JAX
Mouse Strain Datasheet - 003897
DBA/1-Abca1tm1Jdm/J
Also Known As: Abc1 KO
These Abca1 knock-out mice exhibit reduced cholesterol and plasma phospholipid levels along with a lack of high density lipoproteins (HDL) . Macrophage ability to engulf apoptotic cells is impaired and lipid rich macrophages and type II pneumocytes accumulate in the lungs.
Donating Investigator
John D. McNeish, Pfizer Central Research
Genetic overview
| Genetic Background | Generation |
|---|---|
|
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Abca1tm1Jdm
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Abca1 | ATP-binding cassette, sub-family A (ABC1), member 1 |
Detailed Description
Mice that are homozygous for the Abca1-null allele are at greater risk of perinatal lethality. Autopsied pups exhibit perivisceral hemorrhaging. Pups that survive beyond birth have no detectable Abca1 gene transcript in the tissues of the liver. Homozygous females suffer from impaired placental development and are unable to produce litters. Both plasma lipids and lipoproteins are markedly reduced. Plasma cholesterol is decreased by approximately 70%. HDL-C and apoAI are decreased by greater than 99%. LDL-C and apoB are also reduced (70 % and 20%, respectively). Other characteristics observed are an increase in intestinal absorption of dietary cholesterol, an impaired ability for macrophages to engulf apoptotic cells and an accumulation of lipid rich macrophages and type II pneumocytes the lungs. These mice display pathophysiologic hallmarks similar to those associated with Tangier disease and provide a tool suitable for use in studies examining membrane lipid homeostasis.
Development
A targeting vector containing a neomycin resistance and herpes simplex virus thymidine kinase genes was used to disrupt exons 17 and 22 of the Abca1 gene. This portion of the gene encodes the the entire N-terminal ATP-binding cassette. The construct was electroporated into DBA/1LacJ-derived 252 embryonic stem (ES) cells. Correctly targeted ES cells were injected into C57BL/6J blastocysts to generate chimeric animals.
Control Suggestions
- Wild-type from the colony
- 001140 DBA/1LacJ
Additional Information
Selected References
- Hamon Y; Broccardo C; Chambenoit O; Luciani MF; Toti F; Chaslin S; Freyssinet JM; Devaux PF; McNeish J; Marguet D; Chimini G. 2000. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol 2(7):399-406. PubMed: 10878804MGI: J:63265
Abca1tm1Jdm
Allele Symbol: Abca1tm1Jdm
| Allele Name | targeted mutation 1, John D McNeish |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | Abc1-; Abca1-; Abca1- |
| Gene Symbol and Name | Abca1, ATP-binding cassette, sub-family A (ABC1), member 1 |
| Gene Synonym(s) | ABC-1; ABC1; ATP-binding cassette 1; Abc1; CERP; HDLDT1; TGD |
| Strain of Origin | DBA/1LacJ |
| Chromosome | 4 |
| General Note | When used in bone marrow transplant into Ldlrtm1Her homozygous mice, Abca1tm1Jdm Abcg1tm1Dgen homozygous cells accelerate the development of atherosclerosis. (J:130777) |
| Molecular Note | A 5.7 kb genomic fragment containing exons 17-22 was deleted and replaced with a neomycin selection cassette. These sequences correspond to amino acids 788 to 1093 of the encoded protein. RT-PCR analysis on RNA derived from liver demonstrated that no detectable transcript was produced from this allele in homozygous mice. |
| Mutations Made By | John McNeish, Pfizer Central Research |
Disease Terms
Potential model based on gene homology relationships. Phenotypic similarity to the human disease has not been tested.
