JAX
Mouse Strain Datasheet - 003881
B6.129S7-Sod1tm1Leb/DnJ
Also Known As: Sod1 KO
Homozygous Sod1tm1Leb knock-out mice are characterized by abnormal retinal and cochlear ganglions, and they have age-related defects in hearing, vasculature, and muscle. These mice may be useful in studying retinal dysfunction, autoimmunity, female reproductive development/function, glaucoma, hearing loss, Alzheimer's Disease, familial amyotrophic lateral sclerosis (ALS), and other age-related disorders.
Read More +Genetic overview
| Genetic Background | Generation |
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Sod1tm1Leb
| Allele Type | Gene Symbol | Gene Name |
|---|---|---|
| Targeted (Null/Knockout) | Sod1 | superoxide dismutase 1, soluble |
Detailed Description
The Sod1tm1Leb (formerly SOD1m1BCM) knock-out allele disrupts exons 1 and 2 of the Cu,Zn-superoxide dismutase-1 gene (Sod1). This knock-out allele is the same as carried by B6;129S-Sod1tm1Leb/J (Stock No. 002972) but is fully congenic in the present strain having been backcrossed to C57BL/6JEi for 13 generations. In the original strain no protein expression from the targeted locus is detected in brain tissues. Heterozygous mice are viable and fertile. While homozygous males reproduce normally, homozygous females are infertile. Homozygous mice have abnormalities of the retinal ganglion, cochlear ganglion, and female reproductive development/function. Homozygous mice also exhibit age-related deafness, accelerated vascular aging and age-related skeletal muscle defects. These mutant mice may be useful in studying retinal dysfunction, autoimmunity, glaucoma, hearing loss, Alzheimer's Disease, familial amyotrophic lateral sclerosis (ALS), and other age-related disorders.
Development
This strain was generated in the Laboratory of Muriel Davisson by backcrossing the Sod1tm1Leb mutation from the segregating B6;129S7 background onto the C57BL/6JEi strain for 13 generations. The backcrossing was begun in 1998. In 2004 embryos were generated for cryopreservation via in vitro fertilization using C57BL/6J females and heterozygous males at generation N13.
Sod1tm1Leb
Allele Symbol: Sod1tm1Leb
| Allele Name | targeted mutation 1, Russell M Lebovitz |
|---|---|
| Allele Type | Targeted (Null/Knockout) |
| Allele Synonym(s) | Cu,Zn-SOD-; CuZnSOD-; SOD1-; SOD1m1BCM |
| Gene Symbol and Name | Sod1, superoxide dismutase 1, soluble |
| Gene Synonym(s) | ALS; ALS1; B430204E11Rik; B430204E11Rik; Cu(2+)-Zn2+ superoxide dismutase; Cu/Zn-SOD; CuZnSOD; HEL-S-44; IPOA; Ipo-1; Ipo-1; Ipo1; Ipo1; RIKEN cDNA B430204E11 gene; SOD; SODC; Sod-1; Sod-1; hSod1; homodimer; indophenol oxidase |
| Strain of Origin | 129S7/SvEvBrd-Hprt |
| Chromosome | 16 |
| Molecular Note | Replacement of exons 1 and 2 with a PGK-hprt expression cassette. Protein was not detected in brain of homozygous mutant mice. |
| Mutations Made By | Dr. Russell Lebovitz, SUMA Partners |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
Genotype: Sod1tm1Leb related
- Metabolism Research
- Neurobiology Research
- Metabolic Defects
- Neurodegeneration
Mammalian Phenotype Terms by Genotype
The following phenotype information is associated with a similar, but not exact match to this JAX® Mice strain
Genotype: Sod1tm1Leb/Sod1+
B6;129S-Sod1tm1Leb/J
nervous system phenotype
- cochlear ganglion degeneration
- contrary to previous findings, heterozygotes display no significant differences in ABR thresholds relative to wild-type mice at any age or any frequency tested (MGI Ref ID J:102419)
- however, unlike wild-type mice, aging heterozygotes show a decrease in ganglion cell density at 15 months (MGI Ref ID J:102419)
