B6.CBA-Tg(CETP)5203Tall/J

Stock number: 003904
Product name: CETP

Description

These CETP mice express a transgene containing human CETP mini gene and exhibit and increase of CEPT in the liver and plasma with a high fat diet , and reduced levels of plasma high density lipoprotein.

Detailed description

Mice carrying the human CETP minigene under the control of its own promoter show a marked increase in CETP mRNA in liver when mice are fed a high fat, high cholesterol diet. Less dramatic increases are observed in spleen, small intestine and adipose tissues. Elevated plasma CETP protein levels are also observed. Mice carrying human CETP show reduced levels of plasma high density lipoprotein. This strain has been a useful model in studies related to cholesterol metabolism.

Development

This strain arose on a (C57BL/6J x CBA/J)F1 background and was backcrossed to C57BL/6 for at least ten generations (January 2001).

Allele

Symbol: Tg(CETP)5203Tall
Name: transgene insertion 5203, Alan Tall
MGI accession ID: MGI:3505595
Generation method: Transgenic
Attributes: Inserted expressed sequence; Humanized sequence
Marker symbol: Tg(CETP)5203Tall
Marker name: transgene insertion 5203, Alan Tall
Chromosome: UN
Strain of origin: (C57BL/6J x CBA/J)F1
Expressed genes: CETP,cholesteryl ester transfer protein,human
Molecular note: The transgene contains the human CETP mini gene under the control of its own promoter. The mini gene consists of 3.2 Kb of 5' flanking sequence, exons 1-2 and 13-16, and 2.0 Kb of 3' flanking sequence.
General note: Transgenic mice on a genetic background that involves C57BL/6J and CBA/J show a marked increase in CETP mRNA in liver when mice are fed a high fat, high cholesterol diet. Less dramatic increases are observed in spleen, small intestine and adipose tissues. Elevated plasma CETP protein levels are also observed.