-induced atheromatous plaques via suppression of macrophage apoptosis. Arterioscler Thromb Vasc Biol 31(7):1555-64. PubMed: 21527753 MGI: J:191468
Yamamoto S; Yancey PG; Zuo Y; Ma LJ; Kaseda R; Fogo AB; Ichikawa I; Linton MF; Fazio S; Kon V. 2011. Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis. Arterioscler Thromb Vasc Biol 31(12):2856-64. PubMed: 21979434 MGI: J:191451
Yamauchi T; Kamon J; Waki H; Imai Y; Shimozawa N; Hioki K; Uchida S; Ito Y; Takakuwa K; Matsui J; Takata M; Eto K; Terauchi Y; Komeda K; Tsunoda M; Murakami K; Ohnishi Y; Naitoh T; Yamamura K; Ueyama Y; Froguel P; Kimura S; Nagai R; Kadowaki T. 2003. Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem 278(4):2461-8. PubMed: 12431986 MGI: J:81727
Yan J; Su H; Xu L; Wang C. 2013. OX40-OX40L interaction promotes proliferation and activation of lymphocytes via NFATc1 in ApoE-deficient mice. PLoS One 8(4):e60854. PubMed: 23593329 MGI: J:200581
Yancey PG; Jerome WG; Yu H; Griffin EE; Cox BE; Babaev VR; Fazio S; Linton MF. 2007. Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI. J Lipid Res 48(5):1140-9. PubMed: 17299204 MGI: J:121848
Yang CP; Gilley JA; Zhang G; Kernie SG. 2011. ApoE is required for maintenance of the dentate gyrus neural progenitor pool. Development 138(20):4351-62. PubMed: 21880781 MGI: J:178337
Yang H; Roberts LJ; Shi MJ; Zhou LC; Ballard BR; Richardson A; Guo ZM. 2004. Retardation of atherosclerosis by overexpression of catalase or both Cu/Zn-superoxide dismutase and catalase in mice lacking apolipoprotein E. Circ Res 95(11):1075-81. PubMed: 15528470 MGI: J:103561
Yang J; Sato K; Aprahamian T; Brown NJ; Hutcheson J; Bialik A; Perlman H; Walsh K. 2004. Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 24(8):1466-73. PubMed: 15178561 MGI: J:102307
Yang K; Du C; Wang X; Li F; Xu Y; Wang S; Chen S; Chen F; Shen M; Chen M; Hu M; He T; Su Y; Wang J; Zhao J. 2017. Indoxyl sulfate induces platelet hyperactivity and contributes to chronic kidney disease-associated thrombosis in mice. Blood 129(19):2667-2679. PubMed: 28264799 MGI: J:241583
Yang M; Cooley BC; Li W; Chen Y; Vasquez-Vivar J; Scoggins NO; Cameron SJ; Morrell CN; Silverstein RL. 2017. Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions. Blood 129(21):2917-2927. PubMed: 28336528 MGI: J:241861
Yang X; Peterson L; Thieringer R; Deignan JL; Wang X; Zhu J; Wang S; Zhong H; Stepaniants S; Beaulaurier J; Wang IM; Rosa R; Cumiskey AM; Luo JM; Luo Q; Shah K; Xiao J; Nickle D; Plump A; Schadt EE; Lusis AJ; Lum PY. 2010. Identification and validation of genes affecting aortic lesions in mice. J Clin Invest 120(7):2414-22. PubMed: 20577049 MGI: J:163781
Yao J; Petanceska SS; Montine TJ; Holtzman DM; Schmidt SD; Parker CA; Callahan MJ; Lipinski WJ; Bisgaier CL; Turner BA; Nixon RA; Martins RN; Ouimet C; Smith JD; Davies P; Laska E; Ehrlich ME; Walker LC; Mathews PM; Gandy S. 2004. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. J Neurochem 90(4):1011-8. PubMed: 15287908 MGI: J:107867
Yao Y; Bennett BJ; Wang X; Rosenfeld ME; Giachelli C; Lusis AJ; Bostrom KI. 2010. Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res 107(4):485-94. PubMed: 20576934 MGI: J:175034
Yao Y; Watson AD; Ji S; Bostrom KI. 2009. Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein. Circ Res 105(6):575-84. PubMed: 19661459 MGI: J:169973
Ye X; Jiang X; Guo W; Clark K; Gao Z. 2013. Overexpression of NF-kappaB p65 in macrophages ameliorates atherosclerosis in apoE-knockout mice. Am J Physiol Endocrinol Metab 305(11):E1375-83. PubMed: 24105415 MGI: J:205993
