The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains. This strain can be used in experiments designed to determine the distribution and function of T-cells, and has been used to study the role of T-cell subsets as a function of underlying diabetes development.Read More +
Thy1 is one of the pan T cell markers and is expressed on thymocytes, peripheral T cells, myoblasts, epidermal cells, and keratinocytes. This congenic is useful for the adoptive transfer of diabetes in the NOD/ShiLtJ mouse model. Donor T cells can be easily distinguished from recipient T cells by both flow cytometric and histological analysis.
This strain was created in the laboratory of Dr. Edward Leiter, at The Jackson Laboratory, by continued backcrossing of the NON/HlLt-derived Thy1a allele from NOD.NON-Thy1a/J (N13; Stock Number 002721) onto the NOD/Lt background for an additional 8 generations, to N21. It has since been maintained by crossing siblings homozygous for Thy1a.
|Allele Name||a variant|
|Allele Type||Not Applicable|
|Allele Synonym(s)||Thy-1.1; Thy1.1; Thy1a; theta-AKR; thetaAKR|
|Gene Symbol and Name||Thy1, thymus cell antigen 1, theta|
|Gene Synonym(s)||CD7; CD90; CDw90; T25; Thy 1.2; Thy-1; Thy-1; Thy-1.2; Thy1.1; Thy1.2; theta|
|Site of Expression||The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells.|
|Strain of Origin||Not Applicable|
|General Note|| |
The Thy1 locus determines a surface antigen present on cells of the thymus, a number of mouse leukemias, brain, and in lesser amounts on lymph node and spleen cells. The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains; the allele Thy1b determines an antigenic specificity, Thy-1.2, found in the C3HeB/Fe and many other strains (J:5243, J:5012, J:4469). The Thy1 antigen is probably present on all T lymphocytes and absent from all B lymphocytes, and it thus serves as a valuable T-cell marker (J:5243). It is very widely used in experiments designed to determine the distribution and function of T-cells. Thy1 specifies a T-cell surface glycoprotein, T25, with a molecular weight of 25 kDa (J:5707). The protein appears to be anchored in the cell membrane by a lipid that is either phosphotidylinositol or closely related to it (J:12016). Thy1 may function in the cell membrane as a signal transduction molecule (J:8333). The Thy1 locus, or possibly a gene closely linked to it, controls quantitative expression of a protein that isthe same size as Thy1 and is expressed on thymus and brain but not on lymph node and spleen cells (J:7900).
|Molecular Note||The allele Thy1a determines an antigenic specificity, Thy-1.1, found in the AKR and RF strains.|
|Please inquire about possible genotypes.|
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