- no degenerative changes are noted in the heterozygous stria vascularis even at 18 months of age (MGI Ref ID J:102419)
Genotype: Sod1tm1Leb/Sod1tm1Leb
involves: 129S7/SvEvBrd * C57BL/6
reproductive system phenotype
- abnormal ovary morphology
- at 12 weeks of age, increased stromal cell proliferation is noted in the center of the mutant ovary (MGI Ref ID J:64299)
- decreased corpora lutea number
- (MGI Ref ID J:64299)
- decreased litter size
- over a 2-6 month period, female homozygotes produced a significantly decreased average litter size relative to female heterozygotes (2.7 vs 8.6 offspring/litter, respectively) (MGI Ref ID J:64299)
- decreased mature ovarian follicle number
- while normal-appearing primary follicles and some small antral follicles are present, only a few large antral follicles and corpora lutea are observed (MGI Ref ID J:64299)
- female infertility
- 5 of 16 female homozygotes failed to become pregnant over a 2-6 month period (MGI Ref ID J:64299)
- impaired ovarian folliculogenesis
- at 6-12 weeks of age, female homozygotes show limited follicular development beyond the early antral follicle stage (MGI Ref ID J:64299)
- reduced female fertility
- female homozygotes survive to adulthood and appear to show normal sexual differentiation but are subfertile (MGI Ref ID J:64299)
- however, mutant and control females were shown to produce a similar number of eggs upon pharmacological superovulation (MGI Ref ID J:64299)
- in contrast to females, male homozygotes are fertile with normal testicular morphology (MGI Ref ID J:64299)
- whereas breeding of 5 female heterozygotes with male heterozygotes over a 6 month period produced an average of 1.0 litter/month, only 11 of 16 female homozygotes became pregnant over a 2-6 month period averaging 0.23 litters/month (MGI Ref ID J:64299)
- small ovary
- homozygous mutant ovaries are often smaller than wild-type ovaries (MGI Ref ID J:64299)
endocrine/exocrine gland phenotype
- Meibomian gland inflammation
- increase in periglandular inflammatory infiltrates from 10 to 50 weeks of age (MGI Ref ID J:219024)
- abnormal Meibomian gland acinus morphology
- accumulation of large lipid droplets in the acinar units of meibomian glands of 50 weeks of age; lipid droplets become larger in size and increase in number from 10 to 50 weeks of age (MGI Ref ID J:219024)
- decrease in meibomian gland glandular acinar density from 10 to 50 weeks of age (MGI Ref ID J:219024)
- abnormal Meibomian gland morphology
- increase in periglandular fibrosis from 10 to 50 weeks of age (MGI Ref ID J:219024)
- abnormal Meibomian gland physiology
- increase in apoptosis within the meibomian glands at 50 weeks of age (MGI Ref ID J:219024)
- abnormal ovary morphology
- at 12 weeks of age, increased stromal cell proliferation is noted in the center of the mutant ovary (MGI Ref ID J:64299)
- decreased corpora lutea number
- (MGI Ref ID J:64299)
- decreased mature ovarian follicle number
- while normal-appearing primary follicles and some small antral follicles are present, only a few large antral follicles and corpora lutea are observed (MGI Ref ID J:64299)
- impaired ovarian folliculogenesis
- at 6-12 weeks of age, female homozygotes show limited follicular development beyond the early antral follicle stage (MGI Ref ID J:64299)
- small ovary
- homozygous mutant ovaries are often smaller than wild-type ovaries (MGI Ref ID J:64299)
homeostasis/metabolism phenotype
- decreased circulating luteinizing hormone level
- adult female homozygotes exhibit suppressed serum LH levels relative to control females (17.4 +/- 3.0 ng/ml vs 57.8 +/- 17.7 ng/ml, respectively), as shown by RIA analysis (MGI Ref ID J:64299)