Yesilaltay A; Daniels K; Pal R; Krieger M; Kocher O. 2009. Loss of PDZK1 causes coronary artery occlusion and myocardial infarction in Paigen diet-fed apolipoprotein E deficient mice. PLoS One 4(12):e8103. PubMed: 19956623 MGI: J:155971
Yet SF; Layne MD; Liu X; Chen YH; Ith B; Sibinga NE; Perrella MA. 2003. Absence of heme oxygenase-1 exacerbates atherosclerotic lesion formation and vascular remodeling. FASEB J 17(12):1759-61. PubMed: 12958201 MGI: J:85417
Yi X; Maeda N. 2006. alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet. Diabetes 55(8):2238-44. PubMed: 16873686 MGI: J:116519
Yin Y; Li X; Sha X; Xi H; Li YF; Shao Y; Mai J; Virtue A; Lopez-Pastrana J; Meng S; Tilley DG; Monroy MA; Choi ET; Thomas CJ; Jiang X; Wang H; Yang XF. 2015. Early hyperlipidemia promotes endothelial activation via a caspase-1-sirtuin 1 pathway. Arterioscler Thromb Vasc Biol 35(4):804-16. PubMed: 25705917 MGI: J:241338
Yoshimatsu M; Terasaki Y; Sakashita N; Kiyota E; Sato H; van der Laan LJ; Takeya M. 2004. Induction of macrophage scavenger receptor MARCO in nonalcoholic steatohepatitis indicates possible involvement of endotoxin in its pathogenic process. Int J Exp Pathol 85(6):335-43. PubMed: 15566430 MGI: J:104609
Yoshimura K; Aoki H; Ikeda Y; Fujii K; Akiyama N; Furutani A; Hoshii Y; Tanaka N; Ricci R; Ishihara T; Esato K; Hamano K; Matsuzaki M. 2005. Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase. Nat Med 11(12):1330-8. PubMed: 16311603 MGI: J:104132
You Z; Genest J Jr; Barrette PO; Hafiane A; Behm DJ; D'Orleans-Juste P; Schwertani AG. 2012. Genetic and pharmacological manipulation of urotensin II ameliorate the metabolic and atherosclerosis sequalae in mice. Arterioscler Thromb Vasc Biol 32(8):1809-16. PubMed: 22723440 MGI: J:201487
Young CG; Knight CA; Vickers KC; Westbrook D; Madamanchi NR; Runge MS; Ischiropoulos H; Ballinger SW. 2005. Differential effects of exercise on aortic mitochondria. Am J Physiol Heart Circ Physiol 288(4):H1683-9. PubMed: 15550530 MGI: J:97385
Yu H; Zhang W; Yancey PG; Koury MJ; Zhang Y; Fazio S; Linton MF. 2006. Macrophage apolipoprotein E reduces atherosclerosis and prevents premature death in apolipoprotein E and scavenger receptor-class BI double-knockout mice. Arterioscler Thromb Vasc Biol 26(1):150-6. PubMed: 16269665 MGI: J:127962
Yu J; Deng M; Zhao J; Huang L. 2010. Decreased expression of klotho gene in uremic atherosclerosis in apolipoprotein E-deficient mice. Biochem Biophys Res Commun 391(1):261-6. PubMed: 19912987 MGI: J:156734
Yu KC; David C; Kadambi S; Stahl A; Hirata K; Ishida T; Quertermous T; Cooper AD; Choi SY. 2004. Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice. J Lipid Res 45(9):1614-23. PubMed: 15175355 MGI: J:93268
Yu KC; Jiang Y; Chen W; Cooper AD. 2000. Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E J Lipid Res 41(11):1715-27. PubMed: 11060341 MGI: J:65695
Yu M; Zhou H; Zhao J; Xiao N; Roychowdhury S; Schmitt D; Hu B; Harding CV; Hise AG; Hazen SL; DeFranco AL; Fox PL; Morton RE; Dicorleto PE; Febbraio M; Nagy LE; Smith JD; Wang JA; Li X. 2014. MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases. J Exp Med 211(5):887-907. PubMed: 24752299 MGI: J:211307
Yu Z; Crichton I; Tang SY; Hui Y; Ricciotti E; Levin MD; Lawson JA; Pure E; Fitzgerald GA. 2012. Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proc Natl Acad Sci U S A 109(17):6727-32. PubMed: 22493243 MGI: J:183843
