This strain carries the brachyury allele (Tand the spontaneous Itpr3tf mutation, derived from the now extinct TF/Le strain, and is characterized by tail defects, hair loss and regrowth.
Genetic Background | Generation |
---|---|
|
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | a | nonagouti |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | T | brachyury, T-box transcription factor T |
Allele Type | Gene Symbol | Gene Name |
---|---|---|
Spontaneous | Itpr3 | inositol 1,4,5-triphosphate receptor 3 |
This strain carries the brachyury allele (Tand the spontaneous Itpr3tf mutation, derived from the now extinct TF/Le strain, and is characterized by tail defects, hair loss and regrowth.
Allele Name | nonagouti |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | |
Gene Symbol and Name | a, nonagouti |
Gene Synonym(s) | |
Strain of Origin | old mutant of the mouse fancy |
Chromosome | 2 |
General Note | Insertion of the LV30 retrotransposon without the beta4 retrovirus sequence does not cause the nonagouti phenotype. J:278039 |
Molecular Note | Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats (beta4 retroviral sequence). The host integration site is the same as for at-2Gso and Aw-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. |
Allele Name | brachyury |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | T1 |
Gene Symbol and Name | T, brachyury, T-box transcription factor T |
Gene Synonym(s) | |
Strain of Origin | Laboratory stock |
Chromosome | 17 |
Molecular Note | Pulsed-field gel electrophoresis revealed an altered restriction fragment size consistent with a deletion of 160-200kb. |
Allele Name | tufted |
---|---|
Allele Type | Spontaneous |
Allele Synonym(s) | tf |
Gene Symbol and Name | Itpr3, inositol 1,4,5-triphosphate receptor 3 |
Gene Synonym(s) | |
Strain of Origin | BTBR |
Chromosome | 17 |
General Note | This allele was recovered from a Harwell testing stock carrying multiple recessive markers in an undefined background. (J:273) |
Molecular Note | Complementation mapping was used to demonstrate that this spontaneous mutation was an allele of Itpr3. Sequencing revealed a 12 bp deletion in Exon23 (Chr17: 27238069, Build 38.1) which codes for amino acids 983-986. This mutation arose early in the history of the BTBR strain (in or soon after 1956) and is not found in 18 other strains (129P2/OlaHsd, 129S1/SvImJ, 129S5/SvEvBrd, A/J, AKR/J, BALB/cJ, C3H/HeJ, C57BL/6NJ, CAST/EiJ, CBA/J, DBA/2J, FVB/NJ, LP/J, NOD/ShiLtJ, NZO/HlLtJ, PWK/PhJ, SPRET/EiJ and WSB/EiJ) |
When using the B10;TFLe-a/a T Itpr3tf/+ Itpr3tf/J mouse strain in a publication, please cite the originating article(s) and include JAX stock #003879 in your Materials and Methods section.
Facility Barrier Level Descriptions
Service/Product | Description | Price |
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Homozygous for tf, Heterozygous or Wild-type for T |
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The Jackson Laboratory has rigorous genetic quality control and mutant gene genotyping programs to ensure the genetic background of JAX® Mice strains as well as the genotypes of strains with identified molecular mutations. JAX® Mice strains are only made available to researchers after meeting our standards. However, the phenotype of each strain may not be fully characterized and/or captured in the strain data sheets. Therefore, we cannot guarantee a strain's phenotype will meet all expectations. To ensure that JAX® Mice will meet the needs of individual research projects or when requesting a strain that is new to your research, we suggest ordering and performing tests on a small number of mice to determine suitability for your particular project. We do not guarantee breeding performance and therefore suggest that investigators order more than one breeding pair to avoid delays in their research.
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