JAX
Mouse Strain Datasheet - 003919
STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
Also Known As: Z/AP reporter
These Z/AP reporter mice express a transgene containing a floxed Beta-geo and the human placental alkaline phosphatase gene with widespread expression of lacZ except in erythrocytes, chondrocytes and adipocytes.
Donating Investigator
Corrinne Lobe, Sunnybrook & Women's College HSC
Genetic overview
| Genetic Background | Generation |
|---|---|
|
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Tg(CAG-Bgeo/ALPP)1Lbe
| Allele Type |
|---|
| Transgenic (Reporter) |
Detailed Description
These transgenic mice constitutively express lacZ under the control of the CMV enhancer/chicken actin promoter. Expression is widespread with notable exceptions being erythrocytes, chondrocytes and adipocytes. Expression is observed throughout all embryonic and adult stages. When crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with alkaline phosphatase expression in tissues expressing Cre. This double reporter system makes it possible to distinguish a lack of reporter expression from a lack of Cre recombinase expression while providing a means to assess cre excision activity at the individual cell level.
Development
A transgenic construct containing the CMV enhancer/chicken beta-actin promoter, a loxP-flanked Bgeo reporter/SV40 polyadenylation signal segment, and the human placental alkaline phosphatase gene followed by a rabbit beta-globin polyadenylation sequence, was electroporated into 129X1/SvJ x 129S1/Sv-derived R1 embryonic stem (ES) cells. ES cells expressing lacZ were selected and utilized in ES cell/diploid embryo aggregation in conjunction with CD1 outbred embryos resulting in chimeric animals.
Expression Data
| Expressed Gene | ALPP, alkaline phosphatase, placental, human |
|---|---|
| Expressed Gene | Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes, E. coli |
| Site of Expression | lacZ is widely expressed throughout embryonic and adult tissues with notable exceptions being erythrocytes, chondrocytes and adipocytes; when crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with alkaline phosphatase expression |
Control Suggestions
Selected References
- Lobe CG; Koop KE; Kreppner W; Lomeli H; Gertsenstein M; Nagy A. 1999. Z/AP, a double reporter for cre-mediated recombination. Dev Biol 208(2):281-92. PubMed: 10191045MGI: J:93700
Tg(CAG-Bgeo/ALPP)1Lbe
Allele Symbol: Tg(CAG-Bgeo/ALPP)1Lbe
| Allele Name | transgene insertion 1, Corrinne Lobe |
|---|---|
| Allele Type | Transgenic (Reporter) |
| Allele Synonym(s) | Tg(ACTB-Bgeo/ALPP)1Lbe; Tg(CAG-Bgeo/ALPP)1Lbe; Z/AP; ZAP |
| Gene Symbol and Name | Tg(CAG-Bgeo/ALPP)1Lbe, transgene insertion 1, Corrinne Lobe |
| Gene Synonym(s) | Tg(ACTB-Bgeo/ALPP)1Lbe; Tg(ACTB-Bgeo/ALPP)1Lbe; Z/AP; ZAP |
| Promoter | ACTB, actin, beta, chicken |
| Expressed Gene | ALPP, alkaline phosphatase, placental, human |
| Expressed Gene | Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes, E. coli |
| Site of Expression | lacZ is widely expressed throughout embryonic and adult tissues with notable exceptions being erythrocytes, chondrocytes and adipocytes; when crossed with a Cre recombinase-expressing strain, lacZ expression is replaced with alkaline phosphatase expression |
| Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Chromosome | UN |
