These RC-5 recombinant congenic mice do not develop spontaneous type 2 diabetes on a 6% fat-containing diet.
Read More +September 2004: A recessive head-tilt phenotype has been identified in some mice in this strain and is being bred out, but may be segregating in the mice currently being distributed.
A diabetes-resistant recombinant congenic developed by introgressing selected markers of resistance alleles for all but one known diabesity QTL in the parental strains NZO/HlLt and NON/Lt. The NONcNZO5/LtJ stock has been specifically constructed to exclude 5 NZO-derived and two NON-derived diabetes susceptibility QTL present in the highly diabetes-prone NONcNZO10LtJ recombinant congenic stock. NONcNZO5/LtJ males develop a comparable level of moderate obesity to that developing in the highly diabetes susceptible NONcNZO10/LtJ males, but they do not develop the extreme obesity characteristic of NZO/HlLt. Neither NONcNZO5/LtJ males nor females develop spontaneous type 2 diabetes on a 6% fat-containing diet. Serum insulin and leptin values are close to the NON/Lt parental background range and significantly lower than in NZO/HlLt. Unlike NZO/HlLt, NONcNZO5/LtJ breeds well. Unlike NZO and NONcNZO10/LtJ males, NONcNZO5LtJ males are resistant to adverse hepatic side effects of thiazolidinediones and thus, in combination with NONcNZO10/LtJ mice, may be useful for pharmacogenetic analysis. This strain represents a model of polygenic obesity and may be used as a diabetes resistant control for NONcNZO10/LtJ (Stock No. 004456).
Currently there are no related genes or alleles for this strain.
When using the NONcNZO5/LtJ mouse strain in a publication, please cite the originating article(s) and include JAX stock #004455 in your Materials and Methods section.
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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