JAX Mouse Strain Datasheet - 004262

NOD.Cg-Prkdc^scid Tg(HLA-A2.1)1Enge/Dvs

Stock No:: 004262 |; NOD-scid-HLA-A2

Cryo Recovery

Overview

Also Known As: NOD-scid-HLA-A2

This strain was developed to provide humanized islet allograft donors. NOD-scid-HLA-A2 positive islet grafts in diabetic NOD-RagI^nullPrf1^null mice are rejected by HLA-A2-negative, but not by HLA-A2-positive, human peripheral blood mononuclear cells. Graft rejection occurred in the absence of detectable graft-vs-host disease (GVHD). This strain is useful as a model for the in vivo study of human islet allograft rejection.

Genetic overview

Genetic Background	Generation

Prkdc^scid

Allele Type	Gene Symbol	Gene Name
Spontaneous	Prkdc	protein kinase, DNA activated, catalytic polypeptide

Tg(HLA-A2.1)1Enge

Allele Type
Transgenic (Humanized sequence, Inserted expressed sequence)

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Research Applications

Immunology, Inflammation and Autoimmunity Research
Research Tools
Internal/Organ Research
Virology Research

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Base Price

Starting at:

$2,595.00 Domestic price Cryo Recovery

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Details

Detailed Description

Development

NOD.CB17-Prkdc^scid was crossed once with NOD.B6-TgN(HLA-A2.1)1Enge/Dvs (Stock #003088) and the doubly heterozygous offspring were backcrossed once to NOD.CB17-Prkdc^scid to make the strain homozygous for Prkdc^scid then sibling mated to fix the strain homozygous for TgN(HLA-A2.1)1Enge as well.

Expression Data

Expressed Gene	HLA-A, major histocompatibility complex, class I, A, human
Site of Expression

Selected References

Banuelos SJ; Shultz LD; Greiner DL; Burzenski LM; Gott B; Lyons BL; Rossini AA; Appel MC. 2004. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.. In: . . MGI: J:91764

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Genetics

Prkdc^scid

Allele Symbol: Prkdc^scid

Allele Name	severe combined immunodeficiency
Allele Type	Spontaneous
Allele Synonym(s)	SCID; scid
Gene Symbol and Name	Prkdc, protein kinase, DNA activated, catalytic polypeptide
Gene Synonym(s)	AI326420; AU019811; DNA-PK; DNA-PKcs; DNAPDcs; DNAPK; DNPK1; DOXNPH; HYRC; HYRC1; IMD26; XRCC7; doxorubicin nephropathy; dxnph; dxnph; expressed sequence AI326420; expressed sequence AU019811; p350; scid; severe combined immunodeficiency; slip
Site of Expression	T and B lymphocytes.
Strain of Origin	C.B-17
Chromosome	16
Molecular Note	A T-to-A transversion point mutation at a position corresponding to codon 4095 created a premature stop codon.

Tg(HLA-A2.1)1Enge

Allele Symbol: Tg(HLA-A2.1)1Enge

Allele Name	transgene insertion 1, Victor H Engelhard
Allele Type	Transgenic (Humanized sequence, Inserted expressed sequence)
Allele Synonym(s)
Gene Symbol and Name	Tg(HLA-A2.1)1Enge, transgene insertion 1, Victor H Engelhard
Gene Synonym(s)
Promoter	HLA-A2.1, major histocompatibility complex, class I, subtype A2.1, human
Expressed Gene	HLA-A, major histocompatibility complex, class I, A, human
Strain of Origin	C57BL/6
Chromosome	UN
General Note	Expression of this human class I molecule in transgenic mice does not result in expansion of the number of cytotoxic T lymphocyte (CTL) precursors specific for other human class I Ag, HLA-B27 or HLA-A2.2.
Molecular Note	The transgene contains the full length HLA-A2.1 gene. Expression of human class I MHC Ag HLA-A2.1 was detected on cells from homozygous transgenic spleen, bone marrow, and thymus.
Mutations Made By	Dr. Ai-Xuan Le, Stanford University

Disease/Phenotype

Disease Terms

Research Areas By Genotype

This mouse can be used to support research in many areas including:

Immunology, Inflammation and Autoimmunity Research
- HLA transgenics
Research Tools
- Immunology, Inflammation and Autoimmunity Research
  - B and T cell deficiency

Genotype: Prkdc^scid related

Immunology, Inflammation and Autoimmunity Research
- Immunodeficiency
  - B and T cell deficiency
Internal/Organ Research
- Lymphoid Tissue Defects
  - B and T cell deficiency
Research Tools
- Cancer Research
  - B and T cell deficiency, xenograft/transplant host
- Toxicology Research
  - xenograft/transplant host
Virology Research
- B and T Cell Deficiency
  - AIDS research tool