| General Note | Cre excision of lacZ and the neomycin resistance gene results in expression of the ALPP reporter. |
| Molecular Note | The transgene contains the CMV enhancer/chicken beta-actin promoter, a floxed Beta-geo reporter/SV40 polyadenylation signal segment, and the human placental alkaline phosphatase gene followed by a rabbit Hbb polyadenylation sequence. In transgenic mice expression of lacZ is widespread, with notable exceptions being erythrocytes, chondrocytes and adipocytes. This expression is observed throughout all embryonic and adult stages. |
| Mutations Made By | Corrinne Lobe, Sunnybrook & Women's College HSC |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- lacZ Expression
- Cre-lox System
- loxP-flanked Sequences
- loxP-flanked Sequences: Test/Reporter
- Genetics Research
- Tissue/Cell Markers
- Tissue/Cell Markers: Cre-lox System
- Tissue/Cell Markers: multiple
Genotype: Bgeo related
- Research Tools
- lacZ Expression
Mammalian Phenotype Terms by Genotype
Genotype: Tg(CAG-Bgeo/ALPP)1Lbe/Tg(CAG-Bgeo/ALPP)1Lbe
involves: 129S1/Sv * 129X1/SvJ * ICR
mortality/aging
- prenatal lethality, complete penetrance
- homozygotes are not viable; line is maintained and used in hemizygous state (MGI Ref ID J:62916)
References
- Lobe CG; Koop KE; Kreppner W; Lomeli H; Gertsenstein M; Nagy A. 1999. Z/AP, a double reporter for cre-mediated recombination. Dev Biol 208(2):281-92. PubMed: 10191045MGI: J:93700
Additional - Tg(CAG-Bgeo/ALPP)1Lbe related
- Abdulkadir SA; Magee JA; Peters TJ; Kaleem Z; Naughton CK; Humphrey PA; Milbrandt J. 2002. Conditional loss of nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol 22(5):1495-503. PubMed: 11839815MGI: J:74350
- Alfaro LA; Dick SA; Siegel AL; Anonuevo AS; McNagny KM; Megeney LA; Cornelison DD; Rossi FM. 2011. CD34 promotes satellite cell motility and entry into proliferation to facilitate efficient skeletal muscle regeneration. Stem Cells 29(12):2030-41. PubMed: 21997891MGI: J:190197
- Anderson MP; Mochizuki T; Xie J; Fischler W; Manger JP; Talley EM; Scammell TE; Tonegawa S. 2005. Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A 102(5):1743-8. PubMed: 15677322MGI: J:96099
- Appler JM; Lu CC; Druckenbrod NR; Yu WM; Koundakjian EJ; Goodrich LV. 2013. Gata3 is a critical regulator of cochlear wiring. J Neurosci 33(8):3679-91. PubMed: 23426694MGI: J:196086
- Araya R; Kudo M; Kawano M; Ishii K; Hashikawa T; Iwasato T; Itohara S; Terasaki T; Oohira A; Mishina Y; Yamada M. 2008. BMP signaling through BMPRIA in astrocytes is essential for proper cerebral angiogenesis and formation of the blood-brain-barrier. Mol Cell Neurosci 38(3):417-30. PubMed: 18501628MGI: J:137057
- Arcourt A; Gorham L; Dhandapani R; Prato V; Taberner FJ; Wende H; Gangadharan V; Birchmeier C; Heppenstall PA; Lechner SG. 2017. Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination. Neuron 93(1):179-193. PubMed: 27989460MGI: J:253253
- Ashery-Padan R; Marquardt T; Zhou X; Gruss P. 2000. Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye Genes Dev 14(21):2701-11. PubMed: 11069887MGI: J:65765
- Azhar M; Wang PY; Frugier T; Koishi K; Deng C; Noakes PG; McLennan IS. 2010. Myocardial deletion of Smad4 using a novel alpha skeletal muscle actin Cre recombinase transgenic mouse causes misalignment of the cardiac outflow tract. Int J Biol Sci 6(6):546-55. PubMed: 20877696MGI: J:164492
