JAX
Mouse Strain Datasheet - 004319
B6.129S1-Mapk8tm1Flv/J
Also Known As: Jnk1 KO
Mice that are homozygous for the knock-out mutation are susceptible to Leishmania major infection. This mutant mouse strain represents a model that may be useful in studies related to signal transduction.
Donating Investigator
Dr. Richard A. Flavell, Yale University School of Medicine
Genetic overview
| Genetic Background | Generation |
|---|---|
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Mapk8tm1Flv
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Mapk8 | mitogen-activated protein kinase 8 |
Research Applications
- Immunology, Inflammation and Autoimmunity Research
Detailed Description
Mice that are homozygous for the targeted mutation are viable, normal in size, do not display any gross physical or behavioral abnormalities and are fertile but poor breeders. No gene product, protein or mRNA, is detected. Lymphocyte development, T cell to B cell ratio and CD4 to CD8 ratio are normal. Naive Th cells activated in vitro preferentially differentiate into Th2 cells. Mutant mice are susceptible to infection when challenged with the intracellular pathogen, Leishmania major. Primary murine embryonic fibroblasts prepared from mutant embryos are partially protected from UV-induced apoptosis. This mutant mouse strain represents a model that may be useful in studies related to signal transduction.
Development
A targeting vector containing a hygromycin phosphotransferase gene driven by the mouse phosphoglycerate kinase promoter and a herpes simplex virus thymidine kinase gene was used to disrupt 5.5kb of genomic sequence, encoding four exons of the targeted gene. The construct was electroporated into 129S1 derived W9.5 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6 blastocysts. The resulting chimeric animals were backcrossed to C57BL/6 mice.
A 32 SNP (single nucleotide polymorphism) panel analysis, with 27 markers covering all 19 chromosomes and the X chromosome, as well as 5 markers that distinguish between the C57BL/6J and C57BL/6N substrains, was performed on the rederived living colony at The Jackson Laboratory Repository. While the 27 markers throughout the genome suggested a C57BL/6 genetic background, 2 of 5 markers that determine C57BL/6J from C57BL/6N were found to be segregating. These data suggest the mice sent to The Jackson Laboratory Repository may have been on a mixed C57BL/6J x C57BL/6N genetic background.
Control Suggestions
- Wild-type from the colony
Approximate Controls
Additional Information
Selected References
- Dong C; Yang DD; Wysk M; Whitmarsh AJ; Davis RJ; Flavell RA. 1998. Defective T cell differentiation in the absence of Jnk1. Science 282(5396):2092-5. PubMed: 9851932MGI: J:51510
Mapk8tm1Flv
Allele Symbol: Mapk8tm1Flv
| Allele Name | targeted mutation 1, Richard Flavell |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | Jnk1 -; Jnk1 KO |
| Gene Symbol and Name | Mapk8, mitogen-activated protein kinase 8 |
| Gene Synonym(s) | AI849689; JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; PRKM8; Prkm8; Prkm8; SAPK1; SAPK1c; c-Jun N-terminal kinase; expressed sequence AI849689; protein kinase mitogen-activated 8 |
| Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Chromosome | 14 |
| Molecular Note | A hygromycin resistance cassette replaced a 5.5 kb genomic fragment containing four exons of the gene. Western blot analysis on extracts derived from embryonic fibroblasts of homozygous mice confirmed that no detectable protein was expressed from this allele. |
| Mutations Made By | Dr. Richard Flavell, Yale University School of Medicine |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Mapk8tm1Flv related
- Immunology, Inflammation and Autoimmunity Research
- Intracellular Signaling Molecules
Mammalian Phenotype Terms by Genotype
Genotype: Mapk8tm1Flv/Mapk8tm1Flv
B6.129S1-Mapk8tm1Flv
integument phenotype
- abnormal epidermis stratum basale morphology
- number of proliferating cells in the stratum basale is reduced (MGI Ref ID J:93433)
- absent keratohyalin granules
- keratohyalin granules, markers of epidermal differentiation, are missing (MGI Ref ID J:93433)