Mammalian Phenotype Terms by Genotype

Genotype: Prkdc^scid/Prkdc^scid Tg(HLA-A2.1)1Enge/0
NOD.Cg-Prkdc^scid Tg(HLA-A2.1)1Enge/Dvs

hematopoietic system phenotype

abnormal splenocyte morphology
- more than 95% of splenocytes express high levels of human HLA-A2.1 protein on their cell surface

immune system phenotype

abnormal splenocyte morphology
- more than 95% of splenocytes express high levels of human HLA-A2.1 protein on their cell surface

References

Banuelos SJ; Shultz LD; Greiner DL; Burzenski LM; Gott B; Lyons BL; Rossini AA; Appel MC. 2004. Rejection of human islets and human HLA-A2.1 transgenic mouse islets by alloreactive human lymphocytes in immunodeficient NOD-scid and NOD-Rag1(null)Prf1(null) mice.. In: . . MGI: J:91764

Additional - Prkdc^scid related

Accardi R; Gruffat H; Sirand C; Fusil F; Gheit T; Hernandez-Vargas H; Le Calvez-Kelm F; Traverse-Glehen A; Cosset FL; Manet E; Wild CP; Tommasino M. 2015. The mycotoxin aflatoxin B1 stimulates Epstein-Barr virus-induced B-cell transformation in in vitro and in vivo experimental models.. In: . . MGI: J:226625
Agerstam H; Jaras M; Andersson A; Johnels P; Hansen N; Lassen C; Rissler M; Gisselsson D; Olofsson T; Richter J; Fan X; Ehinger M; Fioretos T. 2010. Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.. In: . . MGI: J:164507
Agliano A; Martin-Padura I; Mancuso P; Marighetti P; Rabascio C; Pruneri G; Shultz LD; Bertolini F. 2008. Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rgamma null mice generate a faster and more efficient disease compared to other NOD/scid-related strains.. In: . . MGI: J:142410
Ahsmann EJ; van Tol MJ; Oudeman-Gruber J; Lokhorst H; Uytdehaag FG; Schuurman HJ; Bloem AC. 1995. The SCID mouse as a model for multiple myeloma.. In: . . MGI: J:22989
Akiba H; Takeda K; Kojima Y; Usui Y; Harada N; Yamazaki T; Ma J; Tezuka K; Yagita H; Okumura K. 2005. The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo.. In: . . MGI: J:107507
Al-Qaoud KM; Fleischer B; Hoerauf A. 1998. The Xid defect imparts susceptibility to experimental murine filariosis--association with a lack of antibody and IL-10 production by B cells in response to phosphorylcholine.. In: . . MGI: J:110480
Alba A; Puertas MC; Carrillo J; Planas R; Ampudia R; Pastor X; Bosch F; Pujol-Borrell R; Verdaguer J; Vives-Pi M. 2004. IFNbeta accelerates autoimmune type 1 diabetes in nonobese diabetic mice and breaks the tolerance to beta cells in nondiabetes-prone mice.. In: . . MGI: J:94366
Alfaro MP; Pagni M; Vincent A; Atkinson J; Hill MF; Cates J; Davidson JM; Rottman J; Lee E; Young PP. 2008. The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair.. In: . . MGI: J:142215
Ali N; Flutter B; Sanchez Rodriguez R; Sharif-Paghaleh E; Barber LD; Lombardi G; Nestle FO. 2012. Xenogeneic graft-versus-host-disease in NOD-scid IL-2Rgammanull mice display a T-effector memory phenotype.. In: . . MGI: J:191672
Alugupalli KR; Gerstein RM; Chen J; Szomolanyi-Tsuda E; Woodland RT; Leong JM. 2003. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1b lymphocytes.. In: . . MGI: J:125443
Amarnath S; Foley JE; Farthing DE; Gress RE; Laurence A; Eckhaus MA; Metais JY; Rose JJ; Hakim FT; Felizardo TC; Cheng AV; Robey PG; Stroncek DE; Sabatino M; Battiwalla M; Ito S; Fowler DH; Barrett AJ. 2015. Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.. In: . . MGI: J:224046
Ambrosino E; Spadaro M; Iezzi M; Curcio C; Forni G; Musiani P; Wei WZ; Cavallo F. 2006. Immunosurveillance of Erbb2 carcinogenesis in transgenic mice is concealed by a dominant regulatory T-cell self-tolerance.. In: . . MGI: J:112102
Amezcua Vesely MC; Schwartz M; Bermejo DA; Montes CL; Cautivo KM; Kalergis AM; Rawlings DJ; Acosta-Rodriguez EV; Gruppi A. 2012. FcgammaRIIb and BAFF differentially regulate peritoneal B1 cell survival.. In: . . MGI: J:188666
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Andoh M; Zhang G; Russell-Lodrigue KE; Shive HR; Weeks BR; Samuel JE. 2007. T Cells Are Essential for Bacterial Clearance, and Gamma Interferon, Tumor Necrosis Factor Alpha, and B Cells Are Crucial for Disease Development in Coxiella burnetii Infection in Mice.. In: . . MGI: J:122426
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Yi Z; Li L; Garland A; He Q; Wang H; Katz JD; Tisch R; Wang B. 2012. IFN-gamma receptor deficiency prevents diabetes induction by diabetogenic CD4+, but not CD8+, T cells.. In: . . MGI: J:187880
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Yui MA; Rothenberg EV. 2004. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice.. In: . . MGI: J:132809
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Zhang B; Strauss AC; Chu S; Li M; Ho Y; Shiang KD; Snyder DS; Huettner CS; Shultz L; Holyoake T; Bhatia R. 2010. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate.. In: . . MGI: J:160523
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Zhang JQ; Okumura C; McCarty T; Shin MS; Mukhopadhyay P; Hori M; Torrey TA; Naghashfar Z; Zhou JX; Lee CH; Roopenian DC; Morse HC 3rd; Davidson WF. 2004. Evidence for selective transformation of autoreactive immature plasma cells in mice deficient in Fasl.. In: . . MGI: J:94696
Zhang Q; Hossain DM; Duttagupta P; Moreira D; Zhao X; Won H; Buettner R; Nechaev S; Majka M; Zhang B; Cai Q; Swiderski P; Kuo YH; Forman S; Marcucci G; Kortylewski M. 2016. Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia.. In: . . MGI: J:232638
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Additional - Tg(HLA-A2.1)1Enge related