- Bajenaru ML; Zhu Y; Hedrick NM; Donahoe J; Parada LF; Gutmann DH. 2002. Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation. Mol Cell Biol 22(14):5100-13. PubMed: 12077339MGI: J:77208
- Berger J; Eckert S; Scardigli R; Guillemot F; Gruss P; Stoykova A. 2004. E1-Ngn2/Cre is a new line for regional activation of Cre recombinase in the developing CNS. Genesis 40(4):195-9. PubMed: 15593326MGI: J:95642
- Biondi CA; Gartside MG; Waring P; Loffler KA; Stark MS; Magnuson MA; Kay GF; Hayward NK. 2004. Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues. Mol Cell Biol 24(8):3125-31. PubMed: 15060136MGI: J:89898
- Braren R; Hu H; Kim YH; Beggs HE; Reichardt LF; Wang R. 2006. Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation. J Cell Biol 172(1):151-62. PubMed: 16391003MGI: J:104401
- Breckenridge R; Kotecha S; Towers N; Bennett M; Mohun T. 2007. Pan-myocardial expression of Cre recombinase throughout mouse development. Genesis 45(3):135-44. PubMed: 17334998MGI: J:121704
- Brown TM; Gias C; Hatori M; Keding SR; Semo M; Coffey PJ; Gigg J; Piggins HD; Panda S; Lucas RJ. 2010. Melanopsin contributions to irradiance coding in the thalamo-cortical visual system. PLoS Biol 8(12):e1000558. PubMed: 21151887MGI: J:170401
- Brzezinski JA 4th; Prasov L; Glaser T. 2012. Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle. Dev Biol 365(2):395-413. PubMed: 22445509MGI: J:184871
- Bugeon L; Danou A; Carpentier D; Langridge P; Syed N; Dallman MJ. 2003. Inducible gene silencing in podocytes: a new tool for studying glomerular function. J Am Soc Nephrol 14(3):786-91. PubMed: 12595517MGI: J:106338
- Butterfield NC; Metzis V; McGlinn E; Bruce SJ; Wainwright BJ; Wicking C. 2009. Patched 1 is a crucial determinant of asymmetry and digit number in the vertebrate limb. Development 136(20):3515-24. PubMed: 19783740MGI: J:153595
- Cairns DM; Liu R; Sen M; Canner JP; Schindeler A; Little DG; Zeng L. 2012. Interplay of Nkx3.2, Sox9 and Pax3 regulates chondrogenic differentiation of muscle progenitor cells. PLoS One 7(7):e39642. PubMed: 22768305MGI: J:189523
- Campsall KD; Mazerolle CJ; De Repentingy Y; Kothary R; Wallace VA. 2002. Characterization of transgene expression and Cre recombinase activity in a panel of Thy-1 promoter-Cre transgenic mice. Dev Dyn 224(2):135-43. PubMed: 12112467MGI: J:77070
- Cantrup R; Dixit R; Palmesino E; Bonfield S; Shaker T; Tachibana N; Zinyk D; Dalesman S; Yamakawa K; Stell WK; Wong RO; Reese BE; Kania A; Sauve Y; Schuurmans C. 2012. Cell-type specific roles for PTEN in establishing a functional retinal architecture. PLoS One 7(3):e32795. PubMed: 22403711MGI: J:186938
- Casper KB; McCarthy KD. 2006. GFAP-positive progenitor cells produce neurons and oligodendrocytes throughout the CNS. Mol Cell Neurosci 31(4):676-84. PubMed: 16458536MGI: J:108621
- Chen JC; Mortimer J; Marley J; Goldhamer DJ. 2005. MyoD-cre transgenic mice: A model for conditional mutagenesis and lineage tracing of skeletal muscle. Genesis 41(3):116-21. PubMed: 15729689MGI: J:97107
- Chen SK; Badea TC; Hattar S. 2011. Photoentrainment and pupillary light reflex are mediated by distinct populations of ipRGCs. Nature 476(7358):92-5. PubMed: 21765429MGI: J:174940
