Homozygous Sod1tm1Leb knock-out mice are characterized by abnormal retinal and cochlear ganglions, and they have age-related defects in hearing, vasculature, and muscle. These mice may be useful in studying retinal dysfunction, autoimmunity, female reproductive development/function, glaucoma, hearing loss, Alzheimer's Disease, familial amyotrophic lateral sclerosis (ALS), and other age-related disorders.
Read More +Genetic Background | Generation |
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Allele Type | Gene Symbol | Gene Name |
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Targeted (Null/Knockout) | Sod1 | superoxide dismutase 1, soluble |
The Sod1tm1Leb (formerly SOD1m1BCM) knock-out allele disrupts exons 1 and 2 of the Cu,Zn-superoxide dismutase-1 gene (Sod1). This knock-out allele is the same as carried by B6;129S-Sod1tm1Leb/J (Stock No. 002972) but is fully congenic in the present strain having been backcrossed to C57BL/6JEi for 13 generations. In the original strain no protein expression from the targeted locus is detected in brain tissues. Heterozygous mice are viable and fertile. While homozygous males reproduce normally, homozygous females are infertile. Homozygous mice have abnormalities of the retinal ganglion, cochlear ganglion, and female reproductive development/function. Homozygous mice also exhibit age-related deafness, accelerated vascular aging and age-related skeletal muscle defects. These mutant mice may be useful in studying retinal dysfunction, autoimmunity, glaucoma, hearing loss, Alzheimer's Disease, familial amyotrophic lateral sclerosis (ALS), and other age-related disorders.
This strain was generated in the Laboratory of Muriel Davisson by backcrossing the Sod1tm1Leb mutation from the segregating B6;129S7 background onto the C57BL/6JEi strain for 13 generations. The backcrossing was begun in 1998. In 2004 embryos were generated for cryopreservation via in vitro fertilization using C57BL/6J females and heterozygous males at generation N13.
Allele Name | targeted mutation 1, Russell M Lebovitz |
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Allele Type | Targeted (Null/Knockout) |
Allele Synonym(s) | Cu,Zn-SOD-; CuZnSOD-; SOD1-; SOD1m1BCM |
Gene Symbol and Name | Sod1, superoxide dismutase 1, soluble |
Gene Synonym(s) | |
Strain of Origin | 129S7/SvEvBrd-Hprtb-m2 |
Chromosome | 16 |
Molecular Note | Replacement of exons 1 and 2 with a PGK-hprt expression cassette. Protein was not detected in brain of homozygous mutant mice. |
Mutations Made By | Dr. Russell Lebovitz, SUMA Partners |
When using the Sod1 KO mouse strain in a publication, please cite the originating article(s) and include JAX stock #003881 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Heterozygous or wildtype for Sod1<tm1Leb> |
Frozen Mouse Embryo | B6.129S7-Sod1<tm1Leb>/DnJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.129S7-Sod1<tm1Leb>/DnJ Frozen Embryos | $2595.00 |
Frozen Mouse Embryo | B6.129S7-Sod1<tm1Leb>/DnJ Frozen Embryos | $3373.50 |
Frozen Mouse Embryo | B6.129S7-Sod1<tm1Leb>/DnJ Frozen Embryos | $3373.50 |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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