- thin epidermis
- epidermis is thin and consists of fewer cell layers (MGI Ref ID J:93433)
Genotype: Mapk8tm1Flv/Mapk8tm1Flv
B6.129S1-Mapk8tm1Flv/J
liver/biliary system phenotype
- liver/biliary system phenotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Mapk8tm1Flv/Mapk8tm1Flv
involves: 129S1/Sv
immune system phenotype
- abnormal T-helper 1 cell differentiation
- abnormal cytokine secretion
- T helper 2 cells secrete greatly increased amounts of T helper 2 cytokines (10x as much IL-4, 5x as much IL-5, and moderate increase in IL-10), indicating enhanced T helper 2 cell response (MGI Ref ID J:51510)
- increased T cell proliferation
- splenocytes and CD4+ T cells display enhanced proliferation in response to stimulation and CD4+ helper T cells show a moderate reduction of activation-induced cell death (MGI Ref ID J:51510)
hematopoietic system phenotype
- abnormal T-helper 1 cell differentiation
- increased T cell proliferation
- splenocytes and CD4+ T cells display enhanced proliferation in response to stimulation and CD4+ helper T cells show a moderate reduction of activation-induced cell death (MGI Ref ID J:51510)
neoplasm
- increased incidence of tumors by chemical induction
- exhibit increased incidence and number of TPA-induced carcinomas, indicating that papillomas have an increased risk of undergoing malignant conversion compared to wild-type (MGI Ref ID J:75228)
- exhibit increased susceptibility to TPA-induced skin tumor development compared to wild-type, with increased rate and number of papillomas (MGI Ref ID J:75228)
cardiovascular system phenotype
- cardiac fibrosis
- exhibit inflammatory lesions that lead to the development of significant fibrosis following pressure overload compared to wild-type (MGI Ref ID J:108253)
- decreased cardiac muscle contractility
- exhibit a significant reduction in fractional shortening after 3 and 7 days of pressure overload compared to wild-type, however cardiac function improves over time and is similar to wild-type after 12 weeks of TAC (MGI Ref ID J:108253)
- increased cardiomyocyte apoptosis
- exhibit increased rates of myocyte death following pressure overload compared to wild-type (MGI Ref ID J:108253)
- increased response of heart to induced stress
- develop cardiac hypertrophy similar to wild-type after pressure overload, however display a reduction in fractional shortening, increased inflammatory infiltrate and fibrosis and increased myocyte death compared to wild-type (MGI Ref ID J:108253)
muscle phenotype
- decreased cardiac muscle contractility
- exhibit a significant reduction in fractional shortening after 3 and 7 days of pressure overload compared to wild-type, however cardiac function improves over time and is similar to wild-type after 12 weeks of TAC (MGI Ref ID J:108253)
- increased cardiomyocyte apoptosis
- exhibit increased rates of myocyte death following pressure overload compared to wild-type (MGI Ref ID J:108253)
homeostasis/metabolism phenotype
- increased incidence of tumors by chemical induction
- exhibit increased incidence and number of TPA-induced carcinomas, indicating that papillomas have an increased risk of undergoing malignant conversion compared to wild-type (MGI Ref ID J:75228)
- exhibit increased susceptibility to TPA-induced skin tumor development compared to wild-type, with increased rate and number of papillomas (MGI Ref ID J:75228)
- increased response of heart to induced stress
- develop cardiac hypertrophy similar to wild-type after pressure overload, however display a reduction in fractional shortening, increased inflammatory infiltrate and fibrosis and increased myocyte death compared to wild-type (MGI Ref ID J:108253)
cellular phenotype
- increased cardiomyocyte apoptosis
- exhibit increased rates of myocyte death following pressure overload compared to wild-type (MGI Ref ID J:108253)
Genotype: Mapk8tm1Flv/Mapk8tm1Flv
involves: 129S1/Sv * C57BL/6
cardiovascular system phenotype
- abnormal myocardium layer morphology