- Cheng J; Rosario G; Cohen TV; Hu J; Stewart CL. 2017. Tissue-Specific Ablation of the LIF Receptor in the Murine Uterine Epithelium Results in Implantation Failure. Endocrinology 158(6):1916-1928. PubMed: 28368537MGI: J:245455
- Chew KS; Renna JM; McNeill DS; Fernandez DC; Keenan WT; Thomsen MB; Ecker JL; Loevinsohn GS; VanDunk C; Vicarel DC; Tufford A; Weng S; Gray PA; Cayouette M; Herzog ED; Zhao H; Berson DM; Hattar S. 2017. A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice. Elife 6:. PubMed: 28617242MGI: J:256669
- Chmielowiec J; Borowiak M; Morkel M; Stradal T; Munz B; Werner S; Wehland J; Birchmeier C; Birchmeier W. 2007. c-Met is essential for wound healing in the skin. J Cell Biol 177(1):151-62. PubMed: 17403932MGI: J:133551
- Comai G; Sambasivan R; Gopalakrishnan S; Tajbakhsh S. 2014. Variations in the efficiency of lineage marking and ablation confound distinctions between myogenic cell populations. Dev Cell 31(5):654-67. PubMed: 25490270MGI: J:228101
- Davis N; Mor E; Ashery-Padan R. 2011. Roles for Dicer1 in the patterning and differentiation of the optic cup neuroepithelium. Development 138(1):127-38. PubMed: 21138975MGI: J:180843
- Davis N; Yoffe C; Raviv S; Antes R; Berger J; Holzmann S; Stoykova A; Overbeek PA; Tamm ER; Ashery-Padan R. 2009. Pax6 dosage requirements in iris and ciliary body differentiation. Dev Biol 333(1):132-42. PubMed: 19563798MGI: J:152253
- Davis-Silberman N; Kalich T; Oron-Karni V; Marquardt T; Kroeber M; Tamm ER; Ashery-Padan R. 2005. Genetic dissection of Pax6 dosage requirements in the developing mouse eye. Hum Mol Genet 14(15):2265-76. PubMed: 15987699MGI: J:100401
- Dor Y; Brown J; Martinez OI; Melton DA. 2004. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429(6987):41-6. PubMed: 15129273MGI: J:124161
- Dora NJ; Collinson JM; Hill RE; West JD. 2014. Hemizygous Le-Cre transgenic mice have severe eye abnormalities on some genetic backgrounds in the absence of LoxP sites. PLoS One 9(10):e109193. PubMed: 25272013MGI: J:223480
- Dubois NC; Hofmann D; Kaloulis K; Bishop JM; Trumpp A. 2006. Nestin-Cre transgenic mouse line Nes-Cre1 mediates highly efficient Cre/loxP mediated recombination in the nervous system, kidney, and somite-derived tissues. Genesis 44(8):355-60. PubMed: 16847871MGI: J:111945
- Durland JL; Sferlazzo M; Logan M; Burke AC. 2008. Visualizing the lateral somitic frontier in the Prx1Cre transgenic mouse. J Anat 212(5):590-602. PubMed: 18430087MGI: J:209265
- Ecker JL; Dumitrescu ON; Wong KY; Alam NM; Chen SK; LeGates T; Renna JM; Prusky GT; Berson DM; Hattar S. 2010. Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision. Neuron 67(1):49-60. PubMed: 20624591MGI: J:167871
- El-Hoss J; Sullivan K; Cheng T; Yu NY; Bobyn JD; Peacock L; Mikulec K; Baldock P; Alexander IE; Schindeler A; Little DG. 2012. A murine model of neurofibromatosis type 1 tibial pseudarthrosis featuring proliferative fibrous tissue and osteoclast-like cells. J Bone Miner Res 27(1):68-78. PubMed: 21956219MGI: J:226592
- Fernandez DC; Chang YT; Hattar S; Chen SK. 2016. Architecture of retinal projections to the central circadian pacemaker. Proc Natl Acad Sci U S A 113(21):6047-52. PubMed: 27162356MGI: J:232174
- Fossat N; Chatelain G; Brun G; Lamonerie T. 2006. Temporal and spatial delineation of mouse Otx2 functions by conditional self-knockout. EMBO Rep 7(8):824-30. PubMed: 16845372MGI: J:116888