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Abca1tm1Jdm related
- Cardiovascular Research
- Hypocholesterolemia
- Metabolism Research
- Lipid Metabolism
Mammalian Phenotype Terms by Genotype
Genotype: Abca1tm1Jdm/Abca1+
DBA/1LacJ-Abca1tm1Jdm
homeostasis/metabolism phenotype
- abnormal circulating phospholipid level
- (MGI Ref ID J:61679)
- abnormal lipid homeostasis
- decreased circulating HDL cholesterol level
- reduced relative to wild-type on chow and Western-type diets (MGI Ref ID J:61679)
- decreased circulating LDL cholesterol level
- 20% reduction on chow diet (MGI Ref ID J:61679)
- decreased circulating cholesterol level
- (MGI Ref ID J:61679)
respiratory system phenotype
Genotype: Abca1tm1Jdm/Abca1tm1Jdm
DBA/1-Abca1tm1Jdm/J
cellular phenotype
- increased cholesterol efflux
- (MGI Ref ID J:130777)
homeostasis/metabolism phenotype
- increased cholesterol efflux
- (MGI Ref ID J:130777)
Genotype: Abca1tm1Jdm/Abca1tm1Jdm
DBA/1LacJ-Abca1tm1Jdm
mortality/aging
- perinatal lethality, incomplete penetrance
- postnatal lethality, incomplete penetrance
- numbers of homozygous offspring recovered at weaning is significantly reduced from expected (MGI Ref ID J:63265)
reproductive system phenotype
- female infertility
- due to abnormal placental development (MGI Ref ID J:63265)
respiratory system phenotype
- abnormal lung morphology
- abnormal pulmonary alveolus morphology
cardiovascular system phenotype
- hemorrhage
- perivisceral (MGI Ref ID J:63265)
digestive/alimentary phenotype
- increased intestinal cholesterol absorption
- more cholesterol absorbed, relative to wild-type, on both chow and Western diets (MGI Ref ID J:61679)
embryo phenotype
- abnormal placenta development
- (MGI Ref ID J:63265)
endocrine/exocrine gland phenotype
- enlarged adrenal glands
- (MGI Ref ID J:60210)
growth/size/body region phenotype
- decreased body weight
- (MGI Ref ID J:60210)
hematopoietic system phenotype
- enlarged spleen
- (MGI Ref ID J:60210)
- impaired macrophage phagocytosis
- of apoptotic cells (MGI Ref ID J:63265)
- thrombocytopenia
- (MGI Ref ID J:60210)
homeostasis/metabolism phenotype
- abnormal circulating phospholipid level
- (MGI Ref ID J:61679)
- abnormal fat-soluble vitamin level
- decreased levels of fat-soluble vitamins in plasma (MGI Ref ID J:60210)
- abnormal lipid homeostasis
- decreased circulating HDL cholesterol level
- decreased circulating LDL cholesterol level
- 70% reduction relative to wild-type on chow diet (MGI Ref ID J:61679)
- decreased circulating cholesterol level
- increased intestinal cholesterol absorption
- more cholesterol absorbed, relative to wild-type, on both chow and Western diets (MGI Ref ID J:61679)
immune system phenotype
- enlarged spleen
- (MGI Ref ID J:60210)
- impaired macrophage phagocytosis
- of apoptotic cells (MGI Ref ID J:63265)
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Abca1tm1Jdm/Abca1tm1Jdm
involves: DBA/1LacJ
homeostasis/metabolism phenotype
- abnormal circulating phytosterol level
- strong reduction of plasma beta-sitosterol and campesterol levels (MGI Ref ID J:87209)
Genotype: Abca1tm1Jdm/Abca1tm1Jdm
involves: C57BL/6 * DBA/1LacJ
mortality/aging
- perinatal lethality, incomplete penetrance
- numbers of homozygous offspring recovered at weaning is significantly reduced from expected (MGI Ref ID J:132254)
hematopoietic system phenotype
- abnormal thymus morphology