- increased circulating interleukin-6 level
- increase in the mean serum IL-6 concentration from 10 to 50 weeks of age (MGI Ref ID J:219024)
- increased circulating tumor necrosis factor level
- increase in serum TNF-alpha levels from 10 weeks of age (MGI Ref ID J:219024)
- suppressed circulating follicle stimulating hormone level
- adult female homozygotes exhibit suppressed serum FSH levels relative to control females (38.5 +/- 3.1 ng/ml vs 105.0 +/- 17.3 ng/ml, respectively), as shown by RIA analysis (MGI Ref ID J:64299)
cellular phenotype
- abnormal mitochondrion morphology
- mitochondrial swelling, disorientation, shortening, and disorganization of cristae are seen in 80% of 50 week old mice compared to 40% of wild-type mice at this age (MGI Ref ID J:219024)
- dilated mitochondria
- in 50 week old mice (MGI Ref ID J:219024)
- disorganized mitochondrial cristae
- in 50 week old mice (MGI Ref ID J:219024)
- oxidative stress
- mice exhibit changes in oxidative stress markers in the meibomian glands (MGI Ref ID J:219024)
immune system phenotype
- blepharitis
- increased circulating interleukin-6 level
- increase in the mean serum IL-6 concentration from 10 to 50 weeks of age (MGI Ref ID J:219024)
- increased circulating tumor necrosis factor level
- increase in serum TNF-alpha levels from 10 weeks of age (MGI Ref ID J:219024)
- increased interleukin-6 secretion
- increase in tear IL-6 concentration from 10 to 50 weeks of age (MGI Ref ID J:219024)
- increased tumor necrosis factor secretion
- increase in mean tear TNF-alpha concentration from 10 to 50 weeks of age (MGI Ref ID J:219024)
integument phenotype
- Meibomian gland inflammation
- increase in periglandular inflammatory infiltrates from 10 to 50 weeks of age (MGI Ref ID J:219024)
- abnormal Meibomian gland acinus morphology
- accumulation of large lipid droplets in the acinar units of meibomian glands of 50 weeks of age; lipid droplets become larger in size and increase in number from 10 to 50 weeks of age (MGI Ref ID J:219024)
- decrease in meibomian gland glandular acinar density from 10 to 50 weeks of age (MGI Ref ID J:219024)
- abnormal Meibomian gland morphology
- increase in periglandular fibrosis from 10 to 50 weeks of age (MGI Ref ID J:219024)
- abnormal Meibomian gland physiology
- increase in apoptosis within the meibomian glands at 50 weeks of age (MGI Ref ID J:219024)
vision/eye phenotype
- abnormal Meibomian gland acinus morphology
- accumulation of large lipid droplets in the acinar units of meibomian glands of 50 weeks of age; lipid droplets become larger in size and increase in number from 10 to 50 weeks of age (MGI Ref ID J:219024)
- decrease in meibomian gland glandular acinar density from 10 to 50 weeks of age (MGI Ref ID J:219024)
- abnormal Meibomian gland morphology
- increase in periglandular fibrosis from 10 to 50 weeks of age (MGI Ref ID J:219024)
- abnormal corneal epithelium morphology
- mean corneal vital staining score is worse at 10 and 50 weeks of age indicating ocular surface epithelial cell damage (MGI Ref ID J:219024)
- abnormal tear production
- lower tear break up time is seen at 50 weeks of age compared to wild-type mice indicating decreased tear stability (MGI Ref ID J:219024)
- blepharitis
- decreased tear production
- mean weight adjusted aqueous tear production is lower at 10 and 50 weeks of age and mice show a significant decrease in tear quantity from 10 to 50 weeks of age (MGI Ref ID J:219024)
Genotype: Sod1tm1Leb/Sod1tm1Leb
B6;129S-Sod1tm1Leb/J
hearing/vestibular/ear phenotype
- deafness
- at 12 and 15 months, homozygotes exhibit an earlier and significantly greater hearing loss than age-matched C57BL/6, wild-type or heterozygous mice (MGI Ref ID J:102419)