- Garcia-Gonzalez MA; Outeda P; Zhou Q; Zhou F; Menezes LF; Qian F; Huso DL; Germino GG; Piontek KB; Watnick T. 2010. Pkd1 and Pkd2 are required for normal placental development. PLoS One 5(9):. PubMed: 20862291MGI: J:165114
- Geisen MJ; Di Meglio T; Pasqualetti M; Ducret S; Brunet JF; Chedotal A; Rijli FM. 2008. Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling. PLoS Biol 6(6):e142. PubMed: 18547144MGI: J:139385
- Gelman DM; Noain D; Avale ME; Otero V; Low MJ; Rubinstein M. 2003. Transgenic mice engineered to target Cre/loxP-mediated DNA recombination into catecholaminergic neurons. Genesis 36(4):196-202. PubMed: 12929090MGI: J:85520
- Gensch N; Borchardt T; Schneider A; Riethmacher D; Braun T. 2008. Different autonomous myogenic cell populations revealed by ablation of Myf5-expressing cells during mouse embryogenesis. Development 135(9):1597-604. PubMed: 18367555MGI: J:134484
- Godde K; Gschwend O; Puchkov D; Pfeffer CK; Carleton A; Jentsch TJ. 2016. Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination. Nat Commun 7:12043. PubMed: 27389623MGI: J:240779
- Gopalakrishnan S; Comai G; Sambasivan R; Francou A; Kelly RG; Tajbakhsh S. 2015. A Cranial Mesoderm Origin for Esophagus Striated Muscles. Dev Cell 34(6):694-704. PubMed: 26387456MGI: J:225351
- Gorski JA; Talley T; Qiu M; Puelles L; Rubenstein JL; Jones KR. 2002. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J Neurosci 22(15):6309-14. PubMed: 12151506MGI: J:78098
- Greenwood AL; Li S; Jones K; Melton DA. 2007. Notch signaling reveals developmental plasticity of Pax4(+) pancreatic endocrine progenitors and shunts them to a duct fate. Mech Dev 124(2):97-107. PubMed: 17196797MGI: J:119944
- Gu G; Dubauskaite J; Melton DA. 2002. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 129(10):2447-57. PubMed: 11973276MGI: J:76095
- Guo C; Yang W; Lobe CG. 2002. A Cre recombinase transgene with mosaic, widespread tamoxifen-inducible action. Genesis 32(1):8-18. PubMed: 11835669MGI: J:81562
- Hagglund AC; Dahl L; Carlsson L. 2011. Lhx2 is required for patterning and expansion of a distinct progenitor cell population committed to eye development. PLoS One 6(8):e23387. PubMed: 21886788MGI: J:176341
- Hatori M; Gill S; Mure LS; Goulding M; O'Leary DD; Panda S. 2014. Lhx1 maintains synchrony among circadian oscillator neurons of the SCN. Elife 3:e03357. PubMed: 25035422MGI: J:228603
- Hayashi S; Lewis P; Pevny L; McMahon AP. 2002. Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain. Mech Dev 119 Suppl 1:S97-S101. PubMed: 14516668MGI: J:83040
- Hayashi Y; Call MK; Liu CY; Hayashi M; Babcock G; Ohashi Y; Kao WW. 2010. Monoallelic expression of Krt12 gene during corneal-type epithelium differentiation of limbal stem cells. Invest Ophthalmol Vis Sci 51(9):4562-8. PubMed: 20393120MGI: J:164088
- Hebert JM; McConnell SK. 2000. Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Dev Biol 222(2):296-306. PubMed: 10837119MGI: J:62916
- Hill TP; Taketo MM; Birchmeier W; Hartmann C. 2006. Multiple roles of mesenchymal beta-catenin during murine limb patterning. Development 133(7):1219-29. PubMed: 16495310MGI: J:144140
- Husse J; Zhou X; Shostak A; Oster H; Eichele G. 2011. Synaptotagmin10-Cre, a Driver to Disrupt Clock Genes in the SCN. J Biol Rhythms 26(5):379-89. PubMed: 21921292MGI: J:175596