- massive thymic involution induced by dexamethasone treatment results in significant decrease in thymic weight and cellularity compared to wild-type, and similar to single null mice (MGI Ref ID J:132254)
- impaired macrophage phagocytosis
- after massive thymic involution induced by dexamethasone treatment, macrophages display reduced phagocytosis ability compared to wild-type, and similar to single-null mice (MGI Ref ID J:132254)
- isolated peritoneal macrophages exposed to apoptotic thymocytes internalize similar numbers of cells (1-2 cells) as wild-type after 15-30 minutes, but this number does not increase with time as with wild-type which internalize 4-5 cells at 60-120 minutes (MGI Ref ID J:132254)
immune system phenotype
- abnormal thymus morphology
- massive thymic involution induced by dexamethasone treatment results in significant decrease in thymic weight and cellularity compared to wild-type, and similar to single null mice (MGI Ref ID J:132254)
- impaired macrophage phagocytosis
- after massive thymic involution induced by dexamethasone treatment, macrophages display reduced phagocytosis ability compared to wild-type, and similar to single-null mice (MGI Ref ID J:132254)
- isolated peritoneal macrophages exposed to apoptotic thymocytes internalize similar numbers of cells (1-2 cells) as wild-type after 15-30 minutes, but this number does not increase with time as with wild-type which internalize 4-5 cells at 60-120 minutes (MGI Ref ID J:132254)
homeostasis/metabolism phenotype
- decreased circulating HDL cholesterol level
- adult mice show nearly complete loss of HDL cholesterol in fasting mice (MGI Ref ID J:132254)
- decreased circulating cholesterol level
- levels are reduced compared to adult wild-type or Tgm2-null mice (MGI Ref ID J:132254)
- homeostasis/metabolism phenotype
- circulating triglyceride levels are normal in fasting mice (MGI Ref ID J:132254)
endocrine/exocrine gland phenotype
- abnormal thymus morphology
- massive thymic involution induced by dexamethasone treatment results in significant decrease in thymic weight and cellularity compared to wild-type, and similar to single null mice (MGI Ref ID J:132254)
References
- Hamon Y; Broccardo C; Chambenoit O; Luciani MF; Toti F; Chaslin S; Freyssinet JM; Devaux PF; McNeish J; Marguet D; Chimini G. 2000. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol 2(7):399-406. PubMed: 10878804MGI: J:63265
Additional References
- Wahrle SE; Jiang H; Parsadanian M; Legleiter J; Han X; Fryer JD; Kowalewski T; Holtzman DM. 2004. ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. J Biol Chem 279(39):40987-93. PubMed: 15269217MGI: J:93336
Additional - Abca1tm1Jdm related
- Adorni MP; Zimetti F; Billheimer JT; Wang N; Rader DJ; Phillips MC; Rothblat GH. 2007. The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res 48(11):2453-62. PubMed: 17761631MGI: J:127358
- Bates SR; Tao JQ; Collins HL; Francone OL; Rothblat GH. 2005. Pulmonary abnormalities due to ABCA1 deficiency in mice. Am J Physiol Lung Cell Mol Physiol 289(6):L980-9. PubMed: 16055479MGI: J:105011
- Bravo I; Amigo L; Cohen DE; Nervi F; Rigotti A; Francone O; Zanlungo S. 2007. Role of plasma and liver cholesterol- and lipoprotein-metabolism determinants in LpX formation in the mouse. Biochim Biophys Acta 1770(6):979-88. PubMed: 17399905MGI: J:121757