- after induced ischemia-reperfusion (I-R) injury, mice show significant protection compared to wild-type controls as indicated by reduced viable myocardium area at risk (AAR) versus nonviable infarcted area (IA) (MGI Ref ID J:102152)
- decreased cardiomyocyte apoptosis
- significantly less cleavage of caspase-3 (reduced by about 50%) is observed compared to wild-type (MGI Ref ID J:102152)
muscle phenotype
- decreased cardiomyocyte apoptosis
- significantly less cleavage of caspase-3 (reduced by about 50%) is observed compared to wild-type (MGI Ref ID J:102152)
homeostasis/metabolism phenotype
- abnormal enzyme/coenzyme activity
- upon UV irradiation, mutant MEFs (mouse embryonic fibroblasts) show an even larger decrease in JNK activity than Mapk9-null MEFs, compared to wild-type (MGI Ref ID J:112737)
cellular phenotype
- decreased cardiomyocyte apoptosis
- significantly less cleavage of caspase-3 (reduced by about 50%) is observed compared to wild-type (MGI Ref ID J:102152)
References
- Dong C; Yang DD; Wysk M; Whitmarsh AJ; Davis RJ; Flavell RA. 1998. Defective T cell differentiation in the absence of Jnk1. Science 282(5396):2092-5. PubMed: 9851932MGI: J:51510
Additional References
- Constant SL; Dong C; Yang DD; Wysk M; Davis RJ; Flavell RA. 2000. JNK1 is required for T cell-mediated immunity against Leishmania major infection. J Immunol 165(5):2671-6. PubMed: 10946297MGI: J:64050
Additional - Mapk8tm1Flv related
- Abdelli S; Puyal J; Bielmann C; Buchillier V; Abderrahmani A; Clarke PG; Beckmann JS; Bonny C. 2009. JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis. Diabetologia 52(9):1871-80. PubMed: 19609503MGI: J:154878
- Adam F; Kauskot A; Nurden P; Sulpice E; Hoylaerts MF; Davis RJ; Rosa JP; Bryckaert M. 2010. Platelet JNK1 is involved in secretion and thrombus formation. Blood 115(20):4083-92. PubMed: 20231429MGI: J:160229
- Adhikary G; Sun Y; Pearlman E. 2008. C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation. J Leukoc Biol 83(4):991-7. PubMed: 18218857MGI: J:134160
- Alcorn JF; Guala AS; van der Velden J; McElhinney B; Irvin CG; Davis RJ; Janssen-Heininger YM. 2008. Jun N-terminal kinase 1 regulates epithelial-to-mesenchymal transition induced by TGF-beta1. J Cell Sci 121(Pt 7):1036-45. PubMed: 18334556MGI: J:138475
- Alcorn JF; van der Velden J; Brown AL; McElhinney B; Irvin CG; Janssen-Heininger YM. 2009. c-Jun N-terminal kinase 1 is required for the development of pulmonary fibrosis. Am J Respir Cell Mol Biol 40(4):422-32. PubMed: 18836136MGI: J:159273
- Anbalagan M; Sabapathy K. 2012. JNK1 and JNK2 play redundant functions in Myc-induced B cell lymphoma formation. Int J Cancer 130(8):1967-9. PubMed: 21630260MGI: J:181076
- Barnat M; Enslen H; Propst F; Davis RJ; Soares S; Nothias F. 2010. Distinct roles of c-Jun N-terminal kinase isoforms in neurite initiation and elongation during axonal regeneration. J Neurosci 30(23):7804-16. PubMed: 20534829MGI: J:160890
- Bjorkblom B; Ostman N; Hongisto V; Komarovski V; Filen JJ; Nyman TA; Kallunki T; Courtney MJ; Coffey ET. 2005. Constitutively active cytoplasmic c-Jun N-terminal kinase 1 is a dominant regulator of dendritic architecture: role of microtubule-associated protein 2 as an effector. J Neurosci 25(27):6350-61. PubMed: 16000625MGI: J:99429
- Bonnesen B; Orskov C; Rasmussen S; Holst PJ; Christensen JP; Eriksen KW; Qvortrup K; Odum N; Labuda T. 2005. MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver. Blood 106(10):3396-404. PubMed: 16081685MGI: J:124072
- Bourdi M; Korrapati MC; Chakraborty M; Yee SB; Pohl LR. 2008. Protective role of c-Jun N-terminal kinase 2 in acetaminophen-induced liver injury. Biochem Biophys Res Commun 374(1):6-10. PubMed: 18586006MGI: J:139164
- Brecht S; Kirchhof R; Chromik A; Willesen M; Nicolaus T; Raivich G; Wessig J; Waetzig V; Goetz M; Claussen M; Pearse D; Kuan CY; Vaudano E; Behrens A; Wagner E; Flavell RA; Davis RJ; Herdegen T. 2005. Specific pathophysiological functions of JNK isoforms in the brain. Eur J Neurosci 21(2):363-77. PubMed: 15673436MGI: J:100808
- Casals-Casas C; Alvarez E; Serra M; de la Torre C; Farrera C; Sanchez-Tillo E; Caelles C; Lloberas J; Celada A. 2009. CREB and AP-1 activation regulates MKP-1 induction by LPS or M-CSF and their kinetics correlate with macrophage activation versus proliferation. Eur J Immunol 39(7):1902-1913. PubMed: 19585511MGI: J:150260
