B6.CBy-H60a^c/2Dcr

Stock number: 004137
Research areas: Immunology, Inflammation and Autoimmunity Research

Description

This congenic encodes the BALB/c variant of the H60a minor histocompatibility antigen.

Detailed description

This congenic encodes the BALB/c variant of the H60a minor histocompatibility antigen. The strain C57BL/6 is H60a^b.

Development

The H60a^c allele from BALB/cBy was backcrosssed onto C57BL/6J for at least 16 backcrosses. When maintained in the laboratory of Dr. Derry Roopenian The SSLP marker D10Dcr2, which is polymorphic between C57BL/6J and BALB, was used as a genotyping marker closely linked to this allele.

Allele

Symbol: H60a^c
Name: c variant
MGI accession ID: MGI:4939047
Generation method: Not Applicable
Marker symbol: H60a
Marker name: histocompatibility 60a
Chromosome: 10
Strain of origin: BALB/c
Molecular note: There are three markers whose symbols begin "H60" - H60a, H60b and H60c. All three reside on Chr 10. The original is now H60a; the others were reported in J Immunol in February, 2008 (J:131505). H60a^c encodes the BALB/c variant of the H60a minor histocompatibility antigen (J:49824).