- Brunham LR; Singaraja RR; Duong M; Timmins JM; Fievet C; Bissada N; Kang MH; Samra A; Fruchart JC; McManus B; Staels B; Parks JS; Hayden MR. 2009. Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Arterioscler Thromb Vasc Biol 29(4):548-54. PubMed: 19201688MGI: J:159775
- Burns MP; Vardanian L; Pajoohesh-Ganji A; Wang L; Cooper M; Harris DC; Duff K; Rebeck GW. 2006. The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. J Neurochem 98(3):792-800. PubMed: 16771834MGI: J:119294
- Calpe-Berdiel L; Rotllan N; Palomer X; Ribas V; Blanco-Vaca F; Escola-Gil JC. 2005. Direct evidence in vivo of impaired macrophage-specific reverse cholesterol transport in ATP-binding cassette transporter A1-deficient mice. Biochim Biophys Acta 1738(1-3):6-9. PubMed: 16413225MGI: J:107452
- Combes V; Coltel N; Alibert M; van Eck M; Raymond C; Juhan-Vague I; Grau GE; Chimini G. 2005. ABCA1 gene deletion protects against cerebral malaria: potential pathogenic role of microparticles in neuropathology. Am J Pathol 166(1):295-302. PubMed: 15632021MGI: J:95235
- Coutinho JM; Singaraja RR; Kang M; Arenillas DJ; Bertram LN; Bissada N; Staels B; Fruchart JC; Fievet C; Joseph-George AM; Wasserman WW; Hayden MR. 2005. Complete functional rescue of the ABCA1-/- mouse by human BAC transgenesis. J Lipid Res 46(6):1113-23. PubMed: 15772424MGI: J:99808
- Cuchel M; Lund-Katz S; de la Llera-Moya M; Millar JS; Chang D; Fuki I; Rothblat GH; Phillips MC; Rader DJ. 2010. Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages. Arterioscler Thromb Vasc Biol 30(3):526-32. PubMed: 20018934MGI: J:172105
- Duka A; Fotakis P; Georgiadou D; Kateifides A; Tzavlaki K; von Eckardstein L; Stratikos E; Kardassis D; Zannis VI. 2013. ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT. J Lipid Res 54(1):107-15. PubMed: 23132909MGI: J:192256
- Fan J; Stukas S; Wong C; Chan J; May S; Devalle N; Hirsch-Reinshagen V; Wilkinson A; Oda MN; Wellington CL. 2011. An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia. J Lipid Res 52(9):1605-16. PubMed: 21705806MGI: J:175557
- Fitz NF; Cronican AA; Saleem M; Fauq AH; Chapman R; Lefterov I; Koldamova R. 2012. Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice. J Neurosci 32(38):13125-36. PubMed: 22993429MGI: J:188282
- Francone OL; Royer L; Boucher G; Haghpassand M; Freeman A; Brees D; Aiello RJ. 2005. Increased cholesterol deposition, expression of scavenger receptors, and response to chemotactic factors in Abca1-deficient macrophages. Arterioscler Thromb Vasc Biol 25(6):1198-205. PubMed: 15831807MGI: J:114227
- Francone OL; Subbaiah PV; van Tol A; Royer L; Haghpassand M. 2003. Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1. Biochemistry 42(28):8569-78. PubMed: 12859204MGI: J:84572
- Gautier EL; Westerterp M; Bhagwat N; Cremers S; Shih A; Abdel-Wahab O; Lutjohann D; Randolph GJ; Levine RL; Tall AR; Yvan-Charvet L. 2013. HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders. J Exp Med 210(2):339-53. PubMed: 23319699MGI: J:195890
- Groen AK; Bloks VW; Bandsma RH; Ottenhoff R; Chimini G; Kuipers F. 2001. Hepatobiliary cholesterol transport is not impaired in Abca1-null mice lacking HDL. J Clin Invest 108(6):843-50. PubMed: 11560953MGI: J:71689
- Hirsch-Reinshagen V; Maia LF; Burgess BL; Blain JF; Naus KE; McIsaac SA; Parkinson PF; Chan JY; Tansley GH; Hayden MR; Poirier J; Van Nostrand W; Wellington CL. 2005. The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease. J Biol Chem 280(52):43243-56. PubMed: 16207707MGI: J:105900
