This Chr 7 congenic strain in which the tyrosinase allele Tyr+ of the CBA/JLsLt strain is fixed on the NOD/Lt background, therefore making the strain agouti in color. This strain should be a good donor for blastocysts in which to microinject targeted NOD ES cells, and may alleviate unwanted genome integration experienced with use of the C57BL/6 blastocysts. The congenic segment on Chromosome 7 slightly supresses spontaneous T1D development which is an asset when these females are used as blastocyst recipients.

These congenic mice carry the Tyr+ allele from CBA/JLsLt and are agouti in color making them suitable blastocyst donors for microinjection of NOD ES cells.

Typically mice are recovered in 12-16 weeks. Contact Customer Service to place an order or for more information.

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