JAX
Mouse Strain Datasheet - 003802
B6.Cg-Tg(Lck-cre)548Jxm/J
This transgenic strain expresses Cre under the control of the Lck (lymphocyte protein tyrosine kinase) promoter, enabling thymocyte-specific excision of loxP-flanked sequences of interest. The Lck gene is primarily expressed by T lymphocytes and it plays a key role in the selection and maturation of developing T-cells in the thymus and in the activity of mature T-cells.
Donating Investigator
Jamey D Marth, Burnham Inst at Univ Calif Santa Barbara
Genetic overview
| Genetic Background | Generation |
|---|---|
|
N4+6N2F6
|
Tg(Lck-cre)548Jxm
| Allele Type |
|---|
| Transgenic (Recombinase-expressing) |
Detailed Description
This transgenic strain expresses Cre under the control of the Lck (lymphocyte protein tyrosine kinase) promoter, enabling thymocyte-specific excision of loxP-flanked sequences of interest. Homozygous mice are viable and have no major defects.
When crossed with floxed Galnt13 mice (see Stock No. 006896), excision occurs at high efficiency in thymocytes. Splenic CD4+ T cells show excision at somewhat lower rates (66-83%).
The Lck gene is primarily expressed by T lymphocytes where it phosphorylates tyrosine residues of proteins involved with intracellular signaling pathways. Associating with CD4 and CD8, LCK is part of a cascade of responses to antigen that control the proliferation and activation of T cells. It plays a key role in the selection and maturation of developing T-cells in the thymus and in the activity of mature T-cells.
View cre expression characterization.
Development
A transgenic construct containing a Cre recombinase gene under the control of the Lck promoter was used to create this mutation. The construct was injected either into B6D2F1 or B6CBAF2 zygotes to obtain founder animals.
Expression Data
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
|---|---|
| Site of Expression | thymocytes |
Control Suggestions
Selected References
- Hennet T; Hagen FK; Tabak LA; Marth JD. 1995. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A 92(26):12070-4. PubMed: 8618846MGI: J:67674
Tg(Lck-cre)548Jxm
Allele Symbol: Tg(Lck-cre)548Jxm
| Allele Name | transgene insertion 548, Jamey Marth |
|---|---|
| Allele Type | Transgenic (Recombinase-expressing) |
| Allele Synonym(s) | Lck-cre; Tg(Lck-cre); TgN(Lck-cre)548Jxm; pLck-cre |
| Gene Symbol and Name | Tg(Lck-cre)548Jxm, transgene insertion 548, Jamey Marth |
| Gene Synonym(s) | Lck-cre; Tg(Lck-cre); TgN(Lck-cre)548Jxm |
| Promoter | Lck, lymphocyte protein tyrosine kinase, mouse, laboratory |
| Expressed Gene | cre, cre recombinase, bacteriophage P1 |
| Site of Expression | thymocytes |
| Strain of Origin | (C57BL/6 x CBA)F2 |
| Chromosome | UN |
| General Note | Homozygous transgenic mice are viable and have no major defects. |
| Molecular Note | This transgene expresses Cre recombinase under the control of the mouse lck promoter, active in the T cell lineage. |
| Mutations Made By | Jamey Marth, Burnham Inst at Univ Calif Santa Barbara |
Disease Terms
Research Areas By Genotype
This mouse can be used to support research in many areas including:
- Research Tools
- Cre-lox System
- Cre Recombinase Expression
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
- Cre-lox System
Genotype: cre related
- Research Tools
- Cre-lox System
- Genetics Research
- Mutagenesis and Transgenesis
- Mutagenesis and Transgenesis: Cre-lox System
References
- Hennet T; Hagen FK; Tabak LA; Marth JD. 1995. T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination. Proc Natl Acad Sci U S A 92(26):12070-4. PubMed: 8618846MGI: J:67674
Additional References
- Garvin AM; Pawar S; Marth JD; Perlmutter RM. 1988. Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line. Mol Cell Biol 8(8):3058-64. PubMed: 2850479MGI: J:9539
- McPherson JP; Lemmers B; Hirao A; Hakem A; Abraham J; Migon E; Matysiak-Zablocki E; Tamblyn L; Sanchez-Sweatman O; Khokha R; Squire J; Hande MP; Mak TW; Hakem R. 2004. Collaboration of Brca1 and Chk2 in tumorigenesis. Genes Dev 18(10):1144-53. PubMed: 15131084MGI: J:90512