- Hirsch-Reinshagen V; Zhou S; Burgess BL; Bernier L; McIsaac SA; Chan JY; Tansley GH; Cohn JS; Hayden MR; Wellington CL. 2004. Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain. J Biol Chem 279(39):41197-207. PubMed: 15269218MGI: J:93331
- Hossain MA; Tsujita M; Akita N; Kobayashi F; Yokoyama S. 2009. Cholesterol homeostasis in ABCA1/LCAT double-deficient mouse. Biochim Biophys Acta 1791(12):1197-205. PubMed: 19729076MGI: J:164846
- Hu W; Abe-Dohmae S; Tsujita M; Iwamoto N; Ogikubo O; Otsuka T; Kumon Y; Yokoyama S. 2008. Biogenesis of HDL by SAA is dependent on ABCA1 in the liver in vivo. J Lipid Res 49(2):386-93. PubMed: 18033752MGI: J:131875
- Huang ZH; Fitzgerald ML; Mazzone T. 2006. Distinct cellular loci for the ABCA1-dependent and ABCA1-independent lipid efflux mediated by endogenous apolipoprotein E expression. Arterioscler Thromb Vasc Biol 26(1):157-62. PubMed: 16254198MGI: J:127981
- Iadevaia V; Rinaldi A; Falasca L; Pucillo LP; Alonzi T; Chimini G; Piacentini M. 2006. ATP-binding cassette transporter 1 and transglutaminase 2 act on the same genetic pathway in the apoptotic cell clearance. Cell Death Differ 13(11):1998-2001. PubMed: 16691213MGI: J:132254
- Iwamoto N; Abe-Dohmae S; Sato R; Yokoyama S. 2006. ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J Lipid Res 47(9):1915-27. PubMed: 16788211MGI: J:114490
- Kappus MS; Murphy AJ; Abramowicz S; Ntonga V; Welch CL; Tall AR; Westerterp M. 2014. Activation of liver X receptor decreases atherosclerosis in Ldlr(-)/(-) mice in the absence of ATP-binding cassette transporters A1 and G1 in myeloid cells. Arterioscler Thromb Vasc Biol 34(2):279-84. PubMed: 24311381MGI: J:222827
- Koldamova R; Staufenbiel M; Lefterov I. 2005. Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice. J Biol Chem 280(52):43224-35. PubMed: 16207713MGI: J:105902
- Koseki M; Hirano K; Masuda D; Ikegami C; Tanaka M; Ota A; Sandoval JC; Nakagawa-Toyama Y; Sato SB; Kobayashi T; Shimada Y; Ohno-Iwashita Y; Matsuura F; Shimomura I; Yamashita S. 2007. Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages. J Lipid Res 48(2):299-306. PubMed: 17079792MGI: J:118227
- Kypreos KE. 2008. ABCA1 promotes the de novo biogenesis of apolipoprotein CIII-containing HDL particles in vivo and modulates the severity of apolipoprotein CIII-induced hypertriglyceridemia. Biochemistry 47(39):10491-502. PubMed: 18767813MGI: J:141173
- Kypreos KE; Zannis VI. 2007. Pathway of biogenesis of apolipoprotein E-containing HDL in vivo with the participation of ABCA1 and LCAT. Biochem J 403(2):359-67. PubMed: 17206937MGI: J:121679
- Lammers B; Zhao Y; Foks AC; Hildebrand RB; Kuiper J; Van Berkel TJ; Van Eck M. 2012. Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice. PLoS One 7(10):e48080. PubMed: 23133551MGI: J:192253
- Lammers B; Zhao Y; Hoekstra M; Hildebrand RB; Ye D; Meurs I; Van Berkel TJ; Van Eck M. 2011. Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE. PLoS One 6(10):e26095. PubMed: 22022523MGI: J:178098
- Lefterov I; Fitz NF; Cronican AA; Fogg A; Lefterov P; Kodali R; Wetzel R; Koldamova R. 2010. Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice. J Biol Chem 285(47):36945-57. PubMed: 20739292MGI: J:166877
