C57BLKS/J-Car8^wdl/GrsrJ

Stock number: 004625
Product name: waddles
Research areas: Neurobiology Research

Detailed description

wdl homozygotes display a side-to-side wobble in their gait as early as two weeks of age and this persists throughout life. Despite this, they can swim in a straight line.

Development

The waddles mutation arose spontaneously in the C57BLKS/J production colony at The Jackson Laboratory in 1995 when that strain was at F104. The waddles bearing strain has been maintained by sibling mating and in 2004 reached F24.

Allele

Symbol: Car8^wdl
Name: waddles
MGI accession ID: MGI:2449035
Generation method: Spontaneous
Attributes: Null/Knockout
Synonyms: rig; rigoletto
Marker symbol: Car8
Marker name: carbonic anhydrase 8
Marker synonyms: Ca8; CALS; Cals1; CAMRQ3; Carp; CA-RP; CA-RP VIII; CA-VIII; wdl
Chromosome: 4
Strain of origin: C57BLKS/J
Molecular note: Mutant mice contain a 19-nucleotide deletion, 15 of which are flanked by two AAGG motifs. Car8 transcript is absent in homozygous mice, suggesting that this is a null mutation.
General note: This mutation arose at The Jackson Laboratory.