- Cellurale C; Sabio G; Kennedy NJ; Das M; Barlow M; Sandy P; Jacks T; Davis RJ. 2011. Requirement of c-Jun NH2-Terminal Kinase for Ras-Initiated Tumor Formation. Mol Cell Biol 31(7):1565-76. PubMed: 21282468MGI: J:170101
- Cellurale C; Weston CR; Reilly J; Garlick DS; Jerry DJ; Sluss HK; Davis RJ. 2010. Role of JNK in a Trp53-dependent mouse model of breast cancer. PLoS One 5(8):. PubMed: 20814571MGI: J:163993
- Chaudhury H; Zakkar M; Boyle J; Cuhlmann S; van der Heiden K; Luong le A; Davis J; Platt A; Mason JC; Krams R; Haskard DO; Clark AR; Evans PC. 2010. c-Jun N-terminal kinase primes endothelial cells at atheroprone sites for apoptosis. Arterioscler Thromb Vasc Biol 30(3):546-53. PubMed: 20056910MGI: J:172150
- Chen X; Xu H; Ding L; Lou G; Liu Y; Yao Y; Chen L; Huang W; Fu X. 2015. Identification of miR-26a as a target gene of bile acid receptor GPBAR-1/TGR5. PLoS One 10(6):e0131294. PubMed: 26107166MGI: J:233800
- Choi HS; Bode AM; Shim JH; Lee SY; Dong Z. 2009. c-Jun N-terminal kinase 1 phosphorylates Myt1 to prevent UVA-induced skin cancer. Mol Cell Biol 29(8):2168-80. PubMed: 19204086MGI: J:147767
- Choi J; Kim JR; Kim H; Kim YA; Lee HJ; Kim J; Lee KW. 2013. The atopic dermatitis-like symptoms induced by MC903 were alleviated in JNK1 knockout mice. Toxicol Sci 136(2):443-9. PubMed: 24046278MGI: J:207545
- Chromik AM; Muller AM; Korner J; Belyaev O; Holland-Letz T; Schmitz F; Herdegen T; Uhl W; Mittelkotter U. 2007. Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice. J Invest Surg 20(1):23-33. PubMed: 17365404MGI: J:130576
- Constant SL; Dong C; Yang DD; Wysk M; Davis RJ; Flavell RA. 2000. JNK1 is required for T cell-mediated immunity against Leishmania major infection. J Immunol 165(5):2671-6. PubMed: 10946297MGI: J:64050
- Conze D; Krahl T; Kennedy N; Weiss L; Lumsden J; Hess P; Flavell RA; Le Gros G; Davis RJ; Rincon M. 2002. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation. J Exp Med 195(7):811-23. PubMed: 11927626MGI: J:124416
- Das M; Sabio G; Jiang F; Rincon M; Flavell RA; Davis RJ. 2009. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136(2):249-60. PubMed: 19167327MGI: J:147632
- Denninger K; Rasmussen S; Larsen JM; Orskov C; Seier Poulsen S; Sorensen P; Christensen JP; Illges H; Odum N; Labuda T. 2011. JNK1, but Not JNK2, Is Required in Two Mechanistically Distinct Models of Inflammatory Arthritis. Am J Pathol 179(4):1884-93. PubMed: 21839715MGI: J:176299
- Diaz-Delfin J; Hondares E; Iglesias R; Giralt M; Caelles C; Villarroya F. 2012. TNF-alpha represses beta-Klotho expression and impairs FGF21 action in adipose cells: involvement of JNK1 in the FGF21 pathway. Endocrinology 153(9):4238-45. PubMed: 22778214MGI: J:189171
- Diaz-Delfin J; Morales M; Caelles C. 2007. Hypoglycemic action of thiazolidinediones/peroxisome proliferator-activated receptor gamma by inhibition of the c-Jun NH2-terminal kinase pathway. Diabetes 56(7):1865-71. PubMed: 17416798MGI: J:126454
- Dolinay T; Wu W; Kaminski N; Ifedigbo E; Kaynar AM; Szilasi M; Watkins SC; Ryter SW; Hoetzel A; Choi AM. 2008. Mitogen-activated protein kinases regulate susceptibility to ventilator-induced lung injury. PLoS One 3(2):e1601. PubMed: 18270588MGI: J:132187
- Dong C; Yang DD; Tournier C; Whitmarsh AJ; Xu J; Davis RJ; Flavell RA. 2000. JNK is required for effector T-cell function but not for T-cell activation. Nature 405(6782):91-4. PubMed: 10811224MGI: J:61895
- Fujii N; Boppart MD; Dufresne SD; Crowley PF; Jozsi AC; Sakamoto K; Yu H; Aschenbach WG; Kim S; Miyazaki H; Rui L; White MF; Hirshman MF; Goodyear LJ. 2004. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. Am J Physiol Cell Physiol 287(1):C200-8. PubMed: 15013949MGI: J:95346
- Fukuda K; Tesch GH; Nikolic-Paterson DJ. 2008. c-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury. Biochem Biophys Res Commun 366(3):710-6. PubMed: 18082135MGI: J:130705