- Lindegaard ML; Wassif CA; Vaisman B; Amar M; Wasmuth EV; Shamburek R; Nielsen LB; Remaley AT; Porter FD. 2008. Characterization of placental cholesterol transport: ABCA1 is a potential target for in utero therapy of Smith-Lemli-Opitz syndrome. Hum Mol Genet 17(23):3806-13. PubMed: 18775956MGI: J:141147
- McNeish J; Aiello RJ; Guyot D; Turi T; Gabel C; Aldinger C; Hoppe KL; Roach ML; Royer LJ; de Wet J; Broccardo C; Chimini G; Francone OL. 2000. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc Natl Acad Sci U S A 97(8):4245-50. PubMed: 10760292MGI: J:61679
- Murphy AJ; Akhtari M; Tolani S; Pagler T; Bijl N; Kuo CL; Wang M; Sanson M; Abramowicz S; Welch C; Bochem AE; Kuivenhoven JA; Yvan-Charvet L; Tall AR. 2011. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J Clin Invest 121(10):4138-49. PubMed: 21968112MGI: J:178453
- Murphy AJ; Bijl N; Yvan-Charvet L; Welch CB; Bhagwat N; Reheman A; Wang Y; Shaw JA; Levine RL; Ni H; Tall AR; Wang N. 2013. Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis. Nat Med 19(5):586-94. PubMed: 23584088MGI: J:198517
- Orso E; Broccardo C; Kaminski WE; Bottcher A; Liebisch G; Drobnik W; Gotz A; Chambenoit O; Diederich W; Langmann T; Spruss T; Luciani MF; Rothe G; Lackner KJ; Chimini G; Schmitz G. 2000. Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice. Nat Genet 24(2):192-6. PubMed: 10655069MGI: J:60210
- Out R; Jessup W; Le Goff W; Hoekstra M; Gelissen IC; Zhao Y; Kritharides L; Chimini G; Kuiper J; Chapman MJ; Huby T; Van Berkel TJ; Van Eck M. 2008. Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1. Circ Res 102(1):113-20. PubMed: 17967783MGI: J:141462
- Pagler TA; Wang M; Mondal M; Murphy AJ; Westerterp M; Moore KJ; Maxfield FR; Tall AR. 2011. Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling. Circ Res 108(2):194-200. PubMed: 21148432MGI: J:183506
- Pascual-Garcia M; Carbo JM; Leon T; Matalonga J; Out R; Van Berkel T; Sarrias MR; Lozano F; Celada A; Valledor AF. 2011. Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4. J Immunol 186(8):4656-67. PubMed: 21398609MGI: J:172455
- Plosch T; Bloks VW; Terasawa Y; Berdy S; Siegler K; Van Der Sluijs F; Kema IP; Groen AK; Shan B; Kuipers F; Schwartz M. 2004. Sitosterolemia in ABC-Transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Gastroenterology 126(1):290-300. PubMed: 14699507MGI: J:87209
- Plosch T; Kok T; Bloks VW; Smit MJ; Havinga R; Chimini G; Groen AK; Kuipers F. 2002. Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. J Biol Chem 277(37):33870-7. PubMed: 12105210MGI: J:78949
- Pradel LC; Mitchell AJ; Zarubica A; Dufort L; Chasson L; Naquet P; Broccardo C; Chimini G. 2009. ATP-binding cassette transporter hallmarks tissue macrophages and modulates cytokine-triggered polarization programs. Eur J Immunol 39(8):2270-80. PubMed: 19609977MGI: J:151985
- Reboul E; Trompier D; Moussa M; Klein A; Landrier JF; Chimini G; Borel P. 2009. ATP-binding cassette transporter A1 is significantly involved in the intestinal absorption of alpha- and gamma-tocopherol but not in that of retinyl palmitate in mice. Am J Clin Nutr 89(1):177-84. PubMed: 19056557MGI: J:163801
- Samyn H; Moerland M; van Gent T; van Haperen R; van Tol A; de Crom R. 2009. Reduction of HDL levels lowers plasma PLTP and affects its distribution among lipoproteins in mice. Biochim Biophys Acta 1791(8):790-6. PubMed: 19422933MGI: J:153479