- Orban PC; Chui D; Marth JD. 1992. Tissue- and site-specific DNA recombination in transgenic mice. Proc Natl Acad Sci U S A 89(15):6861-5. PubMed: 1495975MGI: J:75414
- Salmena L; Lemmers B; Hakem A; Matysiak-Zablocki E; Murakami K; Au PY; Berry DM; Tamblyn L; Shehabeldin A; Migon E; Wakeham A; Bouchard D; Yeh WC; McGlade JC; Ohashi PS; Hakem R. 2003. Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. Genes Dev 17(7):883-95. PubMed: 12654726MGI: J:82759
Additional - Tg(Lck-cre)548Jxm related
- Azhar M; Yin M; Bommireddy R; Duffy JJ; Yang J; Pawlowski SA; Boivin GP; Engle SJ; Sanford LP; Grisham C; Singh RR; Babcock GF; Doetschman T. 2009. Generation of mice with a conditional allele for transforming growth factor beta 1 gene. Genesis 47(6):423-31. PubMed: 19415629MGI: J:150024
- Bender TP; Kremer CS; Kraus M; Buch T; Rajewsky K. 2004. Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol 5(7):721-9. PubMed: 15195090MGI: J:91122
- Brewer JA; Khor B; Vogt SK; Muglia LM; Fujiwara H; Haegele KE; Sleckman BP; Muglia LJ. 2003. T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation. Nat Med 9(10):1318-22. PubMed: 12949501MGI: J:97484
- Burger ML; Xue L; Sun Y; Kang C; Winoto A. 2014. Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation. Blood 123(26):4089-100. PubMed: 24735967MGI: J:213748
- Carey KT; Tan KH; Ng J; Liddicoat DR; Godfrey DI; Cole TJ. 2013. Nfil3 is a glucocorticoid-regulated gene required for glucocorticoid-induced apoptosis in male murine T cells. Endocrinology 154(4):1540-52. PubMed: 23425966MGI: J:196698
- Case AJ; McGill JL; Tygrett LT; Shirasawa T; Spitz DR; Waldschmidt TJ; Legge KL; Domann FE. 2011. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radic Biol Med 50(3):448-58. PubMed: 21130157MGI: J:168481
- Chang X; Liu F; Wang X; Lin A; Zhao H; Su B. 2011. The Kinases MEKK2 and MEKK3 Regulate Transforming Growth Factor-beta-Mediated Helper T Cell Differentiation. Immunity 34(2):201-12. PubMed: 21333552MGI: J:168978
- Cheng HY; Gaddis DE; Wu R; McSkimming C; Haynes LD; Taylor AM; McNamara CA; Sorci-Thomas M; Hedrick CC. 2016. Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. J Clin Invest 126(9):3236-46. PubMed: 27482882MGI: J:237255
- Cheng Y; Zhang Z; Slape C; Aplan PD. 2007. Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition. Neoplasia 9(4):315-21. PubMed: 17460775MGI: J:123860
- Cheung AM; Hande MP; Jalali F; Tsao MS; Skinnider B; Hirao A; McPherson JP; Karaskova J; Suzuki A; Wakeham A; You-Ten A; Elia A; Squire J; Bristow R; Hakem R; Mak TW. 2002. Loss of Brca2 and p53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis. Cancer Res 62(21):6194-204. PubMed: 12414647MGI: J:79697
- Choi YI; Duke-Cohan JS; Chen W; Liu B; Rossy J; Tabarin T; Ju L; Gui J; Gaus K; Zhu C; Reinherz EL. 2014. Dynamic control of beta1 integrin adhesion by the plexinD1-sema3E axis. Proc Natl Acad Sci U S A 111(1):379-84. PubMed: 24344262MGI: J:206292
- Choi YI; Duke-Cohan JS; Tan J; Gui J; Singh MK; Epstein JA; Reinherz EL. 2013. Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology. Front Immunol 4:392. PubMed: 24312099MGI: J:206838
- Cully M; Elia A; Ong SH; Stambolic V; Pawson T; Tsao MS; Mak TW. 2004. grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten+/- mice. Proc Natl Acad Sci U S A 101(43):15358-63. PubMed: 15492213MGI: J:93530
- Davila SJ; Olive AJ; Starnbach MN. 2014. Integrin alpha4beta1 is necessary for CD4+ T cell-mediated protection against genital Chlamydia trachomatis infection. J Immunol 192(9):4284-93. PubMed: 24659687MGI: J:209989
- Delfino DV; Spinicelli S; Pozzesi N; Pierangeli S; Velardi E; Bruscoli S; Martelli MP; Pettirossi V; Falchi L; Kang TB; Riccardi C. 2011. Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes. Cell Death Differ 18(1):183-90. PubMed: 20671745MGI: J:186338
- Dougan SK; Rava P; Hussain MM; Blumberg RS. 2007. MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med 204(3):533-45. PubMed: 17312007MGI: J:125365