- Gao Y; Tao J; Li MO; Zhang D; Chi H; Henegariu O; Kaech SM; Davis RJ; Flavell RA; Yin Z. 2005. JNK1 is essential for CD8+ T cell-mediated tumor immune surveillance. J Immunol 175(9):5783-9. PubMed: 16237070MGI: J:119340
- Gao Z; Zhang J; Kheterpal I; Kennedy N; Davis RJ; Ye J. 2011. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. J Biol Chem 286(25):22227-34. PubMed: 21540183MGI: J:174806
- Heinonen KM; Vanegas JR; Lew D; Krosl J; Perreault C. 2011. Wnt4 enhances murine hematopoietic progenitor cell expansion through a planar cell polarity-like pathway. PLoS One 6(4):e19279. PubMed: 21541287MGI: J:172379
- Hess P; Pihan G; Sawyers CL; Flavell RA; Davis RJ. 2002. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Nat Genet 32(1):201-5. PubMed: 12161751MGI: J:92945
- Hirai S; Banba Y; Satake T; Ohno S. 2011. Axon Formation in Neocortical Neurons Depends on Stage-Specific Regulation of Microtubule Stability by the Dual Leucine Zipper Kinase-c-Jun N-Terminal Kinase Pathway. J Neurosci 31(17):6468-80. PubMed: 21525288MGI: J:171420
- Hu D; Fang W; Han A; Gallagher L; Davis RJ; Xiong B; Yang W. 2008. c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/beta-catenin signaling through GSK3beta pathway. Carcinogenesis 29(12):2317-24. PubMed: 18952597MGI: J:144866
- Hubner A; Barrett T; Flavell RA; Davis RJ. 2008. Multisite phosphorylation regulates Bim stability and apoptotic activity. Mol Cell 30(4):415-25. PubMed: 18498746MGI: J:137061
- Hubner A; Mulholland DJ; Standen CL; Karasarides M; Cavanagh-Kyros J; Barrett T; Chi H; Greiner DL; Tournier C; Sawyers CL; Flavell RA; Wu H; Davis RJ. 2012. JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proc Natl Acad Sci U S A 109(30):12046-51. PubMed: 22753496MGI: J:186492
- Hunot S; Vila M; Teismann P; Davis RJ; Hirsch EC; Przedborski S; Rakic P; Flavell RA. 2004. JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinson's disease. Proc Natl Acad Sci U S A 101(2):665-70. PubMed: 14704277MGI: J:87428
- Ijaz A; Tejada T; Catanuto P; Xia X; Elliot SJ; Lenz O; Jauregui A; Saenz MO; Molano RD; Pileggi A; Ricordi C; Fornoni A. 2009. Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes. Kidney Int 75(4):381-8. PubMed: 18971923MGI: J:162711
- Jaeschke A; Karasarides M; Ventura JJ; Ehrhardt A; Zhang C; Flavell RA; Shokat KM; Davis RJ. 2006. JNK2 is a positive regulator of the cJun transcription factor. Mol Cell 23(6):899-911. PubMed: 16973441MGI: J:112737
- Junyent F; de Lemos L; Verdaguer E; Folch J; Ferrer I; Ortuno-Sahagun D; Beas-Zarate C; Romero R; Pallas M; Auladell C; Camins A. 2011. Gene expression profile in JNK3 null mice: a novel specific activation of the PI3K/AKT pathway. J Neurochem 117(2):244-252. PubMed: 21255018MGI: J:171529
- Kaiser RA; Liang Q; Bueno O; Huang Y; Lackey T; Klevitsky R; Hewett TE; Molkentin JD. 2005. Genetic inhibition or activation of JNK1/2 protects the myocardium from ischemia-reperfusion-induced cell death in vivo. J Biol Chem 280(38):32602-8. PubMed: 16043490MGI: J:102152
- Kelkar N; Delmotte MH; Weston CR; Barrett T; Sheppard BJ; Flavell RA; Davis RJ. 2003. Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc Natl Acad Sci U S A 100(17):9843-8. PubMed: 12897243MGI: J:85160
- Keramaris E; Vanderluit JL; Bahadori M; Mousavi K; Davis RJ; Flavell R; Slack RS; Park DS. 2005. c-Jun N-terminal kinase 3 deficiency protects neurons from axotomy-induced death in vivo through mechanisms independent of c-Jun phosphorylation. J Biol Chem 280(2):1132-41. PubMed: 15528206MGI: J:96192
- Kim HP; Wang X; Zhang J; Suh GY; Benjamin IJ; Ryter SW; Choi AM. 2005. Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1. J Immunol 175(4):2622-9. PubMed: 16081837MGI: J:107488
- Kodama Y; Taura K; Miura K; Schnabl B; Osawa Y; Brenner DA. 2009. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Gastroenterology 136(4):1423-34. PubMed: 19249395MGI: J:148191
- Kuan CY; Whitmarsh AJ; Yang DD; Liao G; Schloemer AJ; Dong C; Bao J; Banasiak KJ; Haddad GG; Flavell RA; Davis RJ; Rakic P. 2003. A critical role of neural-specific JNK3 for ischemic apoptosis. Proc Natl Acad Sci U S A 100(25):15184-9. PubMed: 14657393MGI: J:86985