- Selva DM; Hirsch-Reinshagen V; Burgess B; Zhou S; Chan J; McIsaac S; Hayden MR; Hammond GL; Vogl AW; Wellington CL. 2004. The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility. J Lipid Res 45(6):1040-50. PubMed: 15026428MGI: J:89906
- Singaraja RR; Stahmer B; Brundert M; Merkel M; Heeren J; Bissada N; Kang M; Timmins JM; Ramakrishnan R; Parks JS; Hayden MR; Rinninger F. 2006. Hepatic ATP-binding cassette transporter A1 is a key molecule in high-density lipoprotein cholesteryl ester metabolism in mice. Arterioscler Thromb Vasc Biol 26(8):1821-7. PubMed: 16728652MGI: J:127977
- Singaraja RR; Van Eck M; Bissada N; Zimetti F; Collins HL; Hildebrand RB; Hayden A; Brunham LR; Kang MH; Fruchart JC; Van Berkel TJ; Parks JS; Staels B; Rothblat GH; Fievet C; Hayden MR. 2006. Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo. Circulation 114(12):1301-9. PubMed: 16940190MGI: J:124718
- Stukas S; May S; Wilkinson A; Chan J; Donkin J; Wellington CL. 2012. The LXR agonist GW3965 increases apoA-I protein levels in the central nervous system independent of ABCA1. Biochim Biophys Acta 1821(3):536-46. PubMed: 21889608MGI: J:182371
- Tang C; Houston BA; Storey C; LeBoeuf RC. 2016. Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages. J Lipid Res 57(5):848-57. PubMed: 26989082MGI: J:231656
- Tang C; Liu Y; Kessler PS; Vaughan AM; Oram JF. 2009. The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor. J Biol Chem 284(47):32336-43. PubMed: 19783654MGI: J:156325
- Tang C; Liu Y; Yang W; Storey C; McMillen TS; Houston BA; Heinecke JW; LeBoeuf RC. 2016. Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice. J Lipid Res 57(1):100-8. PubMed: 26531812MGI: J:228788
- Taylor SR; Gonzalez-Begne M; Dewhurst S; Chimini G; Higgins CF; Melvin JE; Elliott JI. 2008. Sequential shrinkage and swelling underlie P2X7-stimulated lymphocyte phosphatidylserine exposure and death. J Immunol 180(1):300-8. PubMed: 18097031MGI: J:130933
- Terasaka N; Westerterp M; Koetsveld J; Fernandez-Hernando C; Yvan-Charvet L; Wang N; Sessa WC; Tall AR. 2010. ATP-binding cassette transporter G1 and high-density lipoprotein promote endothelial NO synthesis through a decrease in the interaction of caveolin-1 and endothelial NO synthase. Arterioscler Thromb Vasc Biol 30(11):2219-25. PubMed: 20798376MGI: J:183208
- Terasaka N; Yu S; Yvan-Charvet L; Wang N; Mzhavia N; Langlois R; Pagler T; Li R; Welch CL; Goldberg IJ; Tall AR. 2008. ABCG1 and HDL protect against endothelial dysfunction in mice fed a high-cholesterol diet. J Clin Invest 118(11):3701-13. PubMed: 18924609MGI: J:144580
- Tsujita M; Wu CA; Abe-Dohmae S; Usui S; Okazaki M; Yokoyama S. 2005. On the hepatic mechanism of HDL assembly by the ABCA1/apoA-I pathway. J Lipid Res 46(1):154-62. PubMed: 15520446MGI: J:94964
- Vrins CL; Ottenhoff R; van den Oever K; de Waart DR; Kruyt JK; Zhao Y; van Berkel TJ; Havekes LM; Aerts JM; van Eck M; Rensen PC; Groen AK. 2012. Trans-intestinal cholesterol efflux is not mediated through high density lipoprotein. J Lipid Res 53(10):2017-23. PubMed: 22802462MGI: J:188045
- Wahrle SE; Jiang H; Parsadanian M; Hartman RE; Bales KR; Paul SM; Holtzman DM. 2005. Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease. J Biol Chem 280(52):43236-42. PubMed: 16207708MGI: J:105901
- Wahrle SE; Jiang H; Parsadanian M; Kim J; Li A; Knoten A; Jain S; Hirsch-Reinshagen V; Wellington CL; Bales KR; Paul SM; Holtzman DM. 2008. Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease. J Clin Invest 118(2):671-82. PubMed: 18202749MGI: J:131400
