NOD.B6(PL)-(D3Mit93-D3Mit124)/Lt

Stock number: 003853

Allele

Symbol: Idd3^C57BL/6
Name: C57BL/6
MGI accession ID: MGI:2389019
Generation method: QTL
Marker symbol: Idd3
Marker name: insulin dependent diabetes susceptibility 3
Chromosome: 3
Strain of origin: C57BL/6
Molecular note: This allele confers resistance to insulin dependent diabetes compared to NOD.
General note: Idd3 and Idd5 appear to interact additively. C57BL/6-derived alleles at Idd3 in combination with C57BL/10-derived alleles at Idd5 partially reverses autoimmune exocrinopathy markers on an NOD genetic background.

Idd10 and Idd3 interact to promote disease resistance. Homozygosity for C57BL/6-derived alleles at both Idd10 and Idd3 confers significantly increased resistance to type 1 diabetes.

Il2 is a proposed candidate gene for Idd3. The electrophoretic mobility pattern of IL-2 correlates with type 1 diabetes incidence. Resistant strain C57BL/6J displays a heterogenous IL-2 mobility pattern with major protein species ranging from 17-19 kDa while susceptible strains 129 and NOD display a homogenous IL-2 mobility pattern with one major protein species at approximately 21-22 kDa.

Allele

Symbol: Idd10^C57BL/6J
Name: C57BL/6J
MGI accession ID: MGI:3038835
Generation method: QTL
Marker symbol: Idd10
Marker name: insulin dependent diabetes susceptibility 10
Chromosome: 3
Strain of origin: C57BL/6J
Molecular note: This allele confers resistance to insulin dependent diabetes compared to NOD.
General note: Idd10 and Idd18 interact to promote disease resistance. Homozygosity for C57BL/6-derived alleles at both Idd10 and Idd18 confers significantly increased resistance to type 1 diabetes.

Idd10 and Idd17 interact to promote disease resistance. Homozygosity for C57BL/6-derived alleles at both Idd10 and Idd17 confers significantly increased resistance to type 1 diabetes.

Idd10 and Idd3 interact to promote disease resistance. Homozygosity for C57BL/6-derived alleles at both Idd10 and Idd3 confers significantly increased resistance to type 1 diabetes.

Allele

MGI accession ID: MGI:92566
Marker symbol: D3Mit93
Marker name: DNA segment, Chr 3, Massachusetts Institute of Technology 93
Chromosome: 3

Allele

MGI accession ID: MGI:92391
Marker symbol: D3Mit124
Marker name: DNA segment, Chr 3, Massachusetts Institute of Technology 124
Chromosome: 3