- Kuan CY; Yang DD; Samanta Roy DR; Davis RJ; Rakic P; Flavell RA. 1999. The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22(4):667-76. PubMed: 10230788MGI: J:54653
- Li X; Weng H; Xu C; Reece EA; Yang P. 2012. Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy. Diabetes 61(8):2084-92. PubMed: 22688338MGI: J:208533
- Li X; Xu C; Yang P. 2013. c-Jun NH2-terminal kinase 1/2 and endoplasmic reticulum stress as interdependent and reciprocal causation in diabetic embryopathy. Diabetes 62(2):599-608. PubMed: 22961085MGI: J:208480
- Liang Q; Bueno OF; Wilkins BJ; Kuan CY; Xia Y; Molkentin JD. 2003. c-Jun N-terminal kinases (JNK) antagonize cardiac growth through cross-talk with calcineurin-NFAT signaling. EMBO J 22(19):5079-89. PubMed: 14517246MGI: J:85947
- Lou G; Ma X; Fu X; Meng Z; Zhang W; Wang YD; Van Ness C; Yu D; Xu R; Huang W. 2014. GPBAR1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells. PLoS One 9(4):e93567. PubMed: 24755711MGI: J:215174
- Melief EJ; Miyatake M; Bruchas MR; Chavkin C. 2010. Ligand-directed c-Jun N-terminal kinase activation disrupts opioid receptor signaling. Proc Natl Acad Sci U S A 107(25):11608-13. PubMed: 20534436MGI: J:161284
- Morse D; Otterbein LE; Watkins S; Alber S; Zhou Z; Flavell RA; Davis RJ; Choi AM. 2003. Deficiency in the c-Jun NH2-terminal kinase signaling pathway confers susceptibility to hyperoxic lung injury in mice. Am J Physiol Lung Cell Mol Physiol 285(1):L250-7. PubMed: 12651633MGI: J:84268
- Nagelin MH; Srinivasan S; Nadler JL; Hedrick CC. 2009. Murine 12/15-lipoxygenase regulates ATP-binding cassette transporter G1 protein degradation through p38- and JNK2-dependent pathways. J Biol Chem 284(45):31303-14. PubMed: 19713213MGI: J:156345
- Ni HM; Chen X; Ding WX; Schuchmann M; Yin XM. 2008. Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice. Am J Pathol 173(4):962-72. PubMed: 18772342MGI: J:139659
- Ni HM; Chen X; Shi YH; Liao Y; Beg AA; Fan J; Yin XM. 2009. Genetic delineation of the pathways mediated by bid and JNK in tumor necrosis factor-alpha-induced liver injury in adult and embryonic mice. J Biol Chem 284(7):4373-82. PubMed: 19060338MGI: J:147600
- Noh H; Lee H; Park E; Park S. 2016. Proper closure of the optic fissure requires ephrin A5-EphB2-JNK signaling. Development 143(3):461-72. PubMed: 26839344MGI: J:240082
- Peck-Palmer OM; Unsinger J; Chang KC; Davis CG; McDunn JE; Hotchkiss RS. 2008. Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. J Leukoc Biol 83(4):1009-18. PubMed: 18211965MGI: J:134048
- Ramo K; Sugamura K; Craige S; Keaney JF; Davis RJ. 2016. Suppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development. Elife 5:. PubMed: 27504807MGI: J:235606
- Reinecke K; Herdegen T; Eminel S; Aldenhoff JB; Schiffelholz T. 2013. Knockout of c-Jun N-terminal kinases 1, 2 or 3 isoforms induces behavioural changes. Behav Brain Res 245:88-95. PubMed: 23428746MGI: J:197459
- Ricci R; Sumara G; Sumara I; Rozenberg I; Kurrer M; Akhmedov A; Hersberger M; Eriksson U; Eberli FR; Becher B; Boren J; Chen M; Cybulsky MI; Moore KJ; Freeman MW; Wagner EF; Matter CM; Luscher TF. 2004. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science 306(5701):1558-61. PubMed: 15567863MGI: J:94044
- Roberson EC; Tully JE; Guala AS; Reiss JN; Godburn KE; Pociask DA; Alcorn JF; Riches DW; Dienz O; Janssen-Heininger YM; Anathy V. 2012. Influenza induces endoplasmic reticulum stress, caspase-12-dependent apoptosis, and c-Jun N-terminal kinase-mediated transforming growth factor-beta release in lung epithelial cells. Am J Respir Cell Mol Biol 46(5):573-81. PubMed: 21799120MGI: J:196041
- Ruff CA; Staak N; Patodia S; Kaswich M; Rocha-Ferreira E; Da Costa C; Brecht S; Makwana M; Fontana X; Hristova M; Rumajogee P; Galiano M; Bohatschek M; Herdegen T; Behrens A; Raivich G. 2012. Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate. J Neurochem 121(4):607-18. PubMed: 22372722MGI: J:184366
- Sabio G; Cavanagh-Kyros J; Barrett T; Jung DY; Ko HJ; Ong H; Morel C; Mora A; Reilly J; Kim JK; Davis RJ. 2010. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev 24(3):256-64. PubMed: 20080940MGI: J:156939
