Chromosome 1 from A/J has replaced the homologous chromosome of C57BL/6J in this strain of the set of consomic strains with C57BL/6J as background.
Read More +A chromosome substitution or consomic strain is an inbred strain with one of its chromosomes replaced by the homologous chromosome of another inbred strain. The C57BL/6J and A/J strains in this set were chosen because they differ in their susceptibility to diseases such as arthritis, asthma, atherosclerosis, cancer, several infectious diseases, inflammatory responses, and physiological, behavioral and sensory phenotypes. Chromosome substitution strain nomenclature is designated as Host Strain - Chromosome #<Donor Strain>/Laboratory code. For example, C57BL/6J-Chr1A/NaJ carries chromosome 1 for strain A/J (A) on a C57BL/6J background, was constructed in the laboratory of Joseph Nadeau (Na) and is maintained at The Jackson Laboratory (J). Chromosome substitution strains or consomic strains can accelerate quantitative trait loci identification and mapping.
Dr. Joseph Nadeau from Case Western Reserve University developed the C57BL/6J-Chr #A/NaJ strain set by replacing individual chromosomes from the A/J donor strain into the C57BL/6J host strain using a marker-assisted series of backcrosses (Nadeau et al., 2000). The set was donated to The Jackson Laboratory in 2004.
Currently there are no related genes or alleles for this strain.
When using the CSS-1 mouse strain in a publication, please cite the originating article(s) and include JAX stock #004379 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
---|---|---|
Homozygous |
Mouse ES Cells | C57BL/6J-Chr 1A/J/NaJ I11/GrsrJ mES cells | $695.00 |
Frozen Mouse Embryo | C57BL/6J-Chr 1<A/J>/NaJ Frozen Embryos | $2595.00 |
Mouse ES Cells | C57BL/6J-Chr 1A/J/NaJ I11/GrsrJ mES cells | $695.00 |
Frozen Mouse Embryo | C57BL/6J-Chr 1<A/J>/NaJ Frozen Embryos | $2595.00 |
Mouse ES Cells | C57BL/6J-Chr 1A/J/NaJ I11/GrsrJ mES cells | $695.00 |
Frozen Mouse Embryo | C57BL/6J-Chr 1<A/J>/NaJ Frozen Embryos | $3373.50 |
Mouse ES Cells | C57BL/6J-Chr 1A/J/NaJ I11/GrsrJ mES cells | $695.00 |
Frozen Mouse Embryo | C57BL/6J-Chr 1<A/J>/NaJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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