- increased or absent threshold for auditory brainstem response
- at 12 and 15 months, homozygotes exhibit significantly increased ABR thresholds for clicks and tone pip stimuli at 8, 16 and 32 kHz relative to C57BL/6, wild-type or heterozygous mice; however, no differences are noted at 7-9 months (MGI Ref ID J:102419)
- at 12 months, homozygotes show an ~20 dB elevation in ABR thresholds at 32 kHz relative to C57BL/6 control mice; the latter have ABR thresholds that are ~10 dB higher than those in wild-type or heterozygous mice (MGI Ref ID J:102419)
- thin stria vascularis
nervous system phenotype
- cochlear ganglion degeneration
- decreased retinal ganglion cell number
vision/eye phenotype
- abnormal eye electrophysiology
- abnormal retinal ganglion layer morphology
- level of reactive oxygen species (ROS) in the retinal ganglion cell layer is higher in 24-week old mutants than in wild-type mice (MGI Ref ID J:181434)
- abnormal retinal nerve fiber layer morphology
- 24 week old mutants exhibit thinning of the nerve fiber layer (MGI Ref ID J:181434)
References
Additional - Sod1tm1Leb related
- Akhtar S; Grizenkova J; Wenborn A; Hummerich H; Fernandez de Marco M; Brandner S; Collinge J; Lloyd SE. 2013. Sod1 deficiency reduces incubation time in mouse models of prion disease. PLoS One 8(1):e54454. PubMed: 23349894MGI: J:195841
- Asimakis GK; Lick S; Patterson C. 2002. Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts. Circulation 105(8):981-6. PubMed: 11864929MGI: J:103317
- Baumbach GL; Didion SP; Faraci FM. 2006. Hypertrophy of cerebral arterioles in mice deficient in expression of the gene for CuZn superoxide dismutase. Stroke 37(7):1850-5. PubMed: 16763183MGI: J:136409
- Bhattacharya A; Hegazy AN; Deigendesch N; Kosack L; Cupovic J; Kandasamy RK; Hildebrandt A; Merkler D; Kuhl AA; Vilagos B; Schliehe C; Panse I; Khamina K; Baazim H; Arnold I; Flatz L; Xu HC; Lang PA; Aderem A; Takaoka A; Superti-Furga G; Colinge J; Ludewig B; Lohning M; Bergthaler A. 2015. Superoxide Dismutase 1 Protects Hepatocytes from Type I Interferon-Driven Oxidative Damage. Immunity 43(5):974-86. PubMed: 26588782MGI: J:234575
- Carlstrom M; Brown RD; Sallstrom J; Larsson E; Zilmer M; Zabihi S; Eriksson UJ; Persson AE. 2009. SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis. Am J Physiol Regul Integr Comp Physiol 297(1):R82-92. PubMed: 19403858MGI: J:150216
- Carver KA; Lin CM; Bowes Rickman C; Yang D. 2017. Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD. Biochem Biophys Res Commun 482(1):81-86. PubMed: 27810364MGI: J:242333
- Cooke CL; Davidge ST. 2003. Endothelial-dependent vasodilation is reduced in mesenteric arteries from superoxide dismutase knockout mice. Cardiovasc Res 60(3):635-42. PubMed: 14659809MGI: J:162746
- Dayal S; Gu SX; Hutchins RD; Wilson KM; Wang Y; Fu X; Lentz SR. 2015. Deficiency of superoxide dismutase impairs protein C activation and enhances susceptibility to experimental thrombosis. Arterioscler Thromb Vasc Biol 35(8):1798-804. PubMed: 26069236MGI: J:241809
- Didion SP; Kinzenbaw DA; Faraci FM. 2005. Critical role for CuZn-superoxide dismutase in preventing angiotensin II-induced endothelial dysfunction. Hypertension 46(5):1147-53. PubMed: 16216984MGI: J:135455
- Didion SP; Ryan MJ; Didion LA; Fegan PE; Sigmund CD; Faraci FM. 2002. Increased superoxide and vascular dysfunction in CuZnSOD-deficient mice. Circ Res 91(10):938-44. PubMed: 12433839MGI: J:109001
- Groleau J; Dussault S; Haddad P; Turgeon J; Menard C; Chan JS; Rivard A. 2010. Essential role of copper-zinc superoxide dismutase for ischemia-induced neovascularization via modulation of bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 30(11):2173-81. PubMed: 20724700MGI: J:182101