- Ishihara N; Armsen W; Papadopoulos T; Betz H; Eulenburg V. 2010. Generation of a mouse line expressing Cre recombinase in glycinergic interneurons. Genesis 48(7):437-45. PubMed: 20506101MGI: J:160216
- Jacoby JJ; Kalinowski A; Liu MG; Zhang SS; Gao Q; Chai GX; Ji L; Iwamoto Y; Li E; Schneider M; Russell KS; Fu XY. 2003. Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A 100(22):12929-34. PubMed: 14566054MGI: J:86400
- Jaworski A; Burden SJ. 2006. Neuromuscular synapse formation in mice lacking motor neuron- and skeletal muscle-derived Neuregulin-1. J Neurosci 26(2):655-61. PubMed: 16407563MGI: J:104252
- Jin C; McKeehan K; Wang F. 2003. Transgenic mouse with high Cre recombinase activity in all prostate lobes, seminal vesicle, and ductus deferens. Prostate 57(2):160-4. PubMed: 12949940MGI: J:123132
- Juhila J; Roozendaal R; Lassila M; Verbeek SJ; Holthofer H. 2006. Podocyte cell-specific expression of doxycycline inducible Cre recombinase in mice. J Am Soc Nephrol 17(3):648-54. PubMed: 16467448MGI: J:128251
- Jukkola T; Trokovic R; Maj P; Lamberg A; Mankoo B; Pachnis V; Savilahti H; Partanen J. 2005. Meox1Cre: a mouse line expressing Cre recombinase in somitic mesoderm. Genesis 43(3):148-53. PubMed: 16267823MGI: J:102739
- Kim AC; Reuter AL; Zubair M; Else T; Serecky K; Bingham NC; Lavery GG; Parker KL; Hammer GD. 2008. Targeted disruption of beta-catenin in Sf1-expressing cells impairs development and maintenance of the adrenal cortex. Development 135(15):2593-602. PubMed: 18599507MGI: J:138575
- Koundakjian EJ; Appler JL; Goodrich LV. 2007. Auditory neurons make stereotyped wiring decisions before maturation of their targets. J Neurosci 27(51):14078-88. PubMed: 18094247MGI: J:130813
- Libutti SK; Crabtree JS; Lorang D; Burns AL; Mazzanti C; Hewitt SM; O'Connor S; Ward JM; Emmert-Buck MR; Remaley A; Miller M; Turner E; Alexander HR; Arnold A; Marx SJ; Collins FS; Spiegel AM. 2003. Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Cancer Res 63(22):8022-8. PubMed: 14633735MGI: J:86642
- Liu H; Guz Y; Kedees MH; Winkler J; Teitelman G. 2010. Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury. Endocrinology 151(2):520-8. PubMed: 20056825MGI: J:168269
- Liu J; Deutsch U; Fung I; Lobe CG. 2014. Conditional and inducible transgene expression in endothelial and hematopoietic cells using Cre/ and tetracycline-off systems. Exp Ther Med 8(5):1351-1356. PubMed: 25289022MGI: J:214066
- Liu R; Birke O; Morse A; Peacock L; Mikulec K; Little DG; Schindeler A. 2011. Myogenic progenitors contribute to open but not closed fracture repair. BMC Musculoskelet Disord 12:288. PubMed: 22192089MGI: J:234592
- Logan M; Martin JF; Nagy A; Lobe C; Olson EN; Tabin CJ. 2002. Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33(2):77-80. PubMed: 12112875MGI: J:77872
- Lomeli H; Ramos-Mejia V; Gertsenstein M; Lobe CG; Nagy A. 2000. Targeted insertion of Cre recombinase into the TNAP gene: excision in primordial germ cells. Genesis 26(2):116-7. PubMed: 10686602MGI: J:60934
- Long MA; Rossi FM. 2009. Silencing inhibits Cre-mediated recombination of the Z/AP and Z/EG reporters in adult cells. PLoS One 4(5):e5435. PubMed: 19415111MGI: J:148888
- Lu F; Kar D; Gruenig N; Zhang ZW; Cousins N; Rodgers HM; Swindell EC; Jamrich M; Schuurmans C; Mathers PH; Kurrasch DM. 2013. Rax is a selector gene for mediobasal hypothalamic cell types. J Neurosci 33(1):259-72. PubMed: 23283339MGI: J:193919
