Jackson cataract homozygotes have normal lenses at two weeks of age but develop cataracts in both eyes by two months of age. This mutation has been mapped to Chromosome 2, but the underlying mutation remains to be defined.
Read More +Genetic Background | Generation |
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000664 C57BL/6J |
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Allele Type | Gene Symbol | Gene Name |
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Spontaneous | jcat | Jackson cataract |
This recessive phenotypic marker arose spontaneously in the NOD/ShiLtJ inbred background. Homozygotes have normal lenses at two weeks of age but cataracts in both eyes by two months of age. Suture lines are visible and the lens fibers show, but no vacuolization has been found. ERG readings are normal both before and after cataract development. This mutation has been mapped to Chromosome 2, but the underlying mutation remains to be defined.
This mutation was identified in a NOD/ShiLtJ mouse and was backcrossed onto C57BL/6J. Sperm was cryopreserved from homozygous males. at generation N6F10
When using the Jackson cataract mouse strain in a publication, please cite the originating article(s) and include JAX stock #003839 in your Materials and Methods section.
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Heterozygous |
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