- Groleau J; Dussault S; Turgeon J; Haddad P; Rivard A. 2011. Accelerated vascular aging in CuZnSOD-deficient mice: impact on EPC function and reparative neovascularization. PLoS One 6(8):e23308. PubMed: 21858065MGI: J:176492
- Harraz MM; Marden JJ; Zhou W; Zhang Y; Williams A; Sharov VS; Nelson K; Luo M; Paulson H; Schoneich C; Engelhardt JF. 2008. SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model. J Clin Invest 118(2):659-70. PubMed: 18219391MGI: J:131850
- Hashizume K; Hirasawa M; Imamura Y; Noda S; Shimizu T; Shinoda K; Kurihara T; Noda K; Ozawa Y; Ishida S; Miyake Y; Shirasawa T; Tsubota K. 2008. Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice. Am J Pathol 172(5):1325-31. PubMed: 18372426MGI: J:134267
- He C; Ryan AJ; Murthy S; Carter AB. 2013. Accelerated development of pulmonary fibrosis via Cu,Zn-superoxide dismutase-induced alternative activation of macrophages. J Biol Chem 288(28):20745-57. PubMed: 23720777MGI: J:201791
- Homma T; Kurahashi T; Lee J; Kang ES; Fujii J. 2015. SOD1 deficiency decreases proteasomal function, leading to the accumulation of ubiquitinated proteins in erythrocytes. Arch Biochem Biophys 583:65-72. PubMed: 26264915MGI: J:230764
- Homma T; Okano S; Lee J; Ito J; Otsuki N; Kurahashi T; Kang ES; Nakajima O; Fujii J. 2015. SOD1 deficiency induces the systemic hyperoxidation of peroxiredoxin in the mouse. Biochem Biophys Res Commun 463(4):1040-6. PubMed: 26079888MGI: J:228682
- Ibrahim OM; Dogru M; Matsumoto Y; Igarashi A; Kojima T; Wakamatsu TH; Inaba T; Shimizu T; Shimazaki J; Tsubota K. 2014. Oxidative stress induced age dependent meibomian gland dysfunction in Cu, Zn-superoxide dismutase-1 (Sod1) knockout mice. PLoS One 9(7):e99328. PubMed: 25036096MGI: J:219024
- Imamura Y; Noda S; Hashizume K; Shinoda K; Yamaguchi M; Uchiyama S; Shimizu T; Mizushima Y; Shirasawa T; Tsubota K. 2006. Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: a model of age-related macular degeneration. Proc Natl Acad Sci U S A 103(30):11282-7. PubMed: 16844785MGI: J:111796
- Ishii T; Matsuki S; Iuchi Y; Okada F; Toyosaki S; Tomita Y; Ikeda Y; Fujii J. 2005. Accelerated impairment of spermatogenic cells in SOD1-knockout mice under heat stress. Free Radic Res 39(7):697-705. PubMed: 16036348MGI: J:114348
- Iuchi Y; Kibe N; Tsunoda S; Suzuki S; Mikami T; Okada F; Uchida K; Fujii J. 2010. Implication of oxidative stress as a cause of autoimmune hemolytic anemia in NZB mice. Free Radic Biol Med 48(7):935-44. PubMed: 20079426MGI: J:158021
- Iuchi Y; Okada F; Onuma K; Onoda T; Asao H; Kobayashi M; Fujii J. 2007. Elevated oxidative stress in erythrocytes due to a SOD1 deficiency causes anaemia and triggers autoantibody production. Biochem J 402(2):219-27. PubMed: 17059387MGI: J:118550
- Iuchi Y; Okada F; Takamiya R; Kibe N; Tsunoda S; Nakajima O; Toyoda K; Nagae R; Suematsu M; Soga T; Uchida K; Fujii J. 2009. Rescue of anaemia and autoimmune responses in SOD1-deficient mice by transgenic expression of human SOD1 in erythrocytes. Biochem J 422(2):313-20. PubMed: 19515016MGI: J:154894
- Johnson KR; Yu H; Ding D; Jiang H; Gagnon LH; Salvi RJ. 2010. Separate and combined effects of Sod1 and Cdh23 mutations on age-related hearing loss and cochlear pathology in C57BL/6J mice. Hear Res 268(1-2):85-92. PubMed: 20470874MGI: J:163035
- Keithley EM; Canto C; Zheng QY; Wang X; Fischel-Ghodsian N; Johnson KR. 2005. Cu/Zn superoxide dismutase and age-related hearing loss. Hear Res 209(1-2):76-85. PubMed: 16055286MGI: J:102419