Billerbeck E; Horwitz JA; Labitt RN; Donovan BM; Vega K; Budell WC; Koo GC; Rice CM; Ploss A. 2013. Characterization of human antiviral adaptive immune responses during hepatotropic virus infection in HLA-transgenic human immune system mice.. In: . . MGI: J:205706
Keskin DB; Reinhold BB; Zhang GL; Ivanov AR; Karger BL; Reinherz EL. 2015. Physical detection of influenza A epitopes identifies a stealth subset on human lung epithelium evading natural CD8 immunity.. In: . . MGI: J:220012
Le AX; Bernhard EJ; Holterman MJ; Strub S; Parham P; Lacy E; Engelhard VH. 1989. Cytotoxic T cell responses in HLA-A2.1 transgenic mice. Recognition of HLA alloantigens and utilization of HLA-A2.1 as a restriction element.. In: . . MGI: J:52612
Lin SI; Huang MH; Chang YW; Chen IH; Roffler S; Chen BM; Sher YP; Liu SJ. 2016. Chimeric peptide containing both B and T cells epitope of tumor-associated antigen L6 enhances anti-tumor effects in HLA-A2 transgenic mice.. In: . . MGI: J:231900
Marron MP; Graser RT; Chapman HD; Serreze DV. 2002. Functional evidence for the mediation of diabetogenic T cell responses by HLA-A2.1 MHC class I molecules through transgenic expression in NOD mice.. In: . . MGI: J:109851
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Wang Z; Zhu K; Bai W; Jia B; Hu H; Zhou D; Zhang X; Zhang X; Xie Y; Bourgine MM; Michel ML; Lan K; Deng Q. 2014. Adenoviral delivery of recombinant hepatitis B virus expressing foreign antigenic epitopes for immunotherapy of persistent viral infection.. In: . . MGI: J:213029
Whitfield-Larry F; Young EF; Talmage G; Fudge E; Azam A; Patel S; Largay J; Byrd W; Buse J; Calikoglu AS; Shultz LD; Frelinger JA. 2011. HLA-A2-matched peripheral blood mononuclear cells from type 1 diabetic patients, but not nondiabetic donors, transfer insulitis to NOD-scid/gammac(null)/HLA-A2 transgenic mice concurrent with the expansion of islet-specific CD8+ T cells.. In: . . MGI: J:177952
Yang J; Qian J; Wezeman M; Wang S; Lin P; Wang M; Yaccoby S; Kwak LW; Barlogie B; Yi Q. 2006. Targeting beta2-microglobulin for induction of tumor apoptosis in human hematological malignancies.. In: . . MGI: J:114975

Also Known As: NOD-scid-HLA-A2

Genetic overview

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Expression Data

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Prkdcscid

Allele Symbol: Prkdcscid

Tg(HLA-A2.1)1Enge

Allele Symbol: Tg(HLA-A2.1)1Enge

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This mouse can be used to support research in many areas including:

Genotype: Prkdcscid related

Mammalian Phenotype Terms by Genotype

Genotype: Prkdcscid/Prkdcscid Tg(HLA-A2.1)1Enge/0NOD.Cg-Prkdcscid Tg(HLA-A2.1)1Enge/Dvs

hematopoietic system phenotype

immune system phenotype

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Additional - Prkdcscid related

Additional - Tg(HLA-A2.1)1Enge related

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Prkdc^scid

Allele Symbol: Prkdc^scid

Genotype: Prkdc^scid related

Genotype: Prkdc^scid/Prkdc^scid Tg(HLA-A2.1)1Enge/0
NOD.Cg-Prkdc^scid Tg(HLA-A2.1)1Enge/Dvs

Additional - Prkdc^scid related