- Lui VC; Cheng WW; Leon TY; Lau DK; Garcia-Bareclo MM; Miao XP; Kam MK; So MT; Chen Y; Wall NA; Sham MH; Tam PK. 2008. Perturbation of hoxb5 signaling in vagal neural crests down-regulates ret leading to intestinal hypoganglionosis in mice. Gastroenterology 134(4):1104-15. PubMed: 18395091MGI: J:136122
- Luque RM; Amargo G; Ishii S; Lobe C; Franks R; Kiyokawa H; Kineman RD. 2007. Reporter expression, induced by a growth hormone promoter-driven Cre recombinase (rGHp-Cre) transgene, questions the developmental relationship between somatotropes and lactotropes in the adult mouse pituitary gland. Endocrinology 148(5):1946-53. PubMed: 17289844MGI: J:122251
- Marquardt T; Ashery-Padan R; Andrejewski N; Scardigli R; Guillemot F; Gruss P. 2001. Pax6 is required for the multipotent state of retinal progenitor cells. Cell 105(1):43-55. PubMed: 11301001MGI: J:68851
- Martins RA; Davis D; Kerekes R; Zhang J; Bayazitov IT; Hiler D; Karakaya M; Frase S; Gleason S; Zakharenko SS; Johnson DA; Dyer MA. 2011. Retinoblastoma (Rb) regulates laminar dendritic arbor reorganization in retinal horizontal neurons. Proc Natl Acad Sci U S A 108(52):21111-6. PubMed: 22160703MGI: J:180146
- McNeill DS; Sheely CJ; Ecker JL; Badea TC; Morhardt D; Guido W; Hattar S. 2011. Development of melanopsin-based irradiance detecting circuitry. Neural Dev 6:8. PubMed: 21418557MGI: J:171705
- Miao D; He B; Jiang Y; Kobayashi T; Soroceanu MA; Zhao J; Su H; Tong X; Amizuka N; Gupta A; Genant HK; Kronenberg HM; Goltzman D; Karaplis AC. 2005. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J Clin Invest 115(9):2402-11. PubMed: 16138191MGI: J:100918
- Miller LA; Smith AN; Taketo MM; Lang RA. 2006. Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice. BMC Dev Biol 6:14. PubMed: 16539717MGI: J:109351
- Minchin JE; Williams VC; Hinits Y; Low S; Tandon P; Fan CM; Rawls JF; Hughes SM. 2013. Oesophageal and sternohyal muscle fibres are novel Pax3-dependent migratory somite derivatives essential for ingestion. Development 140(14):2972-84. PubMed: 23760954MGI: J:198637
- Minoux M; Antonarakis GS; Kmita M; Duboule D; Rijli FM. 2009. Rostral and caudal pharyngeal arches share a common neural crest ground pattern. Development 136(4):637-45. PubMed: 19168678MGI: J:144017
- Minoux M; Kratochwil CF; Ducret S; Amin S; Kitazawa T; Kurihara H; Bobola N; Vilain N; Rijli FM. 2013. Mouse Hoxa2 mutations provide a model for microtia and auricle duplication. Development 140(21):4386-97. PubMed: 24067355MGI: J:204605
- Monory K; Massa F; Egertova M; Eder M; Blaudzun H; Westenbroek R; Kelsch W; Jacob W; Marsch R; Ekker M; Long J; Rubenstein JL; Goebbels S; Nave KA; During M; Klugmann M; Wolfel B; Dodt HU; Zieglgansberger W; Wotjak CT; Mackie K; Elphick MR; Marsicano G; Lutz B. 2006. The endocannabinoid system controls key epileptogenic circuits in the hippocampus. Neuron 51(4):455-66. PubMed: 16908411MGI: J:122066
- Mora-Blanco EL; Mishina Y; Tillman EJ; Cho YJ; Thom CS; Pomeroy SL; Shao W; Roberts CW. 2014. Activation of beta-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene 33(7):933-8. PubMed: 23435428MGI: J:212380
- Mori M; Gargowitsch L; Bornert JM; Garnier JM; Mark M; Chambon P; Metzger D. 2012. Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium. Genesis 50(11):828-32. PubMed: 22730183MGI: J:189533
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