Yuan H; Zelka S; Burkatovskaya M; Gupte R; Leeman SE; Amar S. 2013. Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. Proc Natl Acad Sci U S A 110(52):E5059-68. PubMed: 24324141 MGI: J:205495
Yuan Z; Miyoshi T; Bao Y; Sheehan JP; Matsumoto AH; Shi W. 2009. Microarray analysis of gene expression in mouse aorta reveals role of the calcium signaling pathway in control of atherosclerosis susceptibility. Am J Physiol Heart Circ Physiol 296(5):H1336-43. PubMed: 19304945 MGI: J:150880
Yuan Z; Pei H; Roberts DJ; Zhang Z; Rowlan JS; Matsumoto AH; Shi W. 2009. Quantitative trait locus analysis of neointimal formation in an intercross between C57BL/6 and C3H/HeJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet 2(3):220-228. PubMed: 19718279 MGI: J:153521
Yuan Z; Su Z; Miyoshi T; Rowlan JS; Shi W. 2008. Quantitative trait locus analysis of circulating adhesion molecules in hyperlipidemic apolipoprotein E-deficient mice. Mol Genet Genomics 280(5):375-83. PubMed: 18704499 MGI: J:153398
Yuldasheva NY; Rashid ST; Haywood NJ; Cordell P; Mughal R; Viswambharan H; Imrie H; Sukumar P; Cubbon RM; Aziz A; Gage M; Mbonye KA; Smith J; Galloway S; Skromna A; Scott DJ; Kearney MT; Wheatcroft SB. 2014. Haploinsufficiency of the insulin-like growth factor-1 receptor enhances endothelial repair and favorably modifies angiogenic progenitor cell phenotype. Arterioscler Thromb Vasc Biol 34(9):2051-8. PubMed: 25012136 MGI: J:233226
Yun SJ; Ha JM; Kim EK; Kim YW; Jin SY; Lee DH; Song SH; Kim CD; Shin HK; Bae SS. 2014. Akt1 isoform modulates phenotypic conversion of vascular smooth muscle cells. Biochim Biophys Acta 1842(11):2184-92. PubMed: 25201081 MGI: J:218454
Zaina S; Pettersson L; Ahren B; Branen L; Hassan AB; Lindholm M; Mattsson R; Thyberg J; Nilsson J. 2002. Insulin-like growth factor II plays a central role in atherosclerosis in a mouse model. J Biol Chem 277(6):4505-11. PubMed: 11726660 MGI: J:74530
Zanotti I; Pedrelli M; Poti F; Stomeo G; Gomaraschi M; Calabresi L; Bernini F. 2011. Macrophage, but not systemic, apolipoprotein E is necessary for macrophage reverse cholesterol transport in vivo. Arterioscler Thromb Vasc Biol 31(1):74-80. PubMed: 20966401 MGI: J:184192
Zeibig S; Li Z; Wagner S; Holthoff HP; Ungerer M; Bultmann A; Uhland K; Vogelmann J; Simmet T; Gawaz M; Munch G. 2011. Effect of the oxLDL binding protein Fc-CD68 on plaque extension and vulnerability in atherosclerosis. Circ Res 108(6):695-703. PubMed: 21293004 MGI: J:183595
Zerbi V; Wiesmann M; Emmerzaal TL; Jansen D; Van Beek M; Mutsaers MP; Beckmann CF; Heerschap A; Kiliaan AJ. 2014. Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice. J Neurosci 34(42):13963-75. PubMed: 25319693 MGI: J:217160
Zernecke A; Bot I; Djalali-Talab Y; Shagdarsuren E; Bidzhekov K; Meiler S; Krohn R; Schober A; Sperandio M; Soehnlein O; Bornemann J; Tacke F; Biessen EA; Weber C. 2008. Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res 102(2):209-17. PubMed: 17991882 MGI: J:145593
Zernecke A; Liehn EA; Fraemohs L; von Hundelshausen P; Koenen RR; Corada M; Dejana E; Weber C. 2006. Importance of junctional adhesion molecule-A for neointimal lesion formation and infiltration in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol 26(2):e10-3. PubMed: 16306427 MGI: J:127969
Zernecke A; Liehn EA; Gao JL; Kuziel WA; Murphy PM; Weber C. 2006. Deficiency in CCR5 but not CCR1 protects against neointima formation in atherosclerosis-prone mice: involvement of IL-10. Blood 107(11):4240-3. PubMed: 16467202 MGI: J:128843
