Mice that are homozygous for the mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Screening of third generation mice (G3) on standard chow identified a 9 week old female (born 4/15/2001) with a mean systolic blood pressure of 133 +/- 16 mmHg, which is approximately 22% higher than controls. This mutant mouse strain may be useful in studies of hypertension.
This phenotypic mutant was identified following multidose ethylnitrosourea (ENU) treatments to induce mutations in male founder C57BL/6J mice (Stock No. 000664), a forward genetic screen was utilized to identify phenotypic deviants in complex heart, lung, blood, and sleep disorders, at the Mouse Heart, Lung, Blood, and Sleep Disorders (HLBS) Center at The Jackson Laboratory. Heterozygotes were crossed to generate homozygotes. The mice have been maintained on a C57BL/6J background.
|Allele Name||heart, lung and blood, 15|
|Allele Type||Chemically induced (ENU)|
|Gene Symbol and Name||hlb15, heart lung and blood, 15|
|Strain of Origin||C57BL/6J|
|Molecular Note||This phenotypic mutant was identified in an ENU mutagenesis screen.|