DBA/1LacJ-Lrp4^mdig/GrsrJ

Stock number: 004423
Product name: malformed digits
Research areas: Developmental Biology Research

Detailed description

Homozygotes have variable brachydactyly and syndactyly of all four feet and incomplete polydactyly can occur in the front feet.

Development

The recessive mdig mutation arose spontaneously in 1999 on the DBA/1LacJ background at The Jackson Laboratory and has been maintained primarily through sibling mating homozygote x heterozygote and vice versa. In 2005 embryos were generated for cryopreservation from DBA/1LacJ females and homozygous mutant males.

Allele

Symbol: Lrp4^mdig
Name: malformed digits
MGI accession ID: MGI:2661383
Generation method: Spontaneous
Marker symbol: Lrp4
Marker name: low density lipoprotein receptor-related protein 4
Chromosome: 2
Strain of origin: DBA/1LacJ
Molecular note: An A to T transversion at the 3' end of exon 15 results in a mutant splice site. As a consequence, exon 15 is skipped.