C57BL/6J-Chr 6^A/J/NaJ

Stock number: 004384
Product name: CSS-6
Strain synonyms: B6.A-Chr6, CSS-6, CSS6, B6.A-Chr6
Research areas: Research Tools

Description

Chromosome 6 from A/J has replaced the homologous chromosome of C57BL/6J in this strain of the set of consomic strains with C57BL/6J as background.

Detailed description

A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and A/J strains in this set were chosen because they differ in their susceptibility to diseases such as arthritis, asthma, atherosclerosis, cancer, several infectious diseases, inflammatory responses, and physiological, behavioral and sensory phenotypes. Chromosome substitution strain nomenclature is designated as Host Strain - Chromosome #<Donor Strain>/Laboratory code. For example, C57BL/6J-Chr1^A/NaJ carries chromosome 1 for strain A/J (A) on a C57BL/6J background, was constructed in the laboratory of Joseph Nadeau (Na) and is maintained at The Jackson Laboratory (J). Chromosome substitution strains or consomic strains can accelerate quantitative trait loci identification and mapping.

Chromosome 6 from the A/J inbred strain contains the naturally-occurring, progressive muscular dystrophy mutation of the dysferlin gene (Dysf^prmd). As a result of Dysf^prmd homozygosity, A/J inbred mice exhibit a late onset (four to five months) progressive muscular dystrophy characterized by degeneration/regeneration and placed nuclei, with proximal muscles more severely affected than distal muscles.

Development

Dr. Joseph Nadeau from Case Western Reserve University developed the C57BL/6J-Chr #^A/NaJ strain set by replacing individual chromosomes from the A/J donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses (Nadeau et al., 2000). The set was donated to The Jackson Laboratory in 2004.