- Dufner A; Kisser A; Niendorf S; Basters A; Reissig S; Schonle A; Aichem A; Kurz T; Schlosser A; Yablonski D; Groettrup M; Buch T; Waisman A; Schamel WW; Prinz M; Knobeloch KP. 2015. The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells. Nat Immunol 16(9):950-60. PubMed: 26214742MGI: J:233111
- Dzhagalov I; Dunkle A; He YW. 2008. The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages. J Immunol 181(1):521-8. PubMed: 18566418MGI: J:137400
- Eddahri F; Denanglaire S; Bureau F; Spolski R; Leonard WJ; Leo O; Andris F. 2009. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 113(11):2426-33. PubMed: 19020307MGI: J:146334
- Elftman MD; Hunzeker JT; Mellinger JC; Bonneau RH; Norbury CC; Truckenmiller ME. 2010. Stress-induced glucocorticoids at the earliest stages of herpes simplex virus-1 infection suppress subsequent antiviral immunity, implicating impaired dendritic cell function. J Immunol 184(4):1867-75. PubMed: 20089700MGI: J:159473
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- Fukuyama T; Kasper LH; Boussouar F; Jeevan T; van Deursen J; Brindle PK. 2009. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol 29(14):3894-904. PubMed: 19433445MGI: J:150146
- Gaudreau MC; Heyd F; Bastien R; Wilhelm B; Moroy T. 2012. Alternative splicing controlled by heterogeneous nuclear ribonucleoprotein L regulates development, proliferation, and migration of thymic pre-T cells. J Immunol 188(11):5377-88. PubMed: 22523384MGI: J:188749
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- Gebuhr TC; Kovalev GI; Bultman S; Godfrey V; Su L; Magnuson T. 2003. The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell development. J Exp Med 198(12):1937-49. PubMed: 14676303MGI: J:87219
- Genetic Resource Science at The Jackson Laboratory. 2012. Expression/Specificity Patterns of Cre Alleles, 2011 Direct Data Submission from Genetic Resource Science :. MGI: J:184578
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- He MX; He YW. 2013. A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. Cell Death Differ 20(2):188-97. PubMed: 23175183MGI: J:205617
- Herroeder S; Reichardt P; Sassmann A; Zimmermann B; Jaeneke D; Hoeckner J; Hollmann MW; Fischer KD; Vogt S; Grosse R; Hogg N; Gunzer M; Offermanns S; Wettschureck N. 2009. Guanine nucleotide-binding proteins of the G12 family shape immune functions by controlling CD4+ T cell adhesiveness and motility. Immunity 30(5):708-20. PubMed: 19409815MGI: J:149560
- Hock H; Meade E; Medeiros S; Schindler JW; Valk PJ; Fujiwara Y; Orkin SH. 2004. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev 18(19):2336-41. PubMed: 15371326MGI: J:93052
- Huang X; Ren L; Ye P; Cheng C; Wu J; Wang S; Sun Y; Liu Z; Xie A; Xia J. 2014. Peroxisome proliferator-activated receptor gamma deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages. PLoS One 9(11):e112953. PubMed: 25383620MGI: J:225311
- Jia W; He YW. 2011. Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy. J Immunol 186(9):5313-22. PubMed: 21421856MGI: J:172749
- Jia W; Pua HH; Li QJ; He YW. 2011. Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. J Immunol 186(3):1564-74. PubMed: 21191072MGI: J:168905
- Jin J; Desai BN; Navarro B; Donovan A; Andrews NC; Clapham DE. 2008. Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science 322(5902):756-60. PubMed: 18974357MGI: J:140630
- Kasper LH; Fukuyama T; Biesen MA; Boussouar F; Tong C; de Pauw A; Murray PJ; van Deursen JM; Brindle PK. 2006. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol 26(3):789-809. PubMed: 16428436MGI: J:105505
- Kasper LH; Fukuyama T; Brindle PK. 2014. T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs. PLoS One 9(7):e102076. PubMed: 25054639MGI: J:217860
- Khandanpour C; Phelan JD; Vassen L; Schutte J; Chen R; Horman SR; Gaudreau MC; Krongold J; Zhu J; Paul WE; Duhrsen U; Gottgens B; Grimes HL; Moroy T. 2013. Growth factor independence 1 antagonizes a p53-induced DNA damage response pathway in lymphoblastic leukemia. Cancer Cell 23(2):200-14. PubMed: 23410974MGI: J:194309