- Sabio G; Cavanagh-Kyros J; Ko HJ; Jung DY; Gray S; Jun JY; Barrett T; Mora A; Kim JK; Davis RJ. 2009. Prevention of steatosis by hepatic JNK1. Cell Metab 10(6):491-8. PubMed: 19945406MGI: J:155978
- Sabio G; Das M; Mora A; Zhang Z; Jun JY; Ko HJ; Barrett T; Kim JK; Davis RJ. 2008. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322(5907):1539-43. PubMed: 19056984MGI: J:142035
- Sabio G; Kennedy NJ; Cavanagh-Kyros J; Jung DY; Ko HJ; Ong H; Barrett T; Kim JK; Davis RJ. 2010. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol 30(1):106-15. PubMed: 19841069MGI: J:156374
- Samak G; Suzuki T; Bhargava A; Rao RK. 2010. c-Jun NH2-terminal kinase-2 mediates osmotic stress-induced tight junction disruption in the intestinal epithelium. Am J Physiol Gastrointest Liver Physiol 299(3):G572-84. PubMed: 20595622MGI: J:163330
- Sanchez-Tillo E; Comalada M; Xaus J; Farrera C; Valledor AF; Caelles C; Lloberas J; Celada A. 2007. JNK1 Is required for the induction of Mkp1 expression in macrophages during proliferation and lipopolysaccharide-dependent activation. J Biol Chem 282(17):12566-73. PubMed: 17337450MGI: J:121267
- She QB; Chen N; Bode AM; Flavell RA; Dong Z. 2002. Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 62(5):1343-8. PubMed: 11888903MGI: J:75228
- Sherrin T; Blank T; Hippel C; Rayner M; Davis RJ; Todorovic C. 2010. Hippocampal c-Jun-N-terminal kinases serve as negative regulators of associative learning. J Neurosci 30(40):13348-61. PubMed: 20926661MGI: J:165097
- Tachibana H; Perrino C; Takaoka H; Davis RJ; Naga Prasad SV; Rockman HA. 2006. JNK1 is required to preserve cardiac function in the early response to pressure overload. Biochem Biophys Res Commun 343(4):1060-6. PubMed: 16579967MGI: J:108253
- Tong C; Yin Z; Song Z; Dockendorff A; Huang C; Mariadason J; Flavell RA; Davis RJ; Augenlicht LH; Yang W. 2007. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. Am J Pathol 171(1):297-303. PubMed: 17591974MGI: J:122824
- Tortoriello G; Morris CV; Alpar A; Fuzik J; Shirran SL; Calvigioni D; Keimpema E; Botting CH; Reinecke K; Herdegen T; Courtney M; Hurd YL; Harkany T. 2014. Miswiring the brain: Delta9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway. EMBO J 33(7):668-85. PubMed: 24469251MGI: J:208048
- Tournier C; Hess P; Yang DD; Xu J; Turner TK; Nimnual A; Bar-Sagi D; Jones SN; Flavell RA; Davis RJ. 2000. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288(5467):870-4. PubMed: 10797012MGI: J:137332
- Tran EH; Azuma YT; Chen M; Weston C; Davis RJ; Flavell RA. 2006. Inactivation of JNK1 enhances innate IL-10 production and dampens autoimmune inflammation in the brain. Proc Natl Acad Sci U S A 103(36):13451-6. PubMed: 16938889MGI: J:112902
- Triaca V; Sposato V; Bolasco G; Ciotti MT; Pelicci P; Bruni AC; Cupidi C; Maletta R; Feligioni M; Nistico R; Canu N; Calissano P. 2016. NGF controls APP cleavage by downregulating APP phosphorylation at Thr668: relevance for Alzheimer's disease. Aging Cell 15(4):661-72. PubMed: 27076121MGI: J:234800
- Unger EK; Piper ML; Olofsson LE; Xu AW. 2010. Functional role of c-Jun-N-terminal kinase in feeding regulation. Endocrinology 151(2):671-82. PubMed: 20022934MGI: J:168180
- Valledor AF; Arpa L; Sanchez-Tillo E; Comalada M; Casals C; Xaus J; Caelles C; Lloberas J; Celada A. 2008. IFN-{gamma}-mediated inhibition of MAPK phosphatase expression results in prolonged MAPK activity in response to M-CSF and inhibition of proliferation. Blood 112(8):3274-82. PubMed: 18682602MGI: J:140209
- Valledor AF; Sanchez-Tillo E; Arpa L; Park JM; Caelles C; Lloberas J; Celada A. 2008. Selective Roles of MAPKs during the Macrophage Response to IFN-{gamma}. J Immunol 180(7):4523-9. PubMed: 18354174MGI: J:132992
- Van der Velden J; Janssen-Heininger YM; Mandalapu S; Scheller EV; Kolls JK; Alcorn JF. 2012. Differential requirement for c-Jun N-terminal kinase 1 in lung inflammation and host defense. PLoS One 7(4):e34638. PubMed: 22514650MGI: J:187081
- Vandevyver S; Dejager L; Van Bogaert T; Kleyman A; Liu Y; Tuckermann J; Libert C. 2012. Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation. J Clin Invest 122(6):2130-40. PubMed: 22585571MGI: J:190494