- Wahrle SE; Jiang H; Parsadanian M; Legleiter J; Han X; Fryer JD; Kowalewski T; Holtzman DM. 2004. ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE. J Biol Chem 279(39):40987-93. PubMed: 15269217MGI: J:93336
- Wang X; Collins HL; Ranalletta M; Fuki IV; Billheimer JT; Rothblat GH; Tall AR; Rader DJ. 2007. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest 117(8):2216-24. PubMed: 17657311MGI: J:123959
- Westerterp M; Gourion-Arsiquaud S; Murphy AJ; Shih A; Cremers S; Levine RL; Tall AR; Yvan-Charvet L. 2012. Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell 11(2):195-206. PubMed: 22862945MGI: J:190966
- Westerterp M; Murphy AJ; Wang M; Pagler TA; Vengrenyuk Y; Kappus MS; Gorman DJ; Nagareddy PR; Zhu X; Abramowicz S; Parks JS; Welch C; Fisher EA; Wang N; Yvan-Charvet L; Tall AR. 2013. Deficiency of ATP-binding cassette transporters A1 and G1 in macrophages increases inflammation and accelerates atherosclerosis in mice. Circ Res 112(11):1456-65. PubMed: 23572498MGI: J:213300
- Williamson P; Halleck MS; Malowitz J; Ng S; Fan X; Krahling S; Remaley AT; Schlegel RA. 2007. Transbilayer phospholipid movements in ABCA1-deficient cells. PLoS One 2(1):e729. PubMed: 17710129MGI: J:129392
- Yamaguchi S; Zhang B; Tomonaga T; Seino U; Kanagawa A; Segawa M; Nagasaka H; Suzuki A; Miida T; Yamada S; Sasaguri Y; Doi T; Saku K; Okazaki M; Tochino Y; Hirano K. 2014. Selective evaluation of high density lipoprotein from mouse small intestine by an in situ perfusion technique. J Lipid Res 55(5):905-18. PubMed: 24569139MGI: J:210266
- Yamamoto S; Tanigawa H; Li X; Komaru Y; Billheimer JT; Rader DJ. 2011. Pharmacologic suppression of hepatic ATP-binding cassette transporter 1 activity in mice reduces high-density lipoprotein cholesterol levels but promotes reverse cholesterol transport. Circulation 124(12):1382-90. PubMed: 21859969MGI: J:189383
- Yvan-Charvet L; Pagler T; Gautier EL; Avagyan S; Siry RL; Han S; Welch CL; Wang N; Randolph GJ; Snoeck HW; Tall AR. 2010. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science 328(5986):1689-93. PubMed: 20488992MGI: J:161310
- Yvan-Charvet L; Pagler TA; Seimon TA; Thorp E; Welch CL; Witztum JL; Tabas I; Tall AR. 2010. ABCA1 and ABCG1 protect against oxidative stress-induced macrophage apoptosis during efferocytosis. Circ Res 106(12):1861-9. PubMed: 20431058MGI: J:175055
- Yvan-Charvet L; Ranalletta M; Wang N; Han S; Terasaka N; Li R; Welch C; Tall AR. 2007. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest 117(12):3900-8. PubMed: 17992262MGI: J:130777
- Yvan-Charvet L; Welch C; Pagler TA; Ranalletta M; Lamkanfi M; Han S; Ishibashi M; Li R; Wang N; Tall AR. 2008. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation 118(18):1837-47. PubMed: 18852364MGI: J:165622
- Zhao Y; Pennings M; Hildebrand RB; Ye D; Calpe-Berdiel L; Out R; Kjerrulf M; Hurt-Camejo E; Groen AK; Hoekstra M; Jessup W; Chimini G; Van Berkel TJ; Van Eck M. 2010. Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet. Circ Res 107(12):e20-31. PubMed: 21071707MGI: J:178508
- van der Veen JN; Kruit JK; Havinga R; Baller JF; Chimini G; Lestavel S; Staels B; Groot PH; Groen AK; Kuipers F. 2005. Reduced cholesterol absorption upon PPAR{delta} activation coincides with decreased intestinal expression of NPC1L1. J Lipid Res 46(3):526-34. PubMed: 15604518MGI: J:96527