Chromosome 6 from A/J has replaced the homologous chromosome of C57BL/6J in this strain of the set of consomic strains with C57BL/6J as background.Read More +
A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and A/J strains in this set were chosen because they differ in their susceptibility to diseases such as arthritis, asthma, atherosclerosis, cancer, several infectious diseases, inflammatory responses, and physiological, behavioral and sensory phenotypes. Chromosome substitution strain nomenclature is designated as Host Strain - Chromosome #<Donor Strain>/Laboratory code. For example, C57BL/6J-Chr1A/NaJ carries chromosome 1 for strain A/J (A) on a C57BL/6J background, was constructed in the laboratory of Joseph Nadeau (Na) and is maintained at The Jackson Laboratory (J). Chromosome substitution strains or consomic strains can accelerate quantitative trait loci identification and mapping.
Chromosome 6 from the A/J inbred strain contains the naturally-occurring, progressive muscular dystrophy mutation of the dysferlin gene (Dysfprmd). As a result of Dysfprmd homozygosity, A/J inbred mice exhibit a late onset (four to five months) progressive muscular dystrophy characterized by degeneration/regeneration and placed nuclei, with proximal muscles more severely affected than distal muscles.
Dr. Joseph Nadeau from Case Western Reserve University developed the C57BL/6J-Chr #A/NaJ strain set by replacing individual chromosomes from the A/J donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses (Nadeau et al., 2000). The set was donated to The Jackson Laboratory in 2004.
Currently there are no related genes or alleles for this strain.
|Homozygous, 1 pair minimum|
We will fulfill your order by providing at least two carriers for each strain ordered. The total number, sex, and genotypes provided will vary, although typically 8 or more animals are provided. Please check genotypes which will be recovered. While the genotypes of all animals produced will be communicated to you prior to scheduling shipment, the genotypes of animals provided may not reflect the mating scheme and genotypes described in the strain description. Animals are typically ready to ship in 11-14 weeks. If a second recovery is required to produce the minimum number of animals, then delivery time would increase to approximately 25 weeks. If we fail to produce animals of the correct genotype, you will not be charged. We cannot guarantee the reproductive success of mice shipped to your facility. If the mice are lost after the first three days (post-arrival) or do not produce progeny at your facility, a new order and fee will be necessary.
Cryorecovery to establish a Dedicated Supply for greater quantities of mice. Mice recovered can be used to establish a dedicated colony to contractually supply you mice according to your requirements. Price by quotation.
|Frozen Mouse Embryo||$2,595.00 per straw or vial|
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