- Varona-Santos JL; Pileggi A; Molano RD; Sanabria NY; Ijaz A; Atsushi M; Ichii H; Pastori RL; Inverardi L; Ricordi C; Fornoni A. 2008. c-Jun N-terminal kinase 1 is deleterious to the function and survival of murine pancreatic islets. Diabetologia 51(12):2271-80. PubMed: 18853132MGI: J:141417
- Wang S; Villablanca EJ; De Calisto J; Gomes DC; Nguyen DD; Mizoguchi E; Kagan JC; Reinecker HC; Hacohen N; Nagler C; Xavier RJ; Rossi-Bergmann B; Chen YB; Blomhoff R; Snapper SB; Mora JR. 2011. MyD88-dependent TLR1/2 signals educate dendritic cells with gut-specific imprinting properties. J Immunol 187(1):141-50. PubMed: 21646294MGI: J:176180
- Wang Y; Singh R; Lefkowitch JH; Rigoli RM; Czaja MJ. 2006. Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway. J Biol Chem 281(22):15258-67. PubMed: 16571730MGI: J:113452
- Wang YD; Chen WD; Li C; Guo C; Li Y; Qi H; Shen H; Kong J; Long X; Yuan F; Wang X; Huang W. 2015. Farnesoid X receptor antagonizes JNK signaling pathway in liver carcinogenesis by activating SOD3. Mol Endocrinol 29(2):322-31. PubMed: 25496033MGI: J:223255
- Wang YQ; Ma X; Lu L; Zhao L; Zhang X; Xu Q; Wang Y. 2014. Defective antiviral CD8 T-cell response and viral clearance in the absence of c-Jun N-terminal kinases. Immunology 142(4):603-13. PubMed: 24673683MGI: J:218572
- Westerlund N; Zdrojewska J; Padzik A; Komulainen E; Bjorkblom B; Rannikko E; Tararuk T; Garcia-Frigola C; Sandholm J; Nguyen L; Kallunki T; Courtney MJ; Coffey ET. 2011. Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate. Nat Neurosci 14(3):305-13. PubMed: 21297631MGI: J:170348
- Weston CR; Wong A; Hall JP; Goad ME; Flavell RA; Davis RJ. 2003. JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure. Genes Dev 17(10):1271-80. PubMed: 12756228MGI: J:83385
- Weston CR; Wong A; Hall JP; Goad ME; Flavell RA; Davis RJ. 2004. The c-Jun NH2-terminal kinase is essential for epidermal growth factor expression during epidermal morphogenesis. Proc Natl Acad Sci U S A 101(39):14114-9. PubMed: 15375216MGI: J:93433
- Wu HJ; Venkataraman C; Estus S; Dong C; Davis RJ; Flavell RA; Bondada S. 2001. Positive signaling through CD72 induces mitogen-activated protein kinase activation and synergizes with B cell receptor signals to induce X-linked immunodeficiency B cell proliferation. J Immunol 167(3):1263-73. PubMed: 11466342MGI: J:120492
- Xu P; Das M; Reilly J; Davis RJ. 2011. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev 25(4):310-22. PubMed: 21325132MGI: J:169060
- Xu P; Davis RJ. 2010. c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal. Mol Cell Biol 30(6):1329-40. PubMed: 20065035MGI: J:161736
- Yang L; Wu D; Wang X; Cederbaum AI. 2012. Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver. Free Radic Biol Med 53(5):1170-80. PubMed: 22749809MGI: J:188051
- Yoshimura K; Ueno M; Lee S; Nakamura Y; Sato A; Yoshimura K; Kishima H; Yoshimine T; Yamashita T. 2011. C-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice. Neurosci Res 71(3):266-77. PubMed: 21824499MGI: J:180900
- Yun B; Lee H; Jayaraja S; Suram S; Murphy RC; Leslie CC. 2016. Prostaglandins from Cytosolic Phospholipase A2alpha/Cyclooxygenase-1 Pathway and Mitogen-activated Protein Kinases Regulate Gene Expression in Candida albicans-infected Macrophages. J Biol Chem 291(13):7070-86. PubMed: 26841868MGI: J:232432
- Zhang L; Huang X; Meng Z; Dong B; Shiah S; Moore DD; Huang W. 2009. Significance and Mechanism of CYP7a1 Gene Regulation during the Acute Phase of Liver Regeneration. Mol Endocrinol 23(2):137-45. PubMed: 19056864MGI: J:144235
- Zhang T; Lu X; Arnold P; Liu Y; Baliga R; Huang H; Bauer JA; Liu Y; Feng Q. 2012. Mitogen-activated protein kinase phosphatase-1 inhibits myocardial TNF-alpha expression and improves cardiac function during endotoxemia. Cardiovasc Res 93(3):471-9. PubMed: 22198506MGI: J:194710
- van der Velden JL; Hoffman SM; Alcorn JF; Tully JE; Chapman DG; Lahue KG; Guala AS; Lundblad LK; Aliyeva M; Daphtary N; Irvin CG; Janssen-Heininger YM. 2014. Absence of c-Jun NH2-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation. Am J Physiol Lung Cell Mol Physiol 306(9):L866-75. PubMed: 24610935MGI: J:210991