Mice homozygous for the transgenic insert are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. Expression of the transgenic <i>lacZ</i> gene is directed by upstream activating sequence (UAS) elements. This strain serves as a reporter for mice employing GAL4/UAS bigenic system for controlled gene expression in the developing CNS. In this system, a transgenic strain expressing the yeast transcriptional activator GAL4 (see Stock No. <a href="https://www.jax.org/strain/003829">003829</a>) is bred to a second transgenic, target strain bearing an UAS-regulated gene. In the double transgenic offspring, an UAS-regulated gene would be selectively expressed in tissues expressing GAL4.

These UAS-lacZ mice express a transgene containing five upstream activating sequence (UAS) elements, a Wnt1 minimal promoter, lacZ, and an SV40 poly A sequence.

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B6;CBA-Tg(UAS-lacZ)65Rth/J Frozen Embryos