The predominant phenotypes of mice homozygous for the small body small eyes mutation (sbse) are small ear pinnae, craniofacial deformities, and a reduced body size such that the body weight is approximately 30% less than normal at 4, 8, 12, and 16 weeks of age. Homozygotes also display hearing loss and reduced litter size. The craniofacial defects include smaller skull, nose, and jaw lengths with domed skull compared with controls.
The small body small eyes mutation arose spontaneously in 2001 in the inbred strain C57BL/6J at The Jackson Laboratory. This strain was maintained on this inbred background primarily through sibling inbreeding of homozygotes with heterozygotes and sperm was cryopreserved from heterozygous males.
When using the small body and small ear mouse strain in a publication, please cite the originating article(s) and include JAX stock #004246 in your Materials and Methods section.