- Kessova IG; Cederbaum AI. 2007. Mitochondrial alterations in livers of Sod1-/- mice fed alcohol. Free Radic Biol Med 42(10):1470-80. PubMed: 17448893MGI: J:121616
- Kojima T; Dogru M; Ibrahim OM; Nagata T; Higa K; Shimizu T; Shirasawa T; Satake Y; Shimazaki S; Shimazaki J; Tsubota K. 2014. The effects of 3% diquafosol sodium application on the tear functions and ocular surface of the Cu,Zn-superoxide dismutase-1 (Sod1)-knockout mice. Mol Vis 20:929-38. PubMed: 24991185MGI: J:212534
- Kojima T; Wakamatsu TH; Dogru M; Ogawa Y; Igarashi A; Ibrahim OM; Inaba T; Shimizu T; Noda S; Obata H; Nakamura S; Wakamatsu A; Shirasawa T; Shimazaki J; Negishi K; Tsubota K. 2012. Age-related dysfunction of the lacrimal gland and oxidative stress: evidence from the cu,zn-superoxide dismutase-1 (sod1) knockout mice. Am J Pathol 180(5):1879-96. PubMed: 22440255MGI: J:183473
- Kostrominova TY. 2010. Advanced age-related denervation and fiber-type grouping in skeletal muscle of SOD1 knockout mice. Free Radic Biol Med 49(10):1582-93. PubMed: 20800676MGI: J:165857
- Kubota M; Shimmura S; Kubota S; Miyashita H; Kato N; Noda K; Ozawa Y; Usui T; Ishida S; Umezawa K; Kurihara T; Tsubota K. 2011. Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. Invest Ophthalmol Vis Sci 52(1):427-33. PubMed: 20847117MGI: J:171558
- Kurahashi T; Hamashima S; Shirato T; Lee J; Homma T; Kang ES; Fujii J. 2015. An SOD1 deficiency enhances lipid droplet accumulation in the fasted mouse liver by aborting lipophagy. Biochem Biophys Res Commun 467(4):866-71. PubMed: 26474701MGI: J:233211
- Kurahashi T; Konno T; Otsuki N; Kwon M; Tsunoda S; Ito J; Fujii J. 2012. A malfunction in triglyceride transfer from the intracellular lipid pool to apoB in enterocytes of SOD1-deficient mice. FEBS Lett 586(24):4289-95. PubMed: 23098755MGI: J:191746
- Lee J; Homma T; Kurahashi T; Kang ES; Fujii J. 2015. Oxidative stress triggers lipid droplet accumulation in primary cultured hepatocytes by activating fatty acid synthesis. Biochem Biophys Res Commun 464(1):229-35. PubMed: 26116535MGI: J:228664
- Matzuk MM; Dionne L; Guo Q; Kumar TR; Lebovitz RM. 1998. Ovarian function in superoxide dismutase 1 and 2 knockout mice. Endocrinology 139(9):4008-11. PubMed: 9724058MGI: J:64299
- Meissner F; Molawi K; Zychlinsky A. 2008. Superoxide dismutase 1 regulates caspase-1 and endotoxic shock. Nat Immunol 9(8):866-72. PubMed: 18604212MGI: J:137865
- Morikawa K; Shimokawa H; Matoba T; Kubota H; Akaike T; Talukder MA; Hatanaka M; Fujiki T; Maeda H; Takahashi S; Takeshita A. 2003. Pivotal role of Cu,Zn-superoxide dismutase in endothelium-dependent hyperpolarization. J Clin Invest 112(12):1871-9. PubMed: 14679182MGI: J:86950
- Murakami K; Inagaki J; Saito M; Ikeda Y; Tsuda C; Noda Y; Kawakami S; Shirasawa T; Shimizu T. 2009. Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative. Biochem Biophys Res Commun 382(2):457-61. PubMed: 19289104MGI: J:148029
- Murakami K; Murata N; Noda Y; Tahara S; Kaneko T; Kinoshita N; Hatsuta H; Murayama S; Barnham KJ; Irie K; Shirasawa T; Shimizu T. 2011. SOD1 (Copper/Zinc Superoxide Dismutase) Deficiency Drives Amyloid beta Protein Oligomerization and Memory Loss in Mouse Model of Alzheimer Disease. J Biol Chem 286(52):44557-68. PubMed: 22072713MGI: J:178835
- Noda Y; Ota K; Shirasawa T; Shimizu T. 2012. Copper/zinc superoxide dismutase insufficiency impairs progesterone secretion and fertility in female mice. Biol Reprod 86(1):1-8. PubMed: 21900685MGI: J:185784
- Nojiri H; Saita Y; Morikawa D; Kobayashi K; Tsuda C; Miyazaki T; Saito M; Marumo K; Yonezawa I; Kaneko K; Shirasawa T; Shimizu T. 2011. Cytoplasmic superoxide causes bone fragility owing to low-turnover osteoporosis and impaired collagen cross-linking. J Bone Miner Res 26(11):2682-94. PubMed: 22025246MGI: J:233285