- King CG; Kobayashi T; Cejas PJ; Kim T; Yoon K; Kim GK; Chiffoleau E; Hickman SP; Walsh PT; Turka LA; Choi Y. 2006. TRAF6 is a T cell-intrinsic negative regulator required for the maintenance of immune homeostasis. Nat Med 12(9):1088-92. PubMed: 16921377MGI: J:131909
- Kirkland D; Benson A; Mirpuri J; Pifer R; Hou B; Defranco AL; Yarovinsky F. 2012. B Cell-Intrinsic MyD88 Signaling Prevents the Lethal Dissemination of Commensal Bacteria during Colonic Damage. Immunity 36(2):228-38. PubMed: 22306056MGI: J:181331
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- Konkel JE; Maruyama T; Carpenter AC; Xiong Y; Zamarron BF; Hall BE; Kulkarni AB; Zhang P; Bosselut R; Chen W. 2011. Control of the development of CD8alphaalpha(+) intestinal intraepithelial lymphocytes by TGF-beta. Nat Immunol 12(4):312-9. PubMed: 21297643MGI: J:170346
- Kosaka A; Ohkuri T; Ikeura M; Kohanbash G; Okada H. 2015. Transgene-derived overexpression of miR-17-92 in CD8+ T-cells confers enhanced cytotoxic activity. Biochem Biophys Res Commun 458(3):549-54. PubMed: 25677619MGI: J:220491
- Krajewska M; You Z; Rong J; Kress C; Huang X; Yang J; Kyoda T; Leyva R; Banares S; Hu Y; Sze CH; Whalen MJ; Salmena L; Hakem R; Head BP; Reed JC; Krajewski S. 2011. Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity. PLoS One 6(9):e24341. PubMed: 21957448MGI: J:177668
- Kugler DG; Mittelstadt PR; Ashwell JD; Sher A; Jankovic D. 2013. CD4+ T cells are trigger and target of the glucocorticoid response that prevents lethal immunopathology in toxoplasma infection. J Exp Med 210(10):1919-27. PubMed: 23980098MGI: J:202852
- Lassen LB; Fuchtbauer A; Schmitz A; Sorensen AB; Pedersen FS; Fuchtbauer EM. 2013. Septin9 is involved in T-cell development and CD8+ T-cell homeostasis. Cell Tissue Res 352(3):695-705. PubMed: 23644740MGI: J:205027
- Lieu YK; Kumar A; Pajerowski AG; Rogers TJ; Reddy EP. 2004. Requirement of c-myb in T cell development and in mature T cell function. Proc Natl Acad Sci U S A 101(41):14853-8. PubMed: 15466706MGI: J:93481
- Liu HH; Xie M; Schneider MD; Chen ZJ. 2006. Essential role of TAK1 in thymocyte development and activation. Proc Natl Acad Sci U S A 103(31):11677-82. PubMed: 16857737MGI: J:111794
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- Luche H; Nageswara Rao T; Kumar S; Tasdogan A; Beckel F; Blum C; Martins VC; Rodewald HR; Fehling HJ. 2013. In vivo fate mapping identifies pre-TCRalpha expression as an intra- and extrathymic, but not prethymic, marker of T lymphopoiesis. J Exp Med 210(4):699-714. PubMed: 23509324MGI: J:197923
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- Mak TW; Hakem A; McPherson JP; Shehabeldin A; Zablocki E; Migon E; Duncan GS; Bouchard D; Wakeham A; Cheung A; Karaskova J; Sarosi I; Squire J; Marth J; Hakem R. 2000. Brcal required for T cell lineage development but not TCR loci rearrangement. Nat Immunol 1(1):77-82. PubMed: 10881179MGI: J:63282
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- Maresz K; Pryce G; Ponomarev ED; Marsicano G; Croxford JL; Shriver LP; Ledent C; Cheng X; Carrier EJ; Mann MK; Giovannoni G; Pertwee RG; Yamamura T; Buckley NE; Hillard CJ; Lutz B; Baker D; Dittel BN. 2007. Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells. Nat Med 13(4):492-7. PubMed: 17401376MGI: J:129619
- Masson F; Ghisi M; Groom JR; Kallies A; Seillet C; Johnstone RW; Nutt SL; Belz GT. 2014. Id2 represses E2A-mediated activation of IL-10 expression in T cells. Blood 123(22):3420-8. PubMed: 24723679MGI: J:213132
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- McPherson JP; Lemmers B; Hirao A; Hakem A; Abraham J; Migon E; Matysiak-Zablocki E; Tamblyn L; Sanchez-Sweatman O; Khokha R; Squire J; Hande MP; Mak TW; Hakem R. 2004. Collaboration of Brca1 and Chk2 in tumorigenesis. Genes Dev 18(10):1144-53. PubMed: 15131084MGI: J:90512
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- Mittelstadt PR; Monteiro JP; Ashwell JD. 2012. Thymocyte responsiveness to endogenous glucocorticoids is required for immunological fitness. J Clin Invest 122(7):2384-94. PubMed: 22653054MGI: J:189951
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