Zernecke A; Schober A; Bot I; von Hundelshausen P; Liehn EA; Mopps B; Mericskay M; Gierschik P; Biessen EA; Weber C. 2005. SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells. Circ Res 96(7):784-91. PubMed: 15761195 MGI: J:137758
Zerr M; Hechler B; Freund M; Magnenat S; Lanois I; Cazenave JP; Leon C; Gachet C. 2011. Major contribution of the P2Y(1)receptor in purinergic regulation of TNFalpha-induced vascular inflammation. Circulation 123(21):2404-13. PubMed: 21576651 MGI: J:184116
Zetterqvist AV; Berglund LM; Blanco F; Garcia-Vaz E; Wigren M; Duner P; Andersson AM; To F; Spegel P; Nilsson J; Bengtsson E; Gomez MF. 2013. Inhibition of nuclear factor of activated T-cells (NFAT) suppresses accelerated atherosclerosis in diabetic mice. PLoS One 8(6):e65020. PubMed: 23755169 MGI: J:203205
Zhang C; van der Voort D; Shi H; Zhang R; Qing Y; Hiraoka S; Takemoto M; Yokote K; Moxon JV; Norman P; Rittie L; Kuivaniemi H; Atkins GB; Gerson SL; Shi GP; Golledge J; Dong N; Perbal B; Prosdocimo DA; Lin Z. 2016. Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J Clin Invest 126(4):1282-99. PubMed: 26974158 MGI: J:234658
Zhang D; Jiang X; Fang P; Yan Y; Song J; Gupta S; Schafer AI; Durante W; Kruger WD; Yang X; Wang H. 2009. Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice. Circulation 120(19):1893-902. PubMed: 19858416 MGI: J:168131
Zhang G; Thomas AL; Marshall AL; Kernan KA; Su Y; Zheng Y; Takano J; Saido TC; Eddy AA. 2011. Nicotinic acetylcholine receptor alpha1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy. Lab Invest 91(1):106-23. PubMed: 20661225 MGI: J:167191
Zhang L; Connelly JJ; Peppel K; Brian L; Shah SH; Nelson S; Crosslin DR; Wang T; Allen A; Kraus WE; Gregory SG; Hauser ER; Freedman NJ. 2010. Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies. Hum Mol Genet 19(14):2754-66. PubMed: 20421368 MGI: J:161330
Zhang L; Peppel K; Sivashanmugam P; Orman ES; Brian L; Exum ST; Freedman NJ. 2007. Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis. Arterioscler Thromb Vasc Biol 27(5):1087-94. PubMed: 17442899 MGI: J:128059
Zhang S; Picard MH; Vasile E; Zhu Y; Raffai RL; Weisgraber KH; Krieger M. 2005. Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor class B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation 111(25):3457-64. PubMed: 15967843 MGI: J:114611
Zhang SH; Reddick RL; Burkey B; Maeda N. 1994. Diet-induced atherosclerosis in mice heterozygous and homozygous for apolipoprotein E gene disruption. J Clin Invest 94(3):937-45. PubMed: 8083379 MGI: J:20459
Zhang SH; Reddick RL; Piedrahita JA; Maeda N. 1992. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258(5081):468-71. PubMed: 1411543 MGI: J:16573
Zhang T; Dai P; Cheng D; Zhang L; Chen Z; Meng X; Zhang F; Han X; Liu J; Pan J; Yang G; Zhang C. 2014. Obesity occurring in apolipoprotein E-knockout mice has mild effects on fertility. Reproduction 147(2):141-51. PubMed: 24196014 MGI: J:207680
Zhang W; Yancey PG; Su YR; Babaev VR; Zhang Y; Fazio S; Linton MF. 2003. Inactivation of macrophage scavenger receptor class B type I promotes atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation 108(18):2258-63. PubMed: 14581413 MGI: J:103014
Zhang WJ; Bird KE; McMillen TS; LeBoeuf RC; Hagen TM; Frei B. 2008. Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. Circulation 117(3):421-8. PubMed: 18158360 MGI: J:145089
Zhang X; Thatcher SE; Rateri DL; Bruemmer D; Charnigo R; Daugherty A; Cassis LA. 2012. Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms. Circ Res 110(11):e73-85. PubMed: 22539767 MGI: J:212660
Zhang X; Zhu X; Chen B. 2010. Inhibition of collar-induced carotid atherosclerosis by recombinant apoA-I cysteine mutants in apoE-deficient mice. J Lipid Res 51(12):3434-42. PubMed: 20817832 MGI: J:167029
Zhao L; Gottesdiener AJ; Parmar M; Li M; Kaminsky SM; Chiuchiolo MJ; Sondhi D; Sullivan PM; Holtzman DM; Crystal RG; Paul SM. 2016. Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models. Neurobiol Aging 44:159-72. PubMed: 27318144 MGI: J:239037
Zhao L; Pratico D; Rader DJ; Funk CD. 2005. 12/15-Lipoxygenase gene disruption and vitamin E administration diminish atherosclerosis and oxidative stress in apolipoprotein E deficient mice through a final common pathway. Prostaglandins Other Lipid Mediat 78(1-4):185-93. PubMed: 16303615 MGI: J:112785
Zhao Y; Chen X; Yang H; Zhou L; Okoro EU; Guo Z. 2011. A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression. PLoS One 6(7):e21453. PubMed: 21779326 MGI: J:223907
Zhao Y; Howatt DA; Gizard F; Nomiyama T; Findeisen HM; Heywood EB; Jones KL; Conneely OM; Daugherty A; Bruemmer D. 2010. Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis. Circ Res 107(4):501-11. PubMed: 20558821 MGI: J:175040
Zhi X; Xu C; Zhang H; Tian D; Li X; Ning Y; Yin L. 2013. Tryptase promotes atherosclerotic plaque haemorrhage in ApoE-/- mice. PLoS One 8(4):e60960. PubMed: 23573292 MGI: J:200146
Zhou AX; Wang X; Lin CS; Han J; Yong J; Nadolski MJ; Boren J; Kaufman RJ; Tabas I. 2015. C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions. Circ Res 116(11):1736-43. PubMed: 25872946 MGI: J:233223
Zhou C; King N; Chen KY; Breslow JL. 2009. Activation of pregnane X receptor induces hypercholesterolemia in wild-type and accelerates atherosclerosis in apolipoprotein E deficient mice. J Lipid Res 50:2004-2013. PubMed: 19436068 MGI: J:154141
Zhou J; Dimayuga PC; Zhao X; Yano J; Lio WM; Trinidad P; Honjo T; Cercek B; Shah PK; Chyu KY. 2014. CD8(+)CD25(+) T cells reduce atherosclerosis in apoE(-/-) mice. Biochem Biophys Res Commun 443(3):864-70. PubMed: 24342615 MGI: J:211854
Zhou J; Lee PL; Tsai CS; Lee CI; Yang TL; Chuang HS; Lin WW; Lin TE; Lim SH; Wei SY; Chen YL; Chien S; Chiu JJ. 2012. Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow. Proc Natl Acad Sci U S A 109(20):7770-5. PubMed: 22550179 MGI: J:184788
Zhou J; Lhotak S; Hilditch BA; Austin RC. 2005. Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice. Circulation 111(14):1814-21. PubMed: 15809369 MGI: J:109687
Zhou X; Hansson GK. 1999. Detection of B cells and proinflammatory cytokines in atherosclerotic plaques of hypercholesterolaemic apolipoprotein E knockout mice. Scand J Immunol 50(1):25-30. PubMed: 10404048 MGI: J:56605
Zhou X; Paulsson G; Stemme S; Hansson GK. 1998. Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout mice. J Clin Invest 101(8):1717-25. PubMed: 9541503 MGI: J:47027
Zhou X; Robertson AK; Rudling M; Parini P; Hansson GK. 2005. Lesion development and response to immunization reveal a complex role for CD4 in atherosclerosis. Circ Res 96(4):427-34. PubMed: 15662027 MGI: J:106869
Zhou X; Stemme S; Hansson GK. 1996. Evidence for a local immune response in atherosclerosis. CD4+ T cells infiltrate lesions of apolipoprotein-E-deficient mice [see comments] Am J Pathol 149(2):359-66. PubMed: 8701976 MGI: J:34435
Zhou Y; Cheshire A; Howell LA; Ryan DH; Harris RB. 1999. Neuroautoantibody immunoreactivity in relation to aging and stress in apolipoprotein E-deficient mice. Brain Res Bull 49(3):173-9. PubMed: 10435780 MGI: J:110915
Zhou Z; Subramanian P; Sevilmis G; Globke B; Soehnlein O; Karshovska E; Megens R; Heyll K; Chun J; Saulnier-Blache JS; Reinholz M; van Zandvoort M; Weber C; Schober A. 2011. Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium. Cell Metab 13(5):592-600. PubMed: 21531341 MGI: J:175811
Zhu B; Kuhel DG; Witte DP; Hui DY. 2000. Apolipoprotein E inhibits neointimal hyperplasia after arterial injury in mice Am J Pathol 157(6):1839-48. PubMed: 11106557 MGI: J:66130
Zhu J; Chen T; Yang L; Li Z; Wong MM; Zheng X; Pan X; Zhang L; Yan H. 2012. Regulation of microRNA-155 in atherosclerotic inflammatory responses by targeting MAP3K10. PLoS One 7(11):e46551. PubMed: 23189122 MGI: J:195455
Zhu L; Zhong M; Elder GA; Sano M; Holtzman DM; Gandy S; Cardozo C; Haroutunian V; Robakis NK; Cai D. 2015. Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer's disease pathogenesis. Proc Natl Acad Sci U S A 112(38):11965-70. PubMed: 26372964 MGI: J:226992
Zimmer S; Steinmetz M; Asdonk T; Motz I; Coch C; Hartmann E; Barchet W; Wassmann S; Hartmann G; Nickenig G. 2011. Activation of endothelial toll-like receptor 3 impairs endothelial function. Circ Res 108(11):1358-66. PubMed: 21493895 MGI: J:185699
d'Uscio LV; Baker TA; Mantilla CB; Smith L; Weiler D; Sieck GC; Katusic ZS. 2001. Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 21(6):1017-22. PubMed: 11397713 MGI: J:103189
d'Uscio LV; Katusic ZS. 2006. Increased vascular biosynthesis of tetrahydrobiopterin in apolipoprotein E-deficient mice. Am J Physiol Heart Circ Physiol 290(6):H2466-71. PubMed: 16428344 MGI: J:111845
d'Uscio LV; Smith LA; Katusic ZS. 2001. Hypercholesterolemia impairs endothelium-dependent relaxations in common carotid arteries of apolipoprotein e-deficient mice. Stroke 32(11):2658-64. PubMed: 11692031 MGI: J:104001
ten Freyhaus H; Calay ES; Yalcin A; Vallerie SN; Yang L; Calay ZZ; Saatcioglu F; Hotamisligil GS. 2012. Stamp2 controls macrophage inflammation through nicotinamide adenine dinucleotide phosphate homeostasis and protects against atherosclerosis. Cell Metab 16(1):81-9. PubMed: 22704678 MGI: J:187419
van Gils JM; Derby MC; Fernandes LR; Ramkhelawon B; Ray TD; Rayner KJ; Parathath S; Distel E; Feig JL; Alvarez-Leite JI; Rayner AJ; McDonald TO; O'Brien KD; Stuart LM; Fisher EA; Lacy-Hulbert A; Moore KJ. 2012. The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques. Nat Immunol 13(2):136-43. PubMed: 22231519 MGI: J:181210
van Haperen R; de Waard M; van Deel E; Mees B; Kutryk M; van Aken T; Hamming J; Grosveld F; Duncker DJ; de Crom R. 2002. Reduction of blood pressure, plasma cholesterol, and atherosclerosis by elevated endothelial nitric oxide. J Biol Chem 277(50):48803-7. PubMed: 12364322 MGI: J:80701
van Meer P; Pfankuch T; Raber J. 2007. Reduced histamine levels and H3 receptor antagonist-induced histamine release in the amygdala of Apoe-/- mice. J Neurochem 103(1):124-30. PubMed: 17573822 MGI: J:128042
von Dehn G; von Dehn O; Volker W; Langer C; Weinbauer GF; Behre HM; Nieschlag E; Assmann G; von Eckardstein A. 2001. Atherosclerosis in apolipoprotein E-deficient mice is decreased by the suppression of endogenous sex hormones. Horm Metab Res 33(2):110-4. PubMed: 11294492 MGI: J:68906

Additional - Tg(GFAP-APOE_i4)1Hol related

Fagan AM; Holtzman DM; Munson G; Mathur T; Schneider D; Chang LK; Getz GS; Reardon CA; Lukens J; Shah JA; LaDu MJ. 1999. Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice. J Biol Chem 274(42):30001-7. PubMed: 10514484 MGI: J:58019
Hayashi H; Campenot RB; Vance DE; Vance JE. 2009. Protection of neurons from apoptosis by apolipoprotein E-containing lipoproteins does not require lipoprotein uptake and involves activation of phospholipase Cgamma1 and inhibition of calcineurin. J Biol Chem 284(43):29605-13. PubMed: 19717566 MGI: J:156971
Koistinaho M; Kettunen MI; Holtzman DM; Kauppinen RA; Higgins LS; Koistinaho J. 2002. Expression of human apolipoprotein E downregulates amyloid precursor protein-induced ischemic susceptibility. Stroke 33(7):1905-10. PubMed: 12105373 MGI: J:133156
Matsuo M; Campenot RB; Vance DE; Ueda K; Vance JE. 2011. Involvement of low-density lipoprotein receptor-related protein and ABCG1 in stimulation of axonal extension by apoE-containing lipoproteins. Biochim Biophys Acta 1811(1):31-8. PubMed: 21040802 MGI: J:170292

Also Known As: GFAP-apoE4, Tg(GFAP-APOE*4)1Hol

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Apoetm1Unc

Allele Symbol: Apoetm1Unc

Tg(GFAP-APOE_i4)1Hol

Allele Symbol: Tg(GFAP-APOE_i4)1Hol

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Genotype: Apoetm1Unc/Apoetm1Unc Tg(GFAP-APOE_i4)1Hol/0B6.Cg-Tg(GFAP-APOE_i4)1Hol Apoetm1Unc/J

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Apoe^tm1Unc

Allele Symbol: Apoe^tm1Unc

Genotype: Apoe^tm1Unc related

Genotype: Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)1Hol/0
B6.Cg-Tg(GFAP-APOE_i4)1Hol Apoe^tm1Unc/J

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