- Ohguchi T; Kojima T; Ibrahim OM; Nagata T; Shimizu T; Shirasawa T; Kawakita T; Satake Y; Tsubota K; Shimazaki J; Ishida S. 2013. The effects of 2% rebamipide ophthalmic solution on the tear functions and ocular surface of the superoxide dismutase-1 (sod1) knockout mice. Invest Ophthalmol Vis Sci 54(12):7793-802. PubMed: 24168989MGI: J:215137
- Plomaritas DR; Herbert LM; Yellowhair TR; Resta TC; Gonzalez Bosc LV; Walker BR; Jernigan NL. 2014. Chronic hypoxia limits H2O2-induced inhibition of ASIC1-dependent store-operated calcium entry in pulmonary arterial smooth muscle. Am J Physiol Lung Cell Mol Physiol 307(5):L419-30. PubMed: 24993130MGI: J:221830
- Ramiro-Diaz JM; Nitta CH; Maston LD; Codianni S; Giermakowska W; Resta TC; Bosc LV. 2013. NFAT is required for spontaneous pulmonary hypertension in superoxide dismutase 1 knockout mice. Am J Physiol Lung Cell Mol Physiol 304(9):L613-25. PubMed: 23475768MGI: J:196362
- Selvaratnam JS; Robaire B. 2016. Effects of Aging and Oxidative Stress on Spermatozoa of Superoxide-Dismutase 1- and Catalase-Null Mice. Biol Reprod 95(3):60. PubMed: 27465136MGI: J:236465
- Starzynski RR; Canonne-Hergaux F; Willemetz A; Gralak MA; Wolinski J; Stys A; Olszak J; Lipinski P. 2009. Haemolytic anaemia and alterations in hepatic iron metabolism in aged mice lacking Cu,Zn-superoxide dismutase. Biochem J 420(3):383-90. PubMed: 19296829MGI: J:151021
- Starzynski RR; Lipinski P; Drapier JC; Diet A; Smuda E; Bartlomiejczyk T; Gralak MA; Kruszewski M. 2005. Down-regulation of iron regulatory protein 1 activities and expression in superoxide dismutase 1 knock-out mice is not associated with alterations in iron metabolism. J Biol Chem 280(6):4207-12. PubMed: 15557328MGI: J:96864
- Tsunoda S; Kawano N; Miyado K; Kimura N; Fujii J. 2012. Impaired fertilizing ability of superoxide dismutase 1-deficient mouse sperm during in vitro fertilization. Biol Reprod 87(5):121. PubMed: 22933517MGI: J:192481
- Tsunoda S; Kibe N; Kurahashi T; Fujii J. 2013. Differential responses of SOD1-deficient mouse embryonic fibroblasts to oxygen concentrations. Arch Biochem Biophys 537(1):5-11. PubMed: 23811199MGI: J:206690
- Usui S; Oveson BC; Iwase T; Lu L; Lee SY; Jo YJ; Wu Z; Choi EY; Samulski RJ; Campochiaro PA. 2011. Overexpression of SOD in retina: Need for increase in H(2)O(2)-detoxifying enzyme in same cellular compartment. Free Radic Biol Med 51(7):1347-54. PubMed: 21736939MGI: J:175696
- Yada T; Shimokawa H; Morikawa K; Takaki A; Shinozaki Y; Mori H; Goto M; Ogasawara Y; Kajiya F. 2008. Role of Cu,Zn-SOD in the synthesis of endogenous vasodilator hydrogen peroxide during reactive hyperemia in mouse mesenteric microcirculation in vivo. Am J Physiol Heart Circ Physiol 294(1):H441-8. PubMed: 18024543MGI: J:132306
- Yuki K; Ozawa Y; Yoshida T; Kurihara T; Hirasawa M; Ozeki N; Shiba D; Noda K; Ishida S; Tsubota K. 2011. Retinal ganglion cell loss in superoxide dismutase 1 deficiency. Invest Ophthalmol Vis Sci 52(7):4143-50. PubMed: 21421868MGI: J:181434
- Yuki K; Yoshida T; Miyake S; Tsubota K; Ozawa Y. 2013. Neuroprotective role of superoxide dismutase 1 in retinal ganglion cells and inner nuclear layer cells against N-methyl-d-aspartate-induced cytotoxicity. Exp Eye Res 115:230-8. PubMed: 23856406MGI: J:210406
- Ziv S; Brenner O; Amariglio N; Smorodinsky NI; Galron R; Carrion DV; Zhang W; Sharma GG; Pandita RK; Agarwal M; Elkon R; Katzin N; Bar-Am I; Pandita TK; Kucherlapati R; Rechavi G; Shiloh Y; Barzilai A. 2005. Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia. Hum Mol Genet 14(19):2929-43. PubMed: 16150740MGI: J:101745