wdl homozygotes display a side-to-side wobble in their gait as early as two weeks of age and this persists throughout life. Despite this, they can swim in a straight line.
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous (Null/Knockout) | Car8 | carbonic anhydrase 8 |
wdl homozygotes display a side-to-side wobble in their gait as early as two weeks of age and this persists throughout life. Despite this, they can swim in a straight line.
The waddles mutation arose spontaneously in the C57BLKS/J production colony at The Jackson Laboratory in 1995 when that strain was at F104. The waddles bearing strain has been maintained by sibling mating and in 2004 reached F24.
Allele Name | waddles |
---|---|
Allele Type | Spontaneous (Null/Knockout) |
Allele Synonym(s) | rig; rigoletto |
Gene Symbol and Name | Car8, carbonic anhydrase 8 |
Gene Synonym(s) | |
Strain of Origin | C57BLKS/J |
Chromosome | 4 |
General Note | This mutation arose at The Jackson Laboratory. |
Molecular Note | Mutant mice contain a 19-nucleotide deletion, 15 of which are flanked by two AAGG motifs. Car8 transcript is absent in homozygous mice, suggesting that this is a null mutation. |
When using the waddles mouse strain in a publication, please cite the originating article(s) and include JAX stock #004625 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Heterozygous for Car8<wdl> |
Frozen Mouse Embryo | C57BLKS/J-Car8<wdl>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C57BLKS/J-Car8<wdl>/GrsrJ | $2595.00 |
Frozen Mouse Embryo | C57BLKS/J-Car8<wdl>/GrsrJ | $3373.50 |
Frozen Mouse Embryo | C57BLKS/J-Car8<